{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:54:09Z","timestamp":1781650449067,"version":"3.54.5"},"reference-count":66,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ischemic stroke (IS) and myocardial infarction (MI) share overlapping etiology and pathology, highlighting the need for dual-effective therapies. Buyang Huanwu Decoction (BHD) has shown efficacy against both diseases individually, but its core ingredients and dual therapeutic mechanisms remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using network-based analysis, we identified shared targets and convergent pathways for IS and MI, prioritized BHD ingredients by network proximity, and performed functional enrichment analyses. Molecular docking validated interactions between the key target GSK-3\u03b2 and core ingredients, and surface plasmon resonance (SPR) experimentally determined the binding affinity of the top-ranked ingredient, Myricanone, to GSK-3\u03b2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirteen shared core targets were identified, with the \u201cLipid and atherosclerosis\u201d pathway as the principal common mechanism. Ten key BHD ingredients with predicted dual therapeutic effects were prioritized. Among the shared targets,\n                      <jats:italic>GSK3B<\/jats:italic>\n                      emerged as a central node. Molecular docking showed stable binding of all core ingredients to GSK-3\u03b2, with Myricanone exhibiting the strongest affinity (\u22129\u00a0kcal\/mol), which was confirmed by SPR (KD = 55.1\u00a0\u00b5M).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings elucidate the shared mechanisms of BHD against IS and MI, supporting its potential as a multi-target phytotherapeutic strategy for ischemic cardio-cerebrovascular disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fgene.2026.1843679","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:10:40Z","timestamp":1781647840000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Network-based analysis identifies shared mechanisms between ischemic stroke and myocardial infarction and therapeutic ingredients of Buyang Huanwu Decoction"],"prefix":"10.3389","volume":"17","author":[{"given":"Shuaixin","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Basic Medicine Sciences, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Basic Medicine Sciences, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenke","family":"Xiao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"Institute of Herbgenomics, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanyin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Innovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]},{"name":"Institute of Herbgenomics, Chengdu University of Traditional Chinese Medicine","place":["Chengdu, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"107848","DOI":"10.1016\/j.pharmthera.2021.107848","article-title":"Targeting autophagy in ischemic stroke: from molecular mechanisms to clinical therapeutics","volume":"225","author":"Ajoolabady","year":"2021","journal-title":"Pharmacol. Ther."},{"key":"B2","doi-asserted-by":"publisher","first-page":"10796","DOI":"10.1038\/s41467-024-55055-7","article-title":"Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis","volume":"15","author":"Alecki","year":"2024","journal-title":"Nat. Commun."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1606","DOI":"10.1080\/15548627.2019.1591672","article-title":"Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation","volume":"15","author":"Baechler","year":"2019","journal-title":"Autophagy"},{"key":"B4","first-page":"67","article-title":"Imaging in acute stroke","volume":"12","author":"Birenbaum","year":"2011","journal-title":"West J. Emerg. Med."},{"key":"B5","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1016\/j.cell.2022.04.004","article-title":"Atherosclerosis: recent developments","volume":"185","author":"Bj\u00f6rkegren","year":"2022","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"D488","DOI":"10.1093\/nar\/gkac1077","article-title":"RCSB Protein Data Bank (RCSB.org): delivery of experimentally-determined PDB structures alongside one million computed structure models of proteins from artificial intelligence\/machine learning","volume":"51","author":"Burley","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"B7","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1471-2105-12-35","article-title":"VennDiagram: a package for the generation of highly-customizable Venn and Euler diagrams in R","volume":"12","author":"Chen","year":"2011","journal-title":"BMC Bioinforma."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1200061","DOI":"10.3389\/fnins.2023.1200061","article-title":"A comprehensive review of stroke-related signaling pathways and treatment in western medicine and traditional Chinese medicine","volume":"17","author":"Chen","year":"2023","journal-title":"Front. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.expneurol.2019.04.005","article-title":"OCT4B-190 protects against ischemic stroke by modulating GSK-3\u03b2\/HDAC6","volume":"316","author":"Chen","year":"2019","journal-title":"Exp. Neurol."