{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:28:07Z","timestamp":1768296487466,"version":"3.49.0"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Natural Killer cells are the first subpopulation of lymphocytes that reconstitute after allogeneic haematopoietic stem cell transplantation (HSCT). Their activity is regulated by various receptor-ligand interactions, including stimulation of the activating NKG2D receptor by the MICA molecule, and inhibitory NKG2A receptor interacting with the HLA-E. In this study the research effort focused on the effect of selected NKG2A and NKG2D receptors and their ligands (HLA-E and MICA molecules) polymorphisms that may affect the pathomechanisms of post-transplant complications after HSCT in children.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> One hundred donor-recipient pairs from a single paediatric transplantation centre were investigated. Altogether six single nucleotide substitutions (<jats:italic>NKG2A<\/jats:italic> rs7301582; <jats:italic>NKG2D<\/jats:italic> rs1049174, rs1154831; <jats:italic>HLA-E<\/jats:italic> rs1264457; <jats:italic>MICA<\/jats:italic> rs1051792, rs1063635) were genotyped, and the influence of polymorphisms was analysed on acute and chronic graft-versus-host disease (GvHD), cytomegalovirus (CMV) infection incidence, disease relapse and survival.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The distribution of the evaluated polymorphisms did not differ between patients and their donors. The results showed a significant influence of <jats:italic>HLA-E<\/jats:italic> rs1264457 polymorphism in patients\u2019 <jats:italic>HLA-E<\/jats:italic>*01:01 allele, which was associated with increased risk of CMV infection (<jats:italic>p <\/jats:italic>= 0.050), especially in children positive for CMV IgG before transplantation (<jats:italic>p<\/jats:italic> = 0.001). Furthermore, the effect of <jats:italic>HLA-E<\/jats:italic>*01:01 allele on CMV infections was more evident in children above the age of 7 years (<jats:italic>p<\/jats:italic> = 0.031). Strong tendencies (0.05 &amp;lt; <jats:italic>p<\/jats:italic> &amp;lt; 0.10) towards association with the risk of acute GvHD were also observed for the <jats:italic>NKG2A<\/jats:italic> or <jats:italic>MICA<\/jats:italic> polymorphisms of the recipients. In addition, <jats:italic>NKG2D<\/jats:italic> rs1154831 <jats:italic>AA<\/jats:italic> and <jats:italic>MICA<\/jats:italic> rs1063635 <jats:italic>GG<\/jats:italic> might play a protective role as they were not present in any recipient who died after transplantation.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> In summary, there is emerging evidence that genotyping results of NKG2 receptors and their ligands, may have prognostic value for the outcome of paediatric allogeneic HSCT, but more extensive studies performed on larger groups of donors and transplant recipients are required to confirm these observations.<\/jats:p>","DOI":"10.3389\/fgene.2023.1186123","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T06:08:13Z","timestamp":1686118093000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The impact of NKG2A and NKG2D receptors and HLA-E and MICA ligands polymorphisms on post-transplant complications after paediatric allogeneic HSCT: a single-centre experience"],"prefix":"10.3389","volume":"14","author":[{"given":"Jagoda","family":"Siemaszko","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Ussowicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanka","family":"Rybka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata","family":"Ryczan-Krawczyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Ka\u0142wak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Bogunia-Kubik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1182\/blood-2011-01-331835","article-title":"Long-term health-related outcomes in survivors of childhood cancer treated with HSCT versus conventional therapy: A report from the bone marrow transplant survivor study (BMTSS) and childhood cancer survivor study (CCSS)","volume":"118","author":"Armenian","year":"2011","journal-title":"Blood"},{"key":"B2","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.bbmt.2016.11.021","article-title":"MHC class I chain-related gene A (MICA) donor-recipient mismatches and MICA-129 polymorphism in unrelated donor hematopoietic cell transplantations has No impact on outcomes in acute lymphoblastic leukemia, acute myeloid leukemia, or myelodysplastic Syndrome: A center for international blood and marrow transplant research study","volume":"23","author":"Askar","year":"2017","journal-title":"Biol. Blood Marrow Transpl."},{"key":"B3","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.pcl.2010.01.001","article-title":"Autologous and allogeneic cellular therapies for high-risk pediatric solid tumors","volume":"57","author":"Barrett","year":"2010","journal-title":"Pediatr. Clin. North. Am."