{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:49:53Z","timestamp":1791528593497,"version":"4.3.4"},"reference-count":188,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>\n                    Far from being \u201cjunk\u201d and devoid of function, transposable elements have been identified as players in genomes evolution and regulation, and are also used as valuable genetic markers to study population differentiation. Here we present a detailed review on how transposons participated in human evolution: from adaptation to extreme environments and response to both internal and external stressors, to phenotypes directly emerging from transposon mobilization activities. We dedicate a section to brain plasticity and neuronal differentiation, highlighting the possible role of transposable elements in neuro-psychiatric disorders in the context of emerging hypotheses such as the\n                    <jats:italic>genomic trade-off<\/jats:italic>\n                    and\n                    <jats:italic>price-to-pay<\/jats:italic>\n                    . Furthermore, we discuss methods and approaches to study the influence of transposable elements on human evolution, covering challenges to include ancient DNA in these studies. To conclude, we propose that transposons are not mere \u201cbackground noise\u201d in host genomes, but that they can be seen as genetic regulators of human phenotypes.\n                  <\/jats:p>","DOI":"10.3389\/fgene.2026.1937765","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T06:01:15Z","timestamp":1791525675000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The \u201cmobile bricks\u201d of human evolution: how transposable elements shaped human phenotypes"],"prefix":"10.3389","volume":"17","author":[{"given":"Giorgia","family":"Modenini","sequence":"first","affiliation":[{"name":"Department of Biology, University of Padua","place":["Padua, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Abondio","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Rome Tor Vergata","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"16127","DOI":"10.1074\/jbc.M113.451500","article-title":"Structure prediction and analysis of DNA transposon and LINE retrotransposon proteins","volume":"288","author":"Abrus\u00e1n","year":"2013","journal-title":"J. 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