{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:54:45Z","timestamp":1790636085029,"version":"4.1.0"},"reference-count":95,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2014.00250","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T12:04:18Z","timestamp":1401710658000},"source":"Crossref","is-referenced-by-count":105,"title":["Immunologic Basis for Long HCDR3s in Broadly Neutralizing Antibodies Against HIV-1"],"prefix":"10.3389","volume":"5","author":[{"given":"Lei","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/72309","article-title":"Human neutralizing monoclonal antibodies of the IgG1 subtype protect against mucosal simian-human immunodeficiency virus infection","volume":"6","author":"Baba","year":"2000","journal-title":"Nat Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/nm.3471","article-title":"Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission","volume":"20","author":"Balazs","year":"2014","journal-title":"Nat Med"},{"key":"B3","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1038\/nature12744","article-title":"Therapeutic efficacy of potent neutralizing HIV-1-specific monoclonal antibodies in SHIV-infected rhesus monkeys","volume":"503","author":"Barouch","year":"2013","journal-title":"Nature"},{"key":"B4","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1038\/nm.1974","article-title":"Effective, low-titer antibody protection against low-dose repeated mucosal SHIV challenge in macaques","volume":"15","author":"Hessell","year":"2009","journal-title":"Nat Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"16538","DOI":"10.1073\/pnas.1315295110","article-title":"HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice","volume":"110","author":"Horwitz","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B6","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1038\/nature11604","article-title":"HIV therapy by a combination of broadly neutralizing antibodies in humanized mice","volume":"492","author":"Klein","year":"2012","journal-title":"Nature"},{"key":"B7","doi-asserted-by":"crossref","first-page":"4009","DOI":"10.1128\/JVI.73.5.4009-4018.1999","article-title":"Protection of Macaques against pathogenic simian\/human immunodeficiency virus 89.6PD by passive transfer of neutralizing antibodies","volume":"73","author":"Mascola","year":"1999","journal-title":"J Virol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"18921","DOI":"10.1073\/pnas.1214785109","article-title":"Highly potent HIV-specific antibody neutralization in vitro translates into effective protection against mucosal SHIV challenge in vivo","volume":"109","author":"Moldt","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B9","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1038\/5568","article-title":"Neutralizing antibody directed against the HIV-1 envelope glycoprotein can completely block HIV-1\/SIV chimeric virus infections of macaque monkeys","volume":"5","author":"Shibata","year":"1999","journal-title":"Nat Med"},{"key":"B10","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1038\/nature12746","article-title":"Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia","volume":"503","author":"Shingai","year":"2013","journal-title":"Nature"},{"key":"B11","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/nm833","article-title":"Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120","volume":"9","author":"Veazey","year":"2003","journal-title":"Nat Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1126\/science.1225416","article-title":"Broadly neutralizing antibodies present new prospects to counter highly antigenically diverse viruses","volume":"337","author":"Burton","year":"2012","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1097\/COH.0b013e328361d178","article-title":"Progress in HIV-1 vaccine development","volume":"8","author":"Haynes","year":"2013","journal-title":"Curr Opin HIV AIDS"},{"issue":"29","key":"B14","doi-asserted-by":"publisher","first-page":"4310","DOI":"10.1016\/j.vaccine.2011.11.014","article-title":"HIV vaccine development: challenges and opportunities towards solving the HIV vaccine-neutralizing antibody problem","volume":"30","author":"Koff","year":"2011","journal-title":"Vaccine"},{"key":"B15","doi-asserted-by":"publisher","first-page":"17407","DOI":"10.7448\/IAS.15.2.17407","article-title":"The changing face of HIV vaccine research","volume":"15","author":"Kwong","year":"2012","journal-title":"J Int AIDS Soc"},{"key":"B16","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/nri3516","article-title":"Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning","volume":"13","author":"Kwong","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/nature12091","article-title":"HIV: roadmaps to a vaccine","volume":"496","author":"Mouquet","year":"2013","journal-title":"Nature"},{"key":"B18","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3410\/B2-60","article-title":"New templates for HIV-1 antibody-based vaccine design","volume":"2","author":"Sattentau","year":"2010","journal-title":"F1000 Biol