{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:14:06Z","timestamp":1792588446159,"version":"4.5.0"},"reference-count":76,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T00:00:00Z","timestamp":1781136000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Glob. Women\u2019s Health"],"abstract":"<jats:p>Preeclampsia (PE) is a pregnancy-specific multisystem disorder and a leading cause of maternal and perinatal morbidity and mortality worldwide. Despite the widely accepted two-stage model involving placental dysfunction and maternal systemic inflammation, the precise cellular and molecular mechanisms underlying its pathogenesis remain incompletely understood. In recent years, single-cell RNA sequencing (scRNA-seq) has emerged as a transformative technology capable of resolving transcriptional heterogeneity at unprecedented resolution, offering new insights into the complex cellular landscape of the maternal-fetal interface. This review systematically summarizes the application of scRNA-seq in advancing the understanding of PE pathogenesis. We first introduce the technical principles and advantages of scRNA-seq over bulk sequencing methods. Subsequently, we highlight key findings from scRNA-seq studies of the normal placenta and decidua, establishing a reference for cellular composition and trophoblast differentiation trajectories. We then focus on studies of PE placentas, which have revealed distinct dysfunction in trophoblast subpopulations\u2014including impaired differentiation, invasion, and accelerated senescence\u2014and have identified novel regulatory molecules such as BHLHE40, NDRG1, and DAB2. Additionally, we discuss scRNA-seq-derived insights into immune dysregulation at the maternal-fetal interface, including altered NK cell subsets, macrophage polarization, and disruption of immune tolerance mediated by molecules such as HLA-F and JUNB. Finally, we explore the translational potential of scRNA-seq in identifying novel biomarkers, constructing predictive models, and enabling disease subtyping for precision medicine. By capturing cell-specific transcriptional changes, scRNA-seq provides a powerful framework for deciphering the complexity of PE and holds promise for improving its prediction, diagnosis, and therapy.<\/jats:p>","DOI":"10.3389\/fgwh.2026.1834711","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:04:51Z","timestamp":1781179491000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Application of single-cell RNA sequencing in preeclampsia"],"prefix":"10.3389","volume":"7","author":[{"given":"Xiaojing","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Affiliated Wenling Maternal and Child Health Care Hospital","place":["Wenling City, Zhejiang Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Affiliated Wenling Maternal and Child Health Care Hospital","place":["Wenling City, Zhejiang Province, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/BF00221122","article-title":"The villous stroma of the human placenta. I. The ultrastructure of fixed connective tissue cells","volume":"177","author":"Kaufmann","year":"1977","journal-title":"Cell Tissue Res"},{"key":"B2","first-page":"1811","article-title":"The fine structure of the human placental villus as revealed by scanning electron microscopy","volume":"1","author":"Burton","year":"1987","journal-title":"Scanning Microsc"},{"key":"B3","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1093\/humupd\/6.5.485","article-title":"Villous sprouting: fundamental mechanisms of human placental development","volume":"6","author":"Castellucci","year":"2000","journal-title":"Hum Reprod Update"},{"key":"B4","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0303-7207(01)00687-6","article-title":"Regulation of trophoblast invasion: from normal implantation to pre-eclampsia","volume":"187","author":"Goldman-Wohl","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.ajog.2010.08.009","article-title":"The \u201cgreat obstetrical syndromes\u201d are associated with disorders of deep placentation","volume":"204","author":"Brosens","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/j.1471-0528.2006.00882.x","article-title":"Maternal medicine: morphometric placental villous and vascular abnormalities in early- and late-onset pre-eclampsia with and without fetal growth restriction","volume":"113","author":"Egbor","year":"2006","journal-title":"BJOG"},{"key":"B7","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1161\/HYPERTENSIONAHA.115.06357","article-title":"Pregnancy and long-term maternal cardiovascular health: progress through harmonization of research cohorts and biobanks","volume":"67","author":"Staff","year":"2016","journal-title":"Hypertension"},{"key":"B8","doi-asserted-by":"publisher","first-page":"S963","DOI":"10.1016\/j.ajog.2020.10.023","article-title":"An