{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:07:33Z","timestamp":1791803253425,"version":"4.3.4"},"reference-count":27,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T00:00:00Z","timestamp":1654473600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Glob. Womens Health"],"abstract":"<jats:p>Preterm birth is a global epidemic and a leading cause of neonatal mortality in Sub-Saharan Africa. We evaluated the prevalence and risk factors of preterm birth among women attending the labor ward for delivery at a tertiary hospital in Ghana. This comparative cross-sectional study was conducted among a cohort of 209 pregnant women admitted to the labor ward of the Komfo Anokye Teaching Hospital (KATH). Pregnant women who delivered between 28 and 36 completed weeks of gestation were classified as preterm delivery whereas those who delivered after 37\u201342 completed weeks were described as term. Sociodemographic, clinical, and obstetric data were collected from patient's folder and hospital archives. Categorical variables were analyzed and expressed as frequencies and proportions. We determined the association between obstetric factors and preterm delivery with multiple logistic regressions. Significance level of the strength of association was determined at <jats:italic>p<\/jats:italic>-value &amp;lt; 0.05. of the 209 participants, the prevalence of preterm birth was 37.3% (78\/209) whereas 62.7% (131\/209) delivered at Term. Intrauterine growth restriction (IUGR) [<jats:italic>aOR<\/jats:italic> = 2.15, 95% <jats:italic>CI<\/jats:italic> = (1.819.55), <jats:italic>p<\/jats:italic> = 0.0390], HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome [<jats:italic>aOR<\/jats:italic> = 3.94, 95% <jats:italic>CI<\/jats:italic> = (1.64\u20139.48), <jats:italic>p<\/jats:italic> = 0.0020], early gestational obesity [aOR = 2.11, 95% <jats:italic>CI<\/jats:italic> = (1.31\u201311.92), <jats:italic>p<\/jats:italic> = 0.0480] and preeclampsia [<jats:italic>aOR<\/jats:italic> = 4.56, 95% <jats:italic>CI<\/jats:italic> = (1.63\u201312.76), <jats:italic>p<\/jats:italic> = 0.004] were identified as independent risk factors of preterm birth. Prevalence of preterm birth was high among women attending labor admission at the Komfo Anokye Teaching Hospital and this was independently influenced by IUGR, HELLP syndrome, early gestational obesity, and preeclampsia. Identifying early signs of adverse pregnancy outcomes would inform the need for management policy to prevent high prevalence of preterm births.<\/jats:p>","DOI":"10.3389\/fgwh.2022.801092","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T06:15:30Z","timestamp":1654496130000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["Prevalence and Risk Factors of Preterm Birth Among Pregnant Women Admitted at the Labor Ward of the Komfo Anokye Teaching Hospital, Ghana"],"prefix":"10.3389","volume":"3","author":[{"given":"Enoch Odame","family":"Anto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wina Ivy","family":"Ofori Boadu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Opoku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebenezer","family":"Senu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine Christian Kodzo Tsatsu","family":"Tamakloe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augustine","family":"Tawiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Ankobea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Acheampong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agartha Odame","family":"Anto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Appiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaw Amo","family":"Wiafe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max Efui","family":"Annani-Akollor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Obirikorang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otchere","family":"Addai-Mensah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2162","DOI":"10.1016\/S0140-6736(12)60820-4","article-title":"National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications","volume":"379","author":"Blencowe","year":"2012","journal-title":"Lancet."},{"key":"B2","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/13569780308319","article-title":"Save the children? \u2013change the world","volume":"8","author":"Prentki","year":"2003","journal-title":"Res Drama Educ."},{"key":"B3","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.ajog.2011.10.865","article-title":"The preterm birth syndrome: issues to consider in creating a classification system","volume":"206","author":"Goldenberg","year":"2012","journal-title":"Am J Obstet Gynecol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S0140-6736(13)60993-9","article-title":"Mortality risk in preterm and small-for-gestational-age infants in low-income and middle-income countries: a pooled country analysis","volume":"382","author":"Katz","year":"2013","journal-title":"Lancet."},{"key":"B5","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1080\/00016340802005126","article-title":"Spontaneous preterm birth, a clinical dilemma: etiologic, pathophysiologic and genetic heterogeneities and racial disparity","volume":"87","author":"Menon","year":"2008","journal-title":"Acta Obstet Gynecol Scand."},{"key":"B6","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1016\/S0140-6736(05)71048-5","article-title":"4 million neonatal deaths: when? where? why?","volume":"365","author":"Lawn","year":"2005","journal-title":"Lancet."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2431-14-58","article-title":"Associations between preterm birth, small-for-gestational age, and neonatal morbidity and cognitive function among school-age children in Nepal","volume":"14","author":"Christian","year":"2014","journal-title":"BMC Pediatr."