{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T00:15:09Z","timestamp":1793924109291,"version":"4.8.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several studies have demonstrated an increased risk of periodontitis (PD) among patients diagnosed with systemic lupus erythematosus (SLE). However, the underlying common mechanism between them remains incompletely understood. Accordingly, the aim of this study is to examine diagnostic biomarkers and potential therapeutic targets for SLE and PD by leveraging publicly accessible microarray datasets and transcriptome analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Datasets pertaining to SLE and PD were retrieved from the Gene Expression Omnibus (GEO) database, and subsequently analyzed for differentially expressed genes (DEGs). Key gene modules were identified through weighted gene co-expression network analysis (WGCNA), and shared genes were obtained by overlapping key genes between DEGs and WGCNA. These shared genes were subsequently subjected to Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses, leading to the establishment of a Protein-Protein Interaction (PPI) network. Random forest (RF) and Least Absolute Shrinkage and Selection Operator (Lasso) regression were employed to identify key hub genes. Receiver operating characteristic (ROC) curves were generated using a new validation dataset to evaluate the performance of candidate genes. Finally, levels of immune cell infiltration in SLE and PD were assessed using CIBERSORTx.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 50 core genes were identified between the genes screened by WGCNA and DEGs. Functional enrichment analysis revealed that these genes are primarily associated with the PI3K-Akt and B-cell receptor signaling pathways. Additionally, using machine learning algorithms and ROC curve analysis, a total of 8 key genes (PLEKHA1, CEACAM1, TNFAIP6, TCN2, GLDC, GNG7, LY96, VCAN) were identified Finally, immune infiltration analysis highlighted the significant roles of neutrophils, monocytes, plasma cells, and gammadelta T cells (\u03b3\u03b4 T cells) in the pathogenesis of both SLE and PD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study identifies 8 hub genes that could potentially serve as diagnostic markers for both SLE and PD, highlighting the importance of VCAN and LY96 in diagnosis. Moreover, the involvement of the PI3K-Akt signaling pathway in both diseases suggests its significant role. These identified key genes and signaling pathways lay the groundwork for deeper comprehension of the interplay between SLE and PD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fgene.2025.1527713","type":"journal-article","created":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T01:26:13Z","timestamp":1744766773000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["The potential crosstalk genes and molecular mechanisms between systemic lupus erythematosus and periodontitis"],"prefix":"10.3389","volume":"16","author":[{"given":"Kai","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmiao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinge","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"126","DOI":"10.4081\/reumatismo.2013.126","article-title":"Temporomandibular joint dysfunction in various rheumatic diseases","volume":"65","author":"Aceves-Avila","year":"2013","journal-title":"Reumatismo"},{"key":"B2","doi-asserted-by":"publisher","first-page":"15330","DOI":"10.3390\/ijms232315330","article-title":"The PI3K\/akt pathway in meta-inflammation","volume":"23","author":"Acosta-Martinez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1007\/s00296-023-05346-x","article-title":"Systemic lupus erythematosus: latest insight into etiopathogenesis","volume":"43","author":"Akhil","year":"2023","journal-title":"Rheumatol. Int."},{"key":"B4","doi-asserted-by":"publisher","first-page":"e30330","DOI":"10.7759\/cureus.30330","article-title":"An overview of systemic lupus erythematosus (SLE) pathogenesis, classification, and management","volume":"14","author":"Ameer","year":"2022","journal-title":"Cureus"},{"key":"B5","doi-asserted-by":"publisher","first-page":"45.7","DOI":"10.4049\/jimmunol.200.Supp.45.7","article-title":"Periodontal pathogen exposure facilitates disease activity in Systemic Lupus Erythematosus","volume":"200","author":"Bagavant","year":"2018","journal-title":"J. Immunol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1111\/odi.13843","article-title":"Shared microbiological and immunological patterns in periodontitis and IBD: a scoping review","volume":"28","author":"Baima","year":"2022","journal-title":"Oral Dis."},{"key":"B7","doi-asserted-by":"publisher","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets\u2014update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"B8","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/odi.13271","article-title":"Orofacial manifestations and dental management of systemic lupus erythematosus: a review","volume":"27","author":"Benli","year":"2021","journal-title":"Oral Dis."