{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:06:31Z","timestamp":1792033591049,"version":"4.4.0"},"reference-count":97,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>SIRT1 is a member of the sirtuin family functioning in the process of removal of acetyl groups from different proteins. This protein has several biological functions and is involved in the pathogenesis of metabolic diseases, malignancy, aging, neurodegenerative disorders and inflammation. Several long non-coding RNAs (lncRNAs), microRNAs (miRNAs) and circular RNAs (circRNAs) have been found to interact with SIRT1. These interactions have been assessed in the contexts of sepsis, cardiomyopathy, heart failure, non-alcoholic fatty liver disease, chronic hepatitis, cardiac fibrosis, myocardial ischemia\/reperfusion injury, diabetes, ischemic stroke, immune-related disorders and cancers. Notably, SIRT1-interacting non-coding RNAs have been found to interact with each other. Several circRNA\/miRNA and lncRNA\/miRNA pairs that interact with SIRT1 have been identified. These axes are potential targets for design of novel therapies for different disorders. In the current review, we summarize the interactions between three classes of non-coding RNAs and SIRT1.<\/jats:p>","DOI":"10.3389\/fgene.2023.1121982","type":"journal-article","created":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T15:36:34Z","timestamp":1687880194000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Interaction between SIRT1 and non-coding RNAs in different disorders"],"prefix":"10.3389","volume":"14","author":[{"given":"Soudeh","family":"Ghafouri-Fard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamed","family":"Shoorei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bashdar Mahmud","family":"Hussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadollah","family":"Poornajaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Taheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guive","family":"Sharifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"147182","DOI":"10.1016\/j.scitotenv.2021.147182","article-title":"Cadmium chloride induces non-alcoholic fatty liver disease in rats by stimulating miR-34a\/SIRT1\/FXR\/p53 axis","volume":"784","author":"Alshehri","year":"2021","journal-title":"Sci. Total Environ."},{"key":"B2","doi-asserted-by":"publisher","first-page":"3915","DOI":"10.1038\/s41598-021-82745-9","article-title":"The miRNA199a\/SIRT1\/P300\/Yy1\/sST2 signaling axis regulates adverse cardiac remodeling following MI","volume":"11","author":"Asensio-Lopez","year":"2021","journal-title":"Sci. Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"20191908","DOI":"10.1042\/BSR20191908","article-title":"miR-122\/SIRT1 axis regulates chondrocyte extracellular matrix degradation in osteoarthritis","volume":"40","author":"Bai","year":"2020","journal-title":"Biosci. Rep."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1038\/sj.leu.2403910","article-title":"Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors","volume":"19","author":"Bradbury","year":"2005","journal-title":"Leukemia"},{"key":"B5","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1186\/s12886-020-01559-x","article-title":"MiR-221\/SIRT1\/Nrf2 signal axis regulates high glucose induced apoptosis in human retinal microvascular endothelial cells","volume":"20","author":"Chen","year":"","journal-title":"BMC Ophthalmol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e22452","DOI":"10.1002\/jbt.22452","article-title":"LncRNA MST1P2\/miR-133b axis affects the chemoresistance of bladder cancer to cisplatin-based therapy via Sirt1\/p53 signaling","volume":"34","author":"Chen","year":"","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"106848","DOI":"10.1016\/j.intimp.2020.106848","article-title":"MiRNA-133a aggravates inflammatory responses in sepsis by targeting SIRT1","volume":"88","author":"Chen","year":"","journal-title":"Int. Immunopharmacol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1080\/15384101.2021.1916272","article-title":"Hsa_circ_0044235 regulates the pyroptosis of rheumatoid arthritis via MiR-135b-5p-SIRT1 axis","volume":"20","author":"Chen","year":"2021","journal-title":"Cell Cycle"},{"key":"B9","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3892\/ol.2020.11635","article-title":"Long non-coding RNA SNHG7 inhibits NLRP3-dependent pyroptosis by targeting the miR-34a\/SIRT1 axis in liver cancer","volume":"20","author":"Chen","year":"","journal-title":"Oncol. Lett."