integrated model of preeclampsia: a multifaceted syndrome of the maternal cardiovascular-placental-fetal array","volume":"226","author":"Yagel","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"bbab024","DOI":"10.1093\/bib\/bbab024","article-title":"Advances in bulk and single-cell multi-omics approaches for systems biology and precision medicine","volume":"22","author":"Li","year":"2021","journal-title":"Brief Bioinform"},{"key":"B10","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1080\/17501911.2024.2343276","article-title":"A review of single-cell transcriptomics and epigenomics studies in maternal and child health","volume":"16","author":"Shu","year":"2024","journal-title":"Epigenomics"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1038\/s12276-020-00499-2","article-title":"Single-cell sequencing techniques from individual to multiomics analyses","volume":"52","author":"Kashima","year":"2020","journal-title":"Exp Mol Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1007\/s10142-024-01432-w","article-title":"Application of single cell sequencing technology in ovarian cancer research (review)","volume":"24","author":"Yuan","year":"2024","journal-title":"Funct Integr Genomics"},{"key":"B13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s13073-017-0467-4","article-title":"A practical guide to single-cell RNA-Sequencing for biomedical research and clinical applications","volume":"9","author":"Haque","year":"2017","journal-title":"Genome Med"},{"key":"B14","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41581-018-0021-7","article-title":"Single-cell RNA sequencing for the study of development, physiology and disease","volume":"14","author":"Potter","year":"2018","journal-title":"Nat Rev Nephrol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e694","DOI":"10.1002\/ctm2.694","article-title":"Single-cell RNA sequencing technologies and applications: a brief overview","volume":"12","author":"Jovic","year":"2022","journal-title":"Clin Transl Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"106201","DOI":"10.1016\/j.nbd.2023.106201","article-title":"An overview of human single-cell RNA sequencing studies in neurobiological disease","volume":"184","author":"Walter","year":"2023","journal-title":"Neurobiol Dis"},{"key":"B17","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/nmeth.1315","article-title":"mRNA-Seq whole-transcriptome analysis of a single cell","volume":"6","author":"Tang","year":"2009","journal-title":"Nat Methods"},{"key":"B18","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nmeth.3629","article-title":"Fixed single-cell transcriptomic characterization of human radial glial diversity","volume":"13","author":"Thomsen","year":"2016","journal-title":"Nat Methods"},{"key":"B19","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature24489","article-title":"A single-cell survey of the small intestinal epithelium","volume":"551","author":"Haber","year":"2017","journal-title":"Nature"},{"key":"B20","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1186\/s13059-020-02048-6","article-title":"Systematic assessment of tissue dissociation and storage biases in single-cell and single-nucleus RNA-seq workflows","volume":"21","author":"Denisenko","year":"2020","journal-title":"Genome Biol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.tig.2015.01.001","article-title":"Alternative mRNA transcription, processing, and translation: insights from RNA sequencing","volume":"31","author":"De Klerk","year":"2015","journal-title":"Trends Genet"},{"key":"B22","doi-asserted-by":"publisher","first-page":"17807","DOI":"10.1073\/pnas.0608512103","article-title":"Transcription factor profiling in individual hematopoietic progenitors by digital RT-PCR","volume":"103","author":"Warren","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B23","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1111\/rda.12737","article-title":"Transcriptome analyses of inner cell mass and trophectoderm cells isolated by magnetic-activated cell sorting from bovine blastocysts using single cell RNA-seq","volume":"51","author":"Zhao","year":"2016","journal-title":"Reprod Domest Anim"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/j.cell.2018.02.001","article-title":"Mapping the mouse cell atlas by microwell-seq","volume":"172","author":"Han","year":"2018","journal-title":"Cell"},{"key":"B25","doi-asserted-by":"publisher","first-page":"807","DOI":"10.3390\/ijms19030807","article-title":"Platforms for single-cell collection and analysis","volume":"19","author":"Valihrach","year":"2018","journal-title":"Int J Mol