{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T19:20:52Z","timestamp":1784661652597,"version":"3.55.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>Preeclampsia is the main cause of maternal and infant mortality and morbidity during pregnancy. Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) and human leukocyte antigen G (HLA-G) play crucial roles in immune tolerance at the maternal-fetal interface. In this case\u2012control study, 154 maternal\u2013fetal pairs were recruited, including 74 pairs with preeclampsia (56 of 74 pairs from family triads) and 80 pairs with a normal pregnancy (78 of 80 pairs from family triads). SNaPshot technology was used to detect genetic polymorphisms for 7 TagSNPs in the <jats:italic>KIR2DL4<\/jats:italic> and <jats:italic>HLA-G<\/jats:italic> genes. Among the fetal <jats:italic>HLA-G<\/jats:italic> gene polymorphisms, rs9380142 (A vs. G: OR = 2.802, 95% CI = 1.761\u20134.458) and rs1063320 (G vs. C: OR = 1.807, 95% CI = 1.144\u20132.852) differed between the preeclampsia group and the control group. The transmission disequilibrium test (TDT) suggested that the differences in the rs9380142G\/A polymorphism in foetuses between preeclampsia triads and control triads were due to differences in transmission from the parents (<jats:italic>P<\/jats:italic> = 0.001). There was no significant difference in the distribution of maternal <jats:italic>KIR2DL4<\/jats:italic> alleles or genotype frequency between the preeclampsia group and the control group. Gene\u2012gene interaction analysis revealed that the combined genotypes of maternal rs649216-CC and fetal rs9380142-GG, maternal rs1051456-CG\/GG and fetal rs9380142-GG, maternal rs34785252-CC and fetal rs9380142-AA\/GA, and maternal rs34785252-CC\/AA and fetal rs9380142-GG were associated with a significantly lower risk of preeclampsia. Therefore, this study suggested that the combination of maternal KIR2DL4 and fetal HLA-G polymorphisms was associated with preeclampsia in a Han Chinese population.<\/jats:p>","DOI":"10.3389\/fgene.2024.1442938","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T04:34:00Z","timestamp":1722400440000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Combined maternal KIR2DL4 and fetal HLA-G polymorphisms were associated with preeclampsia in a Han Chinese population"],"prefix":"10.3389","volume":"15","author":[{"given":"Yantuanjin","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4021\/jocmr1682w","article-title":"A brief overview of preeclampsia","volume":"6","author":"Al-Jameil","year":"2014","journal-title":"J. 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