{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:59:58Z","timestamp":1790830798145,"version":"4.1.0"},"reference-count":154,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>\n                    This review provides a systematic overview of the specific mechanisms by which N6-methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modification regulates lipid synthesis, catabolism, and transport. In addition, we discuss the potential therapeutic significance of m\n                    <jats:sup>6<\/jats:sup>\n                    A modification in lipid metabolism-related diseases. Although considerable progress has been made, the mechanisms by which m\n                    <jats:sup>6<\/jats:sup>\n                    A modification regulates lipid metabolism remain incompletely understood. Notably, m\n                    <jats:sup>6<\/jats:sup>\n                    A regulators such as METTL3 exhibit context-dependent and sometimes opposing effects on lipid accumulation and oxidation. FTO gene variants are significantly associated with an increased risk of obesity; however, the development of FTO inhibitors as therapeutic targets for obesity and lipid metabolism disorders still faces considerable challenges. In non-alcoholic fatty liver disease (NAFLD), m\n                    <jats:sup>6<\/jats:sup>\n                    A modification not only contributes to disease development but also participates in its progression. METTL3 and METTL14 also play important roles in the development of atherosclerosis (AS). Collectively, the important role of m\n                    <jats:sup>6<\/jats:sup>\n                    A regulatory mechanisms in lipid metabolism and related diseases highlights the potential of targeting m\n                    <jats:sup>6<\/jats:sup>\n                    A regulators as a promising therapeutic strategy.\n                  <\/jats:p>","DOI":"10.3389\/fgene.2026.1890451","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:43:44Z","timestamp":1790829824000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["M6A modification in lipid metabolism and related diseases"],"prefix":"10.3389","volume":"17","author":[{"given":"Zhiwen","family":"Hu","sequence":"first","affiliation":[{"name":"Emergency Department, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University)","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didi","family":"Yuan","sequence":"additional","affiliation":[{"name":"Cancer Research Institute, Basic School of Medicine, Central South University","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Feng","sequence":"additional","affiliation":[{"name":"Emergency Department, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University)","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai","family":"Hu","sequence":"additional","affiliation":[{"name":"Emergency Department, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University)","place":["Changsha, Hunan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1016\/j.cell.2015.08.011","article-title":"HNRNPA2B1 is a mediator of m6A-Dependent nuclear RNA processing events","volume":"162","author":"Alarc\u00f3n","year":"2015","journal-title":"Cell"},{"key":"B2","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1038\/nrg.2016.59","article-title":"The molecular hallmarks of epigenetic control","volume":"17","author":"Allis","year":"2016","journal-title":"Nat. Rev. Genet."},{"key":"B3","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1186\/s12943-022-01500-4","article-title":"The role of m6A RNA methylation in cancer metabolism","volume":"21","author":"An","year":"2022","journal-title":"Mol. Cancer"},{"key":"B4","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1002\/iub.1974","article-title":"Loss of m(6) A on FAM134B promotes adipogenesis in porcine adipocytes through m(6) A-YTHDF2-dependent way","volume":"71","author":"Cai","year":"2019","journal-title":"IUBMB Life"},{"key":"B5","doi-asserted-by":"publisher","first-page":"888360","DOI":"10.3389\/fnut.2022.888360","article-title":"Antioxidant and anti-inflammatory extracts from sea cucumbers and tunicates induce a pro-osteogenic effect in zebrafish larvae","volume":"9","author":"Carletti","year":"2022","journal-title":"Front. Nutr."},{"key":"B6","doi-asserted-by":"publisher","first-page":"a040576","DOI":"10.1101\/cshperspect.a040576","article-title":"Lipid metabolism","volume":"13","author":"Chandel","year":"2021","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/j.ccell.2020.10.004","article-title":"YTHDF3 induces the translation of m(6)A-Enriched gene transcripts to promote breast cancer brain metastasis","volume":"38","author":"Chang","year":"2020","journal-title":"Cancer Cell"},{"key":"B8","doi-asserted-by":"publisher","first-page":"116819","DOI":"10.1016\/j.bcp.2025.116819","article-title":"FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism","volume":"235","author":"Chang","year":"2025","journal-title":"Biochem. Pharmacol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1186\/s12864-024-10537-2","article-title":"ALKBH5 regulates chicken adipogenesis by mediating LCAT mRNA stability depending on m(6)A modification","volume":"25","author":"Chao","year":"2024","journal-title":"BMC Genomics"},{"key":"B10","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.lfs.2021.119135","article-title":"The influence of PM\n            2.5\n            exposure on non-alcoholic fatty liver disease","volume":"270","author":"Chen","year":"2021","journal-title":"Life Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1162607","DOI":"10.3389\/fimmu.2023.1162607","article-title":"N6-methyladenosine reader YTHDF family in biological processes: structures, roles, and mechanisms","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Immunol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1186\/s12967-023-04578-6","article-title":"ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner","volume":"21","author":"Chen","year":"","journal-title":"J. Transl. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s10557-022-07348-6","article-title":"Silencing METTL3 stabilizes atherosclerotic plaques by regulating the phenotypic transformation of vascular smooth muscle cells via the miR-375-3p\/PDK1 axis","volume":"37","author":"Chen","year":"","journal-title":"Cardiovasc Drugs Ther."},{"key":"B14","doi-asserted-by":"publisher","first-page":"150399","DOI":"10.1016\/j.bbrc.2024.150399","article-title":"The methyltransferase METTL3 regulates endothelial cell proliferation and inflammation via m(6)A RNA methylation-mediated TRAF1 expression","volume":"732","author":"Chen","year":"2024","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B15","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.7150\/ijbs.103428","article-title":"FTO-induced APOE promotes the malignant progression of pancreatic neuroendocrine neoplasms through FASN-mediated lipid metabolism","volume":"21","author":"Chen","year":"2025","journal-title":"Int. J. Biol. Sci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"e2025070118","DOI":"10.1073\/pnas.2025070118","article-title":"METTL3-dependent N(6)-methyladenosine RNA modification mediates the atherogenic inflammatory cascades in vascular endothelium","volume":"118","author":"Chien","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B17","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1038\/s41586-018-0538-8","article-title":"mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis","volume":"561","author":"Choe","year":"2018","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.cbpa.2020.05.006","article-title":"Targeting epigenetic reader domains by chemical biology","volume":"57","author":"Cipriano","year":"2020","journal-title":"Curr. Opin. Chem. Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"218232","DOI":"10.1016\/j.canlet.2025.218232","article-title":"YTHDF2-mediated stabilization of SREBF1 promotes lipid metabolic reprogramming and ferroptosis-associated radioresistance in anaplastic thyroid carcinoma","volume":"639","author":"Dai","year":"2026","journal-title":"Cancer Lett."},{"key":"B20","doi-asserted-by":"publisher","first-page":"793","DOI":"10.2217\/epi-2020-0372","article-title":"Transcriptome-wide N6-methyladenosine methylation landscape of coronary artery disease","volume":"13","author":"Deng","year":"2021","journal-title":"Epigenomics"},{"key":"B21","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/ejhf.1714","article-title":"A role for m6A RNA methylation in heart failure development?","volume":"22","author":"Devaux","year":"2020","journal-title":"Eur. J. Heart Fail"},{"key":"B22","doi-asserted-by":"publisher","first-page":"731810","DOI":"10.3389\/fcell.2021.731810","article-title":"N6-Methyladenosine methyltransferase METTL3 promotes angiogenesis and atherosclerosis by upregulating the JAK2\/STAT3 pathway via m6A reader IGF2BP1","volume":"9","author":"Dong","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1093\/cvr\/cvaf029","article-title":"METTL3-catalyzed m6A methylation facilitates the contribution of vascular smooth muscle cells to atherosclerosis","volume":"121","author":"Dong","year":"2025","journal-title":"Cardiovasc Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"12626","DOI":"10.1038\/ncomms12626","article-title":"YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex","volume":"7","author":"Du","year":"2016","journal-title":"Nat. Commun."},{"key":"B25","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.ijcard.2020.12.002","article-title":"METTL14 mediated m6A modification to LncRNA ZFAS1\/RAB22A: a novel therapeutic target for atherosclerosis","volume":"328","author":"Gong","year":"2021","journal-title":"Int. J. Cardiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"106800","DOI":"10.1016\/j.intimp.2020.106800","article-title":"IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome","volume":"86","author":"Guo","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1002\/hep.26997","article-title":"Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma","volume":"59","author":"Gutschner","year":"2014","journal-title":"Hepatology"},{"key":"B28","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1080\/15476286.2020.1736868","article-title":"GR-mediated FTO transactivation induces lipid accumulation in hepatocytes via demethylation of m(6)A on lipogenic mRNAs","volume":"17","author":"Hu","year":"2020","journal-title":"RNA Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.canlet.2021.07.016","article-title":"HNRNPC impedes m\n            6\n            A-dependent anti-metastatic alternative splicing events in pancreatic ductal adenocarcinoma","volume":"518","author":"Huang","year":"2021","journal-title":"Cancer Lett."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1275475","DOI":"10.3389\/fcell.2023.1275475","article-title":"m6A demethylase FTO and osteoporosis: potential therapeutic interventions","volume":"11","author":"Huang","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/s00018-023-05076-0","article-title":"IGF2BP3-mediated enhanced stability of MYLK represses MSC adipogenesis and alleviates obesity and insulin resistance in HFD mice","volume":"81","author":"Huang","year":"2024","journal-title":"Cell Mol. Life Sci."},{"key":"B32","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s00011-021-01533-3","article-title":"Dihydroartemisinin alleviates AngII-induced vascular smooth muscle cell proliferation and inflammatory response by blocking the FTO\/NR4A3 axis","volume":"71","author":"Huo","year":"2022","journal-title":"Inflamm. Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.3390\/ijms22031453","article-title":"Resveratrol supplementation attenuates cognitive and molecular alterations under maternal high-fat diet intake: epigenetic inheritance over generations","volume":"22","author":"Izquierdo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/nchembio.687","article-title":"N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO","volume":"7","author":"Jia","year":"2011","journal-title":"Nat. Chem. Biol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"8939","DOI":"10.7150\/thno.45178","article-title":"METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications","volume":"10","author":"Jian","year":"2020","journal-title":"Theranostics"},{"key":"B36","doi-asserted-by":"publisher","first-page":"2971","DOI":"10.1096\/fj.201801393RRR","article-title":"MTCH2 promotes adipogenesis in intramuscular preadipocytes via an m(6)A-YTHDF1-dependent mechanism","volume":"33","author":"Jiang","year":"2019","journal-title":"Faseb J."},{"key":"B37","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"4825","DOI":"10.1016\/j.csbj.2022.08.068","article-title":"RBM15 condensates modulate m(6)A modification of STYK1 to promote tumorigenesis","volume":"20","author":"Jiang","year":"2022","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"B39","doi-asserted-by":"publisher","first-page":"102963","DOI":"10.1016\/j.redox.2023.102963","article-title":"Arbutin alleviates fatty liver by inhibiting ferroptosis via FTO\/SLC7A11 pathway","volume":"68","author":"Jiang","year":"2023","journal-title":"Redox Biol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3390\/nu8020102","article-title":"The fto gene regulates the proliferation and differentiation of pre-adipocytes in vitro","volume":"8","author":"Jiao","year":"2016","journal-title":"Nutrients"},{"key":"B41","doi-asserted-by":"publisher","first-page":"110979","DOI":"10.1016\/j.intimp.2023.110979","article-title":"CircMETTL14(11)S upregulated METTL14 and induced CXCR4 to aggravate endothelial inflammation and atherosclerosis","volume":"126","author":"Kang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e2301645","DOI":"10.1002\/advs.202301645","article-title":"Adipose METTL14-Elicited N(6) -Methyladenosine promotes obesity, insulin resistance, and NAFLD through suppressing beta adrenergic signaling and lipolysis","volume":"10","author":"Kang","year":"2023","journal-title":"Adv. Sci. (Weinh)"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e1800134","DOI":"10.1002\/mnfr.201800134","article-title":"Diet during pregnancy is implicated in the regulation of hypothalamic RNA methylation and risk of obesity in offspring","volume":"62","author":"Kaspi","year":"2018","journal-title":"Mol. Nutr. Food Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"817304","DOI":"10.3389\/fcvm.2021.817304","article-title":"ALKBH5 regulates SPHK1-Dependent endothelial cell angiogenesis following ischemic stress","volume":"8","author":"Kumari","year":"2021","journal-title":"Front. Cardiovasc Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1186\/s11658-022-00350-8","article-title":"WTAP-mediated N(6)-methyladenosine modification of NLRP3 mRNA in kidney injury of diabetic nephropathy","volume":"27","author":"Lan","year":"2022","journal-title":"Cell Mol. Biol. Lett."},{"key":"B46","doi-asserted-by":"publisher","first-page":"7213","DOI":"10.1038\/s41467-021-27539-3","article-title":"The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression","volume":"12","author":"Li","year":"2021","journal-title":"Nat. Commun."},{"key":"B47","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1186\/s40104-022-00795-z","article-title":"m(6)A demethylase FTO regulate CTNNB1 to promote adipogenesis of chicken preadipocyte","volume":"13","author":"Li","year":"2022","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e69906","DOI":"10.7554\/eLife.69906","article-title":"RNA N(6)-methyladenosine modulates endothelial atherogenic responses to disturbed flow in mice","volume":"11","author":"Li","year":"2022","journal-title":"Elife"},{"key":"B49","doi-asserted-by":"publisher","first-page":"e24019","DOI":"10.1002\/jcla.24019","article-title":"Mettl3 promotes oxLDL-mediated inflammation through activating STAT1 signaling","volume":"36","author":"Li","year":"","journal-title":"J. Clin. Lab. Anal."},{"key":"B50","doi-asserted-by":"publisher","first-page":"e2300436","DOI":"10.1002\/advs.202300436","article-title":"Rna M(6) a methylation regulates glycolysis of beige fat and contributes to systemic metabolic homeostasis","volume":"10","author":"Li","year":"","journal-title":"Adv. Sci. (Weinh)"},{"key":"B51","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s12986-023-00762-z","article-title":"METTL3 exacerbates insulin resistance in hepatocytes by regulating m(6)A modification of cytochrome P450 2B6","volume":"20","author":"Li","year":"","journal-title":"Nutr. Metab. (Lond)"},{"key":"B52","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1161\/atvbaha.122.318451","article-title":"METTL3 (methyltransferase like 3)-Dependent N6-Methyladenosine modification on braf mRNA promotes macrophage inflammatory response and atherosclerosis in mice","volume":"43","author":"Li","year":"","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"e13892","DOI":"10.1111\/aji.13892","article-title":"Construction of m6A-Related gene prediction model and subtype analysis in non-obstructive azoospermia based on bioinformatics","volume":"92","author":"Li","year":"2024","journal-title":"Am. J. Reprod. Immunol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1007\/s11427-023-2494-x","article-title":"RNA modifications in the progression of liver diseases: from fatty liver to cancer","volume":"67","author":"Li","year":"","journal-title":"Sci. China Life Sci."