{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T15:26:27Z","timestamp":1785252387242,"version":"3.55.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T00:00:00Z","timestamp":1677196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> Recurrent implantation failure (RIF) is now disturbing numerous infertile couples accepting assisted reproductive technology (ART). And the endometrial factors are crucial causes of recurrent implantation failure. However, its mechanism is still unclear. Thus, the aim of this study is to identify altered biologic processes in endometrium that may contribute to recurrent implantation failure.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We recruited two microarray datasets (GSE103465, GSE111974) from Gene Expression Omnibus database (GEO), which contain endometrium from RIF and normal women during implantation period. Using the online tools GEO2R and Venny, we identified Differentially Expressed Genes (DEGs) of selected datasets, and obtained common DEGs. Gene Ontology (GO) terms, Kyoto Encyclopedia of Genes and Genomes (KEGG) and BioCatar pathway enrichment were conducted with Enrichr platform, \u201cssgsea\u201d and \u201cggplot2\u201d package of RStudio. PPI networks and hub gene related TF-gene interaction and TF-miRNA co-regulation networks were built <jats:italic>via<\/jats:italic> online tools STRING and NetworkAnalyst. Immune infiltration analysis was performed by CIBERSORT platform. Recurrent implantation failure subgroup identification was achieved through \u201cConsensusClusterPlus,\u201d \u201ctsne,\u201d \u201cssgsea\u201d, and \u201cggpubr\u201d package in RStudio. Diagnostic characteristic ROC curves were constructed <jats:italic>via<\/jats:italic> \u201cpROC\u201d and \u201cggplot2\u201d package of RStudio. Enrichr platform was utilized to find drugs targeting hub genes.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> 26 common DEGs were confirmed. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes\/BioCarta analysis determined common DEGs were mainly enriched in inflammation associated pathways including TNF, NF-\u03baB, IL-4, IL-10, IL-6, and TGF-\u03b2 signaling pathways. Five hub genes (<jats:italic>PTGS2<\/jats:italic>, <jats:italic>VCAM1<\/jats:italic>, <jats:italic>EDNRB<\/jats:italic>, <jats:italic>ACTA2<\/jats:italic>, and <jats:italic>LIF<\/jats:italic>) and related TF-gene and TF-miRNA interactions were identified. Immune infiltration analysis indicated the importance of macrophage M2 in recurrent implantation failure patients. Importantly, subgroup identification analysis highlighted that recurrent implantation failure patients can be divided into two subgroups with different phenotypes. Moreover, the ROC curves and drugs may provide new diagnostic and therapeutic thought for recurrent implantation failure.<\/jats:p>","DOI":"10.3389\/fgene.2023.1108805","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T06:09:52Z","timestamp":1677218992000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Gene profiling reveals the role of inflammation, abnormal uterine muscle contraction and vascularity in recurrent implantation failure"],"prefix":"10.3389","volume":"14","author":[{"given":"Xinyi","family":"Dong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1111\/jcmm.16586","article-title":"Construction of circRNA-miRNA-mRNA network in the pathogenesis of recurrent implantation failure using integrated bioinformatics study","volume":"26","author":"Ahmadi","year":"2022","journal-title":"J. Cell Mol. Med."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/j.fertnstert.2018.08.043","article-title":"Simvastatin and uterine fibroids: Opportunity for a novel therapeutic option","volume":"110","author":"Ali","year":"2018","journal-title":"Fertil. Steril."},{"key":"B3","doi-asserted-by":"publisher","first-page":"bqab025","DOI":"10.1210\/endocr\/bqab025","article-title":"Prostaglandin-endoperoxide synthase 2 (PTGS2) in the oviduct: Roles in fertilization and early embryo development","volume":"162","author":"Anamthathmakula","year":"2021","journal-title":"Endocrinology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: Tool for the unification of biology. The gene ontology consortium","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1530\/rep-13-0655","article-title":"Involvement of VCAM1 in the bovine conceptus adhesion to the uterine endometrium","volume":"148","author":"Bai","year":"2014","journal-title":"Reproduction"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3493","DOI":"10.1210\/jc.2011-0501","article-title":"Effects of simvastatin and metformin on polycystic ovary syndrome after six months of