},{"key":"B10","doi-asserted-by":"publisher","first-page":"e24583","DOI":"10.1002\/jcla.24583","article-title":"hsa_circ_0115355 promotes pancreatic \u03b2-cell function in patients with type 2 diabetes through the miR-145\/SIRT1 axis","volume":"36","author":"Dai","year":"2022","journal-title":"J. Clin. Laboratory Analysis"},{"key":"B11","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1124\/jpet.119.256982","article-title":"Inhibiting microRNA-29a protects myocardial ischemia-reperfusion injury by targeting SIRT1 and suppressing oxidative stress and NLRP3-mediated pyroptosis pathway","volume":"372","author":"Ding","year":"2020","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B12","doi-asserted-by":"publisher","first-page":"624989","DOI":"10.3389\/fphys.2021.624989","article-title":"Silencing of miR-150-5p ameliorates diabetic nephropathy by targeting SIRT1\/p53\/AMPK pathway","volume":"12","author":"Dong","year":"2021","journal-title":"Front. physiology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1007\/s12012-020-09620-3","article-title":"MiR-200a-3p aggravates DOX-induced cardiotoxicity by targeting PEG3 through SIRT1\/NF-\u03baB signal pathway","volume":"21","author":"Fu","year":"2021","journal-title":"Cardiovasc. Toxicol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"111759","DOI":"10.1016\/j.biopha.2021.111759","article-title":"MicroRNAs as important contributors in the pathogenesis of colorectal cancer","volume":"140","author":"Ghafouri-Fard","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B15","doi-asserted-by":"publisher","first-page":"153968","DOI":"10.1016\/j.prp.2022.153968","article-title":"Circ_CDR1as: A circular RNA with roles in the carcinogenesis","volume":"236","author":"Ghafouri-Fard","year":"2022","journal-title":"Pathology - Res. Pract."},{"key":"B16","doi-asserted-by":"publisher","first-page":"111721","DOI":"10.1016\/j.biopha.2021.111721","article-title":"Function of circular RNAs in the pathogenesis of colorectal cancer","volume":"140","author":"Ghafouri-Fard","year":"","journal-title":"Biomed. Pharmacother."},{"key":"B17","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1186\/s12950-021-00287-3","article-title":"Dexmedetomidine hydrochloride inhibits hepatocyte apoptosis and inflammation by activating the lncRNA TUG1\/miR-194\/SIRT1 signaling pathway","volume":"18","author":"Gu","year":"2021","journal-title":"J. Inflamm."},{"key":"B18","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1101\/gad.1467506","article-title":"Mammalian sirtuins\u2014Emerging roles in physiology, aging, and calorie restriction","volume":"20","author":"Haigis","year":"2006","journal-title":"Genes and Dev."},{"key":"B19","doi-asserted-by":"publisher","first-page":"108022","DOI":"10.1016\/j.intimp.2021.108022","article-title":"miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-\u03baB pathway","volume":"99","author":"Han","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"117029","DOI":"10.1016\/j.envpol.2021.117029","article-title":"Mir-34a\/sirt1\/p53 signaling pathway contributes to cadmium-induced nephrotoxicity: A preclinical study in mice","volume":"282","author":"Hao","year":"2021","journal-title":"Environ. Pollut."},{"key":"B21","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1038\/s41420-021-00507-y","article-title":"Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p\/Runx3\/Sirt1 axis","volume":"7","author":"Huang","year":"","journal-title":"Cell Death Discov."},{"key":"B22","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.jphs.2021.07.008","article-title":"Ginsenoside Rg1 promoted the wound healing in diabetic foot ulcers via miR-489\u20133p\/Sirt1 axis","volume":"147","author":"Huang","year":"","journal-title":"J. Pharmacol. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"6612","DOI":"10.1158\/0008-5472.CAN-07-0085","article-title":"SIRT1 is significantly elevated in mouse and human prostate cancer","volume":"67","author":"Huffman","year":"2007","journal-title":"Cancer Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"154009","DOI":"10.1016\/j.prp.2022.154009","article-title":"Identification of expression of CCND1-related lncRNAs in breast cancer","volume":"236","author":"Hussen","year":"","journal-title":"Pathology - Res. Pract."