{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:14:13Z","timestamp":1787026453072,"version":"build-2736575974"},"reference-count":83,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2015.00095","type":"journal-article","created":{"date-parts":[[2015,3,9]],"date-time":"2015-03-09T10:55:39Z","timestamp":1425898539000},"source":"Crossref","is-referenced-by-count":33,"title":["Eliminating Schistosomes through Vaccination: What are the Best Immune Weapons?"],"prefix":"10.3389","volume":"6","author":[{"given":"Cristina Toscano","family":"Fonseca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio Costa","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clarice Carvalho","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,3,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"140","DOI":"10.2471\/BLT.07.040089","article-title":"Vaccination greatly reduces disease, disability, death and inequity worldwide","volume":"86","author":"Andre","year":"2008","journal-title":"Bull World Health Organ"},{"key":"B2","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.actatropica.2008.05.023","article-title":"Recent advances in vaccine research against schistosomiasis in Brazil","volume":"108","author":"Oliveira","year":"2008","journal-title":"Acta Trop"},{"key":"B3","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.idc.2012.03.004","article-title":"Schistosomiasis","volume":"26","author":"Gryseels","year":"2012","journal-title":"Infect Dis Clin North Am"},{"key":"B4","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1111\/j.1365-3024.2005.00789.x","article-title":"Modulation of the host\u00e2\u20ac\u2122s immune response by schistosome larvae","volume":"27","author":"Jenkins","year":"2005","journal-title":"Parasite Immunol"},{"key":"B5","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.4269\/ajtmh.1980.29.1263","article-title":"Schistosoma mansoni: comparison of the killing effect of granulocytes and complement with or without antibody on fresh and cultured schistosomula in vitro","volume":"29","author":"Novato-Silva","year":"1980","journal-title":"Am J Trop Med Hyg"},{"key":"B6","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.vaccine.2008.11.039","article-title":"Schistosoma mansoni ex vivo lung-stage larvae excretory-secretory antigens as vaccine candidates against schistosomiasis","volume":"27","author":"El Ridi","year":"2009","journal-title":"Vaccine"},{"key":"B7","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0014-5793(00)01304-1","article-title":"A Schistosoma protein, Sh-TOR, is a novel inhibitor of complement which binds human C2","volume":"470","author":"Inal","year":"2000","journal-title":"FEBS Lett"},{"key":"B8","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.4049\/jimmunol.144.7.2751","article-title":"Host-specific evasion of the alternative complement pathway by schistosomes correlates with the presence of a phospholipase C-sensitive surface molecule resembling human decay accelerating factor","volume":"144","author":"Pearce","year":"1990","journal-title":"J Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1590\/S0074-02761987000800037","article-title":"Decay accelerating factor (DAF) as the host antigen with protective activity to complement killing of schistosomula","volume":"82","author":"Ramalho-Pinto","year":"1987","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"B10","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4049\/jimmunol.141.1.273","article-title":"Proteases secreted by transforming schistosomula of Schistosoma mansoni promote resistance to killing by complement","volume":"141","author":"Marikovsky","year":"1988","journal-title":"J Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1038\/256727a0","article-title":"Eosinophils as mediators of antibody-dependent damage to schistosomula","volume":"256","author":"Butterworth","year":"1975","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/978-1-4684-8326-0_2","article-title":"IgE-dependent platelet cytotoxicity against helminths","volume":"184","author":"Joseph","year":"1985","journal-title":"Adv Exp Med Biol"},{"key":"B13","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.4049\/jimmunol.142.12.4422","article-title":"Functional role of human IgG subclasses in eosinophil-mediated killing of schistosomula of Schistosoma mansoni","volume":"142","author":"Khalife","year":"1989","journal-title":"J Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"6753","DOI":"10.1016\/j.vaccine.2012.09.026","article-title":"Role of antibody dependent cell mediated cytotoxicity (ADCC) in Sm-p80-mediated protection against Schistosoma mansoni","volume":"30","author":"Torben","year":"2012","journal-title":"Vaccine"},{"key":"B15","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/0166-6851(85)90131-8","article-title":"In