{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T05:07:41Z","timestamp":1784092061633,"version":"3.55.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Gastroenterol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection is a major etiological factor for gastric cancer, but its prognostic relevance once invasive gastric cancer has developed remains uncertain in French Guiana.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We conducted a retrospective hospital-based study including all patients diagnosed with histologically confirmed invasive gastric carcinoma at Cayenne Hospital Center between 2018 and 2023.\n                      <jats:italic>H. pylori<\/jats:italic>\n                      status was assessed by routine histopathology. Sociodemographic, clinicopathological, and histological characteristics, including associated gastric lesions, were collected. Overall survival was estimated using the Kaplan\u2013Meier method and compared using the log-rank test according to\n                      <jats:italic>H. pylori<\/jats:italic>\n                      status and initial management strategy. Exploratory multivariable Cox regression analyses were performed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Eighty-two patients were included, of whom 43 (52.4%) were\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -positive.\n                      <jats:italic>H. pylori<\/jats:italic>\n                      positivity was significantly associated with non-active chronic gastritis, whereas\n                      <jats:italic>H. pylori<\/jats:italic>\n                      detection was uncommon in active chronic gastritis.\n                      <jats:italic>H. pylori<\/jats:italic>\n                      status was not associated with tumor location, histological subtype, differentiation, or preneoplastic lesions. Median follow-up was 25.7 months. Overall survival did not differ between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -positive and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      -negative patients. In multivariable analyses,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      status was not associated with survival, whereas initial management was strongly associated with outcome, likely reflecting disease stage at diagnosis rather than a causal treatment effect.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Routine histology detected\n                      <jats:italic>H. pylori<\/jats:italic>\n                      in about half of gastric tumors, with an association with non-active chronic gastritis.\n                      <jats:italic>H. pylori<\/jats:italic>\n                      status was not associated with survival; differences by initial management likely reflected disease severity, with interpretation limited by incomplete TNM staging.\n                    <\/jats:p>\n              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