},{"key":"B25","doi-asserted-by":"publisher","first-page":"111528","DOI":"10.1016\/j.biopha.2021.111528","article-title":"MicroRNA: A signature for cancer progression","volume":"138","author":"Hussen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B26","doi-asserted-by":"publisher","first-page":"153764","DOI":"10.1016\/j.prp.2022.153764","article-title":"Signaling pathways modulated by miRNAs in breast cancer angiogenesis and new therapeutics","volume":"230","author":"Hussen","year":"","journal-title":"Pathology - Res. Pract."},{"key":"B27","doi-asserted-by":"publisher","first-page":"6577799","DOI":"10.1155\/2021\/6577799","article-title":"LncRNA SNHG15 promotes oxidative stress damage to regulate the occurrence and development of cerebral ischemia\/reperfusion injury by targeting the miR-141\/SIRT1 axis","volume":"2021","author":"Kang","year":"2021","journal-title":"J. Healthc. Eng."},{"key":"B28","doi-asserted-by":"publisher","first-page":"949","DOI":"10.2147\/NDT.S237558","article-title":"miR-138 increases depressive-like behaviors by targeting SIRT1 in hippocampus","volume":"16","author":"Li","year":"","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/j.omtn.2020.11.015","article-title":"SIRT1 alleviates hepatic ischemia-reperfusion injury via the miR-182-mediated XBP1\/NLRP3 pathway","volume":"23","author":"Li","year":"","journal-title":"Mol. Therapy-Nucleic Acids."},{"key":"B30","doi-asserted-by":"publisher","first-page":"119017","DOI":"10.1016\/j.lfs.2021.119017","article-title":"Depleting microRNA-183-3p improves renal tubulointerstitial fibrosis after acute kidney injury via SIRT1\/PUMA\/FOXO3a deacetylation","volume":"269","author":"Li","year":"","journal-title":"Life Sci."},{"key":"B31","doi-asserted-by":"publisher","first-page":"111171","DOI":"10.1016\/j.mce.2021.111171","article-title":"Estrogen promotes lncRNA H19 expression to regulate osteogenic differentiation of BMSCs and reduce osteoporosis via miR-532-3p\/SIRT1 axis","volume":"527","author":"Li","year":"","journal-title":"Mol. Cell. Endocrinol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3892\/etm.2021.9617","article-title":"Sulforaphane protects human umbilical vein endothelial cells from oxidative stress via the miR-34a\/SIRT1 axis by upregulating nuclear factor erythroid-2-related factor 2","volume":"21","author":"Li","year":"","journal-title":"Exp. Ther. Med."},{"key":"B33","doi-asserted-by":"publisher","first-page":"152876","DOI":"10.1016\/j.prp.2020.152876","article-title":"miR-34a promotes liver fibrosis in patients with chronic hepatitis via mediating Sirt1\/p53 signaling pathway","volume":"216","author":"Li","year":"","journal-title":"Pathology-Research Pract."},{"key":"B34","doi-asserted-by":"publisher","first-page":"e22435","DOI":"10.1002\/jbt.22435","article-title":"Silencing of lncRNA UCA1 curbs proliferation and accelerates apoptosis by repressing SIRT1 signals by targeting miR-204 in pediatric AML","volume":"34","author":"Liang","year":"2020","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbrc.2021.04.025","article-title":"Inhibition of p53\/miR-34a\/SIRT1 axis ameliorates podocyte injury in diabetic nephropathy","volume":"559","author":"Liang","year":"2021","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B36","doi-asserted-by":"publisher","first-page":"C117","DOI":"10.1152\/ajpcell.00394.2020","article-title":"LncRNA GAS5 inhibits miR-579-3p to activate SIRT1\/PGC-1\u03b1\/Nrf2 signaling pathway to reduce cell pyroptosis in sepsis-associated renal injury","volume":"321","author":"Ling","year":"2021","journal-title":"Am. J. Physiology-Cell Physiology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"7687154","DOI":"10.1155\/2022\/7687154","article-title":"miR-197 participates in lipopolysaccharide-induced cardiomyocyte injury by modulating SIRT1","volume":"2022","author":"Liu","year":"","journal-title":"Cardiol. Res. Pract."},{"key":"B38","doi-asserted-by":"publisher","first-page":"539","DOI":"10.2147\/PGPM.S367978","article-title":"Cancer metastases from lung adenocarcinoma disappeared after molecular targeted therapy: A successfully clinical treatment experience","volume":"183","author":"Liu","year":"","journal-title":"Int. Archives Allergy Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/15384101.2019.1689482","article-title":"MiR-199a-5p represses the stemness of cutaneous squamous cell carcinoma stem cells by targeting Sirt1 and CD44ICD cleavage signaling","volume":"19","author":"Lu","year":"2020","journal-title":"Cell Cycle"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/s41419-021-04117-5","article-title":"Functional delivery of lncRNA TUG1 by endothelial progenitor cells derived extracellular vesicles confers anti-inflammatory macrophage polarization in sepsis via impairing miR-9-5p-targeted SIRT1 inhibition","volume":"12","author":"Ma","year":"2021","journal-title":"Cell death Dis."