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1038\/s41467-019-09186-x","article-title":"Network-based prediction of drug combinations","volume":"10","author":"Cheng","year":"2019","journal-title":"Nat. Commun."},{"key":"B11","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3389\/fnmol.2011.00015","article-title":"GSK-3 as a target for lithium-induced neuroprotection against excitotoxicity in neuronal cultures and animal models of ischemic stroke","volume":"4","author":"Chuang","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1159\/000489547","article-title":"An intersectional study of LncRNAs and mRNAs reveals the potential therapeutic targets of Buyang Huanwu decoction in experimental intracerebral hemorrhage","volume":"46","author":"Cui","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"B13","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1007\/s00281-022-00943-7","article-title":"Inflammatory responses after ischemic stroke","volume":"44","author":"DeLong","year":"2022","journal-title":"Semin. Immunopathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"155276","DOI":"10.1016\/j.phymed.2023.155276","article-title":"Qihuang Zhuyu formula alleviates coronary microthrombosis by inhibiting PI3K\/Akt\/\u03b1IIb\u03b23-mediated platelet activation","volume":"125","author":"Ding","year":"2024","journal-title":"Phytomedicine"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1159\/000494587","article-title":"Buyang huanwu decoction attenuates infiltration of natural killer cells and protects against ischemic brain injury","volume":"50","author":"Dou","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/nar\/30.1.207","article-title":"Gene expression omnibus: NCBI gene expression and hybridization array data repository","volume":"30","author":"Edgar","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"153","DOI":"10.13748\/j.cnki.issn1007-7693.2016.11.009","article-title":"Effects of buyang huanwu decoction on apoptosis of nervous cells and expressions of Bcl-2 and bax in the spinal cord of ischemia-reperfusion injury in rabbits","volume":"26","author":"Fan","year":"2006","journal-title":"J. Tradit. Chin. Med."},{"key":"B18","doi-asserted-by":"publisher","first-page":"894289","DOI":"10.3389\/fneur.2022.894289","article-title":"Bioinformatics analysis to identify potential biomarkers and therapeutic targets for ST-segment-elevation myocardial infarction-related ischemic stroke","volume":"13","author":"Feng","year":"2022","journal-title":"Front. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1055\/s-0040-1714212","article-title":"Antithrombotic therapy in myocardial infarction: historic perils and current Challenges-A 70-Year journey","volume":"120","author":"Fernando","year":"2020","journal-title":"Thromb. Haemost."},{"key":"B20","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1038\/nprot.2016.051","article-title":"Computational protein-ligand docking and virtual drug screening with the AutoDock suite","volume":"11","author":"Forli","year":"2016","journal-title":"Nat. Protoc."},{"key":"B21","doi-asserted-by":"publisher","first-page":"qiaf090","DOI":"10.1093\/jleuko\/qiaf090","article-title":"Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis: a role for microRNAs?","volume":"117","author":"Fresneda Alarcon","year":"2025","journal-title":"J. Leukoc. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"eadh0215","DOI":"10.1126\/sciadv.adh0215","article-title":"Network medicine framework reveals generic herb-symptom effectiveness of traditional Chinese medicine","volume":"9","author":"Gan","year":"2023","journal-title":"Sci. Adv."},{"key":"B23","doi-asserted-by":"publisher","first-page":"19574","DOI":"10.1038\/s41598-019-56047-0","article-title":"Sighting acute myocardial infarction through platelet gene expression","volume":"9","author":"Gobbi","year":"2019","journal-title":"Sci. Rep."},{"key":"B24","doi-asserted-by":"publisher","first-page":"10331","DOI":"10.1038\/ncomms10331","article-title":"Network-based in silico drug efficacy screening","volume":"7","author":"Guney","year":"2016","journal-title":"Nat. Commun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1186\/s12967-016-0921-x","article-title":"Guizhi-Shaoyao-Zhimu decoction attenuates rheumatoid arthritis partially by reversing inflammation-immune system imbalance","volume":"14","author":"Guo","year":"2016","journal-title":"J. Transl. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"e2403093","DOI":"10.1002\/advs.202403093","article-title":"CKB promotes mitochondrial ATP production by suppressing permeability transition pore","volume":"11","author":"He","year":"2024","journal-title":"Adv. Sci."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cytogfr.2016.05.001","article-title":"STAT3 signaling in immunity","volume":"31","author":"Hillmer","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2285","DOI":"10.2147\/dddt.S503424","article-title":"Buyang huanwu decoction alleviates ischemic stroke injury by inhibiting ferroptosis via the Nrf2\/GPX4 pathway","volume":"19","author":"Huang","year":"2025","journal-title":"Drug Des. Devel Ther."