Rep"},{"key":"B19","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1016\/j.coi.2012.04.006","article-title":"HIV vaccine design: the neutralizing antibody conundrum","volume":"24","author":"Stamatatos","year":"2012","journal-title":"Curr Opin Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.cell.2014.01.052","article-title":"Structural insights on the role of antibodies in HIV-1 vaccine and therapy","volume":"156","author":"West","year":"2014","journal-title":"Cell"},{"key":"B21","doi-asserted-by":"publisher","first-page":"9998","DOI":"10.1128\/JVI.05045-11","article-title":"Analysis of a clonal lineage of HIV-1 envelope V2\/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors","volume":"85","author":"Bonsignori","year":"2011","journal-title":"J Virol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"e8805","DOI":"10.1371\/journal.pone.0008805","article-title":"Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals","volume":"5","author":"Corti","year":"2010","journal-title":"PLoS One"},{"key":"B23","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1126\/science.1233989","article-title":"Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization","volume":"340","author":"Georgiev","year":"2013","journal-title":"Science"},{"key":"B24","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/nature11544","article-title":"Broad and potent neutralization of HIV-1 by a gp41-specific human antibody","volume":"491","author":"Huang","year":"2012","journal-title":"Nature"},{"key":"B25","doi-asserted-by":"publisher","first-page":"11231","DOI":"10.1128\/JVI.01543-12","article-title":"HIV-1 neutralizing antibodies display dual recognition of the primary and coreceptor binding sites and preferential binding to fully cleaved envelope glycoproteins","volume":"86","author":"Li","year":"2012","journal-title":"J Virol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/nature12053","article-title":"Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus","volume":"496","author":"Liao","year":"2013","journal-title":"Nature"},{"key":"B27","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/nature07930","article-title":"Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals","volume":"458","author":"Scheid","year":"2009","journal-title":"Nature"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1126\/science.1207227","article-title":"Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding","volume":"333","author":"Scheid","year":"2011","journal-title":"Science"},{"key":"B29","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1038\/nature10373","article-title":"Broad neutralization coverage of HIV by multiple highly potent antibodies","volume":"477","author":"Walker","year":"2011","journal-title":"Nature"},{"key":"B30","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1126\/science.1178746","article-title":"Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target","volume":"326","author":"Walker","year":"2009","journal-title":"Science"},{"key":"B31","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1126\/science.1187659","article-title":"Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1","volume":"329","author":"Wu","year":"2010","journal-title":"Science"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1126\/science.1207532","article-title":"Focused evolution of HIV-1 neutralizing antibodies revealed by structures and deep sequencing","volume":"333","author":"Wu","year":"2011","journal-title":"Science"},{"key":"B33","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.immuni.2013.04.012","article-title":"Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies","volume":"39","author":"Zhou","year":"2013","journal-title":"Immunity"},{"key":"B34","article-title":"Selecting low frequency antigen-specific single B lymphocytes","volume-title":"United States Patent Number 5326696","author":"Chang","year":"1994"},{"key":"B35","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jim.2008.11.012","article-title":"A method for identification of HIV gp140 binding memory B cells in human blood","volume":"343","author":"Scheid","year":"2009","journal-title":"J Immunol Methods"},{"key":"B36","doi-asserted-by":"publisher","first-page":"7337","DOI":"10.1128\/JVI.00110-09","article-title":"Human immunodeficiency virus type 1 elite neutralizers: individuals with broad and potent neutralizing activity identified by using a high-throughput neutralization assay together with an analytical selection algorithm","volume":"83","author":"Simek","year":"2009","journal-title":"J Virol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1126\/science.1086907","article-title":"Predominant autoantibody production by early human B cell precursors","volume":"301","author":"Wardemann","year":"2003","journal-title":"Science"},{"key":"B38","doi-asserted-by":"publisher","first-page":"10690","DOI":"10.1128\/JVI.01110-10","article-title":"Antibody 2G12 recognizes di-mannose equivalently in domain- and nondomain-exchanged forms but only binds the HIV-1 glycan shield if domain exchanged","volume":"84","author":"Doores","year":"2010","journal-title":"J