{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T00:39:20Z","timestamp":1793407160297,"version":"4.5.0"},"reference-count":233,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:00:00Z","timestamp":1708905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>Vascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a senescence-associated secretory phenotype macromolecular damage, and metabolic dysregulation. Vascular senescence has been demonstrated to play a key role in different vascular diseases, such as atherosclerosis, peripheral arterial disease, hypertension, stroke, diabetes, chronic venous disease, and venous ulcers. Even though cellular senescence was first described in 1961, significant gaps persist in comprehending the epigenetic mechanisms driving vascular senescence and its subsequent inflammatory response. Through a comprehensive analysis, we aim to elucidate these knowledge gaps by exploring the network of epigenetic alterations that contribute to vascular senescence. In addition, we describe the consequent inflammatory cascades triggered by these epigenetic modifications. Finally, we explore translational applications involving biomarkers of vascular senescence and the emerging field of senotherapy targeting this biological process.<\/jats:p>","DOI":"10.3389\/fgene.2024.1345459","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T04:52:01Z","timestamp":1708923121000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics"],"prefix":"10.3389","volume":"15","author":[{"given":"Oscar","family":"Fraile-Martinez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"De Leon-Oliva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Liviu","family":"Boaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"De Castro-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cielo","family":"Garcia-Montero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvestra","family":"Barrena-Bl\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Garc\u00eda-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalio","family":"Garc\u00eda-Honduvilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melchor","family":"Alvarez-Mon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Lopez-Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Diaz-Pedrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis G.","family":"Guijarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Ortega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,2,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1170434","DOI":"10.3389\/fragi.2023.1170434","article-title":"Metformin mitigates SASP secretion and LPS-triggered hyper-inflammation in Doxorubicin-induced senescent endothelial cells","volume":"4","author":"Abdelgawad","year":"2023","journal-title":"Front. Aging"},{"key":"B2","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1007\/s10522-017-9710-z","article-title":"Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?","volume":"18","author":"Ademowo","year":"2017","journal-title":"Biogerontology"},{"key":"B3","doi-asserted-by":"publisher","first-page":"134688","DOI":"10.1111\/acel.13468","article-title":"Inhibition of the cGAS-STING pathway ameliorates the premature senescence hallmarks of Ataxia-Telangiectasia brain organoids","volume":"20","author":"Aguado","year":"2021","journal-title":"Aging Cell"},{"key":"B4","first-page":"185","article-title":"Detection of senescence-associated heterochromatin foci (SAHF)","volume-title":"Cell senescence. Methods in molecular biology","author":"Aird","year":"2013"},{"key":"B5","doi-asserted-by":"publisher","first-page":"4527","DOI":"10.1038\/s41467-023-40132-0","article-title":"The intensities of canonical senescence biomarkers integrate the duration of cell-cycle withdrawal","volume":"14","author":"Ashraf","year":"2023","journal-title":"Nat. Commun."},{"key":"B6","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.cell.2017.02.031","article-title":"Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging","volume":"169","author":"Baar","year":"2017","journal-title":"Cell"},{"key":"B7","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/nature16932","article-title":"Naturally occurring p16 Ink4a-positive cells shorten healthy lifespan","volume":"530","author":"Baker","year":"2016","journal-title":"Nature"},{"key":"B8","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1177\/0300985820943841","article-title":"Cellular senescence: mechanisms, morphology, and mouse models","volume":"57","author":"Beck","year":"2020","journal-title":"Vet. Pathol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/ncb2443","article-title":"Senescence is an endogenous trigger for microRNA-directed transcriptional gene silencing in human cells","volume":"14","author":"Benhamed","year":"2012","journal-title":"Nat. Cell Biol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1101\/gad.259341.115","article-title":"Senescent cells communicate via intercellular protein transfer","volume":"29","author":"Biran","year":"2014","journal-title":"Genes Dev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1038\/onc.2009.497","article-title":"Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21 Waf1\/Cip1","volume":"29","author":"Borgdorff","year":"2010","journal-title":"Oncogene"},{"key":"B12","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1161\/CIRCULATIONAHA.122.058794","article-title":"Eliminating senescent cells can promote pulmonary hypertension development and progression","volume":"147","author":"Born","year":"2023","journal-title":"Circulation"},{"key":"B13","doi-asserted-by":"publisher","first-page":"26372","DOI":"10.1039\/d2ra04535d","article-title":"Design, synthesis, and evaluation of a novel PET imaging agent targeting lipofuscin in senescent cells","volume":"12","author":"Brickute","year":"2022","journal-title":"RSC Adv."},{"key":"B14","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/nature09908","article-title":"CPEB and two poly(A) polymerases control miR-122 stability and p53 mRNA translation","volume":"473","author":"Burns","year":"2011","journal-title":"Nature"},{"key":"B15","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.arr.2018.02.001","article-title":"Cellular senescence: immunosurveillance and future immunotherapy","volume":"43","author":"Burton","year":"2018","journal-title":"Ageing Res. Rev."},{"key":"B16","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/s41422-020-0314-9","article-title":"Elimination of senescent cells by \u03b2-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice","volume":"30","author":"Cai","year":"2020","journal-title":"Cell Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"174","DOI":"10.14336\/AD.2017.1213","article-title":"Epigenetic regulation of bone marrow stem cell aging: revealing epigenetic signatures associated with hematopoietic and mesenchymal stem cell aging","volume":"10","author":"Cakouros","year":"2019","journal-title":"Aging Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1146\/annurev-physiol-030212-183653","article-title":"Aging, cellular senescence, and cancer","volume":"75","author":"Campisi","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"7294","DOI":"10.1093\/nar\/gkz555","article-title":"Transcriptome signature of cellular senescence","volume":"47","author":"Casella","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1101\/cshperspect.a026104","article-title":"The cell-cycle arrest and apoptotic and progression","volume":"6","author":"Chen","year":"2016","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"e0185406","DOI":"10.1371\/journal.pone.0185406","article-title":"Exosomal lncRNA GAS5 regulates the apoptosis of macrophages and vascular endothelial cells in atherosclerosis","volume":"12","author":"Chen","year":"2017","journal-title":"PLoS One"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1007\/s00109-017-1581-x","article-title":"Epigenetic regulation in cell senescence","volume":"95","author":"Cheng","year":"2017","journal-title":"J. Mol. Med."