{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:55:09Z","timestamp":1791363309692,"version":"4.3.1"},"reference-count":253,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Genet."],"abstract":"<jats:p>\n                    Chromatin remodeling contributes to skeletal development, tissue homeostasis, and disease by regulating nucleosome positioning, chromatin accessibility, and histone modifications. Bone organoids can partially reproduce the three-dimensional human bone microenvironment and provide new\n                    <jats:italic>in vitro<\/jats:italic>\n                    models for studying skeletal pathophysiology. This review summarizes recent progress in chromatin remodeling and bone organoid research, with a focus on the roles of switch\/sucrose non-fermenting (SWI\/SNF), imitation switch (ISWI), and chromodomain helicase deoxyribonucleic acid (DNA)-binding (CHD) complexes in bone organoid regulation. We also discuss the relationships between bone organoids and enhancer remodeling, DNA methylation, histone modifications, chromatin organization, and cellular metabolism. In addition, we summarize the applications of emerging technologies, including multiomics, spatial epigenomics, and live cell imaging, in bone organoid studies. The current limitations of these models are also considered. Finally, we discuss potential directions for the further development and refinement of bone organoids. We highlight their potential applications in bone disease research, drug screening, and future clinical translation within the context of chromatin remodeling.\n                  <\/jats:p>","DOI":"10.3389\/fgene.2026.1975296","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:31:35Z","timestamp":1790605895000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Chromatin remodeling in bone organoids: from epigenetic regulation to disease modeling and therapeutic translation"],"prefix":"10.3389","volume":"17","author":[{"given":"Yuxin","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Clinical Medicine, Qiqihar Medical University","place":["Qiqihar, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Hospital of Chengdu University of Traditional Chinese Medicine","place":["Chengdu, Sichuan Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hou","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine, Chengdu Medical College, The First Affiliated Hospital of Chengdu Medical College","place":["Chengdu, Sichuan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ding","sequence":"additional","affiliation":[{"name":"Orthopedic Center, Liangjiang Hospital Affiliated to Chongqing Medical University","place":["Chongqing, China"]},{"name":"Orthopedic Center, the People\u2019s Hospital of Chongqing Liangjiang New Area","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"He","sequence":"additional","affiliation":[{"name":"Jiulongpo District Maternal and Child Healthcare Hospital","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2930","DOI":"10.3390\/ijms27072930","article-title":"Emerging CRISPR approaches for countering immune evasion: insight from recent studies","volume":"27","author":"Abubakar","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1158\/1541-7786.MCR-16-0242-T","article-title":"EZH2 or HDAC1 inhibition reverses multiple myeloma-induced epigenetic suppression of osteoblast differentiation","volume":"15","author":"Adamik","year":"2017","journal-title":"Mol. Cancer Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1172\/JCI84424","article-title":"Targeting noncoding RNAs in disease","volume":"127","author":"Adams","year":"2017","journal-title":"J. Clin. Invest."},{"key":"B4","doi-asserted-by":"publisher","first-page":"14648","DOI":"10.1038\/ncomms14648","article-title":"The SWI\/SNF chromatin remodelling complex is required for maintenance of lineage specific enhancers","volume":"8","author":"Alver","year":"2017","journal-title":"Nat. Commun."},{"key":"B5","doi-asserted-by":"publisher","first-page":"e70369","DOI":"10.1002\/mco2.70369","article-title":"Epigenetic regulation of aging and its rejuvenation","volume":"6","author":"An","year":"2025","journal-title":"MedComm"},{"key":"B6","doi-asserted-by":"publisher","first-page":"31568","DOI":"10.1038\/s41598-025-17093-z","article-title":"Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation","volume":"15","author":"Atienza Parraga","year":"2025","journal-title":"Sci. Rep."},{"key":"B7","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41423-022-00959-x","article-title":"RANKL-responsive epigenetic mechanism reprograms macrophages into bone-resorbing osteoclasts","volume":"20","author":"Bae","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1038\/s41413-024-00376-y","article-title":"Engineering bone\/cartilage organoids: strategy, progress, and application","volume":"12","author":"Bai","year":"2024","journal-title":"Bone Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1038\/nature08733","article-title":"CHD7 cooperates with PBAF to control multipotent neural crest formation","volume":"463","author":"Bajpai","year":"2010","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1056\/NEJMc1903253","article-title":"Organoids - preclinical models of human disease","volume":"380","author":"Ballard","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3542","DOI":"10.1158\/0008-5472.CAN-04-3554","article-title":"SWI\/SNF chromatin-remodeling factors induce changes in DNA methylation to promote transcriptional activation","volume":"65","author":"Banine","year":"2005","journal-title":"Cancer Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.cell.2010.12.024","article-title":"SnapShot: chromatin remodeling: INO80 and SWR1","volume":"144","author":"Bao","year":"2011","journal-title":"Cell."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2160551","DOI":"10.1080\/19491034.2022.2160551","article-title":"The chromatin signatures of enhancers and their dynamic regulation","volume":"14","author":"Barral","year":"2023","journal-title":"Nucleus"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e30608","DOI":"10.1002\/jcb.30608","article-title":"Single-cell RNA analysis of chromodomain-encoding genes in mesenchymal stromal cells of the mouse dental pulp","volume":"126","author":"Becker","year":"2025","journal-title":"J. Cell. Biochem."},{"key":"B15","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1146\/annurev-arplant-102820-093218","article-title":"The role and activity of SWI\/SNF chromatin remodelers","volume":"74","author":"Bieluszewski","year":"2023","journal-title":"Annu. Rev. Plant Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.actbio.2020.03.043","article-title":"Co-culture systems of osteoblasts and osteoclasts: simulating in vitro bone remodeling in regenerative approaches","volume":"108","author":"Borciani","year":"2020","journal-title":"Acta Biomater."},{"key":"B17","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/nature14590","article-title":"Single-cell chromatin accessibility reveals principles of regulatory variation","volume":"523","author":"Buenrostro","year":"2015","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"publisher","first-page":"C743","DOI":"10.1152\/ajpcell.00738.2024","article-title":"Estrogen deficiency alters vascularization and mineralization dynamics: insight from a novel 3-D humanized and vascularized bone organoid model","volume":"328","author":"Bukhari","year":"2025","journal-title":"Am. J. Physiol. Cell. Physiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"763392","DOI":"10.3389\/fendo.2021.763392","article-title":"Baf45a mediated chromatin remodeling promotes transcriptional activation for osteogenesis and odontogenesis","volume":"12","author":"Busby","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"B21","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1007\/s12015-024-10807-2","article-title":"Unlocking the epigenetic symphony: histone acetylation orchestration in bone remodeling and diseases","volume":"21","author":"Cai","year":"2025","journal-title":"Stem Cell. Rev. Rep."},{"key":"B22","doi-asserted-by":"publisher","first-page":"11236","DOI":"10.3390\/ijms262211236","article-title":"Biological regulation of HIF-1alpha and its role in therapeutic angiogenesis for treatment of ischemic cardiovascular disease","volume":"26","author":"Carmichael","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"105155","DOI":"10.1016\/j.jbc.2023.105155","article-title":"Inhibition of Ezh2 redistributes bivalent domains within transcriptional regulators associated with WNT and Hedgehog pathways in osteoblasts","volume":"299","author":"Carrasco","year":"2023","journal-title":"J. Biol. Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1038\/s41392-024-01976-0","article-title":"Histone deacetylase inhibition enhances extracellular vesicles from muscle to promote osteogenesis via miR-873-3p","volume":"9","author":"Chen","year":"2024","journal-title":"Signal Transduct. Target Ther."