},{"key":"B4","doi-asserted-by":"publisher","first-page":"3784","DOI":"10.1182\/blood-2007-03-082933","article-title":"Late mortality after allogeneic hematopoietic cell transplantation and functional status of long-term survivors: Report from the bone marrow transplant survivor study","volume":"110","author":"Bhatia","year":"2007","journal-title":"Blood"},{"key":"B5","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/iji.12523","article-title":"Non-KIR NK cell receptors: Role in transplantation of allogeneic haematopoietic stem cells","volume":"48","author":"Bogunia-Kubik","year":"2021","journal-title":"Int. J. Immunogenet"},{"key":"B6","doi-asserted-by":"publisher","first-page":"S734","DOI":"10.1002\/eji.200990056","article-title":"Chromosome 6 gene polymorphisms as the factors affecting the risk of HSCT outcome","volume":"39","author":"Bogunia-Kubik","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"S135","DOI":"10.1038\/bmt.2010.40","article-title":"Non classical HLA-E and G gene polymorphisms affect the HSCT outcome","volume":"45","author":"Bogunia-Kubik","year":"2010","journal-title":"Bone Marrow Transpl."},{"key":"B8","doi-asserted-by":"publisher","first-page":"S95","DOI":"10.1038\/bmt.2011.48","article-title":"The impact of donor-recipient matching for non-classical HLA-E and HLA-G, and HSP70-hom (HSPA1L) on HSCT outcome","volume":"46","author":"Bogunia-Kubik","year":"2011","journal-title":"Bone Marrow Transpl."},{"key":"B9","doi-asserted-by":"publisher","first-page":"5216","DOI":"10.1182\/blood-2009-04-217430","article-title":"MICA-129 genotype, soluble MICA, and anti-MICA antibodies as biomarkers of chronic graft-versus-host disease","volume":"114","author":"Boukouaci","year":"2009","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/35869","article-title":"HLA-E binds to natural killer cell receptors CD94\/NKG2A, B and C","volume":"391","author":"Braud","year":"1998","journal-title":"Nature"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1182\/blood-2016-05-719070","article-title":"Matching for the nonconventional MHC-I MICA gene significantly reduces the incidence of acute and chronic GVHD","volume":"128","author":"Carapito","year":"2016","journal-title":"Blood"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/s41409-020-0886-5","article-title":"Compatibility at amino acid position 98 of MICB reduces the incidence of graft-versus-host disease in conjunction with the CMV status","volume":"55","author":"Carapito","year":"2020","journal-title":"Bone Marrow Transpl."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2666","DOI":"10.3390\/ijms20112666","article-title":"Cytomegalovirus infections after hematopoietic stem cell transplantation: Current status and future immunotherapy","volume":"20","author":"Cho","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1182\/blood-2017-08-752170","article-title":"Strategies to activate NK cells to prevent relapse and induce remission following hematopoietic stem cell transplantation","volume":"131","author":"Cooley","year":"2018","journal-title":"Blood"},{"key":"B15","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1097\/TP.0b013e3181b0e79e","article-title":"Clinical significance of HLA-E*0103 homozygosity on survival after allogeneic hematopoietic stem-cell transplantation","volume":"88","author":"Danzer","year":"2009","journal-title":"Transplantation"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.3324\/haematol.2009.008318","article-title":"NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies","volume":"94","author":"Espinoza","year":"2009","journal-title":"Haematologica"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.3324\/haematol.2009.008318","article-title":"NKG2D gene polymorphism has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies","volume":"94","author":"Espinoza","year":"2009","journal-title":"Haematologica"},{"key":"B18","doi-asserted-by":"publisher","first-page":"39231","DOI":"10.1038\/srep39231","article-title":"A functional polymorphism in the NKG2D gene modulates NK-cell cytotoxicity and is associated with susceptibility to human papilloma virus-related cancers","volume":"6","author":"Espinoza","year":"2016","journal-title":"Sci. Rep."},{"key":"B19","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1182\/blood-2016-05-716357","article-title":"Matching for the MICA-129 polymorphism is beneficial in unrelated hematopoietic stem cell transplantation","volume":"128","author":"Fuerst","year":"2016","journal-title":"Blood"},{"key":"B20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.3389\/fimmu.2017.00079","article-title":"Pathophysiology of GvHD and other HSCT-related major complications","volume":"8","author":"Ghimire","year":"2017","journal-title":"Front. Immunol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1002\/eji.200425843","article-title":"The CD94\/NKG2C killer lectin-like receptor constitutes an alternative activation pathway for a subset of CD8+ T cells","volume":"35","author":"Gum\u00e1","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1158\/0008-5472.CAN-05-2776","article-title":"Identification of the NKG2D haplotypes associated with natural cytotoxic activity of peripheral blood lymphocytes and cancer immunosurveillance","volume":"66","author":"Hayashi","year":"2006","journal-title":"Cancer Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"e0204914","DOI":"10.1371\/journal.pone.0204914","article-title":"Early and late complications following hematopoietic stem cell transplantation in pediatric patients - a retrospective analysis over 11 years","volume":"13","author":"Hierlmeier","year":"2018","journal-title":"PloS One"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1480","DOI":"10.15252\/emmm.201505246","article-title":"The MICA-129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation","volume":"7","author":"Isernhagen","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"588","DOI":"10.3389\/fimmu.2016.00588","article-title":"Impact of the MICA-129Met\/val dimorphism on nkg2d-mediated biological functions and disease risks","volume":"7","author":"Isernhagen","year":"2016","journal-title":"Front. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"3889","DOI":"10.1172\/JCI68989","article-title":"Differentiation and functional regulation of human fetal NK cells","volume":"123","author":"Ivarsson","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B27","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/cei.12696","article-title":"Polymorphisms within the human leucocyte antigen-E gene and their associations with susceptibility to rheumatoid arthritis as well as clinical outcome of anti-tumour necrosis factor therapy","volume":"182","author":"Iwaszko","year":"2015","journal-title":"Clin. Exp. Immunol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jbspin.2015.06.010","article-title":"Influence of CD94 and NKG2A variants on susceptibility to rheumatoid arthritis and efficacy of anti-TNF treatment","volume":"83","author":"Iwaszko","year":"2016","journal-title":"Jt. Bone Spine."},{"key":"B29","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/genes9020064","article-title":"Influence of NKG2D genetic variants on response to anti-TNF agents in patients with rheumatoid arthritis","volume":"9","author":"Iwaszko","year":"2018","journal-title":"Genes."},{"key":"B30","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1038\/s41397-020-0164-3","article-title":"Association of MICA-129Met\/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis","volume":"20","author":"Iwaszko","year":"2020","journal-title":"Pharmacogenomics J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.imlet.2017.04.006","article-title":"NKG2D: A versatile player in the immune system","volume":"189","author":"Jelen\u02c7ci\u00b4c","year":"2017","journal-title":"Immunol. Let."},{"key":"B32","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1046\/j.1526-0968.2003.00053.x","article-title":"Allogeneic hematopoietic stem cell transplantation","volume":"7","author":"Kai","year":"2003","journal-title":"Ther. Apher. Dial."},{"key":"B33","doi-asserted-by":"publisher","first-page":"108510","DOI":"10.1016\/j.clim.2020.108510","article-title":"Development of child immunity in the context of COVID-19 pandemic","volume":"217","author":"Kloc","year":"2020","journal-title":"Clin. Immunol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1007\/s11912-018-0719-5","article-title":"Long-term effects of myeloablative allogeneic hematopoietic stem cell transplantation in pediatric patients with acute lymphoblastic leukemia","volume":"20","author":"Lawitschka","year":"2018","journal-title":"Curr. Oncol. Rep."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1097\/TP.0b013e3181bbb8fe","article-title":"Association of HLA-E polymorphism with the outcome of hematopoietic stem-cell transplantation with unrelated donors","volume":"88","author":"Ludajic","year":"2009","journal-title":"Transplantation"},{"key":"B36","doi-asserted-by":"publisher","first-page":"651751","DOI":"10.3389\/fimmu.2021.651751","article-title":"Role of polymorphisms of NKG2D receptor and its ligands in acute myeloid leukemia and human stem cell transplantation","volume":"12","author":"Machuldova","year":"2021","journal-title":"Front. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"4636","DOI":"10.3390\/jcm10204636","article-title":"Single-nucleotide polymorphisms in MICA and MICB genes could play a role in the outcome in AML patients after HSCT","volume":"10","author":"Machuldova","year":"2021","journal-title":"J. Clin. Med."},{"key":"B38","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1111\/cei.12891","article-title":"Association of NKG2D gene variants with susceptibility and severity of rheumatoid arthritis","volume":"187","author":"Mariaselvam","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"3224","DOI":"10.1182\/bloodadvances.2020001927","article-title":"Recipient and donor genetic variants associated with mortality after allogeneic hematopoietic cell transplantation","volume":"4","author":"Martin","year":"2020","journal-title":"Blood Adv."},{"key":"B40","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.humimm.2014.12.017","article-title":"HLA-E polymorphism and clinical outcome after allogeneic hematopoietic stem cell transplantation in Egyptian patients","volume":"76","author":"Mossallam","year":"2015","journal-title":"Hum. Immunol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2884","DOI":"10.1182\/blood-2009-05-223172","article-title":"Donor-recipient mismatches in MHC class I chain-related gene A in unrelated donor transplantation lead to increased incidence of acute graft-versus-host disease","volume":"114","author":"Parmar","year":"2009","journal-title":"Blood"},{"key":"B42","doi-asserted-by":"publisher","first-page":"575492","DOI":"10.3389\/fimmu.2020.575492","article-title":"Review of genetic variation as a predictive biomarker for chronic graft-versus-host-disease after allogeneic stem cell transplantation","volume":"11","author":"Partanen","year":"2020","journal-title":"Front. Immunol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1038\/s41409-021-01227-8","article-title":"Hematopoietic cell transplantation and cellular therapy survey of the EBMT: Monitoring of activities and trends over 30 years","volume":"56","author":"Passweg","year":"2021","journal-title":"Bone Marrow Transpl."