{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:10:12Z","timestamp":1790676612237,"version":"4.1.0"},"reference-count":51,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Glob. Womens Health"],"abstract":"<jats:p>Endometriosis is associated with painful symptoms, infertility, sexological difficulties, and psychological suffering. All these symptoms have a negative impact on the overall quality of life of women with the disease, with significant personal, social and economic costs. Several medical options are available to manage symptomatic endometriosis. The pharmacological treatment for endometriosis-related pain may be necessary for decades, or at least until there is a desire for pregnancy or physiologic menopause occurs. In this perspective, clinicians should consider not only the efficacy, but also side effects, tolerability, and costs, along with women's preferences toward different treatments. In this mini-review, we analyzed the pros and cons of the available drugs for the medical therapy of endometriosis, such as estrogen-progestins, progestins, GnRH agonist and GnRH antagonists.<\/jats:p>","DOI":"10.3389\/fgwh.2021.729601","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T16:24:53Z","timestamp":1632759893000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":57,"title":["Medical Treatment for Endometriosis: Tolerability, Quality of Life and Adherence"],"prefix":"10.3389","volume":"2","author":[{"given":"Giussy","family":"Barbara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Buggio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Facchin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Vercellini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/j.fertnstert.2016.10.022","article-title":"Estrogen-progestins and progestins for the management of endometriosis","volume":"106","author":"Vercellini","year":"2016","journal-title":"Fertil Steril."},{"key":"B2","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.fertnstert.2017.05.004","article-title":"Reevaluating response and failure of medical treatment of endometriosis: a systematic review","volume":"108","author":"Becker","year":"2017","journal-title":"Fertil Steril."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1080\/14656566.2018.1494154","article-title":"Current and emerging treatment options for endometriosis","volume":"19","author":"Ferrero","year":"2018","journal-title":"Expert Opin Pharmacother."},{"key":"B4","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1080\/14656566.2020.1738386","article-title":"The role of pharmacotherapy in the treatment of endometriosis across the lifespan","volume":"21","author":"Schwartz","year":"2020","journal-title":"Expert Opin Pharmacother."},{"key":"B5","doi-asserted-by":"publisher","first-page":"455","DOI":"10.2741\/e41","article-title":"Treatment of endometriosis-related pain: options and outcomes","volume":"1","author":"Somigliana","year":"2009","journal-title":"Front Biosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1093\/humupd\/dmq050","article-title":"Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications","volume":"17","author":"Stratton","year":"2011","journal-title":"Hum Reprod Update."},{"key":"B7","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.bpobgyn.2018.01.014","article-title":"Pathophysiology of endometriosis-associated pain: A review of pelvic and central nervous system mechanisms","volume":"51","author":"Coxon","year":"2018","journal-title":"Best Pract Res Clin Obstet Gynaecol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"135","DOI":"10.3109\/0167482X.2015.1074173","article-title":"Impact of endometriosis on quality of life and mental health: pelvic pain makes the difference","volume":"36","author":"Facchin","year":"2015","journal-title":"J Psychosom Obstet Gynaecol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1111\/aogs.13031","article-title":"When love hurts. 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