{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T17:10:59Z","timestamp":1788628259650,"version":"build-2803163510"},"reference-count":22,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T00:00:00Z","timestamp":1729728000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Gastroenterol."],"abstract":"<jats:p>Pancreatic schwannomas are exceedingly rare tumors arising from Schwann cells of the peripheral nerve sheath within the pancreas. Often asymptomatic or presenting with nonspecific symptoms, these tumors pose a diagnostic challenge due to their mimicry of other pancreatic neoplasms on imaging studies. Histologically, pancreatic schwannomas demonstrate spindle cell proliferation with a distinct Immunohistochemical profile, including positive staining for S-100 protein. Surgical resection remains the cornerstone of treatment, with excellent long-term prognosis following complete excision. Here, we present a case report of a pancreatic schwannoma in a woman presenting with a cystic pancreatic mass, underscoring the importance of considering this rare entity in the differential diagnosis of pancreatic lesions.<\/jats:p>","DOI":"10.3389\/fgstr.2024.1425831","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T05:10:45Z","timestamp":1729746645000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Case report: Initial presentation of pancreatic schwannoma as cystic pancreatic mass treated with classic Whipple\u2019s procedure"],"prefix":"10.3389","volume":"3","author":[{"given":"Zekewos Demissie","family":"Jemaneh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahom","family":"Zemedkun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serkalem","family":"Nurlegn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanuel Mamuye","family":"Woldeamanuel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henok","family":"Seife","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohannes","family":"Birhanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethelhem Berhanu","family":"Belachew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2016.03.014","article-title":"Pancreatic schwannoma: A rare case and a brief literature review","volume":"22","author":"Ercan","year":"2016","journal-title":"Int J Surg Case Rep"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2022.07.029","article-title":"Pancreatic schwannoma: Case report, clinico-pathologic correlation, and review of the literature","volume":"17","author":"Ntafam","year":"2022","journal-title":"Radiol Case Rep"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i13.1538","article-title":"Pancreatic schwannoma: Case report and an updated 30-year review of the literature yielding 47 cases","volume":"18","author":"Moriya","year":"2012","journal-title":"World J Gastroenterol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930360106","article-title":"Solitary Malignant schwannoma of the pancreas: report of a case and ultrastructural examination","volume":"36","author":"Eggermont","year":"1987","journal-title":"J Surg Oncol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.20.4.228","article-title":"Tumors of peripheral nerve origin: benign and Malignant solitary schwannomas","volume":"20","author":"Das Gupta","year":"1970","journal-title":"CA Cancer J Clin"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2004.05.010","article-title":"Clinical characteristics, treatment, and outcome of pancreatic Schwannomas","volume":"8","author":"Paranjape","year":"2004","journal-title":"J Gastrointest Surg"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/s1091-255x(01)80062-7","article-title":"Pancreatic schwannoma: an uncommon but important entity","volume":"5","author":"Almo","year":"2001","journal-title":"J Gastrointest Surg"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199303000-00022","article-title":"Pancreatic schwannoma","volume":"8","author":"David","year":"1993","journal-title":"Pancreas"},{"key":"B9","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s00401-012-0954-z","article-title":"Pathology of peripheral nerve sheath tumors: diagnostic overview and update on selected diagnostic problems","volume":"123","author":"Rodriguez","year":"2012","journal-title":"Acta Neuropathol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsurg.2008.12.001","article-title":"Pancreatic schwannoma: literature review","volume":"66","author":"Gupta","year":"2009","journal-title":"J Surg Educ"},{"key":"B11","doi-asserted-by":"publisher","first-page":"E12","DOI":"10.3171\/foc.2003.15.2.12","article-title":"Nerve sheath tumors involving the sacrum. Case report and classification scheme","volume":"15","author":"Klimo","year":"2003","journal-title":"Neurosurg Focus"},{"key":"B12","article-title":"The role of immunohistochemical staining in the diagnosis of schwann cell neoplasms","volume":"33","author":"Coyne","year":"2001","journal-title":"Pathology"},{"key":"B13","article-title":"Pancreatic schwannoma: a case report and literature review with special reference to imaging features","volume":"11","author":"Suzuki","year":"2010","journal-title":"JOP"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2005.04.017","article-title":"MRI features of a pancreatic schwannoma","volume":"29","author":"Novellas","year":"2005","journal-title":"Clin Imaging"},{"key":"B15","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/00006676-199707000-00014","article-title":"Pancreatic schwannoma: report of two cases and review of the literature","volume":"15","author":"Feldman","year":"1997","journal-title":"Pancreas"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20985","article-title":"Intrapancreatic schwannoma diagnosed by endoscopic ultrasound-guided fine-needle aspiration cytology","volume":"37","author":"Li","year":"2009","journal-title":"Diagn Cytopathol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4103\/2303-9027.195873","article-title":"Endoscopic ultrasound features of pancreatic schwannoma","volume":"5","author":"Crin\u00f2","year":"2016","journal-title":"Endoscopic Ultrasound"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2015.08.041","article-title":"Contrast-enhanced harmonic EUS of pancreatic schwannoma","volume":"83","author":"Nishikawa","year":"2015","journal-title":"Gastrointest Endosc"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000028874","article-title":"Successful treatment of pancreatic schwannoma by enucleation: A case report","volume":"101","author":"Xu","year":"2022","journal-title":"Med (Baltimore)"},{"key":"B20","article-title":"Cytological features of the cystic fluid of pancreatic schwannoma with cystic degeneration. A case report","volume":"9","author":"Hirabayashi","year":"2008","journal-title":"JOP"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199116020-00030","article-title":"Radiation therapy for giant intrasacral schwannoma","volume":"16","author":"Kotoura","year":"1991","journal-title":"Spine (Phila Pa 1976)"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.4103\/jmas.JMAS_26_17","article-title":"Evolution of minimally invasive distal pancreatectomies at a single institution","volume":"14","author":"Goh","year":"2018","journal-title":"J Minim Access Surg"}],"container-title":["Frontiers in Gastroenterology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgstr.2024.1425831\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T05:10:49Z","timestamp":1729746649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgstr.2024.1425831\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,24]]},"references-count":22,"alternative-id":["10.3389\/fgstr.2024.1425831"],"URL":"https:\/\/doi.org\/10.3389\/fgstr.2024.1425831","relation":{},"ISSN":["2813-1169"],"issn-type":[{"value":"2813-1169","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,24]]},"article-number":"1425831"}}