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.15252\/embr.201439245","article-title":"Senescence and apoptosis: dueling or complementary cell fates?","volume":"15","author":"Childs","year":"2014","journal-title":"EMBO Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1126\/science.aaf6659","article-title":"Senescent intimal foam cells are deleterious at all stages of atherosclerosis","volume":"354","author":"Childs","year":"2016","journal-title":"Science"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1093\/eurjpc\/zwad028","article-title":"Vascular ageing: moving from bench towards bedside","volume":"30","author":"Climie","year":"2023","journal-title":"Eur. J. Prev. Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"29568","DOI":"10.1074\/jbc.M603307200","article-title":"Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence","volume":"281","author":"Coppe","year":"2006","journal-title":"J. Biol. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"724","DOI":"10.15252\/embj.201592862","article-title":"Mitochondria are required for pro\u2010ageing features of the senescent phenotype","volume":"35","author":"Correia\u2010Melo","year":"2016","journal-title":"EMBO J."},{"key":"B29","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1016\/j.cmet.2021.01.011","article-title":"Pathological angiogenesis in retinopathy engages cellular senescence and is amenable to therapeutic elimination via BCL-xL inhibition","volume":"33","author":"Crespo-Garcia","year":"2021","journal-title":"Cell Metab."},{"key":"B30","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.tig.2016.09.005","article-title":"The chromatin landscape of cellular senescence","volume":"32","author":"Criscione","year":"2016","journal-title":"Trends Genet."},{"key":"B31","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3390\/cells11040672","article-title":"Epigenetic regulation of cellular senescence","volume":"11","author":"Crouch","year":"2022","journal-title":"Cells"},{"key":"B32","doi-asserted-by":"publisher","first-page":"990","DOI":"10.3390\/ijms18050990","article-title":"Folic acid supplementation delays atherosclerotic lesion development by modulating MCP1 and VEGF DNA methylation levels in vivo and in vitro","volume":"18","author":"Cui","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"B33","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3390\/biology9120485","article-title":"The senescence-associated secretory phenotype (Sasp) in the challenging future of cancer therapy and age-related diseases","volume":"9","author":"Cuollo","year":"2020","journal-title":"Biol. (Basel)"},{"key":"B34","doi-asserted-by":"publisher","first-page":"1798","DOI":"10.1038\/nprot.2009.191","article-title":"Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo","volume":"4","author":"Debacq-Chainiaux","year":"2009","journal-title":"Nat. Protoc."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.3390\/ijms19123701","article-title":"Inflammation-accelerated senescence and the cardiovascular system: mechanisms and perspectives","volume":"19","author":"Del Pinto","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fcell.2021.623175","article-title":"Is senescence-associated \u03b2-galactosidase a reliable in vivo marker of cellular senescence during embryonic development?","volume":"9","author":"de Mera-Rodr\u00edguez","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/embor.2011.110","article-title":"Regulation of mammalian DNA methyltransferases: a route to new mechanisms","volume":"12","author":"Denis","year":"2011","journal-title":"EMBO Rep."},{"key":"B38","doi-asserted-by":"publisher","first-page":"535395","DOI":"10.3389\/fphar.2020.535395","article-title":"Epigenetics and vascular senescence\u2013potential new therapeutic targets?","volume":"11","author":"Ding","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B39","doi-asserted-by":"crossref","DOI":"10.1007\/978-981-13-1117-8_4","article-title":"Epigenetic regulation of vascular aging and age-related vascular diseases","volume-title":"Aging and aging-related diseases. Advances in experimental medicine and biology","author":"Ding","year":"2018"},{"key":"B40","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1242\/jcs.158360","article-title":"The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4","volume":"128","author":"Du","year":"2015","journal-title":"J. Cell Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/978-1-4939-6670-7","article-title":"Sudan black B, the specifi c histochemical stain for lipofuscin: a novel method to detect senescent cells","author":"Evangelou","year":"2017","journal-title":"Oncogene-Induced Senescence"},{"key":"B42","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/acel.12545","article-title":"Robust, universal biomarker assay to detect senescent cells in biological specimens","volume":"16","author":"Evangelou","year":"2017","journal-title":"Aging Cell"},{"key":"B43","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.1091\/mbc.E11-10-0884","article-title":"Lamin B1 loss is a senescence-associated biomarker","volume":"23","author":"Freund","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"B44","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.cellsig.2018.08.019","article-title":"Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity","volume":"52","author":"Frismantiene","year":"2018","journal-title":"Cell. Signal."},{"key":"B45","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/s41467-017-00314-z","article-title":"Identification of HSP90 inhibitors as a novel class of senolytics","volume":"8","author":"Fuhrmann-Stroissnigg","year":"","journal-title":"Nat. Commun."},{"key":"B46","doi-asserted-by":"publisher","first-page":"955","DOI":"10.18632\/aging.101202","article-title":"New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463","volume":"9","author":"Fuhrmann-Stroissnigg","year":"","journal-title":"Aging (Albany. NY)"},{"key":"B47","doi-asserted-by":"publisher","first-page":"22624","DOI":"10.1073\/pnas.1915905116","article-title":"Graded regulation of cellular quiescence depth between proliferation and senescence by a lysosomal dimmer switch","volume":"116","author":"Fujimaki","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e0202051","DOI":"10.1371\/journal.pone.0202051","article-title":"Boysenberry polyphenol inhibits endothelial dysfunction and improves vascular health","volume":"13","author":"Furuuchi","year":"2018","journal-title":"PLoS One"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1161\/ATVBAHA.115.305896","article-title":"Senescent vascular smooth muscle cells drive inflammation through an interleukin-1\u03b1-dependent senescence-associated secretory phenotype","volume":"35","author":"Gardner","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1093\/cvr\/cvab208","article-title":"Efficacy and limitations of senolysis in atherosclerosis","volume":"118","author":"Garrido","year":"2022","journal-title":"Cardiovasc. Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"37","DOI":"10.18632\/aging.100527","article-title":"Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues","volume":"5","author":"Georgakopoulou","year":"2013","journal-title":"Aging (Albany. NY)"},{"key":"B52","doi-asserted-by":"publisher","first-page":"183","DOI":"10.4172\/2161-1025.1000183","article-title":"Vascular aging: implications for cardiovascular disease and therapy","volume":"6","author":"Ghebre","year":"2016","journal-title":"Transl. Med."