{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T19:18:02Z","timestamp":1784143082302,"version":"3.55.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T00:00:00Z","timestamp":1689897600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Sugar beets are an important crop for global sugar production. Intense drought and the increasing lack of water resources pose a great threat to sugar beet cultivation. It is a priority to investigate favourable germplasms and functional genes to improve the breeding of drought tolerant plants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Thus, in this study, 328 sugar beet germplasms were used in a genome-wide association study (GWAS) to identify single nucleotide polymorphism (SNP) markers and candidate genes associated with drought tolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results showed that under drought stress (9% PEG-6000), there were 11 significantly associated loci on chromosomes 2, 3, 5, 7, and 9 from the 108946 SNPs filtered using a mixed linear model (MLM). Genome-wide association analysis combined with qRT-PCR identified 13 genes that were significantly differentially expressed in drought-tolerant extreme materials.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>These candidate genes mainly exhibited functions such as regulating sugar metabolism, maintaining internal environmental stability and participating in photosystem repair. This study provides valuable information for exploring the molecular mechanisms of drought tolerance and improvement in sugar beet.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fgene.2023.1198600","type":"journal-article","created":{"date-parts":[[2023,7,21]],"date-time":"2023-07-21T14:33:20Z","timestamp":1689950000000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Genome-wide association study of drought tolerance traits in sugar beet germplasms at the seedling stage"],"prefix":"10.3389","volume":"14","author":[{"given":"Wangsheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xilong","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanhang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,7,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1105\/tpc.110.074005","article-title":"The PP2A regulatory subunit Tap46, a component of the TOR signaling pathway, modulates growth and metabolism in plants","volume":"23","author":"Ahn","year":"2011","journal-title":"Plant Cell."},{"key":"B2","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.jare.2019.10.013","article-title":"Gwas: Fast-forwarding gene identification and characterization in temperate cereals: Lessons from barley\u2013a review","volume":"22","author":"Alqudah","year":"2020","journal-title":"J. Adv. Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.3390\/plants11111443","article-title":"Genome-wide association study of six forage traits in ramie (boehmeria nivea L. Gaud)","volume":"11","author":"Bai","year":"2022","journal-title":"Plants"},{"key":"B4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/978-1-61779-600-5_26","volume-title":"Lipases and phospholipases, methods and protocols","author":"Baldessari","year":"2012"},{"key":"B5","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.eja.2005.08.004","article-title":"Impact of water supply on photosynthesis, water use and carbon isotope discrimination of sugar beet genotypes","volume":"24","author":"Bloch","year":"2006","journal-title":"Eur. J. Agron."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12042-019-09236-0","article-title":"Population structure of the world vegetable center mungbean mini core collection and genome-wide association mapping of loci associated with variation of seed coat luster","volume":"13","author":"Breria","year":"2020","journal-title":"Trop. Plant Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"4556","DOI":"10.1038\/s41467-020-18418-4","article-title":"Dutch population structure across space, time and GWAS design","volume":"11","author":"Byrne","year":"2020","journal-title":"Nat. Commun."},{"key":"B8","doi-asserted-by":"publisher","first-page":"293","DOI":"10.3389\/fgene.2014.00293","article-title":"A bioinformatics workflow for detecting signatures of selection in genomic data","volume":"5","author":"Cadzow","year":"2014","journal-title":"Front. Genet."},{"key":"B9","doi-asserted-by":"publisher","first-page":"e0116646","DOI":"10.1371\/journal.pone.0116646","article-title":"A key ABA catabolic gene, OsABA8ox3, is involved in drought stress resistance in rice","volume":"10","author":"Cai","year":"2015","journal-title":"PLoS One"},{"key":"B10","first-page":"1","article-title":"Protocol: Extraction and determination of proline","volume":"2011","author":"Carillo","year":"2011","journal-title":"PrometheusWiki"},{"key":"B11","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3389\/fpls.2016.00291","article-title":"Target of rapamycin is a key player for auxin signaling transduction in Arabidopsis","volume":"7","author":"Deng","year":"2016","journal-title":"Front. Plant