},{"key":"B55","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/shk.0000000000002294","article-title":"The role of N6-methyladenosine methyltransferase RBM15 in nonalcoholic fatty liver disease","volume":"61","author":"Li","year":"","journal-title":"Shock"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1007\/s11010-023-04858-1","article-title":"N(6)-methyladenosine (m(6)A) reader YTHDF2 accelerates endothelial cells ferroptosis in cerebrovascular atherosclerosis","volume":"479","author":"Li","year":"2024","journal-title":"Mol. Cell Biochem."},{"key":"B57","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s11658-025-00720-y","article-title":"Follicle-stimulating hormone promotes EndMT in endothelial cells by upregulating ALKBH5 expression","volume":"30","author":"Li","year":"2025","journal-title":"Cell Mol. Biol. Lett."},{"key":"B58","doi-asserted-by":"publisher","first-page":"e14954","DOI":"10.7717\/peerj.14954","article-title":"m(6)A reader IGF2BP1 accelerates apoptosis of high glucose-induced vascular endothelial cells in a m(6)A-HMGB1 dependent manner","volume":"11","author":"Liang","year":"2023","journal-title":"PeerJ"},{"key":"B59","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1080\/1061186x.2022.2071906","article-title":"Metformin combats obesity by targeting FTO in an m(6)A-YTHDF2-dependent manner","volume":"30","author":"Liao","year":"2022","journal-title":"J. Drug Target"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1447135","DOI":"10.3389\/fcell.2024.1447135","article-title":"The role of RNA m6A demethylase ALKBH5 in the mechanisms of fibrosis","volume":"12","author":"Liao","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"key":"B61","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1080\/15476286.2019.1658508","article-title":"ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m(6)A dependent manner","volume":"16","author":"Liu","year":"2019","journal-title":"RNA Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3816","DOI":"10.1093\/nar\/gkaa048","article-title":"The m6A reader YTHDF1 promotes ovarian cancer progression via augmenting EIF3C translation","volume":"48","author":"Liu","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"11832","DOI":"10.1080\/21655979.2022.2031409","article-title":"Methyltransferase-like 14 silencing relieves the development of atherosclerosis via m(6)A modification of p65 mRNA","volume":"13","author":"Liu","year":"2022","journal-title":"Bioengineered"},{"key":"B64","doi-asserted-by":"publisher","first-page":"109738","DOI":"10.1016\/j.jnutbio.2024.109738","article-title":"Betaine alleviates nonalcoholic fatty liver disease (NAFLD) via a manner involving BHMT\/FTO\/m(6)A\/PGC1\u03b1 signaling","volume":"134","author":"Liu","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"780617","DOI":"10.3389\/fendo.2021.780617","article-title":"Analysis of N6-Methyladenosine methylation modification in fructose-induced non-alcoholic fatty liver disease","volume":"12","author":"Luo","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B66","doi-asserted-by":"publisher","first-page":"2565","DOI":"10.1080\/10495398.2022.2105229","article-title":"FTO promoted adipocyte differentiation by regulating ADRB1 gene through m(6)A modification in hycole rabbits","volume":"34","author":"Luo","year":"2023","journal-title":"Anim. Biotechnol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"2397","DOI":"10.1007\/s12010-024-05106-y","article-title":"WTAP promotes atherosclerosis by inducing macrophage pyroptosis and M1 polarization through upregulating NLRP3","volume":"197","author":"Luo","year":"2025","journal-title":"Appl. Biochem. Biotechnol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"e2415563","DOI":"10.1002\/advs.202415563","article-title":"Homocysteine promotes the pathogenesis of atherosclerosis through the Circ-PIAS1-5\/miR-219a-2-3p\/TEAD1 axis","volume":"12","author":"Ma","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"B69","doi-asserted-by":"publisher","first-page":"5332","DOI":"10.1038\/s41467-019-13317-9","article-title":"m(6)A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2","volume":"10","author":"Mao","year":"2019","journal-title":"Nat. Commun."},{"key":"B70","doi-asserted-by":"publisher","first-page":"985","DOI":"10.33549\/physiolres.935289","article-title":"LDHA- mediated histone lactylation promotes the nonalcoholic fatty liver disease progression through targeting the METTL3\/YTHDF1\/SCD1 m6A axis","volume":"73","author":"Meng","year":"2024","journal-title":"Physiol. Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/nrm3785","article-title":"The dynamic epitranscriptome: N6-methyladenosine and gene expression control","volume":"15","author":"Meyer","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"e70066","DOI":"10.1002\/jbt.70066","article-title":"Mechanisms of METTL14-Mediated m6A modification in promoting iron overload-induced lipid peroxidative damage in vascular endothelial cells to aggravate atherosclerosis","volume":"38","author":"Min","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"B73","doi-asserted-by":"publisher","first-page":"8062791","DOI":"10.1155\/2024\/8062791","article-title":"The role of FTO risk haplotype in overweight\/obesity and lipid parameters-results from the central China population study","volume":"2024","author":"Ning","year":"2024","journal-title":"Int. J. Endocrinol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1038\/s12276-024-01235-w","article-title":"The m(6)A writer RBM15 drives the growth of triple-negative breast cancer cells through the stimulation of serine and glycine metabolism","volume":"56","author":"Park","year":"2024","journal-title":"Exp. Mol. Med."