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.3390\/cells10061420","article-title":"NKG2D natural killer cell receptor\u2014a short description and potential clinical applications","volume":"10","author":"Siemaszko","year":"2021","journal-title":"Cells"},{"key":"B45","doi-asserted-by":"publisher","first-page":"20143085","DOI":"10.1098\/rspb.2014.3085","article-title":"Evolution of the immune system in humans from infancy to old age","volume":"282","author":"Simon","year":"2015","journal-title":"Proc. R. Soc. B"},{"key":"B46","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1056\/NEJM199907013410103","article-title":"Long-term survival and late deaths after allogeneic bone marrow transplantation. Late effects working committee of the international bone marrow transplant registry","volume":"341","author":"Soci\u00e9","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.humimm.2014.10.005","article-title":"Significance of association of HLA-C and HLA-E with psoriatic arthritis","volume":"75","author":"Sokolik","year":"2014","journal-title":"Hum. Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s002510100325","article-title":"Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family","volume":"53","author":"Steinle","year":"2001","journal-title":"Immunogenetics"},{"key":"B49","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1097\/01.tp.0000158711.37550.a0","article-title":"Association of HLA-E polymorphism with severe bacterial infection and early transplant-related mortality in matched unrelated bone marrow transplantation","volume":"80","author":"Tamouza","year":"2005","journal-title":"Transplantation"},{"key":"B50","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1097\/01.tp.0000244598.92049.dd","article-title":"Homozygous status for HLA-E*0103 confers protection from acute graft-versus-host disease and transplant-related mortality in HLA-matched sibling hematopoietic stem cell transplantation","volume":"82","author":"Tamouza","year":"2006","journal-title":"Transplantation"},{"key":"B51","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1186\/s13287-021-02655-5","article-title":"Cytokine-induced memory-like natural killer cells for cancer immunotherapy","volume":"12","author":"Tarannum","year":"2021","journal-title":"Stem Cell. Res. Ther."},{"key":"B52","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.exphem.2011.04.003","article-title":"T cells expressing the activating NK-cell receptors KIR2DS4, NKG2C and NKG2D are elevated in paroxysmal nocturnal hemoglobinuria and cytotoxic toward hematopoietic progenitor cell lines","volume":"39","author":"van Bijnen","year":"2011","journal-title":"Exp. Hematol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.humimm.2019.07.276","article-title":"Haplotype block 1 variant (HB-1v) of the NKG2 family of receptors","volume":"80","author":"Vazquez-Gonzalez","year":"2019","journal-title":"Hum. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1038\/ni1582","article-title":"Functions of natural killer cells","volume":"9","author":"Vivier","year":"2008","journal-title":"Nat. Immunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.bbmt.2017.04.017","article-title":"Survival and late effects after allogeneic hematopoietic cell transplantation for hematologic malignancy at less than three years of age","volume":"23","author":"Vrooman","year":"2017","journal-title":"Biol. Blood Marrow Transpl."},{"key":"B56","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.transci.2018.05.012","article-title":"Development and current use of in hematopoietic stem cell transplantation in children and adolescents in Poland: Report of the Polish pediatric study group for hematopoietic stem cell transplantation of the Polish society for pediatric oncology and hematology","volume":"57","author":"Wachowiak","year":"2018","journal-title":"Transfus. Apher. Sci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"92","DOI":"10.5114\/ceji.2021.104425","article-title":"Shared epitope and polymorphism of MICA and NKG2D encoding genes in Greek and Polish patients with rheumatoid arthritis","volume":"46","author":"Wieli\u0144ska","year":"2021","journal-title":"Cent. Eur. J. Immunol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/tan.12478","article-title":"Clinical and immunological significance of HLA-E in stem cell transplantation and cancer","volume":"84","author":"Wieten","year":"2014","journal-title":"Tissue antigens"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2510","DOI":"10.4049\/jimmunol.1202725","article-title":"Cytotoxic NKG2C+ CD4 T cells target oligodendrocytes in multiple sclerosis","volume":"190","author":"Zaguia","year":"2013","journal-title":"J. Immunol."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2023.1186123\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T06:08:15Z","timestamp":1686118095000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2023.1186123\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":59,"alternative-id":["10.3389\/fgene.2023.1186123"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2023.1186123","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]},"article-number":"1186123"}}