{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T06:32:02Z","timestamp":1764570722963,"version":"3.46.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Glob. Women\u2019s Health"],"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Lower serum vitamin D levels are inversely correlated with the risk of uterine fibroids (UFs). The existing vitamin D deficiency cutoffs are defined based on the risk of bone loss instead of asymptomatic fibroids. This study aimed to clarify the relationship between vitamin D deficiency and first-time diagnosed asymptomatic UFs, and identify the optimal threshold for assessing the risk of newly-developed fibroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this case-control study, 171 asymptomatic UFs patients and 125 normal controls aged 34\u201345 were enrolled. A total of 64 pairs matched by age, BMI, gravity and parity were created. Logistic regression models were used to examine the correlation between vitamin D and the risk of asymptomatic UFs, and the receiver operating characteristic curve was employed to evaluate the diagnostic performance of vitamin D deficiency thresholds for the risk of asymptomatic fibroids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Both in the unmatched and matched groups, serum vitamin D levels of asymptomatic patients were lower than those of normal control individuals [(12.79\u2009\u00b1\u20095.55 vs. 16.19\u2009\u00b1\u20094.64,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001) and (11.95\u2009\u00b1\u20095.27 vs. 17.29\u2009\u00b1\u20094.99,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001)], and multivariate logistic regression revealed that vitamin D deficiency was related to an increased risk of asymptomatic UFs [(OR\u2009=\u20090.81; 95% Cl\u2009=\u20090.76\u20130.87) and (OR\u2009=\u20090.79; 95% Cl\u2009=\u20090.72\u20130.87)]. Compared to the widely-used vitamin D deficiency thresholds (12.00\u2005ng\/mL, 20.00\u2005ng\/mL and 30.00\u2005ng\/mL), the new cutoff of 14.34\u2005ng\/mL achieved the highest sensitivity and specificity to asymptomatic UFs (sensitivity 70.3%, specificity 76.6%, accuracy: 73.4%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The newly-developed vitamin D deficiency threshold pf 14.34\u2005ng\/mL generates a balanced screening efficacy in women at a higher risk of UFs, and provides a possible approach for the secondary prevention strategy of UFs.<\/jats:p>\n                  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