},{"key":"B75","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1038\/nature19342","article-title":"m(6)A RNA methylation promotes XIST-mediated transcriptional repression","volume":"537","author":"Patil","year":"2016","journal-title":"Nature"},{"key":"B76","doi-asserted-by":"publisher","first-page":"eaau7116","DOI":"10.1126\/scitranslmed.aau7116","article-title":"Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1","volume":"11","author":"Peng","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"B77","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.ymthe.2021.09.016","article-title":"METTL3-m(6)A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease","volume":"30","author":"Peng","year":"2022","journal-title":"Mol. Ther."},{"key":"B78","doi-asserted-by":"publisher","first-page":"101235","DOI":"10.1016\/j.plipres.2023.101235","article-title":"Lipid metabolism around the body clocks","volume":"91","author":"Petrenko","year":"2023","journal-title":"Prog. Lipid Res."},{"key":"B79","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1038\/s41569-021-00541-4","article-title":"Global epidemiology of dyslipidaemias","volume":"18","author":"Pirillo","year":"2021","journal-title":"Nat. Rev. Cardiol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"109968","DOI":"10.1016\/j.celrep.2021.109968","article-title":"m(6)A mRNA methylation-directed myeloid cell activation controls progression of NAFLD and obesity","volume":"37","author":"Qin","year":"2021","journal-title":"Cell Rep."},{"key":"B81","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.1007\/s10565-022-09703-7","article-title":"AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance","volume":"39","author":"Qiu","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1016\/j.cell.2024.12.009","article-title":"Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation","volume":"188","author":"Quarto","year":"2025","journal-title":"Cell"},{"key":"B83","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.semcancer.2022.05.009","article-title":"The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer","volume":"86","author":"Ramesh-Kumar","year":"2022","journal-title":"Semin. Cancer Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1016\/j.jhep.2023.06.003","article-title":"A multisociety Delphi consensus statement on new fatty liver disease nomenclature","volume":"79","author":"Rinella","year":"2023","journal-title":"J. Hepatol."},{"key":"B85","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3390\/molecules29010140","article-title":"YTHDF1 in tumor cell metabolism: an updated review","volume":"29","author":"Rong","year":"","journal-title":"Molecules"},{"key":"B86","doi-asserted-by":"publisher","first-page":"1198","DOI":"10.1007\/s12033-022-00614-w","article-title":"m6A 'writer' KIAA1429 regulates the proliferation and migration of endothelial cells in atherosclerosis","volume":"65","author":"Rong","year":"","journal-title":"Mol. Biotechnol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1186\/s40364-025-00857-0","article-title":"Global mapping of RNA N(6)-methyladenosine (m(6)A) in human subcutaneous and visceral adipose tissue reveals novel targets that correlate with clinical variables of obesity","volume":"13","author":"Ronningen","year":"2025","journal-title":"Biomark. Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"2982","DOI":"10.1016\/j.jacc.2020.11.010","article-title":"Global burden of cardiovascular diseases and risk factors, 1990-2019: update from the GBD 2019 study","volume":"76","author":"Roth","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"B89","doi-asserted-by":"publisher","first-page":"e31311","DOI":"10.7554\/eLife.31311","article-title":"YTHDC1 mediates nuclear export of N\n            6\n            - Methyladenosine methylated mRNAs","volume":"6","author":"Roundtree","year":"2017","journal-title":"Elife"},{"key":"B90","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s10495-021-01683-z","article-title":"FTO inhibits UPR(mt)-induced apoptosis by activating JAK2\/STAT3 pathway and reducing m6A level in adipocytes","volume":"26","author":"Shen","year":"2021","journal-title":"Apoptosis"},{"key":"B91","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1093\/carcin\/bgz152","article-title":"YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation","volume":"41","author":"Sheng","year":"2020","journal-title":"Carcinogenesis"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1335774","DOI":"10.3389\/fimmu.2024.1335774","article-title":"The RNA m(6)A writer METTL3 in tumor microenvironment: emerging roles and therapeutic implications","volume":"15","author":"Su","year":"2024","journal-title":"Front. Immunol."},{"key":"B93","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/cbin.11490","article-title":"Fat mass and obesity-associated protein regulates lipogenesis via m(6) A modification in fatty acid synthase mRNA","volume":"45","author":"Sun","year":"2021","journal-title":"Cell Biol. Int."},{"key":"B94","doi-asserted-by":"publisher","first-page":"6523","DOI":"10.1038\/s41467-023-42025-8","article-title":"Lactylation of METTL16 promotes cuproptosis via m(6)A-modification on FDX1 mRNA in gastric cancer","volume":"14","author":"Sun","year":"2023","journal-title":"Nat. Commun."},{"key":"B95","doi-asserted-by":"publisher","first-page":"114766","DOI":"10.1016\/j.bcp.2021.114766","article-title":"m(6)A modification impacts hepatic drug and lipid metabolism properties by regulating carboxylesterase 2","volume":"193","author":"Takemoto","year":"2021","journal-title":"Biochem. Pharmacol."},{"key":"B96","doi-asserted-by":"publisher","first-page":"e14379","DOI":"10.7717\/peerj.14379","article-title":"METTL16-mediated translation of CIDEA promotes non-alcoholic fatty liver disease progression via m6A-dependent manner","volume":"10","author":"Tang","year":"2022","journal-title":"PeerJ"},{"key":"B97","doi-asserted-by":"publisher","first-page":"mjac061","DOI":"10.1093\/jmcb\/mjac061","article-title":"Aberrant elevation of FTO levels promotes liver steatosis by decreasing the m6A methylation and increasing the stability of SREBF1 and ChREBP mRNAs","volume":"14","author":"Tang","year":"2023","journal-title":"J. Mol. Cell Biol."