{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:00:40Z","timestamp":1790834440398,"version":"4.1.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Genome-wide association studies (GWAS) of ischemic heart disease (IHD) remain underrepresented in Central Asian populations. We conducted a pilot GWAS of ischemic heart disease with co-occurring arterial hypertension (IHD-HTN) in an ethnic Kazakh cohort to identify candidate loci for future replication.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included 470 Kazakh individuals, comprising of 240 cases and 230 controls genotyped using the Illumina Infinium Global Screening Array-24 v 3.0. Association testing was performed using logistic regression under an additive genetic model adjusted for age, sex, and the first 10 principal components. Post-imputation GWAS was performed using high-quality imputed variants. Secondary analyses included MAGMA and KGWAS prioritization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the array-based GWAS, no variant reached the Bonferroni-corrected significance threshold (P &amp;lt; 1.53 \u00d7 10\n                      <jats:sup>\u22127<\/jats:sup>\n                      ). The strongest SNP association was observed for rs1511924\u00a0at chromosome 16 mapped to the ZFHX3 gene (OR = 0.49, 95% CI = 0.37\u20130.66; P = 1.00 \u00d7 10\n                      <jats:sup>\u22126<\/jats:sup>\n                      ). Post-imputation GWAS supported the same locus with rs12598508 (P = 4.93 \u00d7 10\n                      <jats:sup>\u22127<\/jats:sup>\n                      ) and rs1511924 (P = 5.15 \u00d7 10\n                      <jats:sup>\u22127<\/jats:sup>\n                      ) among the strongest signals, although neither reached the genome-wide significance. Secondary MAGMA and KGWAS analyses did not provide stable evidence for additional loci.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To our knowledge, this is the first pilot GWAS focused on IHD with co-occurring arterial hypertension in a Kazakh cohort. Although no Bonferroni-significant SNP associations were identified, the ZFHX3 region emerged as the strongest suggestive candidate locus and requires independent replication. Larger Central Asian cohorts and population-specific reference resources are required to validate these findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fgene.2026.1927147","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:40:14Z","timestamp":1790833214000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["A pilot genome-wide association study of ischemic heart disease with co-occurring arterial hypertension in a Kazakh cohort"],"prefix":"10.3389","volume":"17","author":[{"given":"Liliya","family":"Skvortsova","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Genetics, Institute of Genetics and Physiology","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanagat","family":"Yergali","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics, Institute of Genetics and Physiology","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assel","family":"Zhaxylykova","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics, Institute of Genetics and Physiology","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamura","family":"Begmanova","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Genetics, Institute of Genetics and Physiology","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almagul","family":"Mansharipova","sequence":"additional","affiliation":[{"name":"Department of General Medical Practice, Kazakh-Russian Medical University","place":["Almaty, Kazakhstan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2412","DOI":"10.3390\/diagnostics14212412","article-title":"Polymorphism rs564398 of the ANRIL gene as a coronary-artery-disease-associated SNP in diabetic patients of the Kazakh population","volume":"14","author":"Aitkaliyev","year":"2024","journal-title":"Diagnostics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1023\/A:1022496229208","article-title":"Polymorphism of the promoter region of the angiotensinogen gene and the gene for angiotensin I-Converting enzyme in arterial hypertension and cardiovascular disease of the Kazakh ethnic group","volume":"39","author":"Aitkhozhina","year":"2003","journal-title":"Russ. 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