},{"key":"B9","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1002\/JPER.21-0181","article-title":"Periodontitis in patients with systemic lupus erythematosus: a nationwide study of 1,990 patients","volume":"93","author":"Bolstad","year":"2022","journal-title":"J. Periodontol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"894315","DOI":"10.3389\/fimmu.2022.894315","article-title":"\u0393\u03b4 T cells in the tumor microenvironment-interactions with other immune cells","volume":"13","author":"Chan","year":"2022","journal-title":"Front. Immunol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.3324\/haematol.2019.216218","article-title":"CXCR4 upregulation is an indicator of sensitivity to B-cell receptor\/PI3K blockade and a potential resistance mechanism in B-cell receptor-dependent diffuse large B-cell lymphomas","volume":"105","author":"Chen","year":"2020","journal-title":"Haematologica"},{"key":"B12","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1038\/nature14282","article-title":"IL-17-producing \u03b3\u03b4 T cells and neutrophils conspire to promote breast cancer metastasis","volume":"522","author":"Coffelt","year":"2015","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1177\/0961203317719147","article-title":"Impact of systemic lupus erythematosus on oral health-related quality of life","volume":"27","author":"Corr\u00eaa","year":"2018","journal-title":"Lupus"},{"key":"B14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1186\/1471-2105-7-3","article-title":"Gene selection and classification of microarray data using random forest","volume":"7","author":"D\u00edaz-Uriarte","year":"2006","journal-title":"BMC Bioinforma."},{"key":"B15","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.semcdb.2003.12.024","article-title":"PI3K signaling controls cell fate at many points in B lymphocyte development and activation","volume":"15","author":"Donahue","year":"2004","journal-title":"Semin. Cell Dev. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1172\/JCI99386","article-title":"PI3K p110\u03b4 inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression","volume":"129","author":"Dong","year":"2019","journal-title":"J. Clin. Invest."},{"key":"B17","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.matbio.2011.10.004","article-title":"Hyaluronan and versican in the control of human T-lymphocyte adhesion and migration","volume":"31","author":"Evanko","year":"2012","journal-title":"Matrix Biol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s10067-013-2473-2","article-title":"Periodontitis treatment improves systemic lupus erythematosus response to immunosuppressive therapy","volume":"33","author":"Fabbri","year":"2014","journal-title":"Clin. Rheumatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jaut.2018.11.001","article-title":"Systemic lupus erythematosus: diagnosis and clinical management","volume":"96","author":"Fava","year":"2019","journal-title":"J. Autoimmun."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3949","DOI":"10.3390\/ijms20163949","article-title":"T and B Cells in periodontal disease: new functions in A complex scenario","volume":"20","author":"Figueredo","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1186\/s12951-023-02214-5","article-title":"Mesenchymal stem cells-derived extracellular vesicles protect against oxidative stress-induced xenogeneic biological root injury via adaptive regulation of the PI3K\/Akt\/NRF2 pathway","volume":"21","author":"Fu","year":"2023","journal-title":"J. Nanobiotechnology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"Article30","DOI":"10.2202\/1544-6115.1536","article-title":"Lasso logistic regression, GSoft and the cyclic coordinate descent algorithm: application to gene expression data","volume":"9","author":"Garcia-Magari\u00f1os","year":"2010","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1002\/ar.21094","article-title":"Proteoglycans: key regulators of pulmonary inflammation and the innate immune response to lung infection","volume":"293","author":"Gill","year":"2010","journal-title":"Anat. Rec. Hob."},{"key":"B24","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1177\/0022034518805739","article-title":"The oral microbiota is modified by systemic diseases","volume":"98","author":"Graves","year":"2019","journal-title":"J. Dent. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1093\/intimm\/dxz036","article-title":"Monocyte subsets involved in the development of systemic lupus erythematosus and rheumatoid arthritis","volume":"31","author":"Hirose","year":"2019","journal-title":"Int. Immunol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/978-0-387-79311-5_5","article-title":"The role of PI3K signalling in the B cell response to antigen","volume":"633","author":"Hodson","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1016\/S0140-6736(24)00398-2","article-title":"Systemic lupus erythematosus","volume":"403","author":"Hoi","year":"2024","journal-title":"Lancet"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/jre.12936","article-title":"Periodontitis and systemic lupus erythematosus: a systematic review and meta-analysis","volume":"57","author":"Hussain","year":"2022","journal-title":"J. Periodontal Res."},{"key":"B29","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.jdsr.2023.08.002","article-title":"Periodontitis and periodontopathic bacteria as risk factors for rheumatoid arthritis: a review of the last 10 years","volume":"59","author":"Kobayashi","year":"2023","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"B30","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1902\/jop.2003.74.3.378","article-title":"Risk of periodontitis in systemic lupus erythematosus is associated with Fcgamma receptor polymorphisms","volume":"74","author":"Kobayashi","year":"2003","journal-title":"J. Periodontol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1902\/jop.2007.060194","article-title":"The combined genotypes of stimulatory and inhibitory Fc gamma receptors associated with systemic lupus erythematosus and periodontitis in Japanese adults","volume":"78","author":"Kobayashi","year":"2007","journal-title":"J. Periodontol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"2703","DOI":"10.3390\/ijms20112703","article-title":"Akt signaling in macrophage polarization, survival, and