Sci"},{"key":"B26","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/nbt.2282","article-title":"Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells","volume":"30","author":"Ramsk\u00f6ld","year":"2012","journal-title":"Nat Biotechnol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"R31","DOI":"10.1186\/gb-2013-14-4-r31","article-title":"Quartz-Seq: a highly reproducible and sensitive single-cell RNA sequencing method, reveals non-genetic gene-expression heterogeneity","volume":"14","author":"Sasagawa","year":"2013","journal-title":"Genome Biol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/nbt.2325","article-title":"Transcriptome sequencing of single cells with smart-seq","volume":"30","author":"Goetz","year":"2012","journal-title":"Nat Biotechnol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"9026","DOI":"10.1073\/pnas.1017621108","article-title":"Counting individual DNA molecules by the stochastic attachment of diverse labels","volume":"108","author":"Fu","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1161\/CIRCRESAHA.118.313276","article-title":"Preeclampsia: pathophysiology, challenges, and perspectives","volume":"124","author":"Rana","year":"2019","journal-title":"Circ Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1016\/j.cell.2019.01.031","article-title":"Single-Cell RNA-Seq reveals AML hierarchies relevant to disease progression and immunity","volume":"176","author":"Van Galen","year":"2019","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.tibtech.2020.05.006","article-title":"Uncovering an organ\u2019s molecular architecture at single-cell resolution by spatially resolved transcriptomics","volume":"39","author":"Liao","year":"2021","journal-title":"Trends Biotechnol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1126\/science.abb9536","article-title":"Embryo-scale, single-cell spatial transcriptomics","volume":"373","author":"Srivatsan","year":"2021","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1038\/s41467-021-22801-0","article-title":"Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer","volume":"12","author":"Wu","year":"2021","journal-title":"Nat Commun"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1264774","DOI":"10.3389\/fimmu.2023.1264774","article-title":"Novel tumor-associated macrophage populations and subpopulations by single cell RNA sequencing","volume":"14","author":"Wang","year":"2023","journal-title":"Front Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"R155","DOI":"10.1530\/REP-20-0231","article-title":"Single cell transcriptome research in human placenta","volume":"160","author":"Li","year":"2020","journal-title":"Reproduction"},{"key":"B37","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/j.placenta.2013.01.002","article-title":"Hubrecht and the naming of the trophoblast","volume":"34","author":"Pijnenborg","year":"2013","journal-title":"Placenta"},{"key":"B38","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1093\/humupd\/dmae006","article-title":"Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies","volume":"30","author":"Derisoud","year":"2024","journal-title":"Hum Reprod Update"},{"key":"B39","doi-asserted-by":"publisher","first-page":"E7786","DOI":"10.1073\/pnas.1710470114","article-title":"Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics","volume":"114","author":"Tsang","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B40","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1038\/s41422-018-0066-y","article-title":"Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta","volume":"28","author":"Liu","year":"2018","journal-title":"Cell Res"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.3389\/fimmu.2019.02317","article-title":"Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface","volume":"10","author":"Yang","year":"2019","journal-title":"Front Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.4161\/epi.21937","article-title":"Paternal uniparental disomy 14 and related disorders: placental gene expression analyses and histological examinations","volume":"7","author":"Kagami","year":"2012","journal-title":"Epigenetics"},{"key":"B43","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/s41586-018-0698-6","article-title":"Single-cell reconstruction of the early maternal-fetal interface in humans","volume":"563","author":"Vento-Tormo","year":"2018","journal-title":"Nature"},{"key":"B44","doi-asserted-by":"publisher","first-page":"eaau4788","DOI":"10.1126\/sciadv.aau4788","article-title":"A single-cell survey of the human first-trimester placenta and decidua","volume":"4","author":"Suryawanshi","year":"2018","journal-title":"Sci Adv"},{"key":"B45","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1101\/gr.207597.116","article-title":"Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface","volume":"27","author":"Pavli\u010dev","year":"2017","journal-title":"Genome Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.molimm.2023.07.005","article-title":"Dissecting