{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:03:10Z","timestamp":1787504590895,"version":"build-2736575974"},"reference-count":77,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2014.00152","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T05:13:36Z","timestamp":1396847616000},"source":"Crossref","is-referenced-by-count":55,"title":["Recombinant BCG: innovations on an old vaccine. Scope of BCG strains and strategies to improve long-lasting memory"],"prefix":"10.3389","volume":"5","author":[{"given":"Adeliane Castro","family":"da Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah Veloso","family":"Nogueira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Kipnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Paula","family":"Junqueira-Kipnis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014]]},"reference":[{"issue":"29","key":"B1","doi-asserted-by":"publisher","first-page":"3753","DOI":"10.1016\/j.vaccine.2005.03.001","article-title":"New live mycobacterial vaccines: the Geneva consensus on essential steps towards clinical development","volume":"23","author":"Kamath","year":"2005","journal-title":"Vaccine"},{"key":"B2","volume-title":"Global Tuberculosis Control\u00e2\u20ac\u201cEpidemiology, Strategy, Financing","year":"2009"},{"key":"B3","volume-title":"Global Tuberculosis Control","year":"1998"},{"key":"B4","volume-title":"The Global Plan to Stop TB 2011\u00e2\u20ac\u201c2015: Transforming the Fight-Towards Elimination of Tuberculosis","author":"Partnership","year":"2010"},{"key":"B5","doi-asserted-by":"publisher","first-page":"2086","DOI":"10.1001\/jama.291.17.2086","article-title":"Long-term efficacy of BCG vaccine in American Indians and Alaska Natives: a 60-year follow-up study","volume":"5","author":"Aronson","year":"2004","journal-title":"JAMA"},{"key":"B6","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1093\/cid\/cit790","article-title":"Protection by BCG vaccine against tuberculosis: a systemic review of randomized controlled trials","volume":"58","author":"Mangtani","year":"2014","journal-title":"Clin Infect Dis"},{"key":"B7","first-page":"819","article-title":"Tuberculosis prevention trials: Madras (1979). Trial of BCG vaccines in South India for tuberculosis prevention","volume":"57","year":"1979","journal-title":"Bull World Health Organ"},{"key":"B8","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1001\/jama.1994.03510330076038","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis: meta-analysis of the published literature","volume":"271","author":"Colditz","year":"1994","journal-title":"JAMA"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/S0140-6736(06)68507-3","article-title":"Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness","volume":"367","author":"Trunz","year":"2006","journal-title":"Lancet"},{"key":"B10","first-page":"89","article-title":"Premunition des nouveaux-nescontre la tuberculoseparlevaccin BCG, 1921\u00e2\u20ac\u201c1926","volume":"40","author":"Calmette","year":"1926","journal-title":"Ann Inst Pasteur (Paris)"},{"key":"B11","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S1438-4221(00)80083-1","article-title":"Comparative genomics of the mycobacteria","volume":"290","author":"Brosch","year":"2000","journal-title":"Int J Med Microbiol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"83","DOI":"10.7774\/cevr.2013.2.2.83","article-title":"BCG vaccine in Korea","volume":"2","author":"Joung","year":"2014","journal-title":"Clin Exp Vaccine Res"},{"key":"B13","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/31159","article-title":"Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence","volume":"393","author":"Cole","year":"1998","journal-title":"Nature"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1126\/science.284.5419.1520","article-title":"Comparative genomics of BCG vaccines by whole-genome DNA microarray","volume":"284","author":"Behr","year":"1999","journal-title":"Science"},{"key":"B15","doi-asserted-by":"publisher","first-page":"4969","DOI":"10.1016\/j.vaccine.2006.03.055","article-title":"Identification of two subpopulations of Bacillus Calmette-Gu\u00c3\u00a9rin (BCG) Tokyo172 substrain with different RD16 regions","volume":"24","author":"Honda","year":"2006","journal-title":"Vaccine"},{"key":"B16","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1186\/1471-2164-9-413","article-title":"Novel genome polymorphisms in BCG vaccine strains and impact on efficacy","volume":"9","author":"Leung","year":"2008","journal-title":"BMC Genomics"},{"key":"B17","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1128\/CVI.00368-09","article-title":"Phenotypic definition of effector and memory T-lymphocyte subsets in mice chronically infected with