Virol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1126\/science.1245625","article-title":"Crystal structure of a soluble cleaved HIV-1 envelope trimer","volume":"342","author":"Julien","year":"2013","journal-title":"Science"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1126\/science.1245627","article-title":"Cryo-EM structure of a fully glycosylated soluble cleaved HIV-1 envelope trimer","volume":"342","author":"Lyumkis","year":"2013","journal-title":"Science"},{"key":"B41","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1038\/nature05580","article-title":"Structural definition of a conserved neutralization epitope on HIV-1 gp120","volume":"445","author":"Zhou","year":"2007","journal-title":"Nature"},{"issue":"7","key":"B42","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1038\/nsmb.2594","article-title":"Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120","volume":"20","author":"Kong","year":"2013","journal-title":"Nat Struct Mol Biol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"E3268","DOI":"10.1073\/pnas.1217207109","article-title":"Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies","volume":"109","author":"Mouquet","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1126\/science.1213256","article-title":"A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield","volume":"334","author":"Pejchal","year":"2011","journal-title":"Science"},{"key":"B45","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1016\/j.immuni.2014.04.008","article-title":"Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers","volume":"40","author":"Blattner","year":"2014","journal-title":"Immunity"},{"key":"B46","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1016\/j.immuni.2014.04.009","article-title":"Broadly neutralizing HIV antibodies define a glycan-dependent epitope on the prefusion conformation of gp41 on cleaved envelope trimers","volume":"40","author":"Falkowska","year":"2014","journal-title":"Immunity"},{"issue":"3","key":"B47","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1016\/j.celrep.2014.04.001","article-title":"Antibody 8ANC195 reveals a site of broad vulnerability on the HIV-1 envelope spike","volume":"7","author":"Scharf","year":"2014","journal-title":"Cell Rep"},{"key":"B48","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1089\/aid.1994.10.359","article-title":"Generation of human monoclonal antibodies against HIV-1 proteins; electrofusion and Epstein-Barr virus transformation for peripheral blood lymphocyte immortalization","volume":"10","author":"Buchacher","year":"1994","journal-title":"AIDS Res Hum Retroviruses"},{"key":"B49","doi-asserted-by":"publisher","first-page":"11401","DOI":"10.1128\/JVI.05312-11","article-title":"Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies","volume":"85","author":"Zhu","year":"2011","journal-title":"J Virol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1111\/imr.12075","article-title":"HIV-1 neutralizing antibodies: understanding nature\u00e2\u20ac\u2122s pathways","volume":"254","author":"Mascola","year":"2013","journal-title":"Immunol Rev"},{"key":"B51","doi-asserted-by":"publisher","first-page":"D1006","DOI":"10.1093\/nar\/gkn838","article-title":"IMGT, the international ImMunoGeneTics information system","volume":"37","author":"Lefranc","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.clim.2012.11.003","article-title":"Contribution of V(H) replacement products to the generation of anti-HIV antibodies","volume":"146","author":"Liao","year":"2013","journal-title":"Clin Immunol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.immuni.2012.08.012","article-title":"Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies","volume":"37","author":"Kwong","year":"2012","journal-title":"Immunity"},{"key":"B54","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.immuni.2007.01.009","article-title":"Autoreactivity in human IgG+ memory B cells","volume":"26","author":"Tiller","year":"2007","journal-title":"Immunity"},{"key":"B55","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1084\/jem.20101352","article-title":"Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection","volume":"208","author":"Wrammert","year":"2011","journal-title":"J Exp Med"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1038\/nm.2985","article-title":"Evolution of an HIV glycan-dependent broadly neutralizing antibody epitope through immune escape","volume":"18","author":"Moore","year":"2012","journal-title":"Nat Med"},{"key":"B57","doi-asserted-by":"publisher","first-page":"e1003738","DOI":"10.1371\/journal.ppat.1003738","article-title":"Viral escape from HIV-1 neutralizing antibodies drives increased plasma neutralization breadth through sequential recognition of multiple epitopes and immunotypes","volume":"9","author":"Wibmer","year":"2013","journal-title":"PLoS Pathog"},{"key":"B58","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1146\/annurev-immunol-020711-075032","article-title":"Germinal centers","volume":"30","author":"Victora","year":"2012","journal-title":"Annu