},{"key":"B8","volume-title":"The Global Action Report on Preterm Birth","author":"Soon","year":"2012"},{"key":"B9","doi-asserted-by":"publisher","first-page":"8367571","DOI":"10.1155\/2018\/8367571","article-title":"Prediction of preterm birth: maternal characteristics, ultrasound markers, and biomarkers: an updated overview","volume":"2018","author":"Oskovi Kaplan","year":"2018","journal-title":"J Pregnancy."},{"key":"B10","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1186\/s12884-018-1740-2","article-title":"Prevalence and factors associated with preterm birth at kenyatta national hospital","volume":"18","author":"Wagura","year":"2018","journal-title":"BMC Pregnancy Childbirth."},{"key":"B11","first-page":"1","year":"2016"},{"key":"B12","doi-asserted-by":"publisher","first-page":"31","DOI":"10.2471\/BLT.08.062554","article-title":"The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity","volume":"88","author":"Beck","year":"2010","journal-title":"Bull World Health Organ."},{"key":"B13","doi-asserted-by":"publisher","first-page":"e0246005","DOI":"10.1371\/journal.pone.0246005","article-title":"Determinants of preterm survival in a tertiary hospital in Ghana: a ten-year review","volume":"16","author":"Agbeno","year":"2021","journal-title":"PLoS ONE."},{"key":"B14","volume-title":"United Nations Millennium Declaration","author":"Information","year":"2000"},{"key":"B15","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.placenta.2019.01.007","article-title":"Determinants and outcomes of preterm births at a tertiary hospital in Ghana","volume":"79","author":"Adu-Bonsaffoh","year":"2019","journal-title":"Placenta."},{"key":"B16","doi-asserted-by":"publisher","first-page":"231842","DOI":"10.1155\/2010\/231842","article-title":"Neonatal outcomes of late-preterm birth associated or not with intrauterine growth restriction","volume":"2010","author":"Ortigosa Rocha","year":"2010","journal-title":"Obstet Gynecol Int."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.3889\/oamjms.2019.832","article-title":"Neonatal morbidity in late preterm infants associated with intrauterine growth restriction","volume":"7","author":"Kreko","year":"2019","journal-title":"Open Access Maced J Med Sci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1186\/s13690-020-00475-2","article-title":"Intrauterine growth restriction and its associated factors in South Gondar zone hospitals, Northwest Ethiopia, 2019","volume":"78","author":"Tesfa","year":"2020","journal-title":"Arch Public Health."},{"key":"B19","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1159\/000506688","article-title":"Prepregnancy overweight and obesity are associated with an increased risk of preterm birth in chinese women","volume":"13","author":"Su","year":"2020","journal-title":"Obes Facts."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2393-14-153","article-title":"Prepregnancy body mass index and risk of preterm birth: association heterogeneity by preterm subgroups","volume":"14","author":"Parker","year":"2014","journal-title":"BMC Pregnancy Childbirth."},{"key":"B21","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.cyto.2018.03.027","article-title":"Increase in serum Interleukin-10 does not alleviate pro-inflammatory MCP-1 production in obese pregnancies","volume":"108","author":"Polari","year":"2018","journal-title":"Cytokine."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2020.1817370","article-title":"Impact of maternal obesity on the risk of preterm delivery: insights into pathogenic mechanisms","author":"Tersigni","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.ajog.2015.02.026","article-title":"Identification of early transcriptome signatures in placenta exposed to insulin and obesity","volume":"212","author":"Lassance","year":"2015","journal-title":"Am J Obstet Gynecol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1080\/10641955.2016.1190846","article-title":"Preeclampsia and preterm delivery: a population-based case\u2013control study","volume":"35","author":"Davies","year":"2016","journal-title":"Hypertens Pregnancy."},{"key":"B25","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1159\/000049406","article-title":"Recurrence risk of preterm birth due to preeclampsia","volume":"53","author":"Koike","year":"2002","journal-title":"Gynecol Obstet Invest."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1111\/1471-0528.16225","article-title":"Maternal risk factors and adverse birth outcomes associated with HELLP syndrome: a population-based study","volume":"127","author":"Lisonkova","year":"2020","journal-title":"BJOG."},{"key":"B27","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.ajog.2021.04.261","article-title":"Incidence and risk factors for severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, and eclampsia at preterm and term gestation: a population-based study","volume":"225","author":"Lisonkova","year":"2021","journal-title":"Am J Obstet Gynecol."}],"container-title":["Frontiers in Global Women's Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgwh.2022.801092\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T06:15:36Z","timestamp":1654496136000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgwh.2022.801092\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,6]]},"references-count":27,"alternative-id":["10.3389\/fgwh.2022.801092"],"URL":"https:\/\/doi.org\/10.3389\/fgwh.2022.801092","relation":{},"ISSN":["2673-5059"],"issn-type":[{"value":"2673-5059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,6]]},"article-number":"801092"}}