treatment","volume":"96","author":"Banaszewska","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B7","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12958-018-0414-2","article-title":"Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions","volume":"16","author":"Bashiri","year":"2018","journal-title":"Reprod. Biol. Endocrinol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1177\/1933719118792104","article-title":"Potential marker pathways in the endometrium that may cause recurrent implantation failure","volume":"26","author":"Bastu","year":"2019","journal-title":"Reprod. Sci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1097\/gco.0000000000000468","article-title":"Implantation failure of endometrial origin: What is new?","volume":"30","author":"Bellver","year":"2018","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1016\/j.fertnstert.2008.06.047","article-title":"Recombinant human leukemia inhibitory factor does not improve implantation and pregnancy outcomes after assisted reproductive techniques in women with recurrent unexplained implantation failure","volume":"91","author":"Brinsden","year":"2009","journal-title":"Fertil. Steril."},{"key":"B11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.rbmo.2019.10.014","article-title":"How common is real repeated implantation failure? An indirect estimate of the prevalence","volume":"40","author":"Busnelli","year":"2020","journal-title":"Reprod. Biomed. Online"},{"key":"B12","doi-asserted-by":"publisher","first-page":"5477","DOI":"10.2147\/cmar.S310346","article-title":"Dissecting prognosis modules and biomarkers in glioblastoma based on weighted gene Co-expression network analysis","volume":"13","author":"Cao","year":"","journal-title":"Cancer Manag. Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2486","DOI":"10.1007\/s10753-021-01518-8","article-title":"Network-based integrated analysis of transcriptomic studies in dissecting gene Signatures for LPS-induced acute lung injury","volume":"44","author":"Cao","year":"","journal-title":"Inflammation"},{"key":"B14","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3389\/fimmu.2014.00253","article-title":"Regulation of the anti-inflammatory cytokines interleukin-4 and interleukin-10 during pregnancy","volume":"5","author":"Chatterjee","year":"2014","journal-title":"Front. Immunol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"54.e1","DOI":"10.1016\/j.ajog.2007.02.010","article-title":"Arrest of preterm labor in rat and mouse by an oral and selective nonprostanoid antagonist of the prostaglandin F2alpha receptor (FP)","volume":"197","author":"Cirillo","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1186\/s12881-017-0505-5","article-title":"ACTA2 mutation and postpartum hemorrhage: A case report","volume":"18","author":"Cooper","year":"2017","journal-title":"BMC Med. Genet."},{"key":"B17","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/cmi.2014.50","article-title":"The activating effect of IFN-\u03b3 on monocytes\/macrophages is regulated by the LIF-trophoblast-IL-10 axis via Stat1 inhibition and Stat3 activation","volume":"12","author":"Dallagi","year":"2015","journal-title":"Cell Mol. Immunol."},{"key":"B18","volume-title":"Tsne: T-distributed stochastic neighbor embedding for R (t-SNE)","author":"Donaldson","year":"2022"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-022-01060-4","article-title":"Bioinformatics analysis identifies key genes in recurrent implantation failure based on immune infiltration","author":"Duan","year":"2022","journal-title":"Reprod. Sci"},{"key":"B20","first-page":"5037","article-title":"Disturbed endometrial NF-\u03baB expression in women with recurrent implantation failure","volume":"20","author":"Ersahin","year":"2016","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1968","DOI":"10.1093\/humrep\/13.7.1968","article-title":"Uterine contractions at the time of embryo transfer alter pregnancy rates after in-vitro fertilization","volume":"13","author":"Fanchin","year":"1998","journal-title":"Hum. Reprod."},{"key":"B22","doi-asserted-by":"publisher","first-page":"d12","DOI":"10.2741\/a171","article-title":"Cytokines in acute and chronic inflammation","volume":"2","author":"Feghali","year":"1997","journal-title":"Front. Biosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/stem.170127","article-title":"Leukemia inhibitory factor, interleukin 6, and other cytokines using the GP130 transducing receptor: Roles in inflammation and injury","volume":"17","author":"Gadient","year":"1999","journal-title":"Stem Cells"},{"key":"B24","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.ijbiomac.2021.08.054","article-title":"Brilliant glycans and glycosylation: Seq and ye shall find","volume":"189","author":"Gao","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1262\/jrd.2016-165","article-title":"Cellular localization, expression and functional implications of the utero-placental endothelin system during maintenance and termination of canine gestation","volume":"63","author":"Gram","year":"2017","journal-title":"J. Reprod. Dev."