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.ebiom.2015.09.015","article-title":"Cellular senescence and inflammatory burden as determinants of mortality in elderly people until the extreme old age","volume":"2","author":"Giacconi","year":"2015","journal-title":"EBioMedicine"},{"key":"B54","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1080\/15384101.2014.1000134","article-title":"Senescence from G2 arrest, revisited","volume":"14","author":"Gire","year":"2015","journal-title":"Cell Cycle"},{"key":"B55","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1002\/mnfr.201200636","article-title":"Methyl nutrients, DNA methylation, and cardiovascular disease","volume":"58","author":"Glier","year":"2014","journal-title":"Mol. Nutr. Food Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/febs.15570","article-title":"A guide to assessing cellular senescence in vitro and in vivo","volume":"288","author":"Gonz\u00e1lez-Gualda","year":"2021","journal-title":"FEBS J."},{"key":"B57","doi-asserted-by":"publisher","first-page":"131422","DOI":"10.1111\/acel.13142","article-title":"Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity","volume":"19","author":"Gonz\u00e1lez-Gualda","year":"2020","journal-title":"Aging Cell"},{"key":"B58","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.cell.2019.10.005","article-title":"Cellular senescence: defining a path forward","volume":"179","author":"Gorgoulis","year":"2019","journal-title":"Cell"},{"key":"B59","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/labinvest.3700241","article-title":"p53-Dependent ICAM-1 overexpression in senescent human cells identified in atherosclerotic lesions","volume":"85","author":"Gorgoulis","year":"2005","journal-title":"Lab. Investig."},{"key":"B60","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.cmet.2020.05.002","article-title":"Defined p16High senescent cell types are indispensable for mouse healthspan","volume":"32","author":"Grosse","year":"2020","journal-title":"Cell Metab."},{"key":"B61","doi-asserted-by":"publisher","first-page":"e0216602","DOI":"10.1371\/journal.pone.0216602","article-title":"GDF15 secreted by senescent endothelial cells improves vascular progenitor cell functions","volume":"14","author":"Ha","year":"2019","journal-title":"PLoS One"},{"key":"B62","doi-asserted-by":"crossref","DOI":"10.1016\/bs.apha.2017.08.012","volume-title":"Basic components of vascular connective tissue and extracellular matrix","author":"Halper","year":"2018"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-022-00906-w","article-title":"Endothelial senescence in vascular diseases: current understanding and future opportunities in senotherapeutics","volume":"55","author":"Han","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"B64","doi-asserted-by":"publisher","first-page":"896907","DOI":"10.3389\/fphar.2022.896907","article-title":"Senolytics in the treatment of diabetic retinopathy","volume":"13","author":"Hassan","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"17018","DOI":"10.1073\/pnas.0607873103","article-title":"Endothelial cellular senescence is inhibited by nitric oxide: implications in atherosclerosis associated with menopause and diabetes","volume":"103","author":"Hayashi","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B66","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid cell strains","volume":"25","author":"Hayflick","year":"1961","journal-title":"Exp. Cell Res."},{"key":"B67","doi-asserted-by":"publisher","first-page":"131177","DOI":"10.1111\/acel.13117","article-title":"Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity","volume":"19","author":"He","year":"2020","journal-title":"Aging Cell"},{"key":"B68","doi-asserted-by":"publisher","first-page":"57782","DOI":"10.3791\/57782","article-title":"Induction and validation of cellular senescence in primary human cells","volume":"136","author":"Hernandez-Segura","year":"2018","journal-title":"J. Vis. Exp."},{"key":"B69","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1172\/JCI95148","article-title":"Mechanisms and functions of cellular senescence","volume":"128","author":"Herranz","year":"2018","journal-title":"J. Clin. Invest."},{"key":"B70","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1093\/cvr\/cvy206","article-title":"Long non-coding RNA H19 regulates endothelial cell aging via inhibition of STAT3 signalling","volume":"115","author":"Hofmann","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"e93203","DOI":"10.1172\/jci.insight.93203","article-title":"mTOR pathway activation drives lung cell senescence and emphysema","volume":"3","author":"Houssaini","year":"2018","journal-title":"JCI insight"},{"key":"B72","doi-asserted-by":"publisher","first-page":"940","DOI":"10.5551\/jat.32177","article-title":"Predictors of carotid intima-media thickness and plaque progression in a Chinese population","volume":"23","author":"Huang","year":"2016","journal-title":"J. Atheroscler. Thromb."},{"key":"B73","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/s41581-022-00601-z","article-title":"Cellular senescence: the good, the bad and the unknown","volume":"18","author":"Huang","year":"2022","journal-title":"Nat. Rev. Nephrol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"4088","DOI":"10.1096\/fj.14-251223","article-title":"MiR-21 normalizes vascular smooth muscle proliferation and improves coronary collateral growth in metabolic syndrome","volume":"28","author":"Hutcheson","year":"2014","journal-title":"FASEB J."},{"key":"B75","doi-asserted-by":"publisher","first-page":"10135","DOI":"10.3390\/ijms231710135","article-title":"Factors and pathways modulating endothelial cell senescence in vascular aging","volume":"23","author":"Hwang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1161\/01.RES.0000159181.06379.63","article-title":"Epigenetic histone modification and cardiovascular lineage programming in mouse embryonic stem cells exposed to laminar shear stress","volume":"96","author":"Illi","year":"2005","journal-title":"Circ. Res."},{"key":"B77","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1016\/j.atherosclerosis.2005.12.031","article-title":"Sirolimus accelerates senescence of endothelial progenitor cells through telomerase inactivation","volume":"189","author":"Imanishi","year":"2006","journal-title":"Atherosclerosis"},{"key":"B78","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1016\/j.jacc.2008.01.058","article-title":"Sirolimus-induced vascular dysfunction. Increased mitochondrial and nicotinamide adenosine dinucleotide phosphate oxidase-dependent superoxide production and decreased vascular nitric oxide formation","volume":"51","author":"Jabs","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1177\/0271678X17705973","article-title":"mTOR drives cerebral blood flow and memory deficits in LDLR\u2212\/\u2212 mice modeling atherosclerosis and vascular cognitive impairment","volume":"38","author":"Jahrling","year":"2018","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1021\/pr501221g","article-title":"Senescent human fibroblasts show increased glycolysis and redox homeostasis with extracellular metabolomes that overlap with those of irreparable DNA damage, aging, and disease","volume":"14","author":"James","year":"2015","journal-title":"J. Proteome Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"121618","DOI":"10.1016\/j.ijpharm.2022.121618","article-title":"Sphingomyelin nanosystems decorated with TSP-1 derived peptide targeting senescent cells","volume":"617","author":"Jatal","year":"2022","journal-title":"Int. J. Pharm."},{"key":"B82","doi-asserted-by":"publisher","first-page":"112421","DOI":"10.1016\/j.biopha.2021.112421","article-title":"Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms","volume":"145","author":"Jayasuriya","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B83","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1126\/science.abb5916","article-title":"Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders","volume":"371","author":"Johmura","year":"2021","journal-title":"Science"},{"key":"B84","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12979-020-00187-9","article-title":"Role of immune cells in the removal of deleterious senescent cells","volume":"17","author":"Kale","year":"2020","journal-title":"Immun. Ageing"},{"key":"B85","doi-asserted-by":"publisher","first-page":"aaa5612","DOI":"10.1126\/science.aaa5612","article-title":"The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4","volume":"349","author":"Kang","year":"2015","journal-title":"Science"},{"key":"B86","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1093\/infdis\/jiq071","article-title":"T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women","volume":"203","author":"Kaplan","year":"2011","journal-title":"J. Infect. Dis."