{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T13:19:34Z","timestamp":1791983974601,"version":"4.4.0"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["Y-MSDPU2022-0547 2016YFC1102805"],"award-info":[{"award-number":["Y-MSDPU2022-0547 2016YFC1102805"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study was to investigate the underlying mechanisms of adenoid cystic carcinoma (ACC) at the transcriptome level.<\/jats:p><jats:p><jats:bold>Materials and methods:<\/jats:bold> We obtained paired tumor and normal salivary gland tissues from 15 ACC patients, which were prepared for RNA sequencing.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Gene enrichment analysis revealed that the upregulated pathways were mainly involved in axonogenesis, and the downregulated pathways were mainly related to leukocyte migration, the adaptive immune response, lymphocyte-mediated immunity, and the humoral immune response. T-cells, B-cells and NK cells showed low infiltration in ACC tissues. In addition to the gene fusions MYB-NFIB and MYBL1-NFIB, a new gene fusion, TVP23C-CDRT4, was also detected in 3 ACC tissues. PRAME was significantly upregulated in ACC tissues, while antigen-presenting human leukocyte antigen (HLA) genes were downregulated.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> We found a new gene fusion, TVP23C-CDRT4, that was highly expressed in ACC. PRAME may be an attractive target for ACC immunotherapy.<\/jats:p>","DOI":"10.3389\/fgene.2023.1144945","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T04:30:58Z","timestamp":1682051458000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Transcriptomic insights into adenoid cystic carcinoma via RNA sequencing"],"prefix":"10.3389","volume":"14","author":[{"given":"Yu-Fang","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pu-Gen","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao-Xin","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105095","DOI":"10.1016\/j.oraloncology.2020.105095","article-title":"The utility of TP53 and PIK3CA mutations as prognostic biomarkers in salivary adenoid cystic carcinoma","volume":"113","author":"Adderley","year":"2021","journal-title":"Oral Oncol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1002\/hed.23710","article-title":"International collaborative validation of intraneural invasion as a prognostic marker in adenoid cystic carcinoma of the head and neck","volume":"37","author":"Amit","year":"2015","journal-title":"Head. 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