atherosclerosis","volume":"20","author":"Linton","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13372","article-title":"Porphyromonas gingivalis-Lipopolysaccharide Induced Gingival Fibroblasts Trained Immunity Sustains Inflammation in Periodontitis","volume":"12","author":"Liu","year":"2024","journal-title":"J Periodontal Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"648636","DOI":"10.3389\/fphar.2021.648636","article-title":"PI3K\/AKT signal pathway: a target of natural products in the prevention and treatment of alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"12","author":"Long","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1177\/0961203316640909","article-title":"Frequency of dental caries in active and inactive systemic lupus erythematous patients: salivary and bacterial factors","volume":"25","author":"Loyola Rodriguez","year":"2016","journal-title":"Lupus"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-025-02244-1","article-title":"Kurarinone mitigates LPS-induced inflammatory osteolysis by inhibiting osteoclastogenesis through the reduction of ROS levels and suppression of the PI3K\/AKT signaling pathway","author":"Lv","year":"2025","journal-title":"Inflammation"},{"key":"B36","doi-asserted-by":"publisher","first-page":"952987","DOI":"10.3389\/fimmu.2022.952987","article-title":"Bioinformatics and systems biology approach to identify the pathogenetic link of Long COVID and Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome","volume":"13","author":"Lv","year":"2022","journal-title":"Front. Immunol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.clim.2019.06.009","article-title":"The contribution of macrophages to systemic lupus erythematosus","volume":"207","author":"Ma","year":"2019","journal-title":"Clin. Immunol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1498","DOI":"10.1136\/annrheumdis-2018-213615","article-title":"TLR4+CXCR4+ plasma cells drive nephritis development in systemic lupus erythematosus","volume":"77","author":"Ma","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"B39","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/cei.12708","article-title":"Possible evidence of systemic lupus erythematosus and periodontal disease association mediated by Toll-like receptors 2 and 4","volume":"183","author":"Marques","year":"2016","journal-title":"Clin. Exp. Immunol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"709438","DOI":"10.3389\/fphys.2021.709438","article-title":"Periodontal inflammation and systemic diseases: an overview","volume":"12","author":"Mart\u00ednez-Garc\u00eda","year":"2021","journal-title":"Front. Physiol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2113","DOI":"10.4049\/jimmunol.0802771","article-title":"Dendritic cells and monocyte\/macrophages that create the IL-6\/APRIL-rich lymph node microenvironments where plasmablasts mature","volume":"182","author":"Mohr","year":"2009","journal-title":"J. Immunol."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.24-0405","article-title":"Inhibition of fibulin-3 ameliorates periodontal inflammation through reducing M1 macrophage polarization via EGFR\/PI3K\/AKT pathway","author":"Mu","year":"2024","journal-title":"J. Periodontol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"6144","DOI":"10.3390\/ijms24076144","article-title":"Low P-selectin glycoprotein ligand-1 expression in neutrophils associates with disease activity and deregulated NET formation in systemic lupus erythematosus","volume":"24","author":"Mu\u00f1oz-Callejas","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B44","first-page":"72","article-title":"Prevalence of periodontal disease, its association with systemic diseases and prevention","volume":"11","author":"Nazir","year":"2017","journal-title":"Int. J. Health Sci. (Qassim)"},{"key":"B45","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1084\/jem.20050500","article-title":"Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production","volume":"202","author":"Nestle","year":"2005","journal-title":"J. Exp. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"key":"B47","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/nri1056","article-title":"PI3K in lymphocyte development, differentiation and activation","volume":"3","author":"Okkenhaug","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"S162","DOI":"10.1111\/jcpe.12946","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 world workshop on the classification of periodontal and peri-implant diseases and conditions","volume":"45","author":"Papapanou","year":"2018","journal-title":"J. Clin. Periodontol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2602","DOI":"10.3389\/fimmu.2019.02602","article-title":"Host-microbial interactions in systemic lupus erythematosus and periodontitis","volume":"10","author":"Pessoa","year":"2019","journal-title":"Front. Immunol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1165\/rcmb.2009-0081OC","article-title":"Polyinosine-polycytidylic acid stimulates versican accumulation in the extracellular matrix promoting monocyte adhesion","volume":"43","author":"Potter-Perigo","year":"2010","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1111\/jre.12112","article-title":"The role of Toll-like receptor 2 and 4 in gingival tissues of chronic periodontitis subjects with type 2 diabetes","volume":"49","author":"Promsudthi","year":"2014","journal-title":"J. Periodontal Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nri.2017.24","article-title":"Altered B cell signalling in autoimmunity","volume":"17","author":"Rawlings","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.3389\/fimmu.2017.01295","article-title":"Association between systemic lupus erythematosus and periodontitis: a systematic review and meta-analysis","volume":"8","author":"Rutter-Locher","year":"2017","journal-title":"Front. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/j.jaci.2022.10.034","article-title":"Neutrophilic granulocyte-derived B-cell activating factor supports B cells in skin lesions in hidradenitis suppurativa","volume":"151","author":"Sabat","year":"2023","journal-title":"J. Allergy Clin. Immunol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"766944","DOI":"10.3389\/fcimb.2021.766944","article-title":"Periodontal disease: the good, the bad, and the unknown","volume":"11","author":"Sedghi","year":"2021","journal-title":"Front. Cell Infect. Microbiol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"9498876","DOI":"10.1155\/2022\/9498876","article-title":"Metformin facilitates osteoblastic differentiation and M2 macrophage polarization by PI3K\/AKT\/mTOR pathway in human umbilical cord mesenchymal stem cells","volume":"2022","author":"Shen","year":"2022","journal-title":"Stem Cells Int."},{"key":"B57","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1097\/BOR.0000000000000197","article-title":"The role of neutrophils in the pathogenesis of systemic lupus erythematosus","volume":"27","author":"Smith","year":"2015","journal-title":"Curr. Opin. Rheumatol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.3390\/jcm10091957","article-title":"Systemic lupus erythematosus and periodontal disease: a complex clinical and biological interplay","volume":"10","author":"Sojod","year":"2021","journal-title":"J. Clin. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"109031","DOI":"10.1016\/j.clim.2022.109031","article-title":"T cell dysregulation in SLE","volume":"239","author":"Tenbrock","year":"2022","journal-title":"Clin. Immunol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"S159","DOI":"10.1002\/JPER.18-0006","article-title":"Staging and grading of periodontitis: framework and proposal of a new classification and case definition","volume":"89","author":"Tonetti","year":"2018","journal-title":"J. Periodontol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3390\/vaccines6020021","article-title":"Linkage of infection to adverse systemic complications: periodontal disease, toll-like receptors, and other pattern recognition systems","volume":"6","author":"Wallet","year":"2018","journal-title":"Vaccines (Basel)"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1038\/s41419-018-1097-5","article-title":"Azithromycin promotes alternatively activated macrophage phenotype in systematic lupus erythematosus via PI3K\/Akt signaling pathway","volume":"9","author":"Wang","year":"2018","journal-title":"Cell Death Dis."},{"key":"B63","doi-asserted-by":"publisher","first-page":"512","DOI":"10.3389\/fimmu.2020.00512","article-title":"Versican-A critical extracellular matrix regulator of immunity and inflammation","volume":"11","author":"Wight","year":"2020","journal-title":"Front. Immunol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.matbio.2014.01.015","article-title":"Versican and the control of inflammation","volume":"35","author":"Wight","year":"2014","journal-title":"Matrix Biol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"e139828","DOI":"10.1172\/JCI139828","article-title":"Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes","volume":"132","author":"Wu","year":"","journal-title":"J. Clin. Invest."},{"key":"B66","doi-asserted-by":"publisher","first-page":"835081","DOI":"10.3389\/fphar.2022.835081","article-title":"Pentamidine alleviates inflammation and lipopolysaccharide-induced sepsis by inhibiting TLR4 activation via targeting MD2","volume":"13","author":"Wu","year":"","journal-title":"Front. Pharmacol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1129524","DOI":"10.3389\/fimmu.2023.1129524","article-title":"An integrated co-expression network analysis reveals novel genetic biomarkers for immune cell infiltration in chronic kidney disease","volume":"14","author":"Xia","year":"2023","journal-title":"Front. Immunol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"109710","DOI":"10.1016\/j.clim.2023.109710","article-title":"Overexpressed CD44 is associated with B-cell activation via the HA-CD44-AIM2 pathway in lupus B cells","volume":"255","author":"Yi","year":"2023","journal-title":"Clin. Immunol."},{"key":"B69","doi-asserted-by":"publisher","first-page":"112933","DOI":"10.1016\/j.intimp.2024.112933","article-title":"Natural compound phloretin restores periodontal immune homeostasis via HIF-1\u03b1-regulated PI3K\/Akt and glycolysis in macrophages","volume":"141","author":"Zeng","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"9561350","DOI":"10.1155\/2019\/9561350","article-title":"Neutrophil-derived MRP14 supports plasma cell commitment and protects myeloma cells from apoptosis","volume":"2019","author":"Zhao","year":"2019","journal-title":"J. Immunol. Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1080\/08916934.2016.1261841","article-title":"The emerging roles of B cells as partners and targets in periodontitis","volume":"50","author":"Zouali","year":"2017","journal-title":"Autoimmunity"}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2025.1527713\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T01:26:14Z","timestamp":1744766774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2025.1527713\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,16]]},"references-count":72,"alternative-id":["10.3389\/fgene.2025.1527713"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2025.1527713","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,16]]},"article-number":"1527713"}}