human placental cells heterogeneity in preeclampsia and gestational diabetes using single-cell sequencing","volume":"161","author":"Jiao","year":"2023","journal-title":"Mol Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"e1730","DOI":"10.1002\/mgg3.1730","article-title":"Dissecting human trophoblast cell transcriptional heterogeneity in preeclampsia using single-cell RNA sequencing","volume":"9","author":"Zhang","year":"2021","journal-title":"Mol Genet Genomic Med"},{"key":"B48","doi-asserted-by":"publisher","first-page":"317","DOI":"10.14348\/molcells.2021.0211","article-title":"Trophoblast cell subtypes and dysfunction in the placenta of individuals with preeclampsia revealed by single-cell RNA sequencing","volume":"45","author":"Zhou","year":"2022","journal-title":"Mol Cells"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1142273","DOI":"10.3389\/fimmu.2023.1142273","article-title":"Single-cell RNA-seq reveals developmental deficiencies in both the placentation and the decidualization in women with late-onset preeclampsia","volume":"14","author":"Yang","year":"2023","journal-title":"Front Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.placenta.2025.06.009","article-title":"Single cell RNA-sequencing reveals BHLHE40 and NDRG1 as key regulatory molecules modulating the trophoblastic senescence in preeclampsia","volume":"168","author":"Zhang","year":"2025","journal-title":"Placenta"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e70101","DOI":"10.1111\/aji.70101","article-title":"Maternal-Fetal interface cell dysfunction in patients with preeclampsia revealed via single-cell RNA sequencing","volume":"94","author":"Xiao","year":"2025","journal-title":"Am J Reprod Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"112033","DOI":"10.1016\/j.cellsig.2025.112033","article-title":"G protein-coupled estrogen receptor promotes human extravillous trophoblast invasion via YAP-snail-mediated CYR61 expression","volume":"135","author":"Wang","year":"2025","journal-title":"Cell Signal"},{"key":"B53","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s00018-024-05212-4","article-title":"Identification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia","volume":"81","author":"Liu","year":"2024","journal-title":"Cell Mol Life Sci"},{"key":"B54","doi-asserted-by":"publisher","first-page":"17448","DOI":"10.1038\/s41598-025-02490-1","article-title":"HSD17B1-mediated Trophoblast differentiation lowers estrogen levels in early-onset preeclampsia","volume":"15","author":"Zheng","year":"2025","journal-title":"Sci Rep"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1959","DOI":"10.1161\/HYPERTENSIONAHA.124.24416","article-title":"c-Fos mediates preeclampsia through p-AMPK\/detyrosinated tubulin pathway","volume":"82","author":"Huang","year":"2025","journal-title":"Hypertension"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1824","DOI":"10.1161\/CIRCULATIONAHA.117.028110","article-title":"Disturbed placental imprinting in preeclampsia leads to altered expression of DLX5, a human-specific early trophoblast marker","volume":"136","author":"Zadora","year":"2017","journal-title":"Circulation"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/08830185.2022.2144291","article-title":"Immune cell profiling of preeclamptic pregnant and postpartum women by single-cell RNA sequencing","volume":"43","author":"Hu","year":"2024","journal-title":"Int Rev Immunol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"880438","DOI":"10.3389\/fimmu.2022.880438","article-title":"Dynamic changes in uterine NK cell subset frequency and function over the menstrual cycle and pregnancy","volume":"13","author":"Whettlock","year":"2022","journal-title":"Front Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.stem.2023.12.013","article-title":"Human uterine natural killer cells regulate differentiation of extravillous trophoblast early in pregnancy","volume":"31","author":"Li","year":"2024","journal-title":"Cell Stem Cell"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/s41423-018-0008-0","article-title":"Three macrophage subsets are identified in the uterus during early human pregnancy","volume":"15","author":"Jiang","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"167194","DOI":"10.1016\/j.bbadis.2024.167194","article-title":"Targeting JUNB to modulate M2 macrophage polarization in preeclampsia","volume":"1870","author":"Jiang","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1234577","DOI":"10.3389\/fimmu.2023.1234577","article-title":"Single-cell profiling reveals immune disturbances landscape and HLA-F-mediated immune tolerance at