{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:48:16Z","timestamp":1790801296562,"version":"4.1.0"},"reference-count":96,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>\n                    Aging is a multifactorial biological process driven by the progressive decline of cellular and tissue homeostasis. Increasing evidence has identified microRNAs (miRNAs) as key epigenetic regulators that fine-tune gene expression networks involved in aging and lifespan determination. Across model organisms\u2014including\n                    <jats:italic>Caenorhabditis elegans, Drosophila melanogaster,<\/jats:italic>\n                    and mammals\u2014numerous miRNAs exhibit age-dependent expression patterns and modulate longevity by targeting conserved signaling pathways such as insulin\/IGF-1 signaling, mTOR, autophagy, mitochondrial homeostasis, and inflammatory responses. These small non-coding RNAs function as network regulators that coordinate multiple biological processes underlying organismal aging. In addition to regulating intrinsic aging pathways, miRNAs have emerged as important mediators of environmental longevity interventions. Moreover, dietary restriction (DR), one of the most robust and evolutionarily conserved lifespan-extending interventions, reshapes miRNA expression programs that control metabolic adaptation, stress resistance, and nutrient-sensing pathways. Furthermore, accumulating evidence indicates that circulating miRNAs detected in body fluids\u2014including blood, serum, and urine\u2014may serve as minimally invasive biomarkers for biological aging and age-related diseases. In this review, we summarize current insights into the roles of miRNAs in lifespan regulation across model organisms, discuss their involvement in DR-mediated longevity, and highlight their emerging applications as diagnostic biomarkers and potential therapeutic targets. Finally, we discuss future directions emphasizing integrative multi-miRNA regulatory networks and miRNA-based aging clocks, which may provide new opportunities for understanding aging mechanisms and developing strategies to promote healthy longevity.\n                  <\/jats:p>","DOI":"10.3389\/fgene.2026.1832187","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T22:10:22Z","timestamp":1785190222000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Roles of microRNA in aging and dietary restriction-induced longevity"],"prefix":"10.3389","volume":"17","author":[{"given":"Jialin","family":"Fan","sequence":"first","affiliation":[{"name":"School of Arts and Sciences, Chemistry and Chemical Biology Cancer Institute of New Jersey (CINJ), Director\u2019s Office Cancer Institute of New Jersey (CINJ), Rutgers University","place":["New Brunswick, NJ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Jilin University","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Urology, The Affiliated Hospital of Changchun University of Chinese Medicine, Changchun University of Chinese Medicine","place":["Changchun, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shenyang Pharmaceutical University","place":["Shenyang, Liaoning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaping","family":"Li","sequence":"additional","affiliation":[{"name":"Princeton Neuroscience Institute, Princeton University","place":["Princeton, NJ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Bakar Aging Research Institute, University of California","place":["San Francisco, CA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Rutgers University","place":["Piscataway, NJ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Rutgers University","place":["Piscataway, NJ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zara","family":"Khanzada","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Rutgers University","place":["Piscataway, NJ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Genomic Medicine and Diabetes Unit, Endocrine Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunpeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Biochemistry, Rutgers University","place":["Piscataway, NJ, United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.1172\/JCI73579","article-title":"MicroRNA-486-dependent modulation of DOCK3\/PTEN\/AKT signaling pathways improves muscular dystrophy-associated symptoms","volume":"124","author":"Alexander","year":"2014","journal-title":"J. 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