},{"key":"B26","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1095\/biolreprod.114.122929","article-title":"Canine placental prostaglandin E2 synthase: Expression, localization, and biological functions in providing substrates for prepartum PGF2alpha synthesis","volume":"91","author":"Gram","year":"2014","journal-title":"Biol. Reprod."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2847","DOI":"10.1093\/bioinformatics\/btw313","article-title":"Complex heatmaps reveal patterns and correlations in multidimensional genomic data","volume":"32","author":"Gu","year":"2016","journal-title":"Bioinformatics"},{"key":"B28","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1093\/humrep\/dey022","article-title":"Decreased PECAM1-mediated TGF-\u03b21 expression in the mid-secretory endometrium in women with recurrent implantation failure","volume":"33","author":"Guo","year":"2018","journal-title":"Hum. Reprod."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/gad.9.1.1","article-title":"Targeted disruption of the murine VCAM1 gene: Essential role of VCAM-1 in chorioallantoic fusion and placentation","volume":"9","author":"Gurtner","year":"1995","journal-title":"Genes Dev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"Gsva: Gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinforma."},{"key":"B31","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3892\/ijmm.2021.5018","article-title":"HO-1 knockdown upregulates the expression of VCAM-1 to induce neutrophil recruitment during renal ischemia-reperfusion injury","volume":"48","author":"He","year":"2021","journal-title":"Int. J. Mol. Med."},{"key":"B32","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1093\/humupd\/dmv016","article-title":"Infertility around the globe: New thinking on gender, reproductive technologies and global movements in the 21st century","volume":"21","author":"Inhorn","year":"2015","journal-title":"Hum. Reprod. Update"},{"key":"B33","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"Kegg: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"B34","volume-title":"ggpubr: 'ggplot2","author":"Kassambara","year":"2020"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1093\/humrep\/der115","article-title":"Estrogen and progesterone regulate expression of the endothelins in the rhesus macaque endometrium","volume":"26","author":"Keator","year":"2011","journal-title":"Hum. Reprod."},{"key":"B36","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1530\/rep.1.00304","article-title":"Leukaemia inhibitory factor in implantation and uterine biology","volume":"130","author":"Kimber","year":"2005","journal-title":"Reproduction"},{"key":"B37","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/s1472-6483(10)60174-5","article-title":"Endometrial mRNA expression of matrix metalloproteinases, their tissue inhibitors and cell adhesion molecules in unexplained infertility and implantation failure patients","volume":"19","author":"Konac","year":"2009","journal-title":"Reprod. Biomed. Online"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.3390\/ijms19041057","article-title":"Emerging roles of vascular cell adhesion molecule-1 (VCAM-1) in immunological disorders and cancer","volume":"19","author":"Kong","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1530\/rep-09-0140","article-title":"Canine placenta: A source of prepartal prostaglandins during normal and antiprogestin-induced parturition","volume":"139","author":"Kowalewski","year":"2010","journal-title":"Reproduction"},{"key":"B40","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1262\/jrd.20171","article-title":"Spontaneous endometrial hyperplasia in the uteri of IL-2 receptor beta-chain transgenic mice","volume":"55","author":"Kusakabe","year":"2009","journal-title":"J. Reprod. Dev."},{"key":"B41","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/path.2948","article-title":"Specific and extensive endometrial deregulation is present before conception in IVF\/ICSI repeated implantation failures (IF) or recurrent miscarriages","volume":"225","author":"L\u00e9d\u00e9e","year":"2011","journal-title":"J. Pathol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.rbmo.2015.08.009","article-title":"The pro-inflammatory and anti-inflammatory cytokine profile in peripheral blood of women with recurrent implantation failure","volume":"31","author":"Liang","year":"2015","journal-title":"Reprod. Biomed. Online"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15027759","article-title":"Polymorphisms in the nuclear factor kappa B gene association with recurrent embryo implantation failure","volume":"15","author":"Luo","year":"2016","journal-title":"Genet. Mol. Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1095\/biolreprod.103.015586","article-title":"Effects of endotoxin and macrophage-related cytokines on the contractile activity of the gravid murine uterus","volume":"69","author":"Mackler","year":"2003","journal-title":"Biol. Reprod."},{"key":"B45","doi-asserted-by":"publisher","first-page":"D52","DOI":"10.1093\/nar\/gkq1237","article-title":"Entrez gene: Gene-centered information at NCBI","volume":"39","author":"Maglott","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/s41419-021-03816-3","article-title":"Proteomics of extracellular vesicles in plasma reveals the characteristics and residual traces of COVID-19 patients without underlying diseases after 3 months of recovery","volume":"12","author":"Mao","year":"2021","journal-title":"Cell Death Dis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"3036","DOI":"10.1093\/humrep\/del305","article-title":"Investigation and treatment of repeated implantation failure following IVF-ET","volume":"21","author":"Margalioth","year":"2006","journal-title":"Hum. Reprod."},{"key":"B48","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/aji.12493","article-title":"Unexplained recurrent miscarriage and recurrent implantation failure: Is there a place for immunomodulation?","volume":"76","author":"Mekinian","year":"2016","journal-title":"Am. J. Reprod. Immunol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1111\/j.1749-6632.2010.05938.x","article-title":"Inflammation and pregnancy: The role of the immune system at the implantation site","volume":"1221","author":"Mor","year":"2011","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"10082","DOI":"10.3390\/ijms221810082","article-title":"Biomolecular markers of recurrent implantation failure-A review","volume":"22","author":"Mrozikiewicz","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/s1472-6483(10)62015-9","article-title":"Progesterone supplementation to prevent recurrent miscarriage and to reduce implantation failure in assisted reproduction cycles","volume":"13","author":"Nardo","year":"2006","journal-title":"Reprod. Biomed. Online"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.3390\/jpm12071154","article-title":"Construction of a miRNA-based nomogram model to predict the prognosis of endometrial cancer","volume":"12","author":"Ni","year":"2022","journal-title":"J. Pers. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"557184","DOI":"10.3389\/fimmu.2020.557184","article-title":"CD206+ M2-like macrophages are essential for successful implantation","volume":"11","author":"Ono","year":"2020","journal-title":"Front. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1111\/j.1365-2826.2008.01668.x","article-title":"Cytokine networks and the regulation of uterine function in pregnancy and parturition","volume":"20","author":"Orsi","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"435","DOI":"10.3109\/09513590.2015.1005595","article-title":"A novel approach to normal responder patient with repeated implantation failures--a case report","volume":"31","author":"Orvieto","year":"2015","journal-title":"Gynecol. Endocrinol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1186\/1471-2105-12-77","article-title":"pROC: an open-source package for R and S+ to analyze and compare ROC curves","volume":"12","author":"Robin","year":"2011","journal-title":"BMC Bioinforma."},{"key":"B57","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1067\/mob.2000.105968","article-title":"Indomethacin blocks interleukin 1beta-induced myometrial contractions in pregnant rhesus monkeys","volume":"183","author":"Sadowsky","year":"2000","journal-title":"Am. J. Obstet. Gynecol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ijgo.2007.12.005","article-title":"Endometrial leukemia inhibitory factor as a predictor of pregnancy after in vitro fertilization","volume":"102","author":"Serafini","year":"2008","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"B59","doi-asserted-by":"publisher","first-page":"919301","DOI":"10.3389\/fgene.2022.919301","article-title":"Identification of key endometrial MicroRNAs and their target genes associated with pathogenesis of recurrent implantation failure by integrated bioinformatics analysis","volume":"13","author":"Shang","year":"2022","journal-title":"Front. Genet."