the maternal-fetal interface in preeclampsia","volume":"14","author":"Luo","year":"2023","journal-title":"Front Immunol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"4986","DOI":"10.1038\/s41598-025-89140-8","article-title":"Identification of metabolism-related subtypes and feature genes of pre-eclampsia","volume":"15","author":"Xiong","year":"2025","journal-title":"Sci Rep"},{"key":"B64","doi-asserted-by":"publisher","first-page":"12945","DOI":"10.1038\/s41598-025-96823-9","article-title":"Cystatin 6 (CST6) and legumain (LGMN) are potential mediators in the pathogenesis of preeclampsia","volume":"15","author":"Botha","year":"2025","journal-title":"Sci Rep"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1161\/HYPERTENSIONAHA.124.22923","article-title":"Overexpressed trophoblast glycoprotein contributes to preeclampsia development by inducing abnormal trophoblast migration and invasion toward the uterine spiral artery","volume":"81","author":"Sun","year":"2024","journal-title":"Hypertension"},{"key":"B66","doi-asserted-by":"publisher","first-page":"e12968","DOI":"10.1111\/cpr.12968","article-title":"Systemic transcriptome comparison between early- and late-onset pre-eclampsia shows distinct pathology and novel biomarkers","volume":"54","author":"Guo","year":"2021","journal-title":"Cell Prolif"},{"key":"B67","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s42003-023-04623-6","article-title":"Placental cell type deconvolution reveals that cell proportions drive preeclampsia gene expression differences","volume":"6","author":"Campbell","year":"2023","journal-title":"Commun Biol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e52004","DOI":"10.7554\/eLife.52004","article-title":"Single cell transcriptional signatures of the human placenta in term and preterm parturition","volume":"8","author":"Pique-Regi","year":"2019","journal-title":"Elife"},{"key":"B69","doi-asserted-by":"publisher","first-page":"10892","DOI":"10.1038\/s41598-022-14516-z","article-title":"Single-cell transcriptional profiling reveals cellular and molecular divergence in human maternal-fetal interface","volume":"12","author":"Wang","year":"2022","journal-title":"Sci Rep"},{"key":"B70","doi-asserted-by":"publisher","first-page":"eadh8335","DOI":"10.1126\/scitranslmed.adh8335","article-title":"Deciphering maternal-fetal cross-talk in the human placenta during parturition using single-cell RNA sequencing","volume":"16","author":"Garcia-Flores","year":"2024","journal-title":"Sci Transl Med"},{"key":"B71","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.cell.2020.03.048","article-title":"Single-Cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer","volume":"181","author":"Zhang","year":"2020","journal-title":"Cell"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1497","DOI":"10.1007\/s12033-023-00777-0","article-title":"Single-Cell RNA sequencing: technological progress and biomedical application in cancer research","volume":"66","author":"Chang","year":"2024","journal-title":"Mol Biotechnol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"e58716","DOI":"10.7554\/eLife.58716","article-title":"Does the human placenta express the canonical cell entry mediators for SARS-CoV-2","volume":"9","author":"Pique-Regi","year":"2020","journal-title":"Elife"},{"key":"B74","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1038\/s41586-023-05869-0","article-title":"Spatial multiomics map of trophoblast development in early pregnancy","volume":"616","author":"Arutyunyan","year":"2023","journal-title":"Nature"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1038\/s41556-023-01169-x","article-title":"Single-cell analysis reveals transcriptomic and epigenomic impacts on the maternal-fetal interface following SARS-CoV-2 infection","volume":"25","author":"Gao","year":"2023","journal-title":"Nat Cell Biol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/s41588-023-01647-w","article-title":"Single-nucleus multi-omic profiling of human placental syncytiotrophoblasts identifies cellular trajectories during pregnancy","volume":"56","author":"Wang","year":"2024","journal-title":"Nat Genet"}],"container-title":["Frontiers in Global Women's Health"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgwh.2026.1834711\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T12:04:58Z","timestamp":1781179498000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fgwh.2026.1834711\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,11]]},"references-count":76,"alternative-id":["10.3389\/fgwh.2026.1834711"],"URL":"https:\/\/doi.org\/10.3389\/fgwh.2026.1834711","relation":{},"ISSN":["2673-5059"],"issn-type":[{"value":"2673-5059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,11]]},"article-number":"1834711"}}