Sci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"3232","DOI":"10.1002\/csc2.20484","article-title":"Genome\u2010wide association analysis of drought adaptive traits in common bean","volume":"61","author":"Dramadri","year":"2021","journal-title":"Crop Sci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e95026","DOI":"10.1371\/journal.pone.0095026","article-title":"A split-ubiquitin yeast two-hybrid screen to examine the substrate specificity of atToc159 and atToc132, two Arabidopsis chloroplast preprotein import receptors","volume":"9","author":"Dutta","year":"2014","journal-title":"PloS One"},{"key":"B14","doi-asserted-by":"crossref","DOI":"10.21203\/rs.3.rs-1609741\/v1","volume-title":"Identification of QTLs and candidate loci associated with drought-related traits of the K\/Z RIL rice population","author":"Dwiningsih","year":"2022"},{"key":"B15","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/jac.12286","article-title":"Methyl jasmonate alleviates drought stress in young sugar beet (Beta vulgaris L) plants","volume":"204","author":"Fugate","year":"2018","journal-title":"J. Agron. Crop Sci."},{"key":"B16","doi-asserted-by":"crossref","DOI":"10.1101\/2021.04.13.439603","volume-title":"Rapid auxin-mediated phosphorylation of Myosin regulates trafficking and polarity in Arabidopsis","author":"Han","year":"2021"},{"key":"B17","doi-asserted-by":"publisher","first-page":"9998","DOI":"10.3390\/ijms23179998","article-title":"Transcriptome analysis reveals critical genes and pathways in carbon metabolism and ribosome biogenesis in poplar fertilized with glutamine","volume":"23","author":"Han","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/pbr.12755","article-title":"Combining abilities of sugar beet genotypes for root\u2010and sugar\u2010related traits under multi\u2010environment trials","volume":"139","author":"Hassani","year":"2020","journal-title":"Plant Breed."},{"key":"B19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/S1674-8301(10)60008-5","article-title":"The potential of carcinoembryonic antigen, p53, Ki-67 and glutathion Stransferase-\u03c0 as clinico-histopathological markers for colorectal cancer","volume":"688","author":"He","year":"2010","journal-title":"Cereals China"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3835\/plantgenome2015.12.0122","article-title":"Genome\u2010wide association analysis for drought tolerance and associated traits in common bean","volume":"10","author":"Hoyos\u2010Villegas","year":"2017","journal-title":"Plant Genome"},{"key":"B21","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1007\/s00122-006-0346-7","article-title":"Molecular detection of QTLs for agronomic and quality traits in a doubled haploid population derived from two Canadian wheats (Triticum aestivum L)","volume":"113","author":"Huang","year":"2006","journal-title":"Theor. Appl. Genet."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1093\/pcp\/pcp115","article-title":"Isozyme-specific modes of activation of CTP: Phosphorylcholine cytidylyltransferase in Arabidopsis thaliana at low temperature","volume":"50","author":"Inatsugi","year":"2009","journal-title":"Plant Cell. Physiology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.3390\/plants9111511","article-title":"Physiological and biochemical changes in sugar beet seedlings to confer stress adaptability under drought condition","volume":"9","author":"Islam","year":"2020","journal-title":"Plants"},{"key":"B24","doi-asserted-by":"publisher","first-page":"655103","DOI":"10.3389\/fpls.2021.655103","article-title":"Major QTLs and potential candidate genes for heat stress tolerance identified in chickpea (Cicer arietinum L)","volume":"12","author":"Jha","year":"2021","journal-title":"Front. Plant Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.3390\/genes12111714","article-title":"An integrative transcriptomic and metabolomic analysis of red pitaya (Hylocereus polyrhizus) seedlings in response to heat stress","volume":"12","author":"Jiao","year":"2021","journal-title":"Genes."},{"key":"B26","volume-title":"R2R3 MYB transcription factor, AhMYB94 plays a crucial role in stress tolerance of a salt susceptible groundnut cultivar","author":"Johnson","year":"2022"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1271\/bbb.68.2215","article-title":"Roles of chloroplast RNA polymerase sigma factors in chloroplast development and stress response in higher plants","volume":"68","author":"Kanamaru","year":"2004","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.1111\/pce.12520","article-title":"Genome\u2010wide association of drought\u2010related and biomass traits with HapMap SNPs in Medicago truncatula","volume":"38","author":"Kang","year":"2015","journal-title":"Plant, Cell. & Environ."