{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T22:05:53Z","timestamp":1788300353752,"version":"build-2803163510"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"publisher","award":["26010212002212"],"award-info":[{"award-number":["26010212002212"]}],"id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the genetic correlation and causal links between sleep traits (including sleep duration, chronotype, and insomnia) and myopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Summary data on three sleep traits (sleep duration, chronotype and insomnia) and myopia from FinnGen (n = 214,211) and UK Biobank (n = 460,536) were analyzed using linkage disequilibrium score regression (LD Score), univariable and multivariable mendelian randomization (MR) experiments and Causal Analysis Using Summary Effect (CAUSE) estimation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LD Score regression detected candidate genetic correlation between sleep traits and myopia, such as sleep duration, chronotype (Genetic Correlation Z-score &amp;gt;10.00, h2<jats:italic>_<\/jats:italic>observed_<jats:italic>p<\/jats:italic> &amp;lt; 0.005, Lambda GC &amp;gt; 1.05, <jats:italic>p<\/jats:italic> &amp;gt; 0.05). Univariable MR analyses indicated that increased sleep duration has a promotional effect on the occurrence of myopia (<jats:italic>p<\/jats:italic> = 0.046 &amp;lt; 0.05, P_FDR = 0.138 &amp;lt; 0.2, OR = 2.872, 95% CI: 1.018\u20138.101). However, after accounting for potential confounding factors, multivariable MR and CAUSE analysis did not provide evidence for a causal effect of the three sleep traits on myopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There may be a potential genetic correlation between sleep duration, chronotype and myopia. However, neither of sleep duration, chronotype or insomnia had causal effect on myopia.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fgene.2024.1378802","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T04:55:19Z","timestamp":1720500919000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic correlation and causal relationship between sleep and myopia: a mendelian randomization study"],"prefix":"10.3389","volume":"15","author":[{"given":"Guandong","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruikang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengke","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"Auton","year":"2015","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"33902","DOI":"10.1038\/srep33902","article-title":"Decreased sleep quality in high myopia children","volume":"6","author":"Ayaki","year":"2016","journal-title":"Sci. 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