},{"key":"B98","doi-asserted-by":"publisher","first-page":"e70090","DOI":"10.1096\/fj.202401337RR","article-title":"METTL3-mediated m6A modification enhances lncRNA H19 stability to promote endothelial cell inflammation and pyroptosis to aggravate atherosclerosis","volume":"38","author":"Tang","year":"2024","journal-title":"Faseb J."},{"key":"B99","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/j.cell.2023.11.040","article-title":"Making the connection: how membrane contact sites have changed our view of organelle biology","volume":"187","author":"Voeltz","year":"2024","journal-title":"Cell"},{"key":"B100","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/s12935-021-01807-0","article-title":"The biological function of m6A reader YTHDF2 and its role in human disease","volume":"21","author":"Wang","year":"2021","journal-title":"Cancer Cell Int."},{"key":"B101","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/ncb2902","article-title":"N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells","volume":"16","author":"Wang","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1038\/s41366-018-0027-z","article-title":"mRNA m(6)A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes","volume":"42","author":"Wang","year":"2018","journal-title":"Int. J. Obes. (Lond)"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1080\/15548627.2019.1659617","article-title":"m(6)A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7","volume":"16","author":"Wang X","year":"2020","journal-title":"Autophagy"},{"key":"B104","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1038\/s41589-020-0601-2","article-title":"NADP modulates RNA m(6)A methylation and adipogenesis via enhancing FTO activity","volume":"16","author":"Wang","year":"2020","journal-title":"Nat. Chem. Biol."},{"key":"B105","doi-asserted-by":"publisher","first-page":"3410","DOI":"10.1021\/acs.biochem.1c00254","article-title":"The m(6)A consensus motif provides a paradigm of epitranscriptomic studies","volume":"60","author":"Wang","year":"2021","journal-title":"Biochemistry"},{"key":"B106","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12935-021-01799-x","article-title":"The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers","volume":"21","author":"Wang","year":"2021","journal-title":"Cancer Cell Int."},{"key":"B107","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1007\/s11596-022-2657-6","article-title":"Maslinic acid suppresses high glucose-induced inflammation by epigenetically inhibiting TXNIP expression","volume":"42","author":"Wang","year":"2022","journal-title":"Curr. Med. Sci."},{"key":"B108","doi-asserted-by":"publisher","first-page":"107721","DOI":"10.1016\/j.jbc.2024.107721","article-title":"Hinokiflavone resists HFD-induced obesity by promoting apoptosis in an IGF2BP2-mediated bim m(6)A modification dependent manner","volume":"300","author":"Wang","year":"","journal-title":"J. Biol. Chem."},{"key":"B109","doi-asserted-by":"publisher","first-page":"e1801","DOI":"10.1002\/ctm2.1801","article-title":"A novel peptide encoded by circ-SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac-mediated CD36 transcription in NAFLD","volume":"14","author":"Wang","year":"","journal-title":"Clin. Transl. Med."},{"key":"B110","doi-asserted-by":"publisher","first-page":"505","DOI":"10.17305\/bb.2023.9698","article-title":"Silencing METTL14 alleviates liver injury in non-alcoholic fatty liver disease by regulating mitochondrial homeostasis","volume":"24","author":"Wang","year":"","journal-title":"Biomol. Biomed."},{"key":"B111","doi-asserted-by":"publisher","first-page":"10610","DOI":"10.3390\/ijms221910610","article-title":"Leptin reduces Plin5 m(6)A methylation through FTO to regulate lipolysis in piglets","volume":"22","author":"Wei","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2026.01.021","article-title":"m6A methylation in ferroptosis regulation: mechanisms, targets, and therapeutic interventions","author":"Wen","year":"2026","journal-title":"J. Adv. Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.bbalip.2018.08.008","article-title":"FTO regulates adipogenesis by controlling cell cycle progression via m(6)A-YTHDF2 dependent mechanism","volume":"1863","author":"Wu","year":"","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1038\/s41366-018-0082-5","article-title":"Epigallocatechin gallate targets FTO and inhibits adipogenesis in an mRNA m(6)A-YTHDF2-dependent manner","volume":"42","author":"Wu","year":"","journal-title":"Int. J. Obes. (Lond)"},{"key":"B115","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.bbagrm.2019.06.008","article-title":"m(6)A methylation modulates adipogenesis through JAK2-STAT3-C\/EBP\u03b2 signaling","volume":"1862","author":"Wu","year":"2019","journal-title":"Biochim. Biophys. Acta Gene Regul. Mech."},{"key":"B116","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1038\/s41419-019-2152-6","article-title":"Association of N(6)-methyladenine DNA with plaque progression in atherosclerosis via myocardial infarction-associated transcripts","volume":"10","author":"Wu","year":"2019","journal-title":"Cell Death Dis."},{"key":"B117","doi-asserted-by":"publisher","first-page":"568006","DOI":"10.3389\/fphar.2020.568006","article-title":"Resveratrol attenuates high-fat diet induced hepatic lipid homeostasis disorder and decreases m(6)A RNA methylation","volume":"11","author":"Wu","year":"2020","journal-title":"Front. Pharmacol."