{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T10:10:16Z","timestamp":1769681416223,"version":"3.49.0"},"reference-count":80,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Hyperuricemia and gout are common public health problems, stemming from both genetic and lifestyle factors. Evidence from multi-ethnic regions in Yunnan Province remains limited. This preliminary study examined hyperuricemia and gout prevalence, related biomarkers, lifestyle patterns, and\n                      <jats:italic>SLC2A9\/SLC22A12<\/jats:italic>\n                      genetics variations among 88 participants from the Miao community in Yunnan Province China.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A cross-sectional survey and biochemical study were conducted. Demographic and lifestyle data were collected, and blood samples were analyzed for serum biochemical indicators. Eight SNPs in\n                      <jats:italic>SLC2A9<\/jats:italic>\n                      and\n                      <jats:italic>SLC22A12<\/jats:italic>\n                      were genotyped. Logistic regression models were applied to allele and genotype data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Demographic and clinical analyses for Miao villagers (n = 88) suggested that the morbidities of hyperuricemia and gout were more frequent in male and showed significant association with alcohol consumption, smoking, and elevated BMI. While dietary patterns showed no significant differences. Compared with non-hyperuricemia\/non-gout individuals (n = 56), the hyperuricemia\/gout group (n = 57) showed 56% higher uric acid (553.13 vs. 354.73\u00a0\u03bcmol\/L), 37% elevated creatinine (84.66 vs. 61.80\u00a0\u03bcmol\/L), and higher triglycerides (3.35 vs. 1.80\u00a0mmol\/L), along with hematological abnormalities, e.g., elevated hemoglobin (162.77 vs. 147.50\u00a0g\/L) and lower platelets counts (161.09 vs. 194.14 \u00d7 10\n                      <jats:sup>9<\/jats:sup>\n                      \/L). Preliminary genetic analyses indicated a possible association between\n                      <jats:italic>SLC2A9_<\/jats:italic>\n                      rs10939650 and hyperuricemia\/gout risk, whereas variant\n                      <jats:italic>SLC22A12<\/jats:italic>\n                      polymorphisms showed no association. After Bonferroni correction, no SNPs remained statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This preliminary study suggested that the relatively higher burden of hyperuricemia and gout in the Miao population may be influenced by ethnicity, sex, lifestyle factors, metabolic alteration, and potential genetic components. Given the small sample size, the genetic findings should be interpreted cautiously and validated in larger studies for that disease (hyperuricemia and gout) and for similar ethnic community.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fgene.2026.1729712","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T22:10:10Z","timestamp":1769638210000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Preliminary analysis of lifestyle and genetic factors for hyperuricemia and gout prevalence in the Yunnan Miao population of China"],"prefix":"10.3389","volume":"17","author":[{"given":"Qiaohong","family":"Li","sequence":"first","affiliation":[{"name":"The First People\u2019s Hospital of Yunnan Province","place":["Kunming, China"]},{"name":"The People\u2019s Hospital of Wuding County","place":["Wuding, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salma Saeed","family":"Khan","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Yunnan Province","place":["Kunming, China"]},{"name":"Medical Faculty, Kunming University of Science and Technology","place":["Kunming, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Yan","sequence":"additional","affiliation":[{"name":"The People\u2019s Hospital of Wuding County","place":["Wuding, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiying","family":"Kong","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Yunnan Province","place":["Kunming, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Qin","sequence":"additional","affiliation":[{"name":"Medical Faculty, Kunming University of Science and Technology","place":["Kunming, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linmei","family":"Wu","sequence":"additional","affiliation":[{"name":"The People\u2019s Hospital of Wuding County","place":["Wuding, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjie","family":"Li","sequence":"additional","affiliation":[{"name":"The People\u2019s Hospital of Wuding County","place":["Wuding, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijun","family":"Gong","sequence":"additional","affiliation":[{"name":"Medical Faculty, Kunming University of Science and Technology","place":["Kunming, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zheng","sequence":"additional","affiliation":[{"name":"Medical Faculty, Kunming University of Science and Technology","place":["Kunming, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Faculty, Kunming University of Science and Technology","place":["Kunming, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"88","DOI":"10.4078\/jrd.2022.0001","article-title":"Epidemiology and treatment-related concerns of gout and hyperuricemia in Korean","volume":"30","author":"Ahn","year":"2023","journal-title":"J. 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