Mycobacterium tuberculosis","volume":"17","author":"Henao-Tamayo","year":"2010","journal-title":"Clin Vaccine Immunol"},{"issue":"1","key":"B18","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1128\/IAI.72.1.570-575.2004","article-title":"Stable T-cell population expressing an effector cell surface phenotype in the lungs of mice chronically infected with Mycobacterium tuberculosis","volume":"72","author":"Junqueira-Kipnis","year":"2004","journal-title":"Infect Immun"},{"key":"B19","doi-asserted-by":"publisher","first-page":"7759","DOI":"10.1128\/IAI.73.11.7759-7764.2005","article-title":"Memory T lymphocytes generated by Mycobacterium bovis BCG vaccination reside within a CD4 CD44lo CD62 ligand (hi) population","volume":"73","author":"Kipnis","year":"2005","journal-title":"Infect Immun"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1084\/jem.178.6.2243","article-title":"Disseminated tuberculosis in interferon gamma gene-disrupted mice","volume":"178","author":"Cooper","year":"1993","journal-title":"J Exp Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1084\/jem.178.6.2249","article-title":"An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection","volume":"178","author":"Flynn","year":"1993","journal-title":"J Exp Med"},{"key":"B22","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1016\/j.tim.2012.06.002","article-title":"New pathways of protective and pathological host defense to mycobacteria","volume":"20","author":"Ottenhoff","year":"2012","journal-title":"Trends Microbiol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1093\/infdis\/jir592","article-title":"Recombinant BCG \u00ce\u201dureC hly+ induces superior protection over parental bcg by stimulating a balanced combination of type 1 and type 17 cytokine responses","volume":"204","author":"Desel","year":"2011","journal-title":"J Infect Dis"},{"issue":"7","key":"B24","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1093\/infdis\/jis941","article-title":"Longitudinal changes in CD4(+) T-cell memory responses induced by BCG vaccination of newborns","volume":"207","author":"Soares","year":"2013","journal-title":"J Infect Dis"},{"key":"B25","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1128\/IAI.00480-13","article-title":"Differentiation of antigen-specific T cells with limited functional capacity during Mycobacterium tuberculosis infection","volume":"82","author":"Jeong","year":"2014","journal-title":"Infect Immun"},{"key":"B26","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/38148","article-title":"Has BCG attenuated to impotence?","volume":"389","author":"Behr","year":"1997","journal-title":"Nature"},{"issue":"8","key":"B27","doi-asserted-by":"publisher","first-page":"e71243","DOI":"10.1371\/journal.pone.0071243","article-title":"Genome sequencing and analysis of BCG vaccine strains","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1128\/IAI.74.3.1718-1724.2006","article-title":"Mycobacterium tuberculosis infection in a BALB\/c model of progressive pulmonary tuberculosis","volume":"74","author":"Castillo-Rodal","year":"2006","journal-title":"Infect Immun"},{"key":"B29","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1086\/499825","article-title":"The effect of bacilli Calmette-Gu\u00c3\u00a9rin vaccine strain and rout of administration on induced immune responses in vaccinated infants","volume":"193","author":"Davids","year":"2006","journal-title":"J Infect Dis"},{"key":"B30","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1006\/bbrc.1998.8724","article-title":"Expression systems for study of mycobacterial gene regulation and development of recombinant BCG vaccines","volume":"246","author":"DasGupta","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"B31","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1111\/j.1600-0463.2011.02815.x","article-title":"Recombinant BCG coexpressing Ag85B, CFP10, and interleukin-12 induces multifunctional Th1 and memory T cells in mice","volume":"120","author":"Lin","year":"2011","journal-title":"APMIS"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1086\/586902","article-title":"Efficacy of recombinant bacille Calmette-Gu\u00c3\u00a9rin vaccine secreting interleukin-15\/antigen 85B fusion protein in providing protection against Mycobacterium tuberculosis","volume":"197","author":"Tang","year":"2008","journal-title":"J Infect Dis"},{"key":"B33","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.tube.2008.09.008","article-title":"Protective efficacy of recombinant BCG Tokyo (Ag85A) in rhesus monkeys (Macaca mulatta) infected intratracheally with H37Rv Mycobacterium tuberculosis","volume":"89","author":"Sugawara","year":"2009","journal-title":"Tuberculosis"},{"key":"B34","doi-asserted-by":"publisher","first-page":"5202","DOI":"10.1128\/IAI.00267-10","article-title":"Surface