},{"key":"B118","doi-asserted-by":"publisher","first-page":"e52348","DOI":"10.15252\/embr.202052348","article-title":"m6A methylation promotes white-to-beige fat transition by facilitating Hif1a translation","volume":"22","author":"Wu","year":"2021","journal-title":"EMBO Rep."},{"key":"B119","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.molcel.2016.01.012","article-title":"Nuclear m\n            6\n            A reader YTHDC1 regulates mRNA splicing","volume":"61","author":"Xiao","year":"2016","journal-title":"Mol. Cell"},{"key":"B120","doi-asserted-by":"publisher","first-page":"138292","DOI":"10.1016\/j.ijbiomac.2024.138292","article-title":"PROTAC-mediated FTO protein degradation effectively alleviates diet-induced obesity and hepatic steatosis","volume":"285","author":"Xiao","year":"2025","journal-title":"Int. J. Biol. Macromol."},{"key":"B121","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1038\/s41467-024-55694-w","article-title":"Divergent roles of m(6)A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism","volume":"16","author":"Xiao","year":"2025","journal-title":"Nat. Commun."},{"key":"B122","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.2337\/db22-0775","article-title":"Activation of METTL3 promotes white adipose tissue beiging and combats obesity","volume":"72","author":"Xie","year":"2023","journal-title":"Diabetes"},{"key":"B123","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1007\/s10616-024-00641-2","article-title":"KLF7 reverses ox-LDL-induced ferroptosis in HMEC-1 cells through transcriptionally activating ALKBH5 to inhibit the m6A modification of ACSL4","volume":"76","author":"Xiong","year":"2024","journal-title":"Cytotechnology"},{"key":"B124","doi-asserted-by":"publisher","first-page":"7529","DOI":"10.1096\/fj.201802644R","article-title":"METTL3 inhibits BMSC adipogenic differentiation by targeting the JAK1\/STAT5\/C\/EBP\u03b2 pathway via an m(6)A-YTHDF2-dependent manner","volume":"33","author":"Yao","year":"2019","journal-title":"Faseb J."},{"key":"B125","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1038\/s41467-023-37100-z","article-title":"Adipocyte YTH N(6)-methyladenosine RNA-binding protein 1 protects against obesity by promoting white adipose tissue beiging in male mice","volume":"14","author":"Yan","year":"2023","journal-title":"Nat. Commun."},{"key":"B126","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.1016\/j.ymthe.2022.02.021","article-title":"Dysregulated m6A modification promotes lipogenesis and development of non-alcoholic fatty liver disease and hepatocellular carcinoma","volume":"30","author":"Yang","year":"2022","journal-title":"Mol. Ther."},{"key":"B127","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.gendis.2021.01.005","article-title":"Critical roles of FTO-mediated mRNA m6A demethylation in regulating adipogenesis and lipid metabolism: implications in lipid metabolic disorders","volume":"9","author":"Yang","year":"2022","journal-title":"Genes Dis."},{"key":"B128","doi-asserted-by":"publisher","first-page":"97001","DOI":"10.1289\/ehp12381","article-title":"Effects of early life oral arsenic exposure on intestinal tract development and lipid homeostasis in neonatal mice: implications for NAFLD development","volume":"131","author":"Yang","year":"","journal-title":"Environ. Health Perspect."},{"key":"B129","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1161\/atvbaha.123.319251","article-title":"Exercise mitigates endothelial pyroptosis and atherosclerosis by downregulating NEAT1 through N6-Methyladenosine modifications","volume":"43","author":"Yang","year":"","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"B130","doi-asserted-by":"publisher","first-page":"113587","DOI":"10.1016\/j.yexcr.2023.113587","article-title":"METTL14\/YTHDF1 axis-modified UCHL5 aggravates atherosclerosis by activating the NLRP3 inflammasome","volume":"427","author":"Yang","year":"","journal-title":"Exp. Cell Res."},{"key":"B131","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1016\/j.ymthe.2020.07.022","article-title":"Role of METTL3-Dependent N(6)-Methyladenosine mRNA modification in the promotion of angiogenesis","volume":"28","author":"Yao","year":"2020","journal-title":"Mol. Ther."},{"key":"B132","doi-asserted-by":"publisher","first-page":"2200662","DOI":"10.1155\/2022\/2200662","article-title":"The traditional Chinese medicine hua tuo zai zao wan alleviates atherosclerosis by deactivation of inflammatory macrophages","volume":"2022","author":"Yu","year":"2022","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"B133","doi-asserted-by":"publisher","first-page":"155939","DOI":"10.1016\/j.phymed.2024.155939","article-title":"Leonurine improves atherosclerosis by activating foam cell autophagy and metabolic remodeling via METTL3-mediated AKT1S1 mRNA stability modulation","volume":"134","author":"Yu","year":"2024","journal-title":"Phytomedicine"},{"key":"B134","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1038\/s41580-019-0168-5","article-title":"Reading, writing and erasing mRNA methylation","volume":"20","author":"Zaccara","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B135","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1080\/00071668.2016.1201199","article-title":"Hepatic expression of FTO and fatty acid metabolic genes changes in response to lipopolysaccharide with alterations in m(6)A modification of relevant mRNAs in the chicken","volume":"57","author":"Zhang","year":"2016","journal-title":"Br. Poult. Sci."},{"key":"B136","doi-asserted-by":"publisher","first-page":"7015","DOI":"10.26355\/eurrev_202006_21694","article-title":"METTL14 regulates M6A methylation-modified primary miR-19a to promote cardiovascular endothelial cell proliferation and invasion","volume":"24","author":"Zhang","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"B137","doi-asserted-by":"publisher","first-page":"101058","DOI":"10.1016\/j.jbc.2021.101058","article-title":"The m(6)A methyltransferase METTL3 modifies PGC-1alpha mRNA promoting mitochondrial dysfunction and oxLDL-induced inflammation in monocytes","volume":"297","author":"Zhang","year":"2021","journal-title":"J. Biol. Chem."