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1007\/s00262-021-02862-2","article-title":"miR-34a induces immunosuppression in colorectal carcinoma through modulating a SIRT1\/NF-\u03baB\/B7-H3\/TNF-\u03b1 axis","volume":"70","author":"Meng","year":"2021","journal-title":"Immunotherapy"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20070140","article-title":"Sirtuins in mammals: Insights into their biological function","volume":"404","author":"Michan","year":"2007","journal-title":"Biochem. J."},{"key":"B43","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1111\/jnc.14998","article-title":"Down-regulation of microRNA-34c-5p alleviates neuropathic pain via the SIRT1\/STAT3 signaling pathway in rat models of chronic constriction injury of sciatic nerve","volume":"154","author":"Mo","year":"2020","journal-title":"J. Neurochem."},{"key":"B44","doi-asserted-by":"publisher","first-page":"e12818","DOI":"10.1111\/cpr.12818","article-title":"lncRNA Oip5-as1 attenuates myocardial ischaemia\/reperfusion injury by sponging miR-29a to activate the SIRT1\/AMPK\/PGC1\u03b1 pathway","volume":"53","author":"Niu","year":"2020","journal-title":"Cell Prolif."},{"key":"B45","doi-asserted-by":"publisher","first-page":"156","DOI":"10.2174\/157489008786263989","article-title":"A review of Sirt1 and Sirt1 modulators in cardiovascular and metabolic diseases","volume":"3","author":"Pillarisetti","year":"2008","journal-title":"Recent Pat. Cardiovasc. Drug Discov. Discontin."},{"key":"B46","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.cmet.2009.02.006","article-title":"Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation","volume":"9","author":"Purushotham","year":"2009","journal-title":"Cell metab."},{"key":"B47","doi-asserted-by":"publisher","first-page":"135465","DOI":"10.1016\/j.neulet.2020.135465","article-title":"Upregulation of mir-132 induces dopaminergic neuronal death via activating SIRT1\/P53 pathway","volume":"740","author":"Qazi","year":"2021","journal-title":"Neurosci. Lett."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1080\/09168451.2020.1750943","article-title":"MiR-181a-5p is involved in the cardiomyocytes apoptosis induced by hypoxia\u2013reoxygenation through regulating SIRT1","volume":"84","author":"Qi","year":"2020","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B49","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1002\/jcp.30262","article-title":"C1q\/tumor necrosis factor-related protein-6 attenuates TNF-\u03b1-induced apoptosis in salivary acinar cells via AMPK\/SIRT1-modulated miR-34a-5p expression","volume":"236","author":"Qu","year":"2021","journal-title":"J. Cell. Physiology"},{"key":"B50","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1478-811X-9-11","article-title":"Mammalian Sirt1: Insights on its biological functions","volume":"9","author":"Rahman","year":"2011","journal-title":"Cell Commun. Signal."},{"key":"B51","doi-asserted-by":"publisher","first-page":"770679","DOI":"10.3389\/fimmu.2021.770679","article-title":"Long non-coding RNA- associated competing endogenous RNA axes in T-cells in multiple sclerosis","volume":"12","author":"Sabaie","year":"2021","journal-title":"Front. Immunol."},{"key":"B52","doi-asserted-by":"publisher","first-page":"153833","DOI":"10.1016\/j.prp.2022.153833","article-title":"The role of circular RNAs in pancreatic cancer: New players in tumorigenesis and potential biomarkers","volume":"232","author":"Sayad","year":"2022","journal-title":"Pathology - Res. Pract."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1080\/21655979.2021.1905247","article-title":"Long non-coding RNA MCM3AP-AS1 protects chondrocytes ATDC5 and CHON-001 from IL-1\u03b2-induced inflammation via regulating miR-138-5p\/SIRT1","volume":"12","author":"Shi","year":"2021","journal-title":"Bioengineered"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1002\/jcp.29031","article-title":"lncRNA ANRIL protects H9c2 cells against hypoxia\u2010induced injury through targeting the miR-7-5p\/SIRT1 axis","volume":"235","author":"Shu","year":"2020","journal-title":"J. Cell. physiology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1002\/biot.200700087","article-title":"Function of the SIRT1 protein deacetylase in cancer","volume":"2","author":"St\u00fcnkel","year":"2007","journal-title":"Biotechnol. J. Healthc. Nutr. Technol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"2525","DOI":"10.2147\/DMSO.S313068","article-title":"Berberine ameliorates hepatic insulin resistance by regulating microRNA-146b\/SIRT1 pathway","volume":"14","author":"Sui","year":"2021","journal-title":"Diabetes, metabolic syndrome Obes. targets Ther."