{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:03:06Z","timestamp":1782975786801,"version":"3.54.5"},"reference-count":23,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Glob. Women\u2019s Health"],"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The number of patients receiving long-term antiresorptive drugs for postmenopausal osteoporosis is increasing worldwide. However, there is limited evidence on when and how to discontinue or switch these drugs. This study evaluated the efficacy of romosozumab in women who had been treated with antiresorptive drugs for over three years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective observational non-randomized study analyzing patients with postmenopausal osteoporosis, which was registered in the jRCT (No. 1051210070). Postmenopausal women with lumbar and femoral neck bone mineral density (BMD) below \u22122.5 SD, as measured by dual-energy x-ray absorptiometry (DXA), despite more than 36 months of antiresorptive treatment, were recruited. They received romosozumab along with calcium and active vitamin D supplementation for 12 months. BMD and bone turnover markers, including serum P1NP and I-CTP, were periodically monitored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty-one patients (median age: 73 years) were observed for a median of 833 days. Baseline BMD was 0.77\u2005g\/cm\u00b2 at the lumbar spine (T-score: \u22122.0) and 0.49\u2005g\/cm\u00b2 at the femoral neck (T-score: \u22122.8). After 12 months, lumbar BMD significantly increased by 6.2% (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001), whereas femoral neck BMD remained unchanged (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.46). P1NP and I-CTP levels significantly increased by 455.8% and 30.3%, respectively (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&amp;lt;\u20090.001). One patient developed periodontitis and a vertebral fracture. Multiple regression analysis identified baseline BMD and P1NP values as significant predictors of lumbar BMD changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Romosozumab significantly increased lumbar BMD and bone turnover markers in patients previously treated with antiresorptive drugs, supporting its use as a potential treatment option.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link>https:\/\/jrct.mhlw.go.jp\/<\/jats:ext-link>\n                      , identifier No. 1051210070.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fgwh.2026.1779730","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:34:38Z","timestamp":1782970478000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Article title efficacy and safety of romosozumab in postmenopausal women with osteoporosis previously treated with antiresorptive drugs: a prospective observational study and literature review"],"prefix":"10.3389","volume":"7","author":[{"given":"Misa","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Osaka","place":["Suita, Osaka, Japan"]},{"name":"Department of Obstetrics and Gynecology, Kansai Rosai Hospital","place":["Amagasaki, Hyogo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Ikenaga","sequence":"additional","affiliation":[{"name":"Department of 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Obstetrics and Gynecology, Graduate School of Medicine, The University of Osaka","place":["Suita, Osaka, Japan"]},{"name":"Department of Obstetrics and Gynecology, Aizenbashi Hospital","place":["Osaka, Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Airi","family":"Kuruma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Osaka","place":["Suita, Osaka, Japan"]},{"name":"Department of Obstetrics and Gynecology, Rinku General Medical Center","place":["Izumisano, Osaka, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Bun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Osaka","place":["Suita, Osaka, Japan"]},{"name":"Department of Obstetrics and Gynecology, Suita Municipal Hospital","place":["Suita, Osaka, 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