},{"key":"B60","doi-asserted-by":"publisher","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J. Cell Physiol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"e25288","DOI":"10.1371\/journal.pone.0025288","article-title":"Leukemia inhibitory factor enhances endometrial stromal cell decidualization in humans and mice","volume":"6","author":"Shuya","year":"2011","journal-title":"PLoS One"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1172\/jci61495","article-title":"MicroRNA-181b regulates NF-\u03baB-mediated vascular inflammation","volume":"122","author":"Sun","year":"2012","journal-title":"J. Clin. Invest."},{"key":"B63","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.tcm.2013.09.002","article-title":"Role of miR-181 family in regulating vascular inflammation and immunity","volume":"24","author":"Sun","year":"2014","journal-title":"Trends Cardiovasc Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1093\/biolre\/iox058","article-title":"Effect of simvastatin on baboon endometriosis","volume":"97","author":"Taylor","year":"2017","journal-title":"Biol. Reprod."},{"key":"B65","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1146\/annurev.pharmtox.38.1.97","article-title":"Cyclooxygenases 1 and 2","volume":"38","author":"Vane","year":"1998","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"B66","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-24277-4","volume-title":"ggplot2: Elegant graphics for data analysis","author":"Wickham","year":"2016"},{"key":"B67","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1093\/bioinformatics\/btq170","article-title":"ConsensusClusterPlus: A class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics"},{"key":"B68","doi-asserted-by":"publisher","first-page":"4616","DOI":"10.1073\/pnas.1218318110","article-title":"ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways","volume":"110","author":"Wu","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B69","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1186\/s12957-019-1605-9","article-title":"Bioinformatic identification of candidate biomarkers and related transcription factors in nasopharyngeal carcinoma","volume":"17","author":"Ye","year":"2019","journal-title":"World J. Surg. Oncol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1038\/s41392-020-00312-6","article-title":"Targeting NF-\u03baB pathway for the therapy of diseases: Mechanism and clinical study","volume":"5","author":"Yu","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"key":"B71","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/s11010-019-03642-4","article-title":"CCAAT\/enhancer-binding protein beta (C\/EBP\u03b2) knockdown reduces inflammation, ER stress, and apoptosis, and promotes autophagy in oxLDL-treated RAW264.7 macrophage cells","volume":"463","author":"Zahid","year":"2020","journal-title":"Mol. Cell Biochem."},{"key":"B72","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/bib\/bbt085","article-title":"Transcription factor and microRNA co-regulatory loops: Important regulatory motifs in biological processes and diseases","volume":"16","author":"Zhang","year":"2015","journal-title":"Brief. Bioinform"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1007\/s43032-021-00751-8","article-title":"Identification of key differentially methylated\/expressed genes and pathways for ovarian endometriosis by bioinformatics analysis","volume":"29","author":"Zhang","year":"2022","journal-title":"Reprod. Sci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/j.cmet.2020.04.006","article-title":"Deamidation shunts RelA from mediating inflammation to aerobic glycolysis","volume":"31","author":"Zhao","year":"2020","journal-title":"Cell Metab."},{"key":"B75","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fonc.2019.00078","article-title":"Development and validation of a prognostic signature for malignant pleural mesothelioma","volume":"9","author":"Zhou","year":"2019","journal-title":"Front. Oncol."},{"key":"B76","doi-asserted-by":"publisher","first-page":"e21872","DOI":"10.1096\/fj.202002298RR","article-title":"circFAM120A participates in repeated implantation failure by regulating decidualization via the miR-29\/ABHD5 axis","volume":"35","author":"Zhou","year":"2021","journal-title":"Faseb J."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2023.1108805\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T06:09:56Z","timestamp":1677218996000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2023.1108805\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,24]]},"references-count":76,"alternative-id":["10.3389\/fgene.2023.1108805"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2023.1108805","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,24]]},"article-number":"1108805"}}