},{"key":"B25","doi-asserted-by":"publisher","first-page":"5445","DOI":"10.3390\/ijms22115445","article-title":"Regulation and role of transcription factors in osteogenesis","volume":"22","author":"Chan","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"116961","DOI":"10.1016\/j.bone.2023.116961","article-title":"Functional defects in cementoblasts with disrupted bone sialoprotein functional domains, in vitro","volume":"179","author":"Chavez","year":"2024","journal-title":"Bone"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1038\/s41375-023-01983-0","article-title":"EZH2 targeting induces CD38 upregulation and response to anti-CD38 immunotherapies in multiple myeloma","volume":"37","author":"Chemlal","year":"2023","journal-title":"Leukemia"},{"key":"B28","doi-asserted-by":"publisher","first-page":"166938","DOI":"10.1016\/j.bbadis.2023.166938","article-title":"Dynamic chromatin accessibility landscapes of osteoblast differentiation and mineralization","volume":"1870","author":"Chen","year":"","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"B29","doi-asserted-by":"publisher","first-page":"754880","DOI":"10.3389\/fcell.2021.754880","article-title":"Crosstalk between MicroRNAs and circular RNAs in human diseases: a bibliographic study","volume":"9","author":"Chen","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"2165604","DOI":"10.1080\/19491034.2023.2165604","article-title":"Mechanism of action of the SWI\/SNF family complexes","volume":"14","author":"Chen","year":"2023","journal-title":"Nucleus"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.3390\/genes14101871","article-title":"Osteogenic differentiation potential of mesenchymal stem cells using single cell multiomic analysis","volume":"14","author":"Chen","year":"2023","journal-title":"Genes. (Basel)"},{"key":"B32","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/s41392-024-02030-9","article-title":"Chromatin accessibility: biological functions, molecular mechanisms and therapeutic application","volume":"9","author":"Chen","year":"","journal-title":"Signal Transduct. Target Ther."},{"key":"B33","doi-asserted-by":"publisher","first-page":"100501","DOI":"10.1016\/j.xgen.2024.100501","article-title":"Integrative high-throughput enhancer surveying and functional verification divulges a YY2-condensed regulatory axis conferring risk for osteoporosis","volume":"4","author":"Chen","year":"2024","journal-title":"Cell. Genom"},{"key":"B34","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1021\/jacsau.3c00658","article-title":"Nucleosome dynamics derived at the single-molecule level bridges its structures and functions","volume":"4","author":"Chen","year":"2024","journal-title":"JACS Au"},{"key":"B35","doi-asserted-by":"publisher","first-page":"19973","DOI":"10.1038\/s41598-024-70814-8","article-title":"LMK-235 suppresses osteoclastogenesis and promotes osteoblastogenesis by inhibiting HDAC4","volume":"14","author":"Chen","year":"2024","journal-title":"Sci. Rep."},{"key":"B36","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.jot.2024.12.003","article-title":"Role of YAP\/TAZ in bone diseases: a transductor from mechanics to biology","volume":"51","author":"Chen","year":"2025","journal-title":"J. Orthop. Transl."},{"key":"B37","doi-asserted-by":"publisher","first-page":"102116","DOI":"10.1016\/j.gendis.2026.102116","article-title":"Ten-eleven translocation 2-mediated DNA demethylation plays a positive regulatory role in BMP9-induced osteogenic differentiation of mesenchymal stem cells","volume":"13","author":"Chen","year":"2026","journal-title":"Genes. Dis."},{"key":"B38","doi-asserted-by":"publisher","first-page":"9765","DOI":"10.3390\/ijms22189765","article-title":"AMPK-mTOR signaling and cellular adaptations in hypoxia","volume":"22","author":"Chun","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1186\/s13046-025-03428-1","article-title":"CHD1L in cancer and beyond: structure, oncogenic functions, and therapeutic potential","volume":"44","author":"Clune","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"B40","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.devcel.2023.11.029","article-title":"YAP and TAZ couple osteoblast precursor mobilization to angiogenesis and mechanoregulation in murine bone development","volume":"59","author":"Collins","year":"2024","journal-title":"Dev. Cell."},{"key":"B41","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/S0140-6736(18)32112-3","article-title":"Osteoporosis","volume":"393","author":"Compston","year":"2019","journal-title":"Lancet"},{"key":"B42","doi-asserted-by":"publisher","first-page":"21931","DOI":"10.1073\/pnas.1016071107","article-title":"Histone H3K27ac separates active from poised enhancers and predicts developmental state","volume":"107","author":"Creyghton","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B43","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s41419-025-07965-7","article-title":"Targeting Irgm1 to combat osteoporosis: suppressing ROS and restoring bone remodeling","volume":"16","author":"Cui","year":"2025","journal-title":"Cell. Death Dis."},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-76382-x","article-title":"Multimodal radiopathomics model predicts postoperative metachronous liver metastasis in gastric cancer","author":"Ding","year":"2026","journal-title":"Nat. Commun."},{"key":"B45","doi-asserted-by":"publisher","first-page":"e2412232","DOI":"10.1002\/advs.202412232","article-title":"Single-cell Hi-C technologies and computational data analysis","volume":"12","author":"Dautle","year":"2025","journal-title":"Adv. Sci. (Weinh)"},{"key":"B46","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13619-025-00225-1","article-title":"Revolutionizing bone healing: the role of 3D models","volume":"14","author":"De Pace","year":"2025","journal-title":"Cell. Regen."},{"key":"B47","doi-asserted-by":"publisher","first-page":"2213551","DOI":"10.1080\/19491034.2023.2213551","article-title":"Transcriptional condensates and phase separation: condensing information across scales and mechanisms","volume":"14","author":"Demmerle","year":"2023","journal-title":"Nucleus"},{"key":"B48","doi-asserted-by":"publisher","first-page":"e19310","DOI":"10.7717\/peerj.19310","article-title":"Mechanical loading regulates osteogenic differentiation and bone formation by modulating non-coding RNAs","volume":"13","author":"Deng","year":"2025","journal-title":"PeerJ"},{"key":"B49","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1038\/s41586-022-05094-1","article-title":"Spatial profiling of chromatin accessibility in mouse and human tissues","volume":"609","author":"Deng","year":"","journal-title":"Nature"},{"key":"B50","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1126\/science.abg7216","article-title":"Spatial-CUT&Tag: spatially resolved chromatin modification profiling at the cellular level","volume":"375","author":"Deng","year":"","journal-title":"Science"},{"key":"B51","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/s41413-024-00360-6","article-title":"Osteoclasts control endochondral ossification via regulating acetyl-CoA availability","volume":"12","author":"Deng","year":"2024","journal-title":"Bone Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/j.annonc.2026.07.004","article-title":"A multimodal deep learning model for preoperative prediction of post-operative complications in gastric cancer","volume":"37","author":"Ding","year":"2026","journal-title":"Ann. Oncol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"5220","DOI":"10.1038\/s41467-026-71347-6","article-title":"A deep learning-based digital biopsy for predicting early recurrence in gastric cancer","volume":"17","author":"Ding","year":"2026","journal-title":"Nat. Commun."},{"key":"B54","doi-asserted-by":"publisher","first-page":"31812","DOI":"10.1039\/d5ra02106e","article-title":"Synthetic scaffolds functionalized with mesenchymal stem\/stromal cells-derived extracellular matrix for bone tissue engineering: a review","volume":"15","author":"Domingues","year":"2025","journal-title":"RSC Adv."},{"key":"B55","doi-asserted-by":"publisher","first-page":"5994","DOI":"10.1038\/s41467-024-50225-z","article-title":"ARID1A safeguards the canalization of the cell fate decision during osteoclastogenesis","volume":"15","author":"Du","year":"2024","journal-title":"Nat. Commun."},{"key":"B56","doi-asserted-by":"publisher","first-page":"e2501376","DOI":"10.1002\/adhm.202501376","article-title":"3D bioprinting of prevascularized bone organoids for rapid in situ cranial bone reconstruction","volume":"14","author":"Duan","year":"2025","journal-title":"Adv. Healthc. Mater"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e22153","DOI":"10.1096\/fj.202101402r","article-title":"Inhibition of TET-mediated DNA demethylation suppresses osteoblast differentiation","volume":"36","author":"Dusadeemeelap","year":"2022","journal-title":"FASEB J."},{"key":"B58","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neuron.2023.10.008","article-title":"The bone transcription factor osterix controls extracellular matrix- and node of Ranvier-related gene expression in oligodendrocytes","volume":"112","author":"Elbaz","year":"2024","journal-title":"Neuron"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1681106","DOI":"10.3389\/frai.2025.1681106","article-title":"Artificial intelligence-organoid-and organ-on-chip-powered models to improve pre-clinical animal testing of vaccines and immunotherapeutics: potential, progress, and challenges","volume":"8","author":"Elfatimi","year":"2025","journal-title":"Front. Artif. Intell."