},{"key":"B87","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/nature12154","article-title":"A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence","volume":"498","author":"Kaplon","year":"2013","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","first-page":"18","DOI":"10.3389\/fcvm.2018.00018","article-title":"Vascular senescence in cardiovascular and metabolic diseases","volume":"5","author":"Katsuumi","year":"2018","journal-title":"Front. Cardiovasc. Med."},{"key":"B89","doi-asserted-by":"publisher","first-page":"39501","DOI":"10.1038\/srep39501","article-title":"Premature senescence of endothelial cells upon chronic exposure to TNF\u03b1 can be prevented by N-acetyl cysteine and plumericin","volume":"7","author":"Khan","year":"2017","journal-title":"Sci. Rep."},{"key":"B90","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.atherosclerosis.2018.01.043","article-title":"The protective effect of resveratrol on vascular aging by modulation of the renin\u2013angiotensin system","volume":"270","author":"Kim","year":"2018","journal-title":"Atherosclerosis"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1126\/science.1211222","article-title":"Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells","volume":"334","author":"Kim","year":"2011","journal-title":"Science"},{"key":"B92","doi-asserted-by":"crossref","DOI":"10.1038\/s41596-021-00505-5","volume-title":"Algorithmic assessment of cellular senescence in experimental and clinical specimens","author":"Kohli","year":"2021"},{"key":"B93","doi-asserted-by":"publisher","first-page":"112","DOI":"10.3389\/fgene.2015.00112","article-title":"Age-related vascular stiffening: causes and consequences","volume":"6","author":"Kohn","year":"2015","journal-title":"Front. Genet."},{"key":"B94","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.redox.2017.07.008","article-title":"Proteostasis, oxidative stress and aging","volume":"13","author":"Korovila","year":"2017","journal-title":"Redox Biol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"2463","DOI":"10.1101\/gad.1971610","article-title":"The essence of senescence","volume":"24","author":"Kuilman","year":"2010","journal-title":"Genes Dev."},{"key":"B96","doi-asserted-by":"publisher","first-page":"645593","DOI":"10.3389\/fcell.2021.645593","article-title":"Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype","volume":"9","author":"Kumari","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1152\/physrev.00003.2017","article-title":"Vascular smooth muscle cells and arterial stiffening: relevance in development, aging, and disease","volume":"97","author":"Lacolley","year":"2017","journal-title":"Physiol. Rev."},{"key":"B98","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.biopha.2017.10.062","article-title":"MicroRNA-574-5p promotes cell growth of vascular smooth muscle cells in the progression of coronary artery disease","volume":"97","author":"Lai","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"B99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yjmcc.2015.04.005","article-title":"So! What\u2019s aging? Is cardiovascular aging a disease?","volume":"83","author":"Lakatta","year":"2015","journal-title":"J. Mol. Cell. Cardiol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1101\/gad.173922.111","article-title":"Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state","volume":"25","author":"Lapasset","year":"2011","journal-title":"Genes Dev."},{"key":"B101","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1186\/s13287-021-02453-z","article-title":"Chronic inflammation-induced senescence impairs immunomodulatory properties of synovial fluid mesenchymal stem cells in rheumatoid arthritis","volume":"12","author":"Lee","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"B102","doi-asserted-by":"publisher","first-page":"569","DOI":"10.11909\/j.issn.1671-5411.2015.05.011","article-title":"Impact of miRNAs on cardiovascular aging","volume":"12","author":"Lee","year":"2015","journal-title":"J. Geriatr. Cardiol."},{"key":"B103","doi-asserted-by":"publisher","first-page":"134477","DOI":"10.1111\/acel.13447","article-title":"Ouabain and chloroquine trigger senolysis of BRAF-V600E-induced senescent cells by targeting autophagy","volume":"20","author":"L\u2019H\u00f4te","year":"2021","journal-title":"Aging Cell"},{"key":"B104","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s12890-021-01439-0","article-title":"Bmi-1 alleviates adventitial fibroblast senescence by eliminating ROS in pulmonary hypertension","volume":"21","author":"Li","year":"2021","journal-title":"BMC Pulm. Med."},{"key":"B105","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","article-title":"Inflammation and aging: signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"B106","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.jacc.2021.12.017","article-title":"Inflammation, aging, and cardiovascular disease: JACC review topic of the week","volume":"79","author":"Liberale","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"20168","DOI":"10.1038\/s41598-021-99643-9","article-title":"Extracellular matrix and cellular senescence in venous leg ulcers","volume":"11","author":"Lim","year":"2021","journal-title":"Sci. Rep."},{"key":"B108","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.bcp.2015.06.013","article-title":"Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts","volume":"96","author":"Lim","year":"2015","journal-title":"Biochem. Pharmacol."},{"key":"B109","doi-asserted-by":"publisher","first-page":"e14002","DOI":"10.1111\/acel.14002","article-title":"Senolytics prevent caveolar CaV 3.2-RyR axis malfunction in old vascular smooth muscle","volume":"22","author":"Lin","year":"2023","journal-title":"Aging Cell"},{"key":"B110","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.ebiom.2018.05.035","article-title":"Oxysterol signatures distinguish age-related macular degeneration from physiologic aging","volume":"32","author":"Lin","year":"2018","journal-title":"EBioMedicine"},{"key":"B111","doi-asserted-by":"publisher","first-page":"6021394","DOI":"10.1155\/2016\/6021394","article-title":"Function, role, and clinical application of MicroRNAs in vascular aging","volume":"2016","author":"Lin","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"B112","doi-asserted-by":"publisher","first-page":"806988","DOI":"10.3389\/fcvm.2021.806988","article-title":"Targeting epigenetic mechanisms in vascular aging","volume":"8","author":"Lin","year":"2022","journal-title":"Front. Cardiovasc. Med."},{"key":"B113","doi-asserted-by":"publisher","first-page":"3925","DOI":"10.1016\/j.bmc.2018.06.013","article-title":"Senolytic activity of piperlongumine analogues: synthesis and biological evaluation","volume":"26","author":"Liu","year":"2018","journal-title":"Bioorg. Med. Chem."},{"key":"B114","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.cell.2022.11.001","article-title":"Hallmarks of aging: an expanding universe","volume":"186","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell"},{"key":"B115","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.1111\/febs.16361","article-title":"Cellular senescence: all roads lead to mitochondria","volume":"290","author":"Martini","year":"2023","journal-title":"FEBS J."