},{"key":"B57","doi-asserted-by":"publisher","first-page":"695","DOI":"10.3892\/ol.2021.12956","article-title":"miR-425 regulates lipophagy via SIRT1 to promote sorafenib resistance in liver cancer","volume":"22","author":"Sun","year":"2021","journal-title":"Oncol. Lett."},{"key":"B58","doi-asserted-by":"publisher","first-page":"e22724","DOI":"10.1002\/jbt.22724","article-title":"LncRNA Snhg8 attenuates microglial inflammation response and blood\u2013brain barrier damage in ischemic stroke through regulating miR-425-5p mediated SIRT1\/NF-\u03baB signaling","volume":"35","author":"Tian","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1007\/s12640-021-00435-w","article-title":"Resveratrol inhibits NLRP3 inflammasome-induced pyroptosis and miR-155 expression in microglia through Sirt1\/AMPK pathway","volume":"39","author":"Tufekci","year":"2021","journal-title":"Neurotox. Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/s0092-8674(01)00527-x","article-title":"hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase","volume":"107","author":"Vaziri","year":"2001","journal-title":"Cell"},{"key":"B61","doi-asserted-by":"publisher","first-page":"147108","DOI":"10.1016\/j.brainres.2020.147108","article-title":"Knockdown of circ0082374 inhibits cell viability, migration, invasion and glycolysis in glioma cells by miR-326\/SIRT1","volume":"1748","author":"Wang","year":"2020","journal-title":"Brain Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.neures.2021.05.010","article-title":"Silencing of miR-324-5p alleviates rat spinal cord injury by Sirt1","volume":"173","author":"Wang","year":"","journal-title":"Neurosci. Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"9141","DOI":"10.1111\/jcmm.16771","article-title":"LincRNA-p21 alleviates atherosclerosis progression through regulating the miR-221\/SIRT1\/Pcsk9 axis","volume":"25","author":"Wang","year":"","journal-title":"J. Cell. Mol. Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"646903","DOI":"10.3389\/fphys.2021.646903","article-title":"miR-22 inhibition alleviates cardiac dysfunction in doxorubicin-induced cardiomyopathy by targeting the sirt1\/PGC-1\u03b1 pathway","volume":"12","author":"Wang","year":"","journal-title":"Front. Physiology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"650666","DOI":"10.3389\/fcell.2021.650666","article-title":"Inhibiting miR-22 alleviates cardiac dysfunction by regulating Sirt1 in septic cardiomyopathy","volume":"9","author":"Wang","year":"","journal-title":"Front. Cell Dev. Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"e0252761","DOI":"10.1371\/journal.pone.0252761","article-title":"LncRNA TUG1\/miR-29c-3p\/SIRT1 axis regulates endoplasmic reticulum stress-mediated renal epithelial cells injury in diabetic nephropathy model in vitro","volume":"16","author":"Wang","year":"","journal-title":"PloS one"},{"key":"B67","doi-asserted-by":"publisher","first-page":"431","DOI":"10.3892\/etm.2021.9848","article-title":"miR-135a-5p inhibitor protects glial cells against apoptosis via targeting SIRT1 in epilepsy","volume":"21","author":"Wang","year":"","journal-title":"Exp. Ther. Med."},{"key":"B68","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1080\/10799893.2020.1825491","article-title":"MiR-155-5p promotes renal interstitial fibrosis in obstructive nephropathy via inhibiting SIRT1 signaling pathway","volume":"41","author":"Wang","year":"","journal-title":"J. Recept. Signal Transduct."},{"key":"B69","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s10735-020-09945-x","article-title":"MiR-217 promotes endothelial cell senescence through the SIRT1\/p53 signaling pathway","volume":"52","author":"Wang","year":"","journal-title":"J. Mol. Histology"},{"key":"B70","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s13105-021-00822-z","article-title":"miR-124-3p targeted SIRT1 to regulate cell apoptosis, inflammatory response, and oxidative stress in acute myocardial infarction in rats via modulation of the FGF21\/CREB\/PGC1\u03b1 pathway","volume":"77","author":"Wei","year":"2021","journal-title":"J. physiology Biochem."