},{"key":"B60","doi-asserted-by":"publisher","first-page":"19873","DOI":"10.1073\/pnas.1003438107","article-title":"Human ISWI chromatin-remodeling complexes sample nucleosomes via transient binding reactions and become immobilized at active sites","volume":"107","author":"Erdel","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B61","doi-asserted-by":"publisher","first-page":"4195","DOI":"10.1038\/s41598-021-82842-9","article-title":"The yeast ISW1b ATP-dependent chromatin remodeler is critical for nucleosome spacing and dinucleosome resolution","volume":"11","author":"Eriksson","year":"2021","journal-title":"Sci. Rep."},{"key":"B62","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/s41580-023-00683-y","article-title":"Energy-driven genome regulation by ATP-dependent chromatin remodellers","volume":"25","author":"Eustermann","year":"2024","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"e70160","DOI":"10.1002\/cbf.70160","article-title":"Venous endothelial cells promote osteoblast differentiation more effectively than arterial cells via TGF-beta\/BMP9 and notch pathway-related gene expression","volume":"44","author":"Fernandes","year":"2026","journal-title":"Cell. Biochem. Funct."},{"key":"B64","doi-asserted-by":"publisher","first-page":"10067","DOI":"10.1074\/jbc.M808782200","article-title":"Antagonistic roles for BRM and BRG1 SWI\/SNF complexes in differentiation","volume":"284","author":"Flowers","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B65","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.bone.2014.08.009","article-title":"p107-Dependent recruitment of SWI\/SNF to the alkaline phosphatase promoter during osteoblast differentiation","volume":"69","author":"Flowers","year":"2014","journal-title":"Bone"},{"key":"B66","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1038\/s42003-021-02116-y","article-title":"DNA methylation changes during long-term in vitro cell culture are caused by epigenetic drift","volume":"4","author":"Franzen","year":"2021","journal-title":"Commun. Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"e50087","DOI":"10.7554\/eLife.50087","article-title":"Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle","volume":"8","author":"Friman","year":"2019","journal-title":"eLife"},{"key":"B68","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1111\/dgd.70023","article-title":"Super-enhancer-mediated DLX5 activation defines regulatory mechanisms in human embryonic stem cell-derived osteoblasts","volume":"67","author":"Fujita","year":"2025","journal-title":"Dev. Growth Differ."},{"key":"B69","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/s41588-021-00790-6","article-title":"ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis","volume":"53","author":"Granja","year":"2021","journal-title":"Nat. Genet."},{"key":"B70","doi-asserted-by":"publisher","first-page":"110537","DOI":"10.1016\/j.isci.2024.110537","article-title":"Time- and cell-specific activation of BMP signaling restrains chondrocyte hypertrophy","volume":"27","author":"Gadomski","year":"2024","journal-title":"iScience"},{"key":"B71","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.bioactmat.2025.02.033","article-title":"Sequential construction of vascularized and mineralized bone organoids using engineered ECM-DNA-CPO-based bionic matrix for efficient bone regeneration","volume":"49","author":"Gai","year":"2025","journal-title":"Bioact. Mater."},{"key":"B72","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.jot.2025.08.008","article-title":"3D bioprinting bone\/cartilage organoids: construction, applications, and challenges","volume":"55","author":"Gao","year":"2025","journal-title":"J. Orthop. Transl."},{"key":"B73","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1038\/s41592-025-02847-4","article-title":"Single-cell multi-omic detection of DNA methylation and histone modifications reconstructs the dynamics of epigenomic maintenance","volume":"22","author":"Geisenberger","year":"2025","journal-title":"Nat. Methods"},{"key":"B74","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3390\/biomedicines14020485","article-title":"The synthetic extracellular matrix as a maestro of the in vitro stem cell niche: orchestrating fate and function","volume":"14","author":"Giri","year":"2026","journal-title":"Biomedicines"},{"key":"B75","doi-asserted-by":"publisher","first-page":"113104","DOI":"10.1016\/j.jbc.2026.113104","article-title":"Regulation of chromatin dynamics by a calcium-dependent nucleoskeleton","volume":"302","author":"Gonzalez","year":"2026","journal-title":"J. Biol. Chem."},{"key":"B76","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/s41576-023-00666-x","article-title":"Context-specific functions of chromatin remodellers in development and disease","volume":"25","author":"Gourisankar","year":"2024","journal-title":"Nat. Rev. Genet."},{"key":"B77","doi-asserted-by":"publisher","first-page":"2318","DOI":"10.1007\/s12672-025-02229-4","article-title":"AMPK: an enzyme that may be effective in cancer and metabolic diseases","volume":"16","author":"Guney Kalkan","year":"2025","journal-title":"Discov. Oncol."},{"key":"B78","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/j.tig.2020.12.006","article-title":"Polycomb gene silencing mechanisms: PRC2 chromatin targeting, H3K27me3 'Readout', and phase separation-based compaction","volume":"37","author":"Guo","year":"2021","journal-title":"Trends Genet."},{"key":"B79","doi-asserted-by":"publisher","first-page":"2065","DOI":"10.1002\/jbmr.4399","article-title":"Inhibition of ACLY leads to suppression of osteoclast differentiation and function via regulation of histone acetylation","volume":"36","author":"Guo","year":"2021","journal-title":"J. Bone Min. Res."},{"key":"B80","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1016\/j.bioactmat.2026.04.008","article-title":"Emerging engineering strategies in bone organoids: from biomimetic scaffolds to dynamic microenvironmental stimulation","volume":"63","author":"Han","year":"2026","journal-title":"Bioact. Mater."},{"key":"B81","doi-asserted-by":"publisher","first-page":"2503","DOI":"10.1038\/s41418-022-01035-7","article-title":"Lineage-specific rearrangement of chromatin loops and epigenomic features during adipocytes and osteoblasts commitment","volume":"29","author":"Hao","year":"2022","journal-title":"Cell. Death Differ."},{"key":"B82","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"7152","DOI":"10.1038\/s41467-024-51454-y","article-title":"Single-nucleosome imaging unveils that condensins and nucleosome-nucleosome interactions differentially constrain chromatin to organize mitotic chromosomes","volume":"15","author":"Hibino","year":"2024","journal-title":"Nat. Commun."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2979","DOI":"10.3390\/ijms24032979","article-title":"Emerging RUNX2-Mediated gene regulatory mechanisms consisting of multi-layered regulatory networks in skeletal development","volume":"24","author":"Hojo","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B85","doi-asserted-by":"publisher","first-page":"111315","DOI":"10.1016\/j.celrep.2022.111315","article-title":"Runx2 regulates chromatin accessibility to direct the osteoblast program at neonatal stages","volume":"40","author":"Hojo","year":"2022","journal-title":"Cell. Rep."},{"key":"B86","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1093\/jbmr\/zjae178","article-title":"Modeling of skeletal development and diseases using human pluripotent stem cells","volume":"40","author":"Hojo","year":"2024","journal-title":"J. Bone Min. Res."},{"key":"B87","doi-asserted-by":"publisher","first-page":"e086005","DOI":"10.1136\/bmj-2025-086005","article-title":"Provision of knee bracing for knee osteoarthritis (PROP OA): Multicentre, parallel group, superiority, statistician blinded, randomised controlled trial","volume":"392","author":"Holden","year":"2026","journal-title":"BMJ"},{"key":"B88","doi-asserted-by":"publisher","first-page":"18","DOI":"10.20517\/evcna.2020.02","article-title":"RANKL and RANK in extracellular vesicles: surprising new players in bone remodeling","volume":"2","author":"Holliday","year":"2021","journal-title":"Extracell. Vesicles Circ. Nucl. Acids"},{"key":"B89","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.jot.2025.06.011","article-title":"Bone organoid construction and evolution","volume":"53","author":"Hong","year":"2025","journal-title":"J. Orthop. Transl."