expression of MPT64 as a fusion with the PE domain of PE_PGRS33 enhances Mycobacterium bovis BCG protective activity against Mycobacterium tuberculosis in mice","volume":"78","author":"Sali","year":"2010","journal-title":"Infect Immun"},{"key":"B35","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1189\/jlb.0608363","article-title":"IL-15 protects antigen-specific CD8 T cell contraction after Mycobacterium bovis bacillus Calmette-Gu\u00c3\u00a9rin infection","volume":"86","author":"Tang","year":"2009","journal-title":"J Leukoc Biol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"e32769","DOI":"10.1371\/journal.pone.0032769","article-title":"Priming with a recombinant pantothenate auxotroph of Mycobacterium bovis BCG and boosting with MVA elicits HIV-1 Gag specific CD8+ T cells","volume":"7","author":"Chapman","year":"2012","journal-title":"PLoS One"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/j.vaccine.2011.12.059","article-title":"Epitope based recombinant BCG vaccine elicits specific TH1 polarized immune responses in BALB\/c mice","volume":"30","author":"Christy","year":"2012","journal-title":"Vaccine"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1016\/j.vaccine.2010.12.070","article-title":"Targeted induction of antigen expression within dendritic cells modulates antigen-specific immunity afforded by recombinant BCG","volume":"29","author":"Kong","year":"2011","journal-title":"Vaccine"},{"key":"B39","doi-asserted-by":"publisher","first-page":"5237","DOI":"10.1016\/j.vaccine.2010.05.063","article-title":"Enhanced protection against tuberculosis by vaccination with recombinant BCG over-expressing HspX protein","volume":"28","author":"Shi","year":"2010","journal-title":"Vaccine"},{"key":"B40","doi-asserted-by":"publisher","first-page":"647","DOI":"10.2119\/molmed.2011.00222","article-title":"Prime-boost vaccination with rBCG\/rAd35 enhances CD8+ cytolytic T-cell responses in lesions from Mycobacterium tuberculosis \u00e2\u20ac\u201c infected primates","volume":"18","author":"Rahman","year":"2012","journal-title":"Mol Med"},{"issue":"8","key":"B41","doi-asserted-by":"publisher","first-page":"e23360","DOI":"10.1371\/journal.pone.0023360","article-title":"A booster vaccine expressing a latency-associated antigen augments BCG induced immunity and confers enhanced protection against tuberculosis","volume":"6","author":"Dey","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"B42","doi-asserted-by":"publisher","first-page":"e18773","DOI":"10.1371\/journal.pone.0018773","article-title":"Latency antigen \u00ce\u00b1-crystallin based vaccination imparts a robust protection against TB by modulating the dynamics of pulmonary cytokines","volume":"6","author":"Dey","year":"2011","journal-title":"PLoS One"},{"key":"B43","doi-asserted-by":"publisher","first-page":"4412","DOI":"10.1016\/j.vaccine.2009.05.048","article-title":"Novel recombinant BCG expressing perfringolysin O and the over expression of key immunodominant antigens; pre-clinical characterization, safety and protection against challenge with Mycobacterium tuberculosis","volume":"27","author":"Sun","year":"2009","journal-title":"Vaccine"},{"issue":"12","key":"B44","doi-asserted-by":"publisher","first-page":"e3869","DOI":"10.1371\/journal.pone.0003869","article-title":"Enhanced and enduring protection against tuberculosis by recombinant BCG-Ag85C and its association with modulation of cytokine profile in lung","volume":"3","author":"Jain","year":"2008","journal-title":"PLoS One"},{"key":"B45","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1111\/j.1365-3083.2009.02231.x","article-title":"More vaccine efficacy studies on the recombinant bacille Calmette-Gu\u00c3\u00a9rin co-expressing Ag85B, Mpt64 190\u00e2\u20ac\u201c198 and Mtb8.4","volume":"69","author":"Qie","year":"2009","journal-title":"Scand J Immunol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.vaccine.2009.09.121","article-title":"Boosting with a DNA vaccine expressing ESAT-6 (DNAE6) obliterates the protection imparted by recombinant BCG (rBCGE6) against aerosol Mycobacterium tuberculosis infection in guinea pigs","volume":"28","author":"Dey","year":"2009","journal-title":"Vaccine"},{"key":"B47","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/j.1365-3083.2012.02726.x","article-title":"Novel recombinant BCG coexpressing Ag85B, ESAT-6 andRv2608 elicits significantly enhanced cellular immune and antibody responses in C57BL \/6 Mice","volume":"76","author":"Lu","year":"2012","journal-title":"Scand J Immunol"},{"issue":"11","key":"B48","doi-asserted-by":"publisher","first-page":"e3790","DOI":"10.1371\/journal.pone.0003790","article-title":"rBCG