},{"key":"B116","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3390\/antiox11061037","article-title":"Curcumin, polydatin and quercetin synergistic activity protects from high-glucose-induced inflammation and oxidative stress","volume":"11","author":"Matacchione","year":"2022","journal-title":"Antioxidants"},{"key":"B117","doi-asserted-by":"crossref","DOI":"10.1016\/bs.apha.2016.08.001","volume-title":"Vascular cells in blood vessel wall development and disease","author":"Mazurek","year":"2017"},{"key":"B118","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1093\/ajh\/hpz052","article-title":"Novel contributors and mechanisms of cellular senescence in hypertension-associated premature vascular aging","volume":"32","author":"McCarthy","year":"2019","journal-title":"Am. J. Hypertens."},{"key":"B119","doi-asserted-by":"publisher","first-page":"1138162","DOI":"10.3389\/fphys.2023.1138162","article-title":"Exercise protects vascular function by countering senescent cells in older adults","volume":"14","author":"Meng","year":"2023","journal-title":"Front. Physiol."},{"key":"B120","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.arr.2014.03.005","article-title":"MicroRNAs in vascular aging and atherosclerosis","volume":"17","author":"Menghini","year":"2014","journal-title":"Ageing Res. Rev."},{"key":"B121","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.4049\/jimmunol.1001866","article-title":"Senescent CD14+CD16+ monocytes exhibit proinflammatory and proatherosclerotic activity","volume":"186","author":"Merino","year":"2011","journal-title":"J. Immunol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"637288","DOI":"10.7554\/eLife.63728","article-title":"Cytoplasmic chromatin fragments\u2014from mechanisms to therapeutic potential","volume":"10","author":"Miller","year":"2021","journal-title":"Elife"},{"key":"B123","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1161\/HYPERTENSIONAHA.120.14515","article-title":"Arterial stiffness in aging: does it have a place in clinical practice? recent advances in hypertension","volume":"77","author":"Mitchell","year":"2021","journal-title":"Hypertension"},{"key":"B124","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1038\/s41590-021-00927-z","article-title":"Hallmarks of T cell aging","volume":"22","author":"Mittelbrunn","year":"2021","journal-title":"Nat. Immunol."},{"key":"B125","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1007\/s11357-021-00475-2","article-title":"The aging venous system: from varicosities to vascular cognitive impairment","volume":"43","author":"Moln\u00e1r","year":"2021","journal-title":"GeroScience"},{"key":"B126","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1177\/17085381211012882","article-title":"Cellular senescence at the saphenofemoral junction in patients with healthy, primary varicose and recurrent varicose veins \u2013 a pilot study","volume":"30","author":"M\u00fchlberger","year":"2022","journal-title":"Vascular"},{"key":"B127","article-title":"Histology, vascular","volume-title":"StatPearls - NCBI bookshelf","author":"Munjal","year":"2023"},{"key":"B128","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1016\/j.cell.2013.10.019","article-title":"Programmed cell senescence during mammalian embryonic development","volume":"155","author":"Mu\u00f1oz-Esp\u00edn","year":"2013","journal-title":"Cell"},{"key":"B129","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1038\/nrm3823","article-title":"Cellular senescence: from physiology to pathology","volume":"15","author":"Mu\u00f1oz-Esp\u00edn","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"866718","DOI":"10.3389\/fragi.2022.866718","article-title":"Cellular senescence and ageing: mechanisms and interventions","volume":"3","author":"Mylonas","year":"2022","journal-title":"Front. Aging"},{"key":"B131","doi-asserted-by":"publisher","first-page":"343","DOI":"10.3390\/genes8120343","article-title":"Epigenetic basis of cellular senescence and its implications in aging","volume":"8","author":"Nacarelli","year":"2017","journal-title":"Genes (Basel)"},{"key":"B132","doi-asserted-by":"publisher","first-page":"H1673","DOI":"10.1152\/ajpheart.00455.2009","article-title":"Replicative senescence of vascular smooth muscle cells enhances the calcification through initiating the osteoblastic transition","volume":"297","author":"Nakano-Kurimoto","year":"2009","journal-title":"Am. J. Physiol. - Hear. Circ. Physiol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/j.1474-9726.2012.00795.x","article-title":"A senescent cell bystander effect: senescence-induced senescence","volume":"11","author":"Nelson","year":"2012","journal-title":"Aging Cell"},{"key":"B134","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.3390\/cells11071185","article-title":"The role of MicroRNAs in endothelial cell senescence","volume":"11","author":"Nikolajevic","year":"2022","journal-title":"Cells"},{"key":"B135","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s41232-022-00197-8","article-title":"The roles and mechanisms of senescence-associated secretory phenotype (SASP): can it be controlled by senolysis?","volume":"42","author":"Ohtani","year":"2022","journal-title":"Inflamm. Regen."},{"key":"B136","doi-asserted-by":"publisher","first-page":"9076485","DOI":"10.1155\/2018\/9076485","article-title":"Cellular senescence and inflammaging in age-Related diseases","volume":"2018","author":"Olivieri","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"B137","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-018-0327-1","article-title":"The pro-inflammatory phenotype of the human non-classical monocyte subset is attributed to senescence article","volume":"9","author":"Ong","year":"2018","journal-title":"Cell Death Dis."},{"key":"B138","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.jjcc.2015.10.017","article-title":"Functions of microRNA-33a\/b and microRNA therapeutics","volume":"67","author":"Ono","year":"2016","journal-title":"J. Cardiol."},{"key":"B139","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.3390\/jcm10153239","article-title":"Understanding chronic venous disease: a critical overview of its pathophysiology and medical management","volume":"10","author":"Ortega","year":"","journal-title":"J. Clin. Med."},{"key":"B140","doi-asserted-by":"publisher","first-page":"547","DOI":"10.14670\/HH-18-322","article-title":"Defective expression of the peroxisome regulators PPAR\u03b1 receptors and lysogenesis with increased cellular senescence in the venous wall of chronic venous disorder","volume":"36","author":"Ortega","year":"","journal-title":"Histol. Histopathol."},{"key":"B141","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1161\/ATVBAHA.110.210500","article-title":"Induction of endothelial nitric oxide synthase, SIRT1, and catalase by statins inhibits endothelial senescence through the Akt pathway","volume":"30","author":"Ota","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"5435","DOI":"10.1038\/s41467-018-07825-3","article-title":"Impaired immune surveillance accelerates accumulation of senescent cells and aging","volume":"9","author":"Ovadya","year":"2018","journal-title":"Nat. Commun."},{"key":"B143","doi-asserted-by":"publisher","first-page":"111788","DOI":"10.1016\/j.biopha.2021.111788","article-title":"Hsa-miR-605 regulates the proinflammatory chemokine CXCL5 in complex regional pain syndrome","volume":"140","author":"Pande","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"B144","doi-asserted-by":"publisher","first-page":"9634","DOI":"10.18632\/oncotarget.7457","article-title":"GDF15 contributes to radiation-induced senescence through the ros-mediated p16 pathway in human endothelial cells","volume":"7","author":"Park","year":"2016","journal-title":"Oncotarget"},{"key":"B145","doi-asserted-by":"publisher","first-page":"111416","DOI":"10.1016\/j.exger.2021.111416","article-title":"Senolytic agents lessen the severity of abdominal aortic aneurysm in aged mice","volume":"151","author":"Parvizi","year":"2021","journal-title":"Exp. Gerontol."