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Genet."],"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Idiopathic normal pressure hydrocephalus (iNPH) is a common disease among the elderly, which brings great harm to the health of patients and imposes a huge economic burden on the healthcare system. Research has shown that it is possible to prevent iNPH through nutritional and dietary interventions. Intake of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) can reduce the risk of many diseases. In this study, we aimed to explore the association between omega-3\/6 PUFAs and iNPH.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We conducted a two-sample Mendelian randomization (MR) study using summary data from publicly available genome-wide association studies (GWAS) to evaluate the potential impact of omega-3 and omega-6 PUFAs on the risk of iNPH in European populations. Inverse variance weighting was used as the main method for MR analysis, with Wald ratio, weighted median, MR-Egger, simple mode, and weighted mode as supplementary methods. In addition, we performed a series of instrument variable strength evaluations and sensitivity analyses to test the reliability of the study results. Finally, we also conducted a linkage disequilibrium score regression (LDSC) analysis to assess the genetic correlation and distinguish between causal associations and shared genetic variants between PUFAs and iNPH.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> One SD increase in genetically predicted levels of total omega-3 PUFAs (OR: 0.748; 95% CI: 0.597\u20130.937; <jats:italic>p<\/jats:italic> = 0.012; IVW), DHA (OR: 0.709; 95% CI: 0.532\u20130.945; <jats:italic>p<\/jats:italic> = 0.019; IVW), ALA (OR: 0.001; 95% CI: 1.17E-06\u20130.423; <jats:italic>p<\/jats:italic> = 0.026; Wald ratio), and DHA (OR: 0.709; 95% CI: 0.532\u20130.945; <jats:italic>p<\/jats:italic> = 0.019; IVW) were associated with a reduced iNPH risk. LDSC did not reveal any significant genetic correlations.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Higher genetically predicted levels of total omega-3 PUFAs, ALA, DHA, and DPA are associated with a reduced risk of iNPH. These findings have important implications for preventing iNPH and future nutritional guidance.<\/jats:p>","DOI":"10.3389\/fgene.2023.1269494","type":"journal-article","created":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T08:25:57Z","timestamp":1702974357000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Positive association between omega-3\/6 polyunsaturated fatty acids and idiopathic normal pressure hydrocephalus: a mendelian randomization study"],"prefix":"10.3389","volume":"14","author":[{"given":"Jilai","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.annepidem.2006.02.001","article-title":"Estimation of bias in nongenetic observational studies using \"mendelian triangulation","volume":"16","author":"Bautista","year":"2006","journal-title":"Ann. 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