},{"key":"B90","doi-asserted-by":"publisher","first-page":"bbaf520","DOI":"10.1093\/bib\/bbaf520","article-title":"Navigating the 3D genome at single-cell resolution: techniques, computation, and mechanistic landscapes","volume":"26","author":"Hong","year":"2025","journal-title":"Brief. Bioinform"},{"key":"B91","doi-asserted-by":"publisher","first-page":"R115","DOI":"10.1186\/gb-2013-14-10-r115","article-title":"DNA methylation age of human tissues and cell types","volume":"14","author":"Horvath","year":"2013","journal-title":"Genome Biol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1038\/s41576-018-0004-3","article-title":"DNA methylation-based biomarkers and the epigenetic clock theory of ageing","volume":"19","author":"Horvath","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"B93","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3390\/biomimetics11010012","article-title":"Biomimetic strategies for bone regeneration: smart scaffolds and multiscale cues","volume":"11","author":"Hossen","year":"2025","journal-title":"Biomimetics (Basel)"},{"key":"B94","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1038\/nsmb.2486","article-title":"Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains","volume":"20","author":"Hota","year":"2013","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B95","doi-asserted-by":"publisher","first-page":"9179111","DOI":"10.1155\/2022\/9179111","article-title":"Mechanical cues regulate histone modifications and cell behavior","volume":"2022","author":"Hu","year":"2022","journal-title":"Stem Cells Int."},{"key":"B96","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.bioactmat.2023.01.016","article-title":"Bone\/cartilage organoid on-chip: construction strategy and application","volume":"25","author":"Hu","year":"2023","journal-title":"Bioact. Mater."},{"key":"B97","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1016\/j.jare.2025.06.011","article-title":"Advancements in bone organoids: perspectives on construction methodologies and application strategies","volume":"81","author":"Huang","year":"2026","journal-title":"J. Adv. Res."},{"key":"B98","doi-asserted-by":"publisher","first-page":"e175486","DOI":"10.1172\/jci.insight.175486","article-title":"Chromatin profiling identifies chondrocyte-specific Sox9 enhancers important for skeletal development","volume":"9","author":"Ichiyama-Kobayashi","year":"2024","journal-title":"JCI Insight"},{"key":"B99","doi-asserted-by":"publisher","first-page":"101592","DOI":"10.1016\/j.patter.2026.101592","article-title":"Multimodal spatial omics: from data acquisition to computational integration","volume":"7","author":"Isik","year":"2026","journal-title":"Patterns (N Y)"},{"key":"B100","doi-asserted-by":"publisher","first-page":"159","DOI":"10.59249\/hsyl8000","article-title":"Epigenetic regulation of bone healing: implications for fracture repair and clinical treatment strategies","volume":"98","author":"Iyer","year":"2025","journal-title":"Yale J. Biol. Med."},{"key":"B101","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1101\/gad.351318.123","article-title":"H2A.Z chaperones converge on E2F target genes for melanoma cell proliferation","volume":"38","author":"Jostes","year":"2024","journal-title":"Genes. Dev."},{"key":"B102","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1007\/s12015-025-11029-w","article-title":"Bromodomain-driven regulation of stem cells: a potential target for cancer therapeutic intervention","volume":"22","author":"Jothi","year":"2026","journal-title":"Stem Cell. Rev. Rep."},{"key":"B103","doi-asserted-by":"publisher","first-page":"124365","DOI":"10.1016\/j.lfs.2026.124365","article-title":"The posttranslational modification landscape of transcription factors in osteoblast differentiation and bone formation","volume":"394","author":"Kang","year":"2026","journal-title":"Life Sci."},{"key":"B104","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1101\/gad.335794.119","article-title":"Dynamic regulation of histone modifications and long-range chromosomal interactions during postmitotic transcriptional reactivation","volume":"34","author":"Kang","year":"2020","journal-title":"Genes. Dev."},{"key":"B105","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1021\/acs.jmedchem.9b01980","article-title":"Structural basis of inhibitor selectivity in the BRD7\/9 subfamily of bromodomains","volume":"63","author":"Karim","year":"2020","journal-title":"J. Med. Chem."},{"key":"B106","doi-asserted-by":"publisher","first-page":"50","DOI":"10.3390\/cells15010050","article-title":"The critical role of transcription factor RUNX2 in bone mechanobiology","volume":"15","author":"Katsianou","year":"2025","journal-title":"Cells"},{"key":"B107","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/nature09342","article-title":"Epigenetic memory in induced pluripotent stem cells","volume":"467","author":"Kim","year":"2010","journal-title":"Nature"},{"key":"B108","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.celrep.2016.08.083","article-title":"Reversible regulation of promoter and enhancer histone landscape by DNA methylation in mouse embryonic stem cells","volume":"17","author":"King","year":"2016","journal-title":"Cell. Rep."},{"key":"B109","doi-asserted-by":"publisher","first-page":"175","DOI":"10.2217\/epi-2023-0298","article-title":"DNA methylation as a window into female reproductive aging","volume":"16","author":"Knight","year":"2024","journal-title":"Epigenomics"},{"key":"B110","doi-asserted-by":"publisher","first-page":"101616","DOI":"10.1016\/j.bonr.2022.101616","article-title":"The role of hypertrophic chondrocytes in regulation of the cartilage-to-bone transition in fracture healing","volume":"17","author":"Kodama","year":"2022","journal-title":"Bone Rep."},{"key":"B111","doi-asserted-by":"publisher","first-page":"100739","DOI":"10.1016\/j.crmeth.2024.100739","article-title":"Modular dual-color BiAD sensors for locus-specific readout of epigenome modifications in single cells","volume":"4","author":"Kohler","year":"2024","journal-title":"Cell. Rep. Methods"},{"key":"B112","doi-asserted-by":"publisher","first-page":"1459891","DOI":"10.3389\/fcell.2024.1459891","article-title":"Advance in the application of organoids in bone diseases","volume":"12","author":"Kong","year":"2024","journal-title":"Front. Cell. Dev. Biol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"RP109280","DOI":"10.7554\/eLife.109280","article-title":"The chromatin remodeller CHD4 regulates transcription factor binding to both prevent activation of silent enhancers and maintain active regulatory elements","volume":"14","author":"Koulle","year":"2026","journal-title":"eLife"},{"key":"B114","doi-asserted-by":"publisher","first-page":"100738","DOI":"10.1016\/j.xgen.2024.100738","article-title":"Response eQTLs, chromatin accessibility, and 3D chromatin structure in chondrocytes provide mechanistic insight into osteoarthritis risk","volume":"5","author":"Kramer","year":"2025","journal-title":"Cell. Genom"},{"key":"B115","doi-asserted-by":"publisher","first-page":"e2211510120","DOI":"10.1073\/pnas.2211510120","article-title":"Modeling human skeletal development using human pluripotent stem cells","volume":"120","author":"Lamande","year":"2023","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B116","doi-asserted-by":"publisher","first-page":"971","DOI":"10.21873\/anticanres.16892","article-title":"BRD4-targeting PROTACs synergize with chemotherapeutics against osteosarcoma cell lines","volume":"44","author":"Lang","year":"2024","journal-title":"Anticancer Res."},{"key":"B117","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s13072-022-00473-4","article-title":"Characterizing chromatin interactions of regulatory elements and nucleosome positions, using Hi-C, Micro-C, and promoter capture Micro-C","volume":"15","author":"Lee","year":"2022","journal-title":"Epigenetics Chromatin"},{"key":"B118","doi-asserted-by":"publisher","first-page":"358","DOI":"10.3389\/fcell.2019.00358","article-title":"SWI\/SNF component BAF250a coordinates OCT4 and WNT signaling pathway to control cardiac lineage differentiation","volume":"7","author":"Lei","year":"2019","journal-title":"Front. Cell. Dev. Biol."},{"key":"B119","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/s41420-021-00472-6","article-title":"Histone modifications centric-regulation in osteogenic differentiation","volume":"7","author":"Li","year":"2021","journal-title":"Cell. Death Discov."},{"key":"B120","doi-asserted-by":"publisher","first-page":"2620","DOI":"10.1158\/2159-8290.cd-20-1219","article-title":"A role for SMARCB1 in synovial sarcomagenesis reveals that SS18-SSX induces canonical BAF destruction","volume":"11","author":"Li","year":"2021","journal-title":"Cancer Discov."},{"key":"B121","doi-asserted-by":"publisher","first-page":"100213","DOI":"10.1016\/j.cellin.2024.100213","article-title":"Phase-separated chromatin compartments: orchestrating gene expression through condensation","volume":"3","author":"Li","year":"2024","journal-title":"Cell. Insight"},{"key":"B122","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s13059-025-03659-7","article-title":"Regulatory roles of three-dimensional structures of chromatin domains","volume":"26","author":"Li","year":"2025","journal-title":"Genome Biol."},{"key":"B123","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41413-025-00417-0","article-title":"Cell communication and relevant signaling pathways in osteogenesis-angiogenesis coupling","volume":"13","author":"Li","year":"2025","journal-title":"Bone Res."},{"key":"B124","doi-asserted-by":"publisher","first-page":"101243","DOI":"10.1016\/j.cels.2025.101243","article-title":"SpaGRN: investigating spatially informed regulatory paths for spatially resolved transcriptomics data","volume":"16","author":"Li","year":"2025","journal-title":"Cell. Syst."