},{"key":"B146","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/cvr\/cvv227","article-title":"The role of inflammatory biomarkers in developing targeted cardiovascular therapies: lessons from the cardiovascular inflammation reduction trials","volume":"109","author":"Passacquale","year":"2016","journal-title":"Cardiovasc. Res."},{"key":"B147","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1039\/d0bm01297a","article-title":"A 3D tissue model-on-a-chip for studying the effects of human senescent fibroblasts on blood vessels","volume":"9","author":"Pauty","year":"2021","journal-title":"Biomater. Sci."},{"key":"B148","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1111\/acel.12518","article-title":"Small molecule compounds that induce cellular senescence","volume":"15","author":"Petrova","year":"2016","journal-title":"Aging Cell"},{"key":"B149","doi-asserted-by":"publisher","first-page":"120677","DOI":"10.1016\/j.biomaterials.2021.120677","article-title":"Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis","volume":"269","author":"Pham","year":"2021","journal-title":"Biomaterials"},{"key":"B151","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.3390\/ijms20112615","article-title":"LncRNAs regulatory networks in cellular senescence","volume":"20","author":"Puvvula","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B152","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12979-016-0076-x","article-title":"Interleukin-6 and C-reactive protein, successful aging, and mortality: the PolSenior study","volume":"13","author":"Puzianowska-Ku\u017anicka","year":"2016","journal-title":"Immun. Ageing"},{"key":"B153","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3390\/jpm12020215","article-title":"Endothelial senescence and the chronic vascular diseases: challenges and therapeutic opportunities in atherosclerosis","volume":"12","author":"Ram\u00edrez","year":"2022","journal-title":"J. Pers. Med."},{"key":"B154","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1002\/ijc.27316","article-title":"Cellular senescence and tumor suppressor gene p16","volume":"130","author":"Rayess","year":"2012","journal-title":"Int. J. Cancer"},{"key":"B155","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1161\/ATVBAHA.115.306770","article-title":"Regulation of vascular smooth muscle cell dysfunction under diabetic conditions by MIR-504","volume":"36","author":"Reddy","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B156","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/j.1440-1681.2008.05042.x","article-title":"Effect of chronic aspirin administration on an experimental model of metabolic syndrome","volume":"36","author":"Renna","year":"2009","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B157","doi-asserted-by":"publisher","first-page":"3761","DOI":"10.3390\/ijms19123761","article-title":"Role of p38 MAPK in atherosclerosis and aortic valve sclerosis","volume":"19","author":"Reustle","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"B158","doi-asserted-by":"publisher","first-page":"dev151837","DOI":"10.1242\/dev.151837","article-title":"Cellular senescence in development, regeneration and disease","volume":"146","author":"Rhinn","year":"2019","journal-title":"Dev"},{"key":"B159","doi-asserted-by":"publisher","first-page":"13173","DOI":"10.3390\/ijms222313173","article-title":"Mechanisms and regulation of cellular senescence","volume":"22","author":"Roger","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B160","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3390\/antiox6020043","article-title":"NOX2-Induced activation of arginase and diabetes-induced retinal endothelial cell senescence","volume":"6","author":"Rojas","year":"2017","journal-title":"Antioxidants"},{"key":"B161","doi-asserted-by":"publisher","first-page":"H890","DOI":"10.1152\/ajpheart.00416.2017","article-title":"Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function","volume":"313","author":"Rossman","year":"2017","journal-title":"Am. J. Physiol. - Hear. Circ. Physiol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/j.cell.2020.03.008","article-title":"Senescence-induced vascular remodeling creates therapeutic vulnerabilities in pancreas cancer","volume":"181","author":"Ruscetti","year":"2020","journal-title":"Cell"},{"key":"B163","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.3390\/biom10091316","article-title":"Regulation of p27kip1 and p57kip2 functions by natural polyphenols","volume":"10","author":"Russo","year":"2020","journal-title":"Biomolecules"},{"key":"B164","doi-asserted-by":"publisher","first-page":"e0187934","DOI":"10.1371\/journal.pone.0187934","article-title":"Fish oil omega-3 polyunsaturated fatty acids attenuate oxidative stress-induced DNA damage in vascular endothelial cells","volume":"12","author":"Sakai","year":"2017","journal-title":"PLoS One"},{"key":"B165","doi-asserted-by":"publisher","first-page":"e0171431","DOI":"10.1371\/journal.pone.0171431","article-title":"Potential roles of DNA methylation in the initiation and establishment of replicative senescence revealed by array-based methylome and transcriptome analyses","volume":"12","author":"Sakaki","year":"2017","journal-title":"PLoS One"},{"key":"B166","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1101\/gad.235184.113","article-title":"Cellular senescence and its effector programs","volume":"28","author":"Salama","year":"2014","journal-title":"Genes Dev."},{"key":"B167","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1158\/0008-5472.CAN-18-3437","article-title":"Tumor cell escape from therapy-induced senescence as a model of disease recurrence after dormancy","volume":"79","author":"Saleh","year":"2019","journal-title":"Cancer Res."},{"key":"B168","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1016\/j.cellsig.2011.12.006","article-title":"Emerging role of NF-\u03baB signaling in the induction of senescence-associated secretory phenotype (SASP)","volume":"24","author":"Salminen","year":"2012","journal-title":"Cell. Signal."},{"key":"B169","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/j.molcel.2020.03.007","article-title":"4D genome rewiring during oncogene-induced and replicative senescence","volume":"78","author":"Sati","year":"2020","journal-title":"Mol. Cell"},{"key":"B170","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.atherosclerosis.2007.09.040","article-title":"Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease","volume":"198","author":"Satoh","year":"2008","journal-title":"Atherosclerosis"},{"key":"B171","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/s41571-022-00668-4","article-title":"Senescence and cancer \u2014 role and therapeutic opportunities","volume":"19","author":"Schmitt","year":"2022","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"B172","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1038\/nm.3487","article-title":"MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1","volume":"20","author":"Schober","year":"2014","journal-title":"Nat. Med."},{"key":"B173","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1111\/j.1476-5381.2011.01230.x","article-title":"Metformin restores endothelial function in aorta of diabetic rats","volume":"163","author":"Sena","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"B174","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.cmet.2013.03.009","article-title":"Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration","volume":"17","author":"Sene","year":"2013","journal-title":"Cell Metab."},{"key":"B175","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1101\/gad.223834.113","article-title":"Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape","volume":"27","author":"Shah","year":"2013","journal-title":"Genes Dev."