},{"key":"B71","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.bbrc.2019.10.083","article-title":"MiR-128-3p mediates TNF-\u03b1-induced inflammatory responses by regulating Sirt1 expression in bone marrow mesenchymal stem cells","volume":"521","author":"Wu","year":"2020","journal-title":"Biochem. biophysical Res. Commun."},{"key":"B72","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s12950-021-00296-2","article-title":"Ginsenoside Rg3 alleviates septic liver injury by regulating the lncRNA TUG1\/miR-200c-3p\/SIRT1 axis","volume":"18","author":"Wu","year":"","journal-title":"J. Inflamm."},{"key":"B73","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1002\/kjm2.12310","article-title":"Inhibition of miR-181a attenuates sepsis-induced inflammation and apoptosis by activating Nrf2 and inhibiting NF-\u03baB pathways via targeting SIRT1","volume":"37","author":"Wu","year":"","journal-title":"Kaohsiung J. Med. Sci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"102679","DOI":"10.1016\/j.ebiom.2020.102679","article-title":"CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p\/SIRT1 axis","volume":"53","author":"Xiang","year":"2020","journal-title":"EBioMedicine"},{"key":"B75","doi-asserted-by":"publisher","first-page":"8873956","DOI":"10.1155\/2021\/8873956","article-title":"Liraglutide regulates the kidney and liver in diabetic nephropathy rats through the miR-34a\/SIRT1 pathway","volume":"2021","author":"Xiao","year":"2021","journal-title":"J. Diabetes Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"20774","DOI":"10.18632\/aging.203466","article-title":"NF-\u03baB inducible miR-30b-5p aggravates joint pain and loss of articular cartilage via targeting SIRT1-FoxO3a-mediated NLRP3 inflammasome","volume":"13","author":"Xu","year":"","journal-title":"Aging (Albany NY)"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.21037\/jgo-21-422","article-title":"Candidate oncogene circularNOP10 mediates gastric cancer progression by regulating miR-204\/SIRT1 pathway","volume":"12","author":"Xu","year":"","journal-title":"J. Gastrointest. Oncol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1210\/me.2007-0079","article-title":"Sirtuin functions in health and disease","volume":"21","author":"Yamamoto","year":"2007","journal-title":"Mol. Endocrinol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1080\/1061186X.2020.1850738","article-title":"Depleting microRNA-146a-3p attenuates lipopolysaccharide-induced acute lung injury via up-regulating SIRT1 and mediating NF-\u03baB pathway","volume":"29","author":"Yang","year":"2021","journal-title":"J. Drug Target."},{"key":"B80","doi-asserted-by":"publisher","first-page":"6884","DOI":"10.3390\/ijms21186884","article-title":"miR-29a modulates GSK3\u03b2\/SIRT1-linked mitochondrial proteostatic stress to ameliorate mouse non-alcoholic steatohepatitis","volume":"21","author":"Yang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B81","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1080\/08916934.2020.1846183","article-title":"LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p\/Sirt1 signalling axis","volume":"54","author":"Yang","year":"2021","journal-title":"Autoimmunity"},{"key":"B82","doi-asserted-by":"publisher","first-page":"199","DOI":"10.22074\/cellj.2021.7038","article-title":"miR-373 suppresses cell proliferation and apoptosis via regulation of SIRT1\/PGC-1\u03b1\/NRF2 axis in pancreatic cancer","volume":"23","author":"Yin","year":"2021","journal-title":"Cell J. (Yakhteh)"},{"key":"B83","doi-asserted-by":"publisher","first-page":"510","DOI":"10.3892\/ijmm.2019.4431","article-title":"miR-195 promotes LPS-mediated intestinal epithelial cell apoptosis via targeting SIRT1\/eIF2a","volume":"45","author":"Yuan","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"B84","doi-asserted-by":"publisher","first-page":"8889195","DOI":"10.1155\/2021\/8889195","article-title":"Downregulation of miR-128 ameliorates Ang II-induced cardiac remodeling via SIRT1\/PIK3R1 multiple targets","volume":"2021","author":"Zhan","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"B85","doi-asserted-by":"publisher","first-page":"20201626","DOI":"10.1042\/BSR20201626","article-title":"KCNQ1OT1 regulates the retinoblastoma cell proliferation, migration and SIRT1\/JNK signaling pathway by targeting miR-124\/SP1 axis","volume":"41","author":"Zhang","year":"","journal-title":"Biosci. Rep."