{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T06:04:24Z","timestamp":1780380264407,"version":"3.54.1"},"reference-count":11,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007672","name":"L\u00e9ka\u0159sk\u00e1 Fakulta v Plzni, Univerzita Karlova","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007672","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Glob. Women\u2019s Health"],"abstract":"\n Objective<\/jats:title>\n To evaluate the influence of partnership status on the perception of menopausal symptoms and quality of life in women undergoing hormone replacement therapy (HRT).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The study included 60 menopausal women aged 40\u201385 years with significant climacteric symptoms. Participants were divided into two groups according to relationship status: women living in a stable partnership (\n n<\/jats:italic>\n \u2009=\u200930) and women without a partner for at least one year (\n n<\/jats:italic>\n \u2009=\u200930). Menopausal symptoms and quality of life were assessed using the Menopause Rating Scale (MRS) and the Manchester Short Assessment of Quality of Life (MANSA). All participants received combined HRT. Assessments were performed at baseline and after three months of therapy. Changes in symptom severity (\u0394MRS) and quality of life (\u0394MANSA) were analyzed, and Pearson correlation coefficients with corresponding\n p<\/jats:italic>\n -values were used to assess relationships between variables.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n HRT was associated with improvement in menopausal symptoms and quality of life in both groups. However, women living in a partnership showed a greater reduction in MRS scores and a greater increase in MANSA scores compared to women without a partner. After three months of HRT, statistically significant correlations (\n p<\/jats:italic>\n \u2009&lt;\u20090.05) between hormonal levels (estradiol, FSH), menopausal symptoms, and quality of life were observed exclusively in partnered women.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n HRT improves menopausal symptoms and quality of life; however, partnership status appears to play a moderating role. A stable partnership may facilitate the integration of psychobiological processes of hormonal changes and contribute to improved subjective adaptation to menopause.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fgwh.2026.1775422","type":"journal-article","created":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:41:57Z","timestamp":1780378917000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Partnership as a modulator of the effects of hormone replacement therapy in menopause"],"prefix":"10.3389","volume":"7","author":[{"given":"Ludek","family":"Fiala","sequence":"first","affiliation":[{"name":"Faculty of Medicine in Pilsen, Charles University","place":["Pilsen, Czechia"]},{"name":"First Faculty of Medicine, Charles University","place":["Prague, Czechia"]},{"name":"General University Hospital in Prague","place":["Prague, Czechia"]},{"name":"University Hospital Pilsen","place":["Pilsen, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Lenz","sequence":"additional","affiliation":[{"name":"Department of Pathology, Znojmo Hospital","place":["Znojmo, Czechia"]},{"name":"University of Veterinary and Pharmaceutical Sciences Brno","place":["Brno, Czechia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.ecl.2015.05.009","article-title":"Menopause and sexuality","volume":"44","author":"Thornton","year":"2015","journal-title":"Endocrinol Metab Clin North Am"},{"key":"B2","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.mcna.2015.01.006","article-title":"Menopause","volume":"99","author":"Takahashi","year":"2015","journal-title":"Med Clin North 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analysis","volume":"23","author":"Honermann","year":"2020","journal-title":"Climacteric."},{"key":"B7","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1177\/002076409904500102","article-title":"Application and results of the Manchester short assessment of quality of life (MANSA)","volume":"45","author":"Priebe","year":"1999","journal-title":"Int J Soc Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"e26836","DOI":"10.1097\/MD.0000000000026836","article-title":"Effect of psychosocial trauma and stress on sexual dysfunction in women with endometriosis","volume":"100","author":"Fiala","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"B9","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/j.ecl.2022.04.006","article-title":"Management of menopause symptoms and quality of life during the menopause transition","volume":"51","author":"Ye","year":"2022","journal-title":"Endocrinol Metab Clin North 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Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgwh.2026.1775422\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T05:41:58Z","timestamp":1780378918000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgwh.2026.1775422\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,2]]},"references-count":11,"alternative-id":["10.3389\/fgwh.2026.1775422"],"URL":"https:\/\/doi.org\/10.3389\/fgwh.2026.1775422","relation":{},"ISSN":["2673-5059"],"issn-type":[{"value":"2673-5059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,2]]},"article-number":"1775422"}}