{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T22:53:29Z","timestamp":1776812009238,"version":"3.51.2"},"reference-count":89,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Synthetic pesticides are widely used in agriculture to manage pests and reduce yield loss. Phytochemicals with antioxidant and antibacterial activities have great potential for treating plant diseases and reducing the use of synthetic chemicals. Identifying compounds from various plant species is crucial for their potential agricultural applications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In the present study,\n                      <jats:italic>Cynoglossum lanceolatum<\/jats:italic>\n                      was screened for potential antioxidant, antimicrobial, and bacterial blight protection abilities. Methanol and aqueous extracts of\n                      <jats:italic>C. Lanceolatum<\/jats:italic>\n                      root was tested for their polyphenol content, antioxidant potential, metabolomics and antimicrobial study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Results revealed that methanol extract exhibited higher phytochemical content and antioxidant activity. FTIR examination of extracts identified functional groups such as OH, C-H, C=C, and C-N, indicating the presence of distinct metabolites. The GC-MS investigation indicated the existence of 59 metabolites, several of which had previously been described as antimicrobial agents. Furthermore,\n                      <jats:italic>in vitro<\/jats:italic>\n                      antibacterial studies confirmed the antimicrobial effect of methanol extract against\n                      <jats:italic>Xanthomonas oryzae<\/jats:italic>\n                      pv.\n                      <jats:italic>oryzae<\/jats:italic>\n                      (\n                      <jats:italic>Xoo<\/jats:italic>\n                      ). Moreover, prediction of antimicrobial metabolites, particularly 7-hydroxy-4-methylcoumarin-3-acetic acid, was confirmed through molecular docking study with D-alanine-D-alanine ligase A (DdlA) and the peptide deformylase (PDF) protein of\n                      <jats:italic>Xoo.<\/jats:italic>\n                      Finally, the study evaluated the effectiveness of\n                      <jats:italic>C. lanceolatu<\/jats:italic>\n                      m root extract against bacterial blight disease, finding a significant reduction in\n                      <jats:italic>Xoo<\/jats:italic>\n                      lesions in pre-treatment and also showing their efficacy in post-treatment. Effect of extract was also observed in the photosynthetic status of rice by measuring chlorophyll A fluorescence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      <jats:italic>C. lanceolatum<\/jats:italic>\n                      is a promising plant for its versatile role as an antioxidant, antimicrobial, and bacterial blight disease protection in rice.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fgene.2026.1775858","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T22:10:33Z","timestamp":1776809433000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated metabolomics and bioactivity analysis of Cynoglossum lanceolatum root extract as a natural inducer of resistance to rice bacterial blight"],"prefix":"10.3389","volume":"17","author":[{"given":"Aadil","family":"Mansoori","sequence":"first","affiliation":[{"name":"Department of Botany, Indira Gandhi National Tribal University (IGNTU)","place":["Amarkantak, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madan","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Botany, Indira Gandhi National Tribal University (IGNTU)","place":["Amarkantak, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subha Narayan","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Botany, Indira Gandhi National Tribal University (IGNTU)","place":["Amarkantak, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Life Sciences, Central University of Karnataka","place":["kalaburagi, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anirudh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Botany, Indira Gandhi National Tribal University (IGNTU)","place":["Amarkantak, India"]},{"name":"Department of Botany, Central Tribal University of Andhra Pradesh","place":["Vizianagaram, India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1515\/psr-2018-0100","article-title":"Secondary metabolites, their structural diversity, bioactivity, and ecological functions: an overview","volume":"4","author":"Abegaz","year":"2019","journal-title":"Phys. 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