{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:10:06Z","timestamp":1777389006341,"version":"3.51.4"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007505","name":"Kirsten og Freddy Johansens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007371","name":"Svend Andersen Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007371","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005111","name":"Rigshospitalet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Gastroenterol."],"abstract":"<jats:p>Hematological abnormalities are common in liver transplant recipients, but evidence beyond the first-year post-transplantation is scarce. We aimed to evaluate hematological abnormalities in liver transplant recipients beyond the first-year post-transplantation. We included 437 liver transplant recipients and 1,744 age- and sex-matched controls from the general population. Odds for cytopenias were assessed using logistic regression analyses adjusted for age, sex, ethnicity, hs-CRP, smoking, and alcohol use. Potential transplant-related risk factors were assessed in liver transplant recipients only. The median time since transplantation was 7.8 years, and 47% had autoimmune liver disease as the indication for transplantation. Compared to controls, liver transplant recipients had a higher prevalence of anemia (24.5% vs. 3.5%), neutropenia (2.1% vs. 0.1%), lymphocytopenia (18.4% vs. 1.5%), and thrombocytopenia (19.2% vs. 2.2%). Living with a transplanted liver was independently associated with higher odds of anemia (aOR, 7.84 [95% CI: 5.04 \u2013 12.18], <jats:italic>p<\/jats:italic>&amp;lt;0.001), lymphocytopenia (aOR 16.69 [95% CI: 9.56 \u2013 29.12], <jats:italic>p<\/jats:italic>&amp;lt;0.001), and thrombocytopenia (aOR 10.19 [95% CI: 6.07 \u2013 17.13], <jats:italic>p<\/jats:italic>&amp;lt;0.001). No association was found between cytopenias, specific types of immunosuppressive treatments, or cirrhosis at transplantation. In conclusion, hematological abnormalities are common in liver transplant recipients, even several years post-transplantation, and increased attention towards cytopenia in this population is warranted.<\/jats:p>","DOI":"10.3389\/fgstr.2025.1543618","type":"journal-article","created":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T04:12:26Z","timestamp":1754453546000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Living with a transplanted liver is associated with cytopenias: a nationwide cohort study"],"prefix":"10.3389","volume":"4","author":[{"given":"Kajinth","family":"Manogarathaas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoline S.","family":"Arentoft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens 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