},{"key":"B176","doi-asserted-by":"publisher","first-page":"H448","DOI":"10.1152\/ajpheart.00287.2018","article-title":"Cellular senescence links aging and diabetes in cardiovascular disease","volume":"315","author":"Shakeri","year":"2018","journal-title":"Am. J. Physiol. - Hear. Circ. Physiol."},{"key":"B177","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1111\/febs.16325","article-title":"P53 in senescence \u2013 it\u2019S a marathon, not a sprint","volume":"290","author":"Sheekey","year":"2023","journal-title":"FEBS J."},{"key":"B178","doi-asserted-by":"publisher","first-page":"2435","DOI":"10.3390\/cells10092435","article-title":"T cell immunosenescence in aging, obesity, and cardiovascular disease","volume":"10","author":"Shirakawa","year":"2021","journal-title":"Cells"},{"key":"B179","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3389\/fgene.2017.00138","article-title":"Epigenetic regulation of cellular senescence and aging","volume":"8","author":"Sidler","year":"2017","journal-title":"Front. Genet."},{"key":"B180","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1146\/annurev-physiol-030212-183802","article-title":"The adventitia: essential regulator of vascular wall structure and function","volume":"75","author":"Stenmark","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1186\/s13148-018-0585-x","article-title":"Trajectories of inflammatory biomarkers over the eighth decade and their associations with immune cell profiles and epigenetic ageing","volume":"10","author":"Stevenson","year":"2018","journal-title":"Clin. Epigenetics"},{"key":"B182","doi-asserted-by":"publisher","first-page":"2983","DOI":"10.1093\/eurheartj\/ehz919","article-title":"Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis","volume":"41","author":"Stojanovic","year":"2020","journal-title":"Eur. Heart J."},{"key":"B183","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.1016\/j.cell.2013.10.041","article-title":"Senescence is a developmental mechanism that contributes to embryonic growth and patterning","volume":"155","author":"Storer","year":"2013","journal-title":"Cell"},{"key":"B184","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.3390\/cells12091296","article-title":"Senescent cells: a therapeutic target in cardiovascular diseases","volume":"12","author":"Suda","year":"2023","journal-title":"Cells"},{"key":"B185","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13578-022-00815-5","article-title":"The multifaceted role of the SASP in atherosclerosis: from mechanisms to therapeutic opportunities","volume":"12","author":"Sun","year":"2022","journal-title":"Cell Biosci."},{"key":"B186","doi-asserted-by":"publisher","first-page":"2031","DOI":"10.1080\/21691401.2019.1617724","article-title":"DNA methylation abnormalities in atherosclerosis","volume":"47","author":"Tabaei","year":"2019","journal-title":"Artif. Cells, Nanomedicine Biotechnol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.cell.2006.07.024","article-title":"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors","volume":"126","author":"Takahashi","year":"2006","journal-title":"Cell"},{"key":"B188","doi-asserted-by":"publisher","first-page":"15729","DOI":"10.1038\/ncomms15728","article-title":"Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2","volume":"8","author":"Takasugi","year":"2017","journal-title":"Nat. Commun."},{"key":"B189","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/1440-1681.12758","article-title":"C-reactive protein and ageing","volume":"44","author":"Tang","year":"2017","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"B190","article-title":"Histology, blood vascular system","volume-title":"StatPearls - NCBI bookshelf","author":"Taylor","year":"2023"},{"key":"B191","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1007\/s11033-016-4065-0","article-title":"The cell fate: senescence or quiescence","volume":"43","author":"Terzi","year":"2016","journal-title":"Mol. Biol. Rep."},{"key":"B192","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-019-12888-x","article-title":"Identification and characterization of Cardiac Glycosides as senolytic compounds","volume":"10","author":"Triana-Mart\u00ednez","year":"2019","journal-title":"Nat. Commun."},{"key":"B193","doi-asserted-by":"publisher","first-page":"e0192252","DOI":"10.1371\/journal.pone.0192252","article-title":"Administration of L-arginine plus L-citrulline or L-citrulline alone successfully retarded endothelial senescence","volume":"13","author":"Tsuboi","year":"2018","journal-title":"PLoS One"},{"key":"B194","doi-asserted-by":"publisher","first-page":"130833","DOI":"10.1111\/acel.13083","article-title":"Cellular senescence and chronological age in various human tissues: a systematic review and meta-analysis","volume":"19","author":"Tuttle","year":"2020","journal-title":"Aging Cell"},{"key":"B195","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/j.jacc.2019.11.061","article-title":"Mechanisms of vascular aging, A geroscience perspective: JACC focus seminar","volume":"75","author":"Ungvari","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"B196","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1038\/s42003-021-02123-z","article-title":"Telomere damage promotes vascular smooth muscle cell senescence and immune cell recruitment after vessel injury","volume":"4","author":"Uryga","year":"2021","journal-title":"Commun. Biol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"2309","DOI":"10.3390\/diagnostics12102309","article-title":"Senescence-associated \u03b2-galactosidase detection in pathology","volume":"12","author":"Valieva","year":"2022","journal-title":"Diagnostics"},{"key":"B198","doi-asserted-by":"publisher","first-page":"13059","DOI":"10.3390\/ijms232113059","article-title":"Targeting immune senescence in atherosclerosis","volume":"23","author":"Vellasamy","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B199","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s13148-016-0170-0","article-title":"Epigenetic associations in relation to cardiovascular prevention and therapeutics","volume":"8","author":"Voelter-Mahlknecht","year":"2016","journal-title":"Clin. Epigenetics"},{"key":"B200","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1111\/acel.12247","article-title":"SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence","volume":"13","author":"Wan","year":"2014","journal-title":"Aging Cell"},{"key":"B201","doi-asserted-by":"publisher","first-page":"980700","DOI":"10.1371\/journal.pone.0098070","article-title":"Dysregulated miR-361-5p\/VEGF axis in the plasma and endothelial progenitor cells of patients with coronary artery disease","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"B202","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1161\/CIRCULATIONAHA.115.016457","article-title":"Vascular smooth muscle cell senescence promotes atherosclerosis and features of plaque vulnerability","volume":"132","author":"Wang","year":"2015","journal-title":"Circulation"},{"key":"B203","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1038\/s41392-022-01211-8","article-title":"Epigenetic regulation of aging: implications for interventions of aging and diseases","volume":"7","author":"Wang","year":"","journal-title":"Signal Transduct. Target. Ther."},{"key":"B204","doi-asserted-by":"publisher","first-page":"5011","DOI":"10.12659\/MSM.898883","article-title":"MiR-206 suppresses the progression of coronary artery disease by modulating vascular endothelial growth factor (VEGF) expression","volume":"22","author":"Wang","year":"","journal-title":"Med. Sci. Monit."},{"key":"B205","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/1755-5922.12187","article-title":"MiR-23a regulates the vasculogenesis of coronary artery disease by targeting epidermal growth factor receptor","volume":"34","author":"Wang","year":"","journal-title":"Cardiovasc. Ther."