Rev Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1126\/science.1111781","article-title":"Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies","volume":"308","author":"Haynes","year":"2005","journal-title":"Science"},{"key":"B60","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1097\/COH.0000000000000049","article-title":"Autoreactivity in HIV-1 broadly neutralizing antibodies: implications for their function and induction by vaccination","volume":"9","author":"Verkoczy","year":"2014","journal-title":"Curr Opin HIV AIDS"},{"key":"B61","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1038\/nbt.2197","article-title":"B-cell-lineage immunogen design in vaccine development with HIV-1 as a case study","volume":"30","author":"Haynes","year":"2012","journal-title":"Nat Biotechnol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1007\/s00018-011-0872-6","article-title":"Polyreactive antibodies in adaptive immune responses to viruses","volume":"69","author":"Mouquet","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"B63","doi-asserted-by":"publisher","first-page":"3179","DOI":"10.4049\/jimmunol.1301283","article-title":"B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates","volume":"191","author":"Ota","year":"2013","journal-title":"J Immunol"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/prot.340160102","article-title":"Length distribution of CDRH3 in antibodies","volume":"16","author":"Wu","year":"1993","journal-title":"Proteins"},{"key":"B65","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/j.jmb.2003.10.007","article-title":"Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures","volume":"334","author":"Zemlin","year":"2003","journal-title":"J Mol Biol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"7773","DOI":"10.4049\/jimmunol.174.12.7773","article-title":"Development of the expressed Ig CDR-H3 repertoire is marked by focusing of constraints in length, amino acid use, and charge that are first established in early B cell progenitors","volume":"174","author":"Ivanov","year":"2005","journal-title":"J Immunol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e22365","DOI":"10.1371\/journal.pone.0022365","article-title":"High-resolution description of antibody heavy-chain repertoires in humans","volume":"6","author":"Arnaout","year":"2011","journal-title":"PLoS One"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e36750","DOI":"10.1371\/journal.pone.0036750","article-title":"Human peripheral blood antibodies with long HCDR3s are established primarily at original recombination using a limited subset of germline genes","volume":"7","author":"Briney","year":"2012","journal-title":"PLoS One"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.1073\/pnas.82.9.2945","article-title":"Antigen-binding specificities of antibodies are primarily determined by seven residues of VH","volume":"82","author":"Ohno","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Suppl","key":"B70","doi-asserted-by":"publisher","first-page":"S45","DOI":"10.1016\/S0092-8674(02)00675-X","article-title":"The mechanism and regulation of chromosomal V(D)J recombination","volume":"109","author":"Bassing","year":"2002","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1038\/302575a0","article-title":"Somatic generation of antibody diversity","volume":"302","author":"Tonegawa","year":"1983","journal-title":"Nature"},{"key":"B72","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fimmu.2013.00042","article-title":"Secondary mechanisms of diversification in the human antibody repertoire","volume":"4","author":"Briney","year":"2013","journal-title":"Front Immunol"},{"key":"B73","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1016\/1074-7613(95)90064-0","article-title":"Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing","volume":"3","author":"Chen","year":"1995","journal-title":"Immunity"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1084\/jem.191.11.1881","article-title":"Receptor revision of immunoglobulin heavy chain variable region genes in normal human B lymphocytes","volume":"191","author":"Wilson","year":"2000","journal-title":"J Exp Med"},{"key":"B75","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1111\/j.0105-2896.2004.0107.x","article-title":"The molecular basis and biological significance of VH replacement","volume":"197","author":"Zhang","year":"2004","journal-title":"Immunol Rev"},{"key":"B76","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/1745-6150-1-24","article-title":"Codon insertion and deletion functions as a somatic diversification mechanism in human antibody repertoires","volume":"1","author":"Reason","year":"2006","journal-title":"Biol Direct"},{"key":"B77","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1084\/jem.187.1.59","article-title":"Somatic hypermutation introduces insertions and deletions into immunoglobulin V genes","volume":"187","author":"Wilson","year":"1998","journal-title":"J Exp Med"},{"key":"B78","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1038\/gene.2012.28","article-title":"Location and