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1007\/s12298-020-00846-7","article-title":"Ameliorative effects of ascorbic acid on tolerance to drought stress on pepper (Capsicum annuum L) plants","volume":"26","author":"Khazaei","year":"2020","journal-title":"Physiology Mol. Biol. Plants"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e0139657","DOI":"10.1371\/journal.pone.0139657","article-title":"Andrographolide analogue induces apoptosis and autophagy mediated cell death in U937 cells by inhibition of PI3K\/Akt\/mTOR pathway","volume":"10","author":"Kumar","year":"2015","journal-title":"PLoS One"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3572","DOI":"10.1038\/s41598-021-80996-0","article-title":"Genome-wide association study in hexaploid wheat identifies novel genomic regions associated with resistance to root lesion nematode (Pratylenchus thornei)","volume":"11","author":"Kumar","year":"2021","journal-title":"Sci. Rep."},{"key":"B32","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/35057062","article-title":"Initial sequencing and analysis of the human genome","volume":"409","author":"Lander","year":"2001","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows\u2013Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"B34","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3390\/genes9020087","article-title":"GWAS uncovers differential genetic bases for drought and salt tolerances in sesame at the germination stage","volume":"9","author":"Li","year":"2018","journal-title":"Genes."},{"key":"B35","first-page":"6305","article-title":"Gene cloning of 1,4-\u03b1-glucan branching enzyme (GBE) from nostoc flagelliforme and its differential expression in response to drought stress","volume":"17","author":"Li","year":"2019","journal-title":"Mol. Plant Breed."},{"key":"B36","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1080\/15226514.2022.2090496","article-title":"Effects of cadmium stress on the morphology, physiology, cellular ultrastructure, and BvHIPP24 gene expression of sugar beet (Beta vulgaris L)","volume":"25","author":"Liu","year":"2023","journal-title":"Int. J. Phytoremediation"},{"key":"B37","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B38","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/978-1-60761-702-0_22","article-title":"Extraction and analysis of soluble carbohydrates","volume-title":"Plant stress tolerance","author":"Maness","year":"2010"},{"key":"B39","doi-asserted-by":"publisher","first-page":"e0225383","DOI":"10.1371\/journal.pone.0225383","article-title":"Genome-wide association study of drought tolerance and biomass allocation in wheat","volume":"14","author":"Mathew","year":"2019","journal-title":"PloS One"},{"key":"B40","doi-asserted-by":"publisher","first-page":"5286","DOI":"10.1093\/emboj\/17.18.5286","article-title":"A nuclear-encoded protein of prokaryotic origin is essential for the stability of photosystem II in Arabidopsis thaliana","volume":"17","author":"Meurer","year":"1998","journal-title":"EMBO J."},{"key":"B41","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s12892-017-0009-0","article-title":"Effect of drought stress on root yield and some morpho-physiological traits in different genotypes of sugar beet (Beta Vulgaris L)","volume":"20","author":"Moosavi","year":"2017","journal-title":"J. Crop Sci. Biotechnol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1042\/BCJ20210202","article-title":"Importance of tyrosine phosphorylation for transmembrane signaling in plants","volume":"478","author":"M\u00fchlenbeck","year":"2021","journal-title":"Biochem. J."},{"key":"B43","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s10709-016-9932-z","article-title":"Genome wide association study (GWAS) for grain yield in rice cultivated under water deficit","volume":"144","author":"Pantaliao","year":"2016","journal-title":"Genetica"},{"key":"B44","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1105\/tpc.105.037689","article-title":"LOW PSII ACCUMULATION1 is involved in efficient assembly of photosystem II in Arabidopsis thaliana","volume":"18","author":"Peng","year":"2006","journal-title":"Plant Cell."},{"key":"B45","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/s0014-5793(02)03634-7","article-title":"The HCF136 protein is essential for assembly of the photosystem II reaction center in Arabidopsis thaliana","volume":"532","author":"Pl\u00fccken","year":"2002","journal-title":"FEBS Lett."},{"key":"B46","doi-asserted-by":"publisher","first-page":"227","DOI":"10.22271\/tpr.2018.v5.i2.029","article-title":"Effect of salinity on osmolytes and relative water content of selected rice genotypes","volume":"5","author":"Polash","year":"2018","journal-title":"Trop. Plant Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1038\/s41588-019-0351-9","article-title":"Retinal transcriptome and eQTL analyses identify genes associated with age-related macular degeneration","volume":"51","author":"Ratnapriya","year":"2019","journal-title":"Nat. Genet."},{"key":"B48","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/j.1439-037x.2004.00087.x","article-title":"Effect of water\u2010deficit stress on germination and early seedling growth in sugar beet","volume":"190","author":"Sadeghian","year":"2004","journal-title":"J. Agron. Crop Sci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"709817","DOI":"10.3389\/fpls.2021.709817","article-title":"Comparative genomic analysis of quantitative trait loci associated with micronutrient contents, grain quality, and agronomic traits in wheat (Triticum aestivum L)","volume":"12","author":"Shariatipour","year":"2021","journal-title":"Front. Plant Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1038\/s41588-019-0493-9","article-title":"Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases","volume":"51","author":"Soskic","year":"2019","journal-title":"Nat. Genet."