induces strong antigen-specific T cell responses in rhesus macaques in a prime-boost setting with an adenovirus 35 tuberculosis vaccine vector","volume":"3","author":"Magalh\u00c3\u00a3es","year":"2008","journal-title":"PLoS One"},{"key":"B49","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1086\/592450","article-title":"A new recombinant bacille Calmette-Gu\u00c3\u00a9rin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers","volume":"198","author":"Hoft","year":"2008","journal-title":"J Infect Dis"},{"key":"B50","doi-asserted-by":"publisher","first-page":"5200","DOI":"10.1128\/IAI.00434-08","article-title":"A replication-limited recombinant Mycobacterium bovis BCG vaccine against tuberculosis designed for human immunodeficiency virus-positive persons is safer and more efficacious than BCG","volume":"76","author":"Tullius","year":"2008","journal-title":"Infect Immun"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/563838","article-title":"Immunogenicity and protective efficacy of a novel recombinant BCG strain over expressing antigens Ag85A e Ag85B","volume":"2012","author":"Wang","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1111\/j.1365-3083.2010.02444.x","article-title":"Improved immunogenicity of recombinant Mycobacterium bovis bacillus Calmette-Gu\u00c3\u00a9rin strains expressing fusion protein Ag85A-ESAT-6 of Mycobacterium tuberculosis","volume":"72","author":"Deng","year":"2010","journal-title":"Scand J Immunol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"S1684","DOI":"10.1016\/j.jmii.2012.11.005","article-title":"Evaluation of protective efficacy conferred by a recombinant Mycobacterium bovis BCG expressing a fusion protein of Ag85A-ESAT-6","volume":"25","author":"Deng","year":"2012","journal-title":"J Microbiol Immunol Infect"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1128\/CVI.00112-09","article-title":"Recombinant Mycobacterium bovis BCG expressing the chimeric protein of antigen 85B and ESAT-6 enhances the Th1 cell-mediated response","volume":"16","author":"Xu","year":"2009","journal-title":"Clin Vaccine Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1016\/j.micinf.2010.04.002","article-title":"Recombinant Mycobacterium bovis BCG expressing chimeric protein of Ag85B and ESAT-6 enhances immunostimulatory activity of human macrophages","volume":"12","author":"Xu","year":"2010","journal-title":"Microbes Infect"},{"key":"B56","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1093\/abbs\/gmr045","article-title":"A novel recombinant Mycobacterium bovis bacillus Calmette-Gu\u00c3\u00a9rin strain expressing human granulocyte macrophage colony-stimulating factor and Mycobacterium tuberculosis early secretory antigenic target 6 complex augments Th1 immunity","volume":"43","author":"Yang","year":"2011","journal-title":"Acta Biochim Biophys Sin"},{"key":"B57","doi-asserted-by":"publisher","first-page":"7608","DOI":"10.1016\/j.vaccine.2012.10.031","article-title":"The recombinant tuberculosis vaccine rBCG \u00ce\u201dureC::hly(+) induces apoptotic vesicles for improved priming of CD4(+) and CD8(+) T cells","volume":"30","author":"Farinacci","year":"2012","journal-title":"Vaccine"},{"key":"B58","doi-asserted-by":"publisher","first-page":"8740","DOI":"10.1016\/j.vaccine.2011.07.144","article-title":"Improved long-term protection against Mycobacterium tuberculosis Beijing\/W in mice after intra-dermal inoculation of recombinant BCG expressing latency associated antigens","volume":"29","author":"Reece","year":"2011","journal-title":"Vaccine"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1016\/j.vaccine.2012.12.053","article-title":"Safety and immunogenicity of the recombinant BCG vaccine VPM1002 in phase 1 open-label randomized clinical trial","volume":"18","author":"Grode","year":"2013","journal-title":"Vaccine"},{"key":"B60","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1128\/IAI.65.9.3680-3685.1997","article-title":"Analysis of the genes encoding the antigen 85 complex and MPT51 from Mycobacterium avium","volume":"65","author":"Ohara","year":"1997","journal-title":"Infect Immun"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1126\/science.276.5317.1420","article-title":"Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis","volume":"276","author":"Belisle","year":"1997","journal-title":"Science"},{"key":"B62","doi-asserted-by":"publisher","first-page":"13853","DOI":"10.1073\/pnas.250480397","article-title":"Recombinant bacillus Calmette-Gu\u00c3\u00a9rin (BCG) vaccines expressing the Mycobacterium tuberculosis 30-kDa major secretory protein induce greater protective immunity against tuberculosis than conventional BCG vaccines in a highly susceptible animal