length distribution of somatic hypermutation-associated DNA insertions and deletions reveals regions of antibody structural plasticity","volume":"13","author":"Briney","year":"2012","journal-title":"Genes Immun"},{"key":"B79","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1365-2567.2012.03605.x","article-title":"Frequency and genetic characterization of V(DD)J recombinants in the human peripheral blood antibody repertoire","volume":"137","author":"Briney","year":"2012","journal-title":"Immunology"},{"key":"B80","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.4049\/jimmunol.162.3.1566","article-title":"Atypical VH-D-JH rearrangements in newborn autoimmune MRL mice","volume":"162","author":"Klonowski","year":"1999","journal-title":"J Immunol"},{"key":"B81","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.4049\/jimmunol.147.5.1720","article-title":"Multiple mechanisms participate in the generation of diversity of human H chain CDR3 regions","volume":"147","author":"Sanz","year":"1991","journal-title":"J Immunol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.4049\/jimmunol.177.2.1120","article-title":"Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-\/- and TdT+\/+ mice","volume":"177","author":"Watson","year":"2006","journal-title":"J Immunol"},{"key":"B83","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1111\/j.1365-2567.2004.02084.x","article-title":"V(H) replacement in rearranged immunoglobulin genes","volume":"114","author":"Darlow","year":"2005","journal-title":"Immunology"},{"key":"B84","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S1074-7613(03)00170-5","article-title":"Contribution of VH gene replacement to the primary B cell repertoire","volume":"19","author":"Zhang","year":"2003","journal-title":"Immunity"},{"key":"B85","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.immuni.2006.04.016","article-title":"Antibody repertoires generated by VH replacement and direct VH to JH joining","volume":"25","author":"Koralov","year":"2006","journal-title":"Immunity"},{"key":"B86","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/nri1939","article-title":"Receptor editing in lymphocyte development and central tolerance","volume":"6","author":"Nemazee","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"452","DOI":"10.4049\/jimmunol.0804060","article-title":"Antibodies in a heavy chain knock-in mouse exhibit characteristics of early heavy chain rearrangement","volume":"183","author":"Yunk","year":"2009","journal-title":"J Immunol"},{"key":"B88","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1016\/j.it.2007.01.003","article-title":"VH replacement in mice and humans","volume":"28","author":"Zhang","year":"2007","journal-title":"Trends Immunol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fimmu.2014.00040","article-title":"VH replacement footprint analyzer-I, a java-based computer program for analyses of immunoglobulin heavy chain genes and potential VH replacement products in human and mouse","volume":"5","author":"Huang","year":"2014","journal-title":"Front Immunol"},{"key":"B90","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fimmu.2014.00010","article-title":"Trials and tribulations with VH replacement","volume":"5","author":"Meng","year":"2014","journal-title":"Front Immunol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"5559","DOI":"10.4049\/jimmunol.1102503","article-title":"Regulation of VH replacement by B cell receptor-mediated signaling in human immature B cells","volume":"190","author":"Liu","year":"2013","journal-title":"J Immunol"},{"key":"B92","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature13036","article-title":"Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies","volume":"509","author":"Doria-Rose","year":"2014","journal-title":"Nature"},{"key":"B93","doi-asserted-by":"publisher","first-page":"2645","DOI":"10.1128\/JVI.03228-13","article-title":"Diverse recombinant HIV-1 Envs fail to activate B cells expressing the germline B cell receptors of the broadly neutralizing anti-HIV-1 antibodies PG9 and 447-52D","volume":"88","author":"McGuire","year":"2014","journal-title":"J Virol"},{"key":"B94","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1126\/science.1234150","article-title":"Rational HIV immunogen design to target specific germline B cell receptors","volume":"340","author":"Jardine","year":"2013","journal-title":"Science"},{"key":"B95","first-page":"13.56","article-title":"A common transitional Env conformation revealed by a new broadly neutralizing antibody as a novel HIV-1 vaccine target","volume-title":"AIDS Vaccine 2013","author":"Guan","year":"2013"}],"container-title":["Frontiers in Immunology"],"original-title":[],"deposited":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T21:24:32Z","timestamp":1689283472000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2014.00250\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,2]]},"references-count":95,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2014.00250","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,2]]}}}