{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T10:21:08Z","timestamp":1771928468254,"version":"3.50.1"},"reference-count":16,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>\n                    Gastroesophageal reflux disease (GERD) exhibits significant epidemiological comorbidity with psychiatric disorders, yet their shared genetic architecture remains poorly characterized in East Asian populations. Leveraging ancestry-specific genome-wide association study (GWAS) summary statistics from East Asian cohorts, we employed linkage disequilibrium score regression and conditional false discovery rate (condFDR) approaches to investigate cross-trait genetic enrichment between GERD and major psychiatric disorders, including major depressive disorder (MDD), schizophrenia (SCZ), and bipolar disorder (BIP). We identified significant genetic correlations between GERD and both MDD (r\n                    <jats:sub>g<\/jats:sub>\n                    = 0.49,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.03) and SCZ (r\n                    <jats:sub>g<\/jats:sub>\n                    = 0.25,\n                    <jats:italic>P<\/jats:italic>\n                    = 0.02), but not with BIP. Through condFDR analysis, two novel loci were discovered: rs3980178 near\n                    <jats:italic>MEIS1<\/jats:italic>\n                    (associated with GERD-MDD pleiotropy) and rs9844126 near\n                    <jats:italic>ZBTB20<\/jats:italic>\n                    (associated with GERD-SCZ pleiotropy). These loci are implicated in neurodevelopment, autonomic regulation, and neural circuit formation, providing mechanistic insights into the gut-brain axis. Our findings demonstrate that cross-trait genetic enrichment significantly enhances locus discovery for GERD in underpowered East Asian GWAS and reveal ancestry-specific genetic links between gastrointestinal and psychiatric phenotypes.\n                  <\/jats:p>","DOI":"10.3389\/fgene.2026.1770067","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T22:10:12Z","timestamp":1770070212000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Cross-trait genetic enrichment between GERD and psychiatric disorders in East Asian populations"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhihao","family":"Gao","sequence":"first","affiliation":[{"name":"First Clinical Medical College, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianjin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Medical Information and Artificial Intelligence, Shandong First Medical University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zekun","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Medical Information and Artificial Intelligence, Shandong First Medical University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Medical Information and Artificial Intelligence, Shandong First Medical University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidi","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Yantai University","place":["Yantai, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalim","family":"Ullah","sequence":"additional","affiliation":[{"name":"College of Medical Information and Artificial Intelligence, Shandong First Medical University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruiwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Medical Information and Artificial Intelligence, Shandong First Medical University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Medical Information and Artificial Intelligence, Shandong First Medical University","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongsen","family":"Wang","sequence":"additional","affiliation":[{"name":"First Clinical Medical College, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]},{"name":"Gastroenterology Department, Affiliated Hospital, Shandong University of Traditional Chinese Medicine","place":["Jinan, Shandong, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"B1","article-title":"Diversity and scale: genetic architecture of 2068 traits in the va million veteran program","author":"Anurag","year":"2024","journal-title":"Sci"},{"key":"B2","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1038\/s41467-019-11968-2","article-title":"Gastroesophageal reflux gwas identifies risk loci that also associate with subsequent severe esophageal diseases","volume":"10","author":"An","year":"2019","journal-title":"Nat. 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