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The endocrine system comprises various highly vascularized ductless organs regulating metabolism, growth and development, and sexual function. Endocrine disorders constitute the fifth principal cause of death worldwide, and they are considered a significant public health problem due to their long-term effects and negative impact on the patient\u2019s quality of life. Over the last few years, miRNAs have been discovered to regulate various biological processes associated with endocrine disorders, which could be advantageous in developing new diagnostic and therapeutic tools. The present review aims to provide an overview of the most recent and significant information regarding the regulatory mechanism of miRNAs during the development of the most relevant endocrine disorders, including diabetes mellitus, thyroid diseases, osteoporosis, pituitary tumors, Cushing\u2019s syndrome, adrenal insufficiency and multiple endocrine neoplasia, and their potential implications as disease biomarkers.<\/jats:p>","DOI":"10.3389\/fgene.2023.1137017","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T06:30:09Z","timestamp":1676961009000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":16,"title":["Regulatory mechanisms of microRNAs in endocrine disorders and their therapeutic potential"],"prefix":"10.3389","volume":"14","author":[{"given":"S. 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