},{"key":"B125","doi-asserted-by":"publisher","first-page":"gkae1298","DOI":"10.1093\/nar\/gkae1298","article-title":"Mapping the spatial atlas of the human bone tissue integrating spatial and single-cell transcriptomics","volume":"53","author":"Lin","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"B126","doi-asserted-by":"publisher","first-page":"e18788","DOI":"10.1002\/advs.202518788","article-title":"Bone organoids: a novel tool for modeling and managing skeletal disorders in diabetes","volume":"13","author":"Lin","year":"2026","journal-title":"Adv. Sci. (Weinh)"},{"key":"B127","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13619-022-00145-4","article-title":"The dynamics of three-dimensional chromatin organization and phase separation in cell fate transitions and diseases","volume":"11","author":"Ling","year":"2022","journal-title":"Cell. Regen."},{"key":"B128","doi-asserted-by":"publisher","first-page":"e13229","DOI":"10.1111\/acel.13229","article-title":"Underlying features of epigenetic aging clocks in vivo and in vitro","volume":"19","author":"Liu","year":"2020","journal-title":"Aging Cell."},{"key":"B129","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1016\/j.cell.2020.10.026","article-title":"High-spatial-resolution multi-omics sequencing via deterministic barcoding in tissue","volume":"183","author":"Liu","year":"2020","journal-title":"Cell."},{"key":"B130","doi-asserted-by":"publisher","first-page":"710203","DOI":"10.3389\/fcell.2021.710203","article-title":"Advances in chromodomain helicase DNA-Binding (CHD) proteins regulating stem cell differentiation and human diseases","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Cell. Dev. Biol."},{"key":"B131","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1007\/978-3-031-11454-0_11","article-title":"Proteins that read DNA methylation","volume":"1389","author":"Liu","year":"2022","journal-title":"Adv. Exp. Med. Biol."},{"key":"B132","doi-asserted-by":"publisher","first-page":"830722","DOI":"10.3389\/fbioe.2022.830722","article-title":"Effects of mechanical stress stimulation on function and expression mechanism of osteoblasts","volume":"10","author":"Liu","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"B133","doi-asserted-by":"publisher","first-page":"14326","DOI":"10.3390\/ijms241814326","article-title":"The mechanotransduction signaling pathways in the regulation of osteogenesis","volume":"24","author":"Liu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B134","doi-asserted-by":"publisher","first-page":"1377238","DOI":"10.3389\/fgene.2024.1377238","article-title":"Hi-C, a chromatin 3D structure technique advancing the functional genomics of immune cells","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Genet."},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-025-02887-3","article-title":"CRISPR live-cell imaging reveals chromatin dynamics and enhancer interactions at multiple non-repetitive loci","author":"Liu","year":"2025","journal-title":"Nat. Biotechnol."},{"key":"B136","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1038\/s41467-025-56506-5","article-title":"EZH2 serves as a viable therapeutic target for myeloma-induced osteolytic bone destruction","volume":"16","author":"Liu","year":"2025","journal-title":"Nat. Commun."},{"key":"B137","doi-asserted-by":"publisher","first-page":"042005","DOI":"10.1088\/1758-5090\/adffb9","article-title":"Advances in bone organoids research and future perspectives","volume":"17","author":"Liu","year":"2025","journal-title":"Biofabrication"},{"key":"B138","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1097\/cm9.0000000000003535","article-title":"From organoids to organoids-on-a-chip: current applications and challenges in biomedical research","volume":"138","author":"Liu","year":"2025","journal-title":"Chin. Med. J. Engl."},{"key":"B139","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1016\/j.cell.2026.02.012","article-title":"New approach methodologies for drug discovery","volume":"189","author":"Liu","year":"2026","journal-title":"Cell."},{"key":"B140","doi-asserted-by":"publisher","first-page":"3118","DOI":"10.3390\/ijms27073118","article-title":"Bone organoids as advanced models for osteoporosis: development, application, and future prospects","volume":"27","author":"Liu","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"B141","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/s41587-022-01603-9","article-title":"Solid-phase capture and profiling of open chromatin by spatial ATAC","volume":"41","author":"Llorens-Bobadilla","year":"2023","journal-title":"Nat. Biotechnol."},{"key":"B142","doi-asserted-by":"publisher","first-page":"e76932","DOI":"10.7554\/eLife.76932","article-title":"Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development","volume":"11","author":"Long","year":"2022","journal-title":"Elife"},{"key":"B143","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.jot.2025.07.010","article-title":"Innovative strategies for bone organoid: synergistic application and exploration of advanced technologies","volume":"54","author":"Lou","year":"","journal-title":"J. Orthop. Transl."},{"key":"B144","doi-asserted-by":"publisher","first-page":"112553","DOI":"10.1016\/j.compositesb.2025.112553","article-title":"Sequential angiogenic-osteogenic coupling via a spatiotemporally graded hydrogel enables vascularized bone organoids for critical-sized calvarial defect reconstruction","volume":"302","author":"Lou","year":"","journal-title":"Compos. Part B Eng."},{"key":"B145","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.bioactmat.2026.02.024","article-title":"Targeting the osteoporotic bone microenvironment: mechanistic insight and therapeutic biomaterials for accelerating bone regeneration","volume":"62","author":"Lu","year":"2026","journal-title":"Bioact. Mater"},{"key":"B146","doi-asserted-by":"publisher","first-page":"626234","DOI":"10.3389\/fgene.2021.626234","article-title":"LncRNAs: architectural scaffolds or more potential roles in phase separation","volume":"12","author":"Luo","year":"2021","journal-title":"Front. Genet."},{"key":"B147","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/s13059-024-03356-x","article-title":"Benchmarking computational methods for single-cell chromatin data analysis","volume":"25","author":"Luo","year":"2024","journal-title":"Genome Biol."},{"key":"B148","doi-asserted-by":"publisher","first-page":"e13233","DOI":"10.1111\/cpr.13233","article-title":"The role of trithorax family regulating osteogenic and chondrogenic differentiation in mesenchymal stem cells","volume":"55","author":"Ma","year":"2022","journal-title":"Cell. Prolif."},{"key":"B149","doi-asserted-by":"publisher","first-page":"D1086","DOI":"10.1093\/nar\/gkac942","article-title":"OrganoidDB: a comprehensive organoid database for the multi-perspective exploration of bulk and single-cell transcriptomic profiles of organoids","volume":"51","author":"Ma","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"B150","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/s41573-024-00978-5","article-title":"Chromatin remodellers as therapeutic targets","volume":"23","author":"Malone","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"B151","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.braindev.2014.08.009","article-title":"Coffin-siris and nicolaides-baraitser syndromes are a common well recognizable cause of intellectual disability","volume":"37","author":"Mari","year":"2015","journal-title":"Brain Dev."},{"key":"B152","doi-asserted-by":"publisher","first-page":"1272","DOI":"10.1016\/j.cell.2018.09.032","article-title":"Modular organization and assembly of SWI\/SNF family chromatin remodeling complexes","volume":"175","author":"Mashtalir","year":"2018","journal-title":"Cell."},{"key":"B153","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.jdsr.2023.10.006","article-title":"Multi-omics analysis in developmental bone biology","volume":"59","author":"Matsushita","year":"2023","journal-title":"Jpn. Dent. Sci. Rev."},{"key":"B154","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"B155","doi-asserted-by":"publisher","first-page":"e83444","DOI":"10.7554\/eLife.83444","article-title":"Live imaging reveals chromatin compaction transitions and dynamic transcriptional bursting during stem cell differentiation in vivo","volume":"12","author":"May","year":"2023","journal-title":"Elife"},{"key":"B156","doi-asserted-by":"publisher","first-page":"9331","DOI":"10.1038\/s41467-025-64350-w","article-title":"Deciphering histone mark-specific fine-scale chromatin organization at high resolution with Micro-C-ChIP","volume":"16","author":"Metelova","year":"2025","journal-title":"Nat. Commun."},{"key":"B157","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1089\/scd.2014.0544","article-title":"Chromodomain helicase DNA-Binding proteins in stem cells and human developmental diseases","volume":"24","author":"Micucci","year":"2015","journal-title":"Stem Cells Dev."