{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:06:07Z","timestamp":1770278767523,"version":"3.49.0"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>Filaggrin gene (<jats:italic>FLG\/FLG2<\/jats:italic>) product deregulations are associated with various allergic skin diseases, including but not limited to atopic dermatitis, alopecia areata, and ichthyosis vulgaris. However, the molecular immunological underpinnings of filaggrin phenotype manifestations are not completely understood. To gain insight into the underlying context, we classified the melanomas based on the filaggrin expression (filaggrin<jats:sup>High\/Low<\/jats:sup>) and profiled the signaling context behind pruritic melanomas. We identified that the major signaling context changes behind filaggrin<jats:sup>High<\/jats:sup> melanomas are active FGFR signaling and impaired GNA14 and Th1 signatures, in addition to many genetic and immune changes that are associated with pruritus.<\/jats:p>","DOI":"10.3389\/fgene.2025.1569403","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T04:10:35Z","timestamp":1752811835000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["FilaggrinHigh melanomas exhibit active FGFR and allergic signatures with impaired GNA14 and Th1 signatures"],"prefix":"10.3389","volume":"16","author":[{"given":"Goodwin G.","family":"Jinesh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isha","family":"Godwin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1158\/0008-5472.CAN-20-2426","article-title":"Inhibition of FGFR reactivates IFN\u03b3 signaling in tumor cells to enhance the combined antitumor activity of lenvatinib with Anti-PD-1 antibodies","volume":"82","author":"Adachi","year":"2022","journal-title":"Cancer Res."},{"key":"B2","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.jaad.2021.09.068","article-title":"Common filaggrin gene loss-of-function variants are associated with skin cancer risk","volume":"87","author":"Adelanwa","year":"2022","journal-title":"J. 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