},{"key":"B29","doi-asserted-by":"publisher","first-page":"4182","DOI":"10.7150\/thno.83714","article-title":"Endothelial TAZ inhibits capillarization of liver sinusoidal endothelium and damage-induced liver fibrosis via nitric oxide production","volume":"13","author":"Hwang","year":"2023","journal-title":"Theranostics"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1093\/eurheartj\/ehu505","article-title":"Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term perspective","volume":"36","author":"Jernberg","year":"2015","journal-title":"Eur. Heart J."},{"key":"B31","doi-asserted-by":"publisher","first-page":"D1516","DOI":"10.1093\/nar\/gkae1059","article-title":"PubChem 2025 update","volume":"53","author":"Kim","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12974-023-02819-5","article-title":"Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia\/reperfusion injury","volume":"20","author":"Li","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"B33","doi-asserted-by":"publisher","first-page":"561396","DOI":"10.1093\/ecam\/neq028","article-title":"The roles of buyang huanwu decoction in anti-inflammation, antioxidation and regulation of lipid metabolism in rats with myocardial ischemia","volume":"2011","author":"Liu","year":"2011","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B34","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"4157","DOI":"10.7150\/ijbs.86492","article-title":"The PTGS2\/COX2-PGE(2) signaling cascade in inflammation: pro or anti? A case study with type 1 diabetes mellitus","volume":"19","author":"Mart\u00edn-V\u00e1zquez","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1161\/cir.0000000000001303","article-title":"Heart disease and stroke statistics: a report of US and global data from the American heart Association","volume":"151","author":"Martin","year":"2025","journal-title":"Circulation"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1257601","DOI":"10.1126\/science.1257601","article-title":"Disease networks. Uncovering disease-disease relationships through the incomplete interactome","volume":"347","author":"Menche","year":"2015","journal-title":"Science"},{"key":"B38","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1073\/pnas.2025581118","article-title":"Network medicine framework for identifying drug-repurposing opportunities for COVID-19","volume":"118","author":"Morselli Gysi","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1228","DOI":"10.1093\/cvr\/cvz061","article-title":"Investigating and re-evaluating the role of glycogen synthase kinase 3 beta kinase as a molecular target for cardioprotection by using novel pharmacological inhibitors","volume":"115","author":"Nikolaou","year":"2019","journal-title":"Cardiovasc Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open babel: an open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J. Cheminform"},{"key":"B41","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pharmthera.2018.01.001","article-title":"Inflammation following acute myocardial infarction: multiple players, dynamic roles, and novel therapeutic opportunities","volume":"186","author":"Ong","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1760","DOI":"10.3390\/antiox12091760","article-title":"Potential role of natural antioxidants in countering reperfusion injury in acute myocardial infarction and ischemic stroke","volume":"12","author":"Orellana-Urz\u00faa","year":"2023","journal-title":"Antioxidants (Basel)"},{"key":"B43","doi-asserted-by":"publisher","first-page":"156471","DOI":"10.1016\/j.phymed.2025.156471","article-title":"Guizhi Shaoyao Zhimu Decoction alleviates rheumatoid arthritis by inhibiting inflammation by targeting SLPI","volume":"139","author":"Pan","year":"2025","journal-title":"Phytomedicine"},{"key":"B44","doi-asserted-by":"publisher","first-page":"12970","DOI":"10.18632\/oncotarget.4001","article-title":"Assessment and diagnostic relevance of novel serum biomarkers for early decision of ST-elevation myocardial infarction","volume":"6","author":"Park","year":"2015","journal-title":"Oncotarget"},{"key":"B45","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.neuropharm.2018.07.006","article-title":"Targeting glycogen synthase kinase-3 for oxidative stress and neuroinflammation: opportunities, challenges and future directions for cerebral stroke management","volume":"139","author":"Rana","year":"2018","journal-title":"Neuropharmacology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"B47","doi-asserted-by":"publisher","first-page":"W463","DOI":"10.1093\/nar\/gkaf361","article-title":"PLIP 2025: introducing protein-protein interactions to the protein-ligand interaction profiler","volume":"53","author":"Schake","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1093\/eurheartj\/ehae371","article-title":"Acute myocardial infarction and ischaemic stroke: differences and similarities in reperfusion therapies-a review","volume":"45","author":"Scheldeman","year":"2024","journal-title":"Eur. Heart J."