{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T07:02:16Z","timestamp":1780038136845,"version":"3.53.1"},"reference-count":15,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Glob. Women\u2019s Health"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Ectopic pregnancy, particularly tubal pregnancy, is a potentially life-threatening condition that often requires prompt intervention. Although methotrexate (MTX) is commonly used for conservative management, cases with high serum beta-human chorionic gonadotropin (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -hCG) levels and visible gestational sac are typically considered beyond the scope of medical therapy and often necessitate surgery. This report describes a patient with a tubal ectopic pregnancy presenting with high serum\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -hCG levels (7,785.00 IU\/L) and a visible gestational sac who was successfully treated with pure Chinese herbal medicine after refusing both surgery and MTX.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      A 31-year-old female patient presented with a left fallopian tube ampullary ectopic pregnancy. Her serum\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -hCG peak reached 7,785.00 IU\/L, and a complete gestational sac was visible on ultrasound, exceeding conventional guidelines for medical conservative management. After the patient explicitly refused surgery and methotrexate therapy, a pure Chinese herbal compound treatment was administered, employing the principles of warming yang, invigorating qi, resolving stasis, and eliminating masses. Following treatment, the patient's serum\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -hCG level rapidly decreased by 32% within 48\u2005h and dropped to 55.07 IU\/L by day 14. During treatment, endometrial tissue was expelled. Post-treatment, the ectopic pregnancy mass was completely absorbed, menstruation resumed on schedule, and the associated ovarian cyst resolved.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This case demonstrates the feasibility of pure Chinese herbal medicine for treating ectopic pregnancies with high serum\n                      <jats:italic>\u03b2<\/jats:italic>\n                      -hCG levels and a visible gestational sac \u2014 features that would conventionally be considered unsuitable for medical conservative management. It also highlights the potential advantages of traditional Chinese medicine in holistically regulating the pelvic environment and promoting tissue resorption.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fgwh.2026.1846529","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T06:09:20Z","timestamp":1780034960000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Successful treatment of an ectopic pregnancy with elevated serum \u03b2-hCG levels (7,989.00 IU\/L) using pure traditional Chinese medicine: a case report"],"prefix":"10.3389","volume":"7","author":[{"given":"Jianjun","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Traditional Chinese Medicine, Guangdong Provincial People's Hospital, Zhuhai Hospital (Jinwan Central Hospital of Zhuhai)","place":["Zhuhai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Internal Chinese Medicine, Shenzhen Sihui Zhiyun Traditional Chinese Medicine Clinic","place":["Shenzhen, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2447997","DOI":"10.1080\/01443615.2024.2447997","article-title":"Predictors of treatment failure of tubal pregnancy with single-dose methotrexate regimen - a systematic review and meta-analysis","volume":"45","author":"Tang","year":"2025","journal-title":"J Obstet Gynaecol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1186\/s12884-024-07122-6","article-title":"Risk factors for methotrexate treatment failure in tubal ectopic pregnancy: a retrospective cohort study","volume":"24","author":"Fu","year":"2024","journal-title":"BMC Pregnancy Childbirth"},{"key":"B3","doi-asserted-by":"publisher","first-page":"17455057231160349","DOI":"10.1177\/17455057231160349","article-title":"Overview of ectopic pregnancy diagnosis, management, and innovation","volume":"9","author":"Mullany","year":"2023","journal-title":"Womens Health (Lond)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"112","DOI":"10.16254\/j.cnki.53-1120\/r.2016.09.052","article-title":"Exploring conservative treatment approaches for ectopic pregnancy in traditional Chinese medicine","volume":"37","author":"Guan","year":"2016","journal-title":"Yunnan J Tradit Chin Med Chin Herb Med"},{"key":"B5","volume-title":"Essential Readings in Medicine. 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