},{"key":"B86","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/2211-5463.13027","article-title":"miR-34a-5p up-regulates the IL-1\u03b2\/COX2\/PGE2 inflammation pathway and induces the release of CGRP via inhibition of SIRT1 in rat trigeminal ganglion neurons","volume":"11","author":"Zhang","year":"","journal-title":"FEBS Open bio"},{"key":"B87","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3892\/or.2020.7825","article-title":"lncRNA GAS5 inhibits malignant progression by regulating macroautophagy and forms a negative feedback regulatory loop with the miR-34a\/mTOR\/SIRT1 pathway in colorectal cancer","volume":"45","author":"Zhang","year":"","journal-title":"Oncol. Rep."},{"key":"B88","doi-asserted-by":"publisher","first-page":"2647","DOI":"10.26355\/eurrev_202003_20534","article-title":"Long noncoding RNA ILF3-AS1 regulates myocardial infarction via the miR-212-3p\/SIRT1 axis and PI3K\/Akt signaling pathway","volume":"24","author":"Zhang","year":"","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1038\/s41598-022-05804-9","article-title":"Tetrahydroxy stilbene glycoside attenuates endothelial cell premature senescence induced by H2O2 through the microRNA-34a\/SIRT1 pathway","volume":"12","author":"Zhang","year":"2022","journal-title":"Sci. Rep."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1490","DOI":"10.1016\/j.bbrc.2020.10.056","article-title":"MiR-204-5p promotes lipid synthesis in mammary epithelial cells by targeting SIRT1","volume":"533","author":"Zhang","year":"","journal-title":"Biochem. Biophysical Res. Commun."},{"key":"B91","doi-asserted-by":"publisher","first-page":"108718","DOI":"10.1016\/j.clim.2021.108718","article-title":"Circ_0001103 alleviates IL-1\u03b2-induced chondrocyte cell injuries by upregulating SIRT1 via targeting miR-375","volume":"227","author":"Zhang","year":"","journal-title":"Clin. Immunol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"2225","DOI":"10.3892\/ijmm.2020.4741","article-title":"lncRNA TUG1 promotes the Brown remodeling of white adipose tissue by regulating miR-204-targeted SIRT1 in diabetic mice","volume":"46","author":"Zhang","year":"","journal-title":"Int. J. Mol. Med."},{"key":"B93","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1089\/cbr.2019.3334","article-title":"Long noncoding RNA SNHG10 sponges miR-543 to upregulate tumor suppressive SIRT1 in nonsmall cell lung cancer","volume":"35","author":"Zhang","year":"","journal-title":"Cancer Biotherapy Radiopharm."},{"key":"B94","doi-asserted-by":"publisher","first-page":"101013","DOI":"10.1016\/j.bonr.2021.101013","article-title":"miR-146a-5p targets Sirt1 to regulate bone mass","volume":"14","author":"Zheng","year":"2021","journal-title":"Bone Rep."},{"key":"B95","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12974-021-02172-5","article-title":"miR-19a\/b-3p promotes inflammation during cerebral ischemia\/reperfusion injury via SIRT1\/FoxO3\/SPHK1 pathway","volume":"18","author":"Zhou","year":"2021","journal-title":"J. neuroinflammation"},{"key":"B96","doi-asserted-by":"publisher","first-page":"2837","DOI":"10.2147\/NDT.S273421","article-title":"Long non-coding RNA SNHG7 alleviates oxygen and glucose deprivation\/reoxygenation-induced neuronal injury by modulating miR-9\/SIRT1 Axis in PC12 cells: Potential role in ischemic stroke","volume":"16","author":"Zhou","year":"2020","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"B97","doi-asserted-by":"publisher","first-page":"729","DOI":"10.2147\/DMSO.S289624","article-title":"CircHIPK3 alleviates high glucose toxicity to human renal tubular epithelial HK-2 cells through regulation of miR-326\/miR-487a-3p\/SIRT1","volume":"14","author":"Zhuang","year":"2021","journal-title":"Targets Ther."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2023.1121982\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T02:39:51Z","timestamp":1687919991000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2023.1121982\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,27]]},"references-count":97,"alternative-id":["10.3389\/fgene.2023.1121982"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2023.1121982","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,27]]},"article-number":"1121982"}}