},{"key":"B49","doi-asserted-by":"publisher","first-page":"816347","DOI":"10.3389\/fphar.2022.816347","article-title":"Effects and mechanisms of taohong siwu decoction on the prevention and treatment of myocardial injury","volume":"13","author":"Shao","year":"2022","journal-title":"Front. Pharmacol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1007\/s10741-020-09961-9","article-title":"Crosstalk between GSK-3\u03b2-actuated molecular cascades and myocardial physiology","volume":"26","author":"Sharma","year":"2021","journal-title":"Heart Fail Rev."},{"key":"B51","doi-asserted-by":"publisher","first-page":"D609","DOI":"10.1093\/nar\/gkae1010","article-title":"UniProt: the Universal Protein Knowledgebase in 2025","volume":"53","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"512","DOI":"10.3390\/cells12030512","article-title":"The role of TP53 in adaptation and evolution","volume":"12","author":"Voskarides","year":"2023","journal-title":"Cells"},{"key":"B53","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1001\/jama.2022.1420","article-title":"What is acute ischemic stroke?","volume":"327","author":"Walter","year":"2022","journal-title":"JAMA"},{"key":"B54","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.jep.2011.06.033","article-title":"Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice","volume":"138","author":"Wang","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/j.jep.2011.05.008","article-title":"The effects of Buyang Huanwu Decoction on hemorheological disorders and energy metabolism in rats with coronary heart disease","volume":"137","author":"Wang","year":"2011","journal-title":"J. Ethnopharmacol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.3892\/etm.2021.10484","article-title":"Network pharmacology-based prediction of the active compounds and mechanism of Buyang Huanwu Decoction for ischemic stroke","volume":"22","author":"Wang","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"B57","doi-asserted-by":"publisher","first-page":"e38877","DOI":"10.1097\/md.0000000000038877","article-title":"Identification of core genes shared by ischemic stroke and myocardial infarction using an integrated approach","volume":"103","author":"Wang","year":"2024","journal-title":"Med. Baltim."},{"key":"B58","doi-asserted-by":"publisher","first-page":"157194","DOI":"10.1016\/j.phymed.2025.157194","article-title":"Colchicine alleviates atherosclerosis combined with diabetes mellitus by targeting PIM2 and regulating the NF-\u03baB signaling pathway","volume":"147","author":"Wang","year":"2025","journal-title":"Phytomedicine"},{"key":"B59","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-24277-4","volume-title":"ggplot2: Elegant Graphics for Data Analysis","author":"Wickham","year":"2016"},{"key":"B60","doi-asserted-by":"publisher","first-page":"101297","DOI":"10.1016\/j.jpha.2025.101297","article-title":"TCMKD: from ancient wisdom to modern insights-A comprehensive platform for traditional Chinese medicine knowledge discovery","volume":"15","author":"Xiao","year":"2025","journal-title":"J. Pharm. Anal."},{"key":"B61","doi-asserted-by":"publisher","first-page":"281","DOI":"10.2147\/dddt.S481499","article-title":"Exploring the cardioprotective mechanisms of Ligusticum wallichii in myocardial infarction through network pharmacology and experimental validation","volume":"19","author":"Yang","year":"2025","journal-title":"Drug Des. Devel Ther."},{"key":"B62","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"B63","doi-asserted-by":"publisher","first-page":"632378","DOI":"10.3389\/fphar.2021.632378","article-title":"Role of PI3K in the progression and regression of atherosclerosis","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3892\/ijmm.2021.5070","article-title":"Neuronal injuries in cerebral infarction and ischemic stroke: from mechanisms to treatment","volume":"49","author":"Zhao","year":"2022","journal-title":"Int. J. Mol. Med."},{"key":"B65","doi-asserted-by":"publisher","first-page":"4275984","DOI":"10.1155\/2019\/4275984","article-title":"Buyang huanwu decoction exerts cardioprotective effects through targeting angiogenesis via Caveolin-1\/VEGF signaling pathway in mice with acute myocardial infarction","volume":"2019","author":"Zhu","year":"2019","journal-title":"Oxid. Med. Cell Longev."},{"key":"B66","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3389\/fneur.2019.00036","article-title":"LncRNA expression profiling of ischemic stroke during the transition from the acute to subacute stage","volume":"10","author":"Zhu","year":"2019","journal-title":"Front. Neurol."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2026.1843679\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:10:42Z","timestamp":1781647842000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2026.1843679\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,17]]},"references-count":66,"alternative-id":["10.3389\/fgene.2026.1843679"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2026.1843679","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,17]]},"article-number":"1843679"}}