},{"key":"B158","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/s41571-020-0357-3","article-title":"The SWI\/SNF complex in cancer - biology, biomarkers and therapy","volume":"17","author":"Mittal","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"B159","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1186\/s13287-025-04608-8","article-title":"Integrin signaling pathways in mesenchymal stem cells","volume":"16","author":"Mohd","year":"2025","journal-title":"Stem Cell. Res. Ther."},{"key":"B160","doi-asserted-by":"publisher","first-page":"611197","DOI":"10.3389\/fcell.2020.611197","article-title":"Epigenetic control of osteogenic lineage commitment","volume":"8","author":"Montecino","year":"2020","journal-title":"Front. Cell. Dev. Biol."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1042\/bst20211084","article-title":"Role of SWI\/SNF chromatin remodeling genes in lung cancer development","volume":"50","author":"Monterde","year":"2022","journal-title":"Biochem. Soc. Trans."},{"key":"B162","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1038\/nrm2693","article-title":"Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes","volume":"10","author":"Morrison","year":"2009","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"B163","doi-asserted-by":"publisher","first-page":"40162","DOI":"10.1038\/s41598-025-23883-2","article-title":"A microfluidic platform for culturing and high-content imaging of adult stem cell-derived organoids","volume":"15","author":"Moshksayan","year":"2025","journal-title":"Sci. Rep."},{"key":"B164","doi-asserted-by":"publisher","first-page":"gkaf008","DOI":"10.1093\/nar\/gkaf008","article-title":"Chromatin remodeler CHD4 establishes chromatin states required for ovarian reserve formation, maintenance and male germ cell survival","volume":"53","author":"Munakata","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"B165","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/s0092-8674(03)00401-x","article-title":"Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence","volume":"113","author":"Narita","year":"2003","journal-title":"Cell."},{"key":"B166","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1002\/stem.2064","article-title":"SWI\/SNF-Mediated lineage determination in mesenchymal stem cells confers resistance to osteoporosis","volume":"33","author":"Nguyen","year":"2015","journal-title":"Stem Cells"},{"key":"B167","doi-asserted-by":"publisher","first-page":"24","DOI":"10.5483\/BMBRep.2024-0191","article-title":"Dynamics of nucleosomes and chromatin fibers revealed by single-molecule measurements","volume":"58","author":"Nho","year":"2025","journal-title":"BMB Rep."},{"key":"B168","doi-asserted-by":"publisher","first-page":"e223","DOI":"10.1002\/mco2.223","article-title":"Biomolecular condensates: formation mechanisms, biological functions, and therapeutic targets","volume":"4","author":"Niu","year":"2023","journal-title":"MedComm"},{"key":"B169","doi-asserted-by":"publisher","first-page":"485","DOI":"10.5483\/bmbrep.2025-0015","article-title":"Recent advances in single-cell bioinformatics for inferring higher-order chromatin contact maps","volume":"58","author":"Noh","year":"2025","journal-title":"BMB Rep."},{"key":"B170","doi-asserted-by":"publisher","first-page":"e35632","DOI":"10.1002\/jbm.b.35632","article-title":"Collagen\/hydroxyapatite hydrogels promote intercellular interactions and osteogenic differentiation","volume":"113","author":"Oh","year":"2025","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"B171","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1038\/s12276-025-01498-x","article-title":"Live genome imaging by CRISPR engineering: progress and problems","volume":"57","author":"Park","year":"2025","journal-title":"Exp. Mol. Med."},{"key":"B172","doi-asserted-by":"publisher","first-page":"eabd6495","DOI":"10.1126\/sciadv.abd6495","article-title":"Trabecular bone organoid model for studying the regulation of localized bone remodeling","volume":"7","author":"Park","year":"2021","journal-title":"Sci. Adv."},{"key":"B173","doi-asserted-by":"publisher","first-page":"103739","DOI":"10.1016\/j.ejmg.2019.103739","article-title":"Striking phenotypic overlap between nicolaides-baraitser and coffin-siris syndromes in monozygotic twins with ARID1B intragenic deletion","volume":"63","author":"Pascolini","year":"2020","journal-title":"Eur. J. Med. Genet."},{"key":"B174","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1186\/s12964-025-02096-0","article-title":"Endothelial-mesenchymal crosstalk drives osteogenic differentiation of human osteoblasts through notch signaling","volume":"23","author":"Perepletchikova","year":"2025","journal-title":"Cell. Commun. Signal"},{"key":"B175","doi-asserted-by":"publisher","first-page":"13119","DOI":"10.1007\/s12035-025-05128-5","article-title":"Tissue-specific chromatin accessibility regions and transcription factor binding sites in pig brain and endocrine tissues","volume":"62","author":"Ponsuksili","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"B176","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13072-017-0113-9","article-title":"PRC2 is required for extensive reorganization of H3K27me3 during epigenetic reprogramming in mouse fetal germ cells","volume":"10","author":"Prokopuk","year":"2017","journal-title":"Epigenetics Chromatin"},{"key":"B177","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1038\/s41467-024-45710-4","article-title":"A microfluidic platform integrating functional vascularized organoids-on-chip","volume":"15","author":"Quintard","year":"2024","journal-title":"Nat. Commun."},{"key":"B178","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1093\/jnci\/djaf278","article-title":"SMARCAL1 is a new osteosarcoma predisposition gene","volume":"118","author":"Rafati","year":"2026","journal-title":"J. Natl. Cancer Inst."},{"key":"B179","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3109\/03008207.2014.923872","article-title":"Sp7 and Runx2 molecular complex synergistically regulate expression of target genes","volume":"55","author":"Rashid","year":"2014","journal-title":"Connect. Tissue Res."},{"key":"B180","doi-asserted-by":"publisher","first-page":"1244372","DOI":"10.3389\/fcell.2023.1244372","article-title":"Bone angiocrine factors","volume":"11","author":"Ribatti","year":"2023","journal-title":"Front. Cell. Dev. Biol."},{"key":"B181","doi-asserted-by":"publisher","first-page":"RP102930","DOI":"10.7554\/elife.102930","article-title":"DNA methylation insulates genic regions from CTCF loops near nuclear speckles","volume":"13","author":"Roseman","year":"2025","journal-title":"eLife"},{"key":"B182","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1016\/j.molcel.2024.03.013","article-title":"Enhancer switching in cell lineage priming is linked to eRNA, Brg1's AT-hook, and SWI\/SNF recruitment","volume":"84","author":"Saha","year":"","journal-title":"Mol. Cell."},{"key":"B183","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1042\/bst20230416","article-title":"The SWI\/SNF ATP-Dependent chromatin remodeling complex in cell lineage priming and early development","volume":"52","author":"Saha","year":"","journal-title":"Biochem. Soc. Trans."},{"key":"B184","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1101\/gr.086983.108","article-title":"Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns","volume":"19","author":"Schnetz","year":"2009","journal-title":"Genome Res."},{"key":"B185","doi-asserted-by":"publisher","first-page":"9619","DOI":"10.1093\/nar\/gkz699","article-title":"EWS-FLI1 modulated alternative splicing of ARID1A reveals novel oncogenic function through the BAF complex","volume":"47","author":"Selvanathan","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"B186","doi-asserted-by":"publisher","first-page":"e00177\u201317","DOI":"10.1128\/MCB.00177-17","article-title":"Tet-mediated DNA demethylation is required for SWI\/SNF-Dependent chromatin remodeling and histone-modifying activities that trigger expression of the Sp7 osteoblast master gene during mesenchymal lineage commitment","volume":"37","author":"Sepulveda","year":"2017","journal-title":"Mol. Cell. Biol."},{"key":"B187","doi-asserted-by":"publisher","first-page":"dev204697","DOI":"10.1242\/dev.204697","article-title":"Chd4 remodels chromatin to control retinal cell type specification and lineage termination","volume":"152","author":"Shah","year":"2025","journal-title":"Development"},{"key":"B188","doi-asserted-by":"publisher","first-page":"bpag019","DOI":"10.1093\/biomethods\/bpag019","article-title":"A low-input Micro-C protocol for high-resolution 3D genome mapping","volume":"11","author":"Shan","year":"2026","journal-title":"Biol. Methods Protoc."