model","volume":"97","author":"Horwitz","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1128\/IAI.71.4.1672-1679.2003","article-title":"A new vaccine against tuberculosis affords greater survival after challenge than the current vaccine in the guinea pig model of pulmonary tuberculosis","volume":"71","author":"Horwitz","year":"2003","journal-title":"Infect Immun"},{"key":"B64","doi-asserted-by":"crossref","first-page":"3038","DOI":"10.1128\/IAI.64.8.3038-3047.1996","article-title":"Novel insights into genetics, biochemistry, and immunocytochemistry of the 30-kilodalton major extracellular protein of Mycobacterium tuberculosis","volume":"64","author":"Harth","year":"1997","journal-title":"Infect Immun"},{"key":"B65","doi-asserted-by":"publisher","first-page":"4237","DOI":"10.1016\/j.vaccine.2008.05.050","article-title":"The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response","volume":"26","author":"Palma","year":"2008","journal-title":"Vaccine"},{"key":"B66","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1046\/j.1365-2958.1999.01310.x","article-title":"Inactivation of the antigen 85C gene profoundly affects the mycolate content and alters the permeability of the Mycobacterium tuberculosis cell envelope","volume":"31","author":"Jackson","year":"1999","journal-title":"Mol Microbiol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/S0264-410X(96)00274-5","article-title":"Immunogenicity and efficacy of a tuberculosis DNA vaccine encoding the components of the secreted antigen 85 complex","volume":"15","author":"Lozes","year":"1997","journal-title":"Vaccine"},{"key":"B68","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.tube.2006.05.001","article-title":"Protective efficacy of recombinant BCG Tokyo (Ag85A) BCG Tokyo with Ag85A peptide boosting against Mycobacterium tuberculosis-infected guinea pigs in comparison with that of DNA vaccine encoding Ag85A","volume":"87","author":"Sugawara","year":"2007","journal-title":"Tuberculosis"},{"key":"B69","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S1472-9792(03)00054-4","article-title":"Vaccination of guinea pigs with DNA encoding Ag85A by gene gun bombardment","volume":"83","author":"Sugawara","year":"2003","journal-title":"Tuberculosis"},{"key":"B70","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1074\/jbc.271.12.7218","article-title":"Mycobacterium tuberculosis 16-kDa antigen (Hsp16.3) functions as an oligomeric structure in vitro to suppress thermal aggregation","volume":"12","author":"Chang","year":"1996","journal-title":"J Biol Chem"},{"key":"B71","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1128\/IAI.63.3.799-803.1995","article-title":"Secretion of human interleukin 2 by recombinant Mycobacterium bovis BCG","volume":"63","author":"Kong","year":"1995","journal-title":"Infect Immun"},{"key":"B72","doi-asserted-by":"publisher","first-page":"1623","DOI":"10.1128\/IAI.70.3.1623-1626.2002","article-title":"Protective immunity against Mycobacterium tuberculosis induced by dendritic cells pulsed with both CD8 (+)- and CD4(+)-T-cell epitopes from antigen 85A","volume":"70","author":"McShane","year":"2002","journal-title":"Infect Immun"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/nm906","article-title":"Apoptosis facilitates antigen presentation to T lymphocytes through MHC-I and CD1 in tuberculosis","volume":"9","author":"Schaible","year":"2003","journal-title":"Nat Med"},{"key":"B74","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0005-2736(02)00368-1","article-title":"Listeriolysin O-liposome mediated cytosolic delivery of macromolecule antigen in vivo: enhancement of antigen-specific cytotoxic T lymphocyte frequency, activity, and tumor protection","volume":"1563","author":"Mandal","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"B75","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.1126\/science.334.6062.1488","article-title":"Infectious disease. Taking a new shot at a TB vaccine","volume":"334","author":"Kupferschmidt","year":"2011","journal-title":"Science"},{"key":"B76","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1196\/annals.1358.010","article-title":"The immune response to BCG vaccination of newborns","volume":"1062","author":"Hanekom","year":"2005","journal-title":"Ann NY Acad Sci"},{"key":"B77","volume-title":"Global Tuberculosis Report","year":"2013"}],"container-title":["Frontiers in Immunology"],"original-title":[],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T06:37:11Z","timestamp":1597646231000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2014.00152\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014]]},"references-count":77,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2014.00152","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014]]}}}