{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:40:20Z","timestamp":1774600820729,"version":"3.50.1"},"reference-count":25,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Cardiovascular diseases (CVDs), including myocardial infarction (MI), heart failure (HF), atrial fibrillation (AF), and arrhythmia, are major contributors to global mortality and often share overlapping risk factors and pathophysiological mechanisms. While genome-wide association studies (GWAS) have identified many loci for individual CVDs, the shared genetic architecture across related traits\u2014particularly in East Asian populations\u2014remains underexplored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We integrated large-scale GWAS summary statistics from East Asian populations to perform genome-wide and local genetic correlation analyses across four CVD phenotypes and five cardiometabolic traits (blood pressure and lipid levels). Using stratified LD score regression, we assessed tissue-specific heritability enrichment. Multi-trait analysis of GWAS (MTAG) was then employed to identify pleiotropic loci associated with multiple traits, with functional annotation and expression quantitative trait loci (eQTL) data used to explore biological relevance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed extensive genetic correlations among CVDs and between CVDs and cardiometabolic traits, with HF showing the strongest connections to both MI and arrhythmia. Notable genome-wide correlations were found between MI and SBP (rg = 0.35, <jats:italic>P<\/jats:italic> = 1.59 \u00d7 10<jats:sup>\u221214<\/jats:sup>) and between HF and DBP (rg = 0.54, <jats:italic>P<\/jats:italic> = 9.84 \u00d7 10<jats:sup>\u22129<\/jats:sup>). Stratified heritability analyses revealed significant enrichment in heart and arterial tissues, highlighting the relevance of cardiovascular-specific regulatory elements. MTAG identified several pleiotropic loci, including established genes such as <jats:italic>APOB<\/jats:italic> and <jats:italic>MC4R<\/jats:italic>, and novel East Asian-enriched signals such as <jats:italic>QSOX2<\/jats:italic> and <jats:italic>GUCY1A1<\/jats:italic>\/<jats:italic>GUCY1B1<\/jats:italic>. Functional data indicated that <jats:italic>QSOX2<\/jats:italic> variants regulate gene expression in arterial and cardiac tissues, implicating redox regulation in HF and hypertension pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings provide comprehensive insight into the shared genetic determinants of cardiovascular and metabolic diseases in East Asian populations. The identification of pleiotropic and ancestry-specific loci, along with tissue-specific regulatory patterns, underscores the need for integrative multi-trait and population-informed approaches in cardiovascular genetics and risk prediction.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fgene.2025.1635378","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T05:22:20Z","timestamp":1750742540000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Shared genetic loci connect cardiovascular disease with blood pressure and lipid traits in East Asian populations"],"prefix":"10.3389","volume":"16","author":[{"given":"Peng","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chumeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinfeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"E517","DOI":"10.1532\/hsf.2955","article-title":"Identification of genetic variants associated with myocardial infarction in Saudi Arabia","volume":"23","author":"Ai-Ghalayini","year":"2020","journal-title":"Heart Surg. forum"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1038\/ng.3406","article-title":"An atlas of genetic correlations across human diseases and traits","volume":"47","author":"Bulik-Sullivan","year":"2015","journal-title":"Nat. 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