},{"key":"B189","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/j.omtn.2020.11.008","article-title":"Circular RNA: an important player with multiple facets to regulate its parental gene expression","volume":"23","author":"Shao","year":"2021","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B190","article-title":"Fracture healing overview. StatPearls. Treasure island (FL) ineligible companies. Disclosure: Ahmed mabrouk declares no relevant financial relationships with ineligible companies","volume-title":"Disclosure: Vishnu Garla Declares No Relevant Financial Relationships with Ineligible Companies","author":"Sheen","year":"2026"},{"key":"B191","doi-asserted-by":"publisher","first-page":"11722","DOI":"10.1039\/d5tb01038a","article-title":"Hybrid photo-crosslinked decellularized extracellular matrix scaffold from porcine achilles tendon: a biocompatible and non-immunogenic matrix for tissue engineering","volume":"13","author":"Shelar","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"B192","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1080\/17501911.2026.2685054","article-title":"Epigenetic regulation of nuclear mechanics","volume":"18","author":"Shi","year":"2026","journal-title":"Epigenomics"},{"key":"B193","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1152\/physiol.00061.2014","article-title":"Physiological bone remodeling: systemic regulation and growth factor involvement","volume":"31","author":"Siddiqui","year":"2016","journal-title":"Physiol. (Bethesda)"},{"key":"B194","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.3390\/cells10071749","article-title":"Vascularization strategies in bone tissue engineering","volume":"10","author":"Simunovic","year":"2021","journal-title":"Cells"},{"key":"B195","doi-asserted-by":"publisher","first-page":"4105","DOI":"10.1039\/d4lc00480a","article-title":"Continuous flow delivery system for the perfusion of scaffold-based 3D cultures","volume":"24","author":"Sitte","year":"2024","journal-title":"Lab. Chip"},{"key":"B196","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1002\/1878-0261.13742","article-title":"Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in ewing sarcoma","volume":"19","author":"Sohn","year":"2025","journal-title":"Mol. Oncol."},{"key":"B197","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1016\/j.stemcr.2021.07.022","article-title":"CHD4 ensures stem cell lineage fidelity during skeletal muscle regeneration","volume":"16","author":"Sreenivasan","year":"2021","journal-title":"Stem Cell. Rep."},{"key":"B198","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1038\/s42255-023-00948-y","article-title":"The serine synthesis pathway drives osteoclast differentiation through epigenetic regulation of NFATc1 expression","volume":"6","author":"Stegen","year":"2024","journal-title":"Nat. Metab."},{"key":"B199","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s11914-025-00923-4","article-title":"Epigenetic control of osteogenesis: pathways toward improved bone regeneration","volume":"23","author":"Stetsiv","year":"2025","journal-title":"Curr. Osteoporos. Rep."},{"key":"B200","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/s41592-021-01282-5","article-title":"Single-cell chromatin state analysis with signac","volume":"18","author":"Stuart","year":"2021","journal-title":"Nat. Methods"},{"key":"B201","doi-asserted-by":"publisher","first-page":"e71155","DOI":"10.1002\/adhm.71155","article-title":"Recapitulating endochondral ossification for bone repair: from development to engineering strategy","volume":"15","author":"Su","year":"2026","journal-title":"Adv. Healthc. Mater."},{"key":"B202","doi-asserted-by":"publisher","first-page":"2443","DOI":"10.1016\/j.gendis.2022.10.030","article-title":"Epigenetic regulation of mesenchymal stem cell aging through histone modifications","volume":"10","author":"Sun","year":"2023","journal-title":"Genes. Dis."},{"key":"B203","doi-asserted-by":"publisher","first-page":"eaaw1668","DOI":"10.1126\/sciadv.aaw1668","article-title":"Principles of genome folding into topologically associating domains","volume":"5","author":"Szabo","year":"2019","journal-title":"Sci. Adv."},{"key":"B204","doi-asserted-by":"publisher","first-page":"100738","DOI":"10.1016\/j.job.2026.100738","article-title":"The Runx2-SMOC axis in skeletal development: expanding roles of Smoc1 and Smoc2 in development and disease","volume":"68","author":"Takahata","year":"2026","journal-title":"J. Oral Biosci."},{"key":"B205","doi-asserted-by":"publisher","first-page":"e1007346","DOI":"10.1371\/journal.pgen.1007346","article-title":"Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions","volume":"14","author":"Tan","year":"2018","journal-title":"PLoS Genet."},{"key":"B206","doi-asserted-by":"publisher","first-page":"111294","DOI":"10.1016\/j.jbc.2026.111294","article-title":"Structural insights into specific recognition of the histone variant H2A.Z by the YL1 subunit of SRCAP chromatin-remodeling complex","volume":"302","author":"Tan","year":"2026","journal-title":"J. Biol. Chem."},{"key":"B207","doi-asserted-by":"publisher","first-page":"112276","DOI":"10.1016\/j.celrep.2023.112276","article-title":"Stem cell-based modeling and single-cell multiomics reveal gene-regulatory mechanisms underlying human skeletal development","volume":"42","author":"Tani","year":"2023","journal-title":"Cell. Rep."},{"key":"B208","doi-asserted-by":"publisher","first-page":"1815809","DOI":"10.3389\/fimmu.2026.1815809","article-title":"Modeling myeloid cell development in health and disease using induced pluripotent stem cells","volume":"17","author":"Tesakov","year":"2026","journal-title":"Front. Immunol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"3560","DOI":"10.1038\/s41467-026-70087-x","article-title":"Mechanisms of gene regulation by SRCAP and H2A.Z","volume":"17","author":"Tollenaere","year":"2026","journal-title":"Nat. Commun."},{"key":"B210","doi-asserted-by":"publisher","first-page":"9717","DOI":"10.1038\/s41598-026-40231-0","article-title":"A modular platform for automated organoid culture and longitudinal imaging","volume":"16","author":"Torres-Montoya","year":"2026","journal-title":"Sci. Rep."},{"key":"B211","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/s41526-025-00556-y","article-title":"Effects of microgravity mechanotransduction in bone tissue and cells: systematic review on primary cilium-dependent mechanisms","volume":"12","author":"Tosi","year":"2026","journal-title":"NPJ Microgravity"},{"key":"B212","doi-asserted-by":"publisher","first-page":"1643","DOI":"10.3390\/biom11111643","article-title":"The role of TGF-beta in bone metastases","volume":"11","author":"Trivedi","year":"2021","journal-title":"Biomolecules"},{"key":"B213","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1016\/s0140-6736(00)02217-0","article-title":"Effects of long-term microgravity exposure on cancellous and cortical weight-bearing bones of cosmonauts","volume":"355","author":"Vico","year":"2000","journal-title":"Lancet"},{"key":"B214","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1038\/s41419-023-06239-4","article-title":"Mesenchymal stem cells under epigenetic control - the role of epigenetic machinery in fate decision and functional properties","volume":"14","author":"Walewska","year":"2023","journal-title":"Cell. Death Dis."},{"key":"B215","doi-asserted-by":"publisher","first-page":"147420","DOI":"10.1016\/j.gene.2023.147420","article-title":"SWI\/SNF complexes and cancers","volume":"870","author":"Wang","year":"2023","journal-title":"Gene"},{"key":"B216","doi-asserted-by":"publisher","first-page":"8836258","DOI":"10.1155\/2020\/8836258","article-title":"Epigenetic regulation in mesenchymal stem cell aging and differentiation and osteoporosis","volume":"2020","author":"Wang","year":"2020","journal-title":"Stem Cells Int."},{"key":"B217","doi-asserted-by":"publisher","first-page":"7644","DOI":"10.1038\/s41467-022-34859-5","article-title":"Structure of nucleosome-bound human PBAF complex","volume":"13","author":"Wang","year":"","journal-title":"Nat. Commun."},{"key":"B218","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/s41413-022-00190-4","article-title":"Mechanical regulation of bone remodeling","volume":"10","author":"Wang","year":"","journal-title":"Bone Res."},{"key":"B219","doi-asserted-by":"publisher","first-page":"5815","DOI":"10.2147\/ijn.s416098","article-title":"Fused deposition modeling printed PLA\/Nano beta-TCP composite bone tissue engineering scaffolds for promoting osteogenic induction function","volume":"18","author":"Wang","year":"2023","journal-title":"Int. J. Nanomedicine"},{"key":"B220","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1038\/s41551-023-01053-x","article-title":"Chromatin reprogramming and bone regeneration in vitro and in vivo via the microtopography-induced constriction of cell nuclei","volume":"7","author":"Wang","year":"2023","journal-title":"Nat. Biomed. Eng."},{"key":"B221","doi-asserted-by":"publisher","first-page":"682","DOI":"10.7150\/thno.105840","article-title":"Standardization and consensus in the development and application of bone organoids","volume":"15","author":"Wang","year":"2025","journal-title":"Theranostics"},{"key":"B222","doi-asserted-by":"publisher","first-page":"835","DOI":"10.3390\/ijms27020835","article-title":"How ATP-dependent chromatin remodeling complexes regulate vertebrate embryonic development","volume":"27","author":"Wang","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"B223","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1038\/s41392-025-02334-4","article-title":"Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications","volume":"11","author":"Wang","year":"2026","journal-title":"Signal Transduct. Target Ther."