},{"key":"B206","doi-asserted-by":"publisher","first-page":"942796","DOI":"10.3389\/fimmu.2022.942796","article-title":"Immunosenescence, aging and successful aging","volume":"13","author":"Wang","year":"","journal-title":"Front. Immunol."},{"key":"B207","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1038\/s42255-021-00483-8","article-title":"The metabolic roots of senescence: mechanisms and opportunities for intervention","volume":"3","author":"Wiley","year":"2021","journal-title":"Nat. Metab."},{"key":"B208","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.cmet.2015.11.011","article-title":"Mitochondrial dysfunction induces senescence with a distinct secretory phenotype","volume":"23","author":"Wiley","year":"2016","journal-title":"Cell Metab."},{"key":"B209","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3389\/fcell.2020.00773","article-title":"Senescence in wound repair: emerging strategies to target chronic healing wounds","volume":"8","author":"Wilkinson","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"B210","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/bjp.2008.272","article-title":"Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms","volume":"155","author":"Xia","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"B211","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1074\/jbc.M109.065235","article-title":"PGC-1 alpha serine 570 phosphorylation and GCN5-mediated acetylation by angiotensin II drive catalase down-regulation and vascular hypertrophy","volume":"285","author":"Xiong","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B212","doi-asserted-by":"publisher","first-page":"699374","DOI":"10.3389\/fcell.2021.699374","article-title":"Roles and mechanisms of DNA methylation in vascular aging and related diseases","volume":"9","author":"Xu","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B213","doi-asserted-by":"publisher","first-page":"E6301","DOI":"10.1073\/pnas.1515386112","article-title":"JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age","volume":"112","author":"Xu","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B214","doi-asserted-by":"publisher","first-page":"11538","DOI":"10.3390\/ijms241411538","article-title":"Vascular ageing: mechanisms, risk factors, and treatment strategies","volume":"24","author":"Ya","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B215","doi-asserted-by":"publisher","first-page":"1068","DOI":"10.1161\/STROKEAHA.115.010835","article-title":"Vascular cell senescence contributes to blood-brain barrier breakdown","volume":"47","author":"Yamazaki","year":"2016","journal-title":"Stroke"},{"key":"B216","doi-asserted-by":"publisher","first-page":"722205","DOI":"10.3389\/fcell.2021.722205","article-title":"The paradoxical role of cellular senescence in cancer","volume":"9","author":"Yang","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B217","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bbrc.2021.12.098","article-title":"Oridonin inhibits SASP by blocking p38 and NF-\u03baB pathways in senescent cells","volume":"590","author":"Yasuda","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B218","doi-asserted-by":"publisher","first-page":"8241","DOI":"10.3390\/ijms21218241","article-title":"New insights into the role of histone changes in aging","volume":"21","author":"Yi","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B219","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.cjca.2016.02.051","article-title":"Cellular senescence and vascular disease: novel routes to better understanding and therapy","volume":"32","author":"Yin","year":"2016","journal-title":"Can. J. Cardiol."},{"key":"B220","doi-asserted-by":"publisher","first-page":"3574","DOI":"10.18632\/aging.101998","article-title":"TGF-\u03b2 mediates aortic smooth muscle cell senescence in Marfan syndrome","volume":"11","author":"You","year":"2019","journal-title":"Aging (Albany. NY)"},{"key":"B221","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ebiom.2018.09.015","article-title":"Fisetin is a senotherapeutic that extends health and lifespan","volume":"36","author":"Yousefzadeh","year":"2018","journal-title":"EBioMedicine"},{"key":"B222","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s10238-015-0376-z","article-title":"T cell senescence and cardiovascular diseases","volume":"16","author":"Yu","year":"2016","journal-title":"Clin. Exp. Med."},{"key":"B223","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1182\/blood-2011-01-326827","article-title":"SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset","volume":"118","author":"Zawada","year":"2011","journal-title":"Blood"},{"key":"B224","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1083\/jcb.200605113","article-title":"HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells","volume":"174","author":"Zeng","year":"2006","journal-title":"J. Cell Biol."},{"key":"B225","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1111\/febs.16350","article-title":"Targeting cellular senescence with senotherapeutics: senolytics and senomorphics","volume":"290","author":"Zhang","year":"2023","journal-title":"FEBS J."},{"key":"B226","doi-asserted-by":"publisher","first-page":"113737","DOI":"10.1016\/j.biopha.2022.113737","article-title":"Targeted delivery strategy: a beneficial partner for emerging senotherapy","volume":"155","author":"Zhang","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"B227","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1161\/CIRCRESAHA.118.312497","article-title":"Epigenetic modifications in cardiovascular aging and diseases","volume":"123","author":"Zhang","year":"2018","journal-title":"Circ. Res."},{"key":"B228","doi-asserted-by":"publisher","first-page":"2308","DOI":"10.18632\/aging.101038","article-title":"SIRT6 delays cellular senescence by promoting p27Kip1 ubiquitin-proteasome degradation","volume":"8","author":"Zhao","year":"2016","journal-title":"Aging (Albany. NY)"},{"key":"B229","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.mad.2006.07.003","article-title":"Clonal senescence alters endothelial ICAM-1 function","volume":"127","author":"Zhou","year":"2006","journal-title":"Mech. Ageing Dev."},{"key":"B230","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/s41368-023-00228-1","article-title":"RANKL+ senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics","volume":"15","author":"Zhou","year":"2023","journal-title":"Int. J. Oral Sci."},{"key":"B231","doi-asserted-by":"publisher","first-page":"106479","DOI":"10.1016\/j.biocel.2023.106479","article-title":"Immunosenescence and macrophages: from basics to therapeutics","volume":"165","author":"Zhu","year":"2023","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"B232","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1038\/s41392-021-00646-9","article-title":"Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention","volume":"6","author":"Zhu","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"key":"B233","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1111\/acel.12445","article-title":"Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors","volume":"15","author":"Zhu","year":"2016","journal-title":"Aging Cell"},{"key":"B234","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/acel.12344","article-title":"The achilles\u2019 heel of senescent cells: from transcriptome to senolytic drugs","volume":"14","author":"Zhu","year":"2015","journal-title":"Aging Cell"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2024.1345459\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T04:52:13Z","timestamp":1708923133000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2024.1345459\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,26]]},"references-count":233,"alternative-id":["10.3389\/fgene.2024.1345459"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2024.1345459","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,26]]},"article-number":"1345459"}}