},{"key":"B138","doi-asserted-by":"publisher","first-page":"e14334","DOI":"10.7717\/peerj.14334","article-title":"The biological function of m6A methyltransferase KIAA1429 and its role in human disease","volume":"10","author":"Zhang","year":"","journal-title":"PeerJ"},{"key":"B139","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/cac2.12325","article-title":"Gene amplification-driven RNA methyltransferase KIAA1429 promotes tumorigenesis by regulating BTG2 via m6A-YTHDF2-dependent in lung adenocarcinoma","volume":"42","author":"Zhang","year":"2022","journal-title":"Cancer Commun. (Lond)"},{"key":"B140","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1515\/med-2022-0484","article-title":"ALKBH5 inhibits TNF-\u03b1-induced apoptosis of HUVECs through Bcl-2 pathway","volume":"17","author":"Zhang","year":"","journal-title":"Open Med. (Wars)"},{"key":"B141","doi-asserted-by":"publisher","first-page":"20230856","DOI":"10.1515\/med-2023-0856","article-title":"METTL16 in human diseases: what should we do next?","volume":"18","author":"Zhang","year":"2023","journal-title":"Open Med. (Wars)"},{"key":"B142","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00011-022-01681-0","article-title":"m6A-related bioinformatics analysis and functional characterization reveals that METTL3-mediated NPC1L1 mRNA hypermethylation facilitates progression of atherosclerosis via inactivation of the MAPK pathway","volume":"72","author":"Zhang","year":"2023","journal-title":"Inflamm. Res."},{"key":"B143","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1038\/cr.2014.151","article-title":"FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis","volume":"24","author":"Zhao","year":"2014","journal-title":"Cell Res."},{"key":"B144","doi-asserted-by":"publisher","first-page":"913039","DOI":"10.3389\/fcvm.2022.913039","article-title":"Methyltransferase like 3-mediated N6-methylatidin methylation inhibits vascular smooth muscle cells phenotype switching via promoting phosphatidylinositol 3-kinase mRNA decay","volume":"9","author":"Zhao","year":"2022","journal-title":"Front. Cardiovasc Med."},{"key":"B145","doi-asserted-by":"publisher","first-page":"8204","DOI":"10.1038\/s41598-025-93062-w","article-title":"The m6A reader IGF2BP3 promotes HCC progression by enhancing MCM10 stability","volume":"15","author":"Zhao","year":"2025","journal-title":"Sci. Rep."},{"key":"B146","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/s00018-022-04331-0","article-title":"Mettl14 mediates the inflammatory response of macrophages in atherosclerosis through the NF-\u03baB\/IL-6 signaling pathway","volume":"79","author":"Zheng","year":"2022","journal-title":"Cell Mol. Life Sci."},{"key":"B147","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.bbrc.2022.10.032","article-title":"RNA-m6A modification of HDGF mediated by Mettl3 aggravates the progression of atherosclerosis by regulating macrophages polarization via energy metabolism reprogramming","volume":"635","author":"Zheng","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B148","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1186\/s12864-023-09878-1","article-title":"Transcriptome-wide N(6)-methyladenosine methylation profile of atherosclerosis in mice","volume":"24","author":"Zheng","year":"2023","journal-title":"BMC Genomics"},{"key":"B149","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1016\/j.celrep.2018.10.068","article-title":"Circadian clock regulation of hepatic lipid metabolism by modulation of m(6)A mRNA methylation","volume":"25","author":"Zhong","year":"2018","journal-title":"Cell Rep."},{"key":"B150","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1093\/qjmed\/hcaa208","article-title":"RUNX1T1 rs34269950 is associated with obesity and metabolic syndrome","volume":"114","author":"Zhou","year":"2021","journal-title":"QJM"},{"key":"B151","doi-asserted-by":"publisher","first-page":"e35467","DOI":"10.1016\/j.heliyon.2024.e35467","article-title":"Overexpression of METTL14 mediates steatohepatitis and insulin resistance in mice","volume":"10","author":"Zhou","year":"2024","journal-title":"Heliyon"},{"key":"B152","doi-asserted-by":"publisher","first-page":"2228","DOI":"10.1016\/j.cmet.2024.07.014","article-title":"Amelioration of nonalcoholic fatty liver disease by inhibiting the deubiquitylating enzyme RPN11","volume":"36","author":"Zhou","year":"2024","journal-title":"Cell Metab."},{"key":"B153","doi-asserted-by":"publisher","first-page":"861734","DOI":"10.3389\/fmicb.2022.861734","article-title":"Vitamin D3 suppresses human cytomegalovirus-induced vascular endothelial apoptosis via rectification of paradoxical m6A modification of mitochondrial calcium uniporter mRNA, which is regulated by METTL3 and YTHDF3","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Microbiol."},{"key":"B154","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.freeradbiomed.2023.12.002","article-title":"UCHL1 deficiency upon HCMV infection induces vascular endothelial inflammatory injury mediated by mitochondrial iron overload","volume":"211","author":"Zhu","year":"2024","journal-title":"Free Radic. Biol. Med."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2026.1890451\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:43:49Z","timestamp":1790829829000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2026.1890451\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":154,"alternative-id":["10.3389\/fgene.2026.1890451"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2026.1890451","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"1890451"}}