},{"key":"B224","doi-asserted-by":"publisher","first-page":"e71975","DOI":"10.1096\/fj.202600715rr","article-title":"Insights into dose-dependent bone toxicity following partial-body exposure to fractionated ionizing radiation in vivo","volume":"40","author":"Wei","year":"2026","journal-title":"FASEB J."},{"key":"B225","doi-asserted-by":"publisher","first-page":"115","DOI":"10.3892\/ijmm.2025.5556","article-title":"Epigenetic roles of chromatin remodeling complexes in bone biology and the pathogenesis of bone-related disease","volume":"56","author":"Wu","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"B226","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s42003-025-09278-z","article-title":"Integrative analysis reveals synergistic regulation of Sp7 by BRD9 and Wnt\/beta-catenin signaling during osteogenic differentiation","volume":"9","author":"Wu","year":"2025","journal-title":"Commun. Biol."},{"key":"B227","doi-asserted-by":"publisher","first-page":"bbag015","DOI":"10.1093\/bib\/bbag015","article-title":"Advances in scCUT&Tag and computational analysis for single-cell gene regulatory element mapping","volume":"27","author":"Wu","year":"2026","journal-title":"Brief. Bioinform"},{"key":"B228","doi-asserted-by":"publisher","first-page":"gkaf1540","DOI":"10.1093\/nar\/gkaf1540","article-title":"Illuminating the genome: emerging approaches in CRISPR-Cas live-cell imaging","volume":"54","author":"Xiao","year":"2026","journal-title":"Nucleic Acids Res."},{"key":"B229","doi-asserted-by":"publisher","first-page":"RP87868","DOI":"10.7554\/elife.87868","article-title":"Spatial chromatin accessibility sequencing resolves high-order spatial interactions of epigenomic markers","volume":"12","author":"Xie","year":"2024","journal-title":"eLife"},{"key":"B230","doi-asserted-by":"publisher","first-page":"eadi3664","DOI":"10.1126\/sciadv.adi3664","article-title":"Single-cell joint profiling of multiple epigenetic proteins and gene transcription","volume":"10","author":"Xiong","year":"2024","journal-title":"Sci. Adv."},{"key":"B231","doi-asserted-by":"publisher","first-page":"5033","DOI":"10.1074\/jbc.M111.279968","article-title":"Essential role of ARID2 protein-containing SWI\/SNF complex in tissue-specific gene expression","volume":"287","author":"Xu","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1016\/j.gendis.2026.102280","article-title":"Epigenetics of bone formation and diseases: from mechanisms to therapies","author":"Yang","year":"2026","journal-title":"Genes. and Dis"},{"key":"B233","doi-asserted-by":"publisher","first-page":"108346","DOI":"10.1016\/j.phrs.2026.108346","article-title":"Acetyl-CoA metabolism in skeletal biology and bone disorders: from mechanisms to therapeutic implications","volume":"231","author":"Yang","year":"2026","journal-title":"Pharmacol. Res."},{"key":"B234","doi-asserted-by":"publisher","first-page":"3147","DOI":"10.3390\/ijms20133147","article-title":"Bone remodeling: Histone modifications as fate determinants of bone cell differentiation","volume":"20","author":"Yi","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"B235","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.stem.2024.11.005","article-title":"Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells","volume":"32","author":"Yin","year":"2025","journal-title":"Cell. Stem Cell."},{"key":"B236","doi-asserted-by":"publisher","first-page":"8029","DOI":"10.3390\/ijms24098029","article-title":"The role of HIF-1alpha in bone regeneration: a new direction and challenge in bone tissue engineering","volume":"24","author":"You","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"B237","doi-asserted-by":"publisher","first-page":"e22056","DOI":"10.1002\/advs.202522056","article-title":"A circuit of mechanically regulated transcription factors balances regenerative and fibrotic memory of mesenchymal stromal cells","volume":"13","author":"Younesi","year":"2026","journal-title":"Adv. Sci. (Weinh)"},{"key":"B238","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1002\/jcb.20332","article-title":"SWI\/SNF chromatin remodeling complex is obligatory for BMP2-induced, Runx2-dependent skeletal gene expression that controls osteoblast differentiation","volume":"94","author":"Young","year":"2005","journal-title":"J. Cell. Biochem."},{"key":"B239","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/s41421-023-00640-1","article-title":"Structural insights into histone exchange by human SRCAP complex","volume":"10","author":"Yu","year":"2024","journal-title":"Cell. Discov."},{"key":"B240","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1038\/s41392-025-02374-w","article-title":"Pancancer outcome prediction via a unified weakly supervised deep learning model","volume":"10","author":"Yuan","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"key":"B241","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1039\/d0lc01186j","article-title":"Vascularized organoids on a chip: strategies for engineering organoids with functional vasculature","volume":"21","author":"Zhang","year":"2021","journal-title":"Lab. Chip"},{"key":"B242","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1038\/s41586-023-05795-1","article-title":"Spatial epigenome-transcriptome co-profiling of mammalian tissues","volume":"616","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"B243","doi-asserted-by":"publisher","first-page":"e2313656121","DOI":"10.1073\/pnas.2313656121","article-title":"Dancr-BRG1 regulates Nfatc1 transcription and Pgc1beta-dependent metabolic shifts in osteoclastogenesis","volume":"121","author":"Zhang","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B244","doi-asserted-by":"publisher","first-page":"101105","DOI":"10.1016\/j.xgen.2025.101105","article-title":"Robust integration and annotation of single-cell and spatial omics data using interpretable gene programs","volume":"6","author":"Zhang","year":"2026","journal-title":"Cell. Genom"},{"key":"B245","doi-asserted-by":"publisher","first-page":"1862466","DOI":"10.3389\/fgene.2026.1862466","article-title":"Epigenetic regulation in osteoarthritis: recent updates and emerging mechanisms","volume":"17","author":"Zhao","year":"2026","journal-title":"Front. Genet."},{"key":"B246","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1021\/acsbiomaterials.1c01525","article-title":"Engineering biomimetic extracellular matrix with Silica Nanofibers: from 1D material to 3D network","volume":"8","author":"Zhou","year":"2022","journal-title":"ACS Biomater. Sci. Eng."},{"key":"B247","doi-asserted-by":"publisher","first-page":"7865","DOI":"10.1038\/s41467-026-74693-7","article-title":"Hierarchical interplay between H3K27ac and H3K4me3 in transcriptional regulation","volume":"17","author":"Zhou","year":"2026","journal-title":"Nat. Commun."},{"key":"B248","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1016\/j.molcel.2012.11.011","article-title":"A SWI\/SNF chromatin-remodeling complex acts in noncoding RNA-mediated transcriptional silencing","volume":"49","author":"Zhu","year":"2013","journal-title":"Mol. Cell."},{"key":"B249","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/s41421-024-00689-6","article-title":"Cell signaling and transcriptional regulation of osteoblast lineage commitment, differentiation, bone formation, and homeostasis","volume":"10","author":"Zhu","year":"2024","journal-title":"Cell. Discov."},{"key":"B250","doi-asserted-by":"publisher","first-page":"e2501254","DOI":"10.1002\/adma.202501254","article-title":"Dynamic GelMA\/DNA dual-network hydrogels promote woven bone organoid formation and enhance bone regeneration","volume":"37","author":"Zhu","year":"2025","journal-title":"Adv. Mater"},{"key":"B251","doi-asserted-by":"publisher","first-page":"9636897241303271","DOI":"10.1177\/09636897241303271","article-title":"Advances in the development and application of human organoids: techniques, applications, and future perspectives","volume":"34","author":"Zhu","year":"2025","journal-title":"Cell. Transpl."},{"key":"B252","doi-asserted-by":"publisher","first-page":"123703","DOI":"10.1016\/j.biomaterials.2025.123703","article-title":"Biomineralization empowers bone organoids","volume":"326","author":"Zhu","year":"2026","journal-title":"Biomaterials"},{"key":"B253","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/s41421-025-00853-6","article-title":"Cell signaling and transcriptional regulation of osteoclast lineage commitment, differentiation, bone resorption and diseases","volume":"12","author":"Zhu","year":"2026","journal-title":"Cell. Discov."}],"container-title":["Frontiers in Genetics"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2026.1975296\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:41:58Z","timestamp":1791362518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgene.2026.1975296\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":253,"alternative-id":["10.3389\/fgene.2026.1975296"],"URL":"https:\/\/doi.org\/10.3389\/fgene.2026.1975296","relation":{},"ISSN":["1664-8021"],"issn-type":[{"value":"1664-8021","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"article-number":"1975296"}}