},{"key":"B51","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/0003-2697(89)90192-9","article-title":"An assay for superoxide dismutase activity in mammalian tissue homogenates","volume":"179","author":"Spitz","year":"1989","journal-title":"Anal. Biochem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13007-019-0432-x","article-title":"Using hyperspectral analysis as a potential high throughput phenotyping tool in GWAS for protein content of rice quality","volume":"15","author":"Sun","year":"2019","journal-title":"Plant Methods"},{"key":"B53","doi-asserted-by":"publisher","first-page":"2192570","DOI":"10.1080\/15592324.2023.2192570","article-title":"Drought resistance evaluation of sugar beet germplasms by response of phenotypic indicators","volume":"18","author":"Tan","year":"2023","journal-title":"Plant Signal. Behav."},{"key":"B54","doi-asserted-by":"publisher","first-page":"5926","DOI":"10.1074\/jbc.M115.683656","article-title":"Rhizobiales-like phosphatase 2 from Arabidopsis thaliana is a novel phospho-tyrosine-specific phospho-protein phosphatase (PPP) family protein phosphatase","volume":"291","author":"Uhrig","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.cub.2007.07.059","article-title":"HUA2 caused natural variation in shoot morphology of A. thaliana","volume":"17","author":"Wang","year":"2007","journal-title":"Curr. Biol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"745361","DOI":"10.3389\/fgene.2021.745361","article-title":"The effect of population structure on murine genome-wide association studies","volume":"12","author":"Wang","year":"","journal-title":"Front. Genet."},{"key":"B57","doi-asserted-by":"publisher","first-page":"6125","DOI":"10.3390\/ijms22116125","article-title":"Multiple functions of MYB transcription factors in abiotic stress responses","volume":"22","author":"Wang","year":"","journal-title":"Int. J. Mol. Sci."},{"key":"B58","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/nature12030","article-title":"Glucose\u2013TOR signalling reprograms the transcriptome and activates meristems","volume":"496","author":"Xiong","year":"2013","journal-title":"Nature"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.3389\/fpls.2018.01311","article-title":"Genome-wide association mapping of starch pasting properties in maize using single-locus and multi-locus models","volume":"9","author":"Xu","year":"2018","journal-title":"Front. Plant Sci."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1038\/nprot.2015.105","article-title":"Genomic variant annotation and prioritization with ANNOVAR and wANNOVAR","volume":"10","author":"Yang","year":"2015","journal-title":"Nat. Protoc."},{"key":"B61","doi-asserted-by":"publisher","first-page":"824461","DOI":"10.3389\/fpls.2022.824461","article-title":"Varying relationship between vascular plant leaf area and leaf biomass along an elevational gradient on the eastern qinghai-tibet plateau","volume":"13","author":"Yang","year":"","journal-title":"Front. Plant Sci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3390\/genes13061095","article-title":"Genome-wide association studies reveal candidate genes related to stem diameter in cucumber (cucumis sativus L)","volume":"13","author":"Yang","year":"","journal-title":"Genes."},{"key":"B63","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s11032-017-0634-8","article-title":"Genome-wide association study (GWAS) of salt tolerance in worldwide soybean germplasm lines","volume":"37","author":"Zeng","year":"2017","journal-title":"Mol. Breed."},{"key":"B64","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/ng.546","article-title":"Mixed linear model approach adapted for genome-wide association studies","volume":"42","author":"Zhang","year":"2010","journal-title":"Nat. Genet."},{"key":"B65","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3390\/plants11010097","article-title":"Genome-wide association analysis of salt-tolerant traits in terrestrial cotton at seedling stage","volume":"11","author":"Zheng","year":"2021","journal-title":"Plants"}],"updated-by":[{"DOI":"10.3389\/fgene.2025.1685028","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000}}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2023.1198600\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T08:08:13Z","timestamp":1761293293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2023.1198600\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,21]]},"references-count":65,"alternative-id":["10.3389\/fgene.2023.1198600"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2023.1198600","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,21]]},"article-number":"1198600"}}