vitro synthesis of a 28 kilodalton antigen present on the surface of the schistosomulum of Schistosoma mansoni","volume":"17","author":"Balloul","year":"1985","journal-title":"Mol Biochem Parasitol"},{"key":"B16","doi-asserted-by":"crossref","first-page":"3448","DOI":"10.4049\/jimmunol.138.10.3448","article-title":"A purified 28,000 dalton protein from Schistosoma mansoni adult worms protects rats and mice against experimental schistosomiasis","volume":"138","author":"Balloul","year":"1987","journal-title":"J Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2420","DOI":"10.1182\/blood-2006-04-015933","article-title":"Schistosoma mansoni infection in eosinophil lineage-ablated mice","volume":"108","author":"Swartz","year":"2006","journal-title":"Blood"},{"key":"B18","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4049\/jimmunol.162.1.345","article-title":"Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-\u00ce\u00b3amma-dependent effector mechanisms","volume":"162","author":"Jankovic","year":"1999","journal-title":"J Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/pim.12091","article-title":"Antibodies are involved in the protective immunity induced in mice by Schistosoma mansoni schistosomula tegument (Smteg) immunization","volume":"36","author":"Melo","year":"2014","journal-title":"Parasite Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1016\/j.vaccine.2011.01.040","article-title":"Role of antibodies in Sm-p80-mediated protection against Schistosoma mansoni challenge infection in murine and nonhuman primate models","volume":"29","author":"Torben","year":"2011","journal-title":"Vaccine"},{"key":"B21","doi-asserted-by":"publisher","first-page":"3539","DOI":"10.1128\/IAI.00252-07","article-title":"In the absence of CD154, administration of interleukin-12 restores Th1 responses but not protective immunity to Schistosoma mansoni","volume":"75","author":"Hewitson","year":"2007","journal-title":"Infect Immun"},{"key":"B22","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1146\/annurev.immunol.16.1.111","article-title":"CD40 and CD154 in cell-mediated immunity","volume":"16","author":"Grewal","year":"1998","journal-title":"Annu Rev Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/j.vaccine.2003.07.010","article-title":"IL-12 enhances protective immunity in mice engendered by immunization with recombinant 14 kDa Schistosoma mansoni fatty acid-binding protein through an IFN-\u00ce\u00b3amma and TNF-\u00ce\u00b1lpha dependent pathway","volume":"22","author":"Fonseca","year":"2004","journal-title":"Vaccine"},{"key":"B24","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.4049\/jimmunol.163.8.4489","article-title":"TNF is essential for the cell-mediated protective immunity induced by the radiation-attenuated schistosome vaccine","volume":"163","author":"Street","year":"1999","journal-title":"J Immunol"},{"key":"B25","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1128\/IAI.66.8.3510-3518.1998","article-title":"Inducible nitric oxide synthase-deficient mice develop enhanced type 1 cytokine-associated cellular and humoral immune responses after vaccination with attenuated Schistosoma mansoni cercariae but display partially reduced resistance","volume":"66","author":"James","year":"1998","journal-title":"Infect Immun"},{"key":"B26","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1128\/IAI.69.1.228-236.2001","article-title":"Signaling via interleukin-4 receptor alpha chain is required for successful vaccination against schistosomiasis in BALB\/c mice","volume":"69","author":"Mountford","year":"2001","journal-title":"Infect Immun"},{"key":"B27","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1645\/GE-3186.1","article-title":"Vaccine-induced protection against murine schistosomiasis mansoni with larval excretory-secretory antigens and papain or type-2 cytokines","volume":"99","author":"El Ridi","year":"2013","journal-title":"J Parasitol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"e1002171","DOI":"10.1371\/journal.ppat.1002171","article-title":"IL-10 blocks the development of resistance to re-infection with Schistosoma mansoni","volume":"7","author":"Wilson","year":"2011","journal-title":"PLoS Pathog"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e1399","DOI":"10.1371\/journal.pntd.0001399","article-title":"Dynamics of Th17 cells and their role in Schistosoma japonicum infection in C57BL\/6 mice","volume":"5","author":"Wen","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"B30","doi-asserted-by":"publisher","first-page":"2440","DOI":"10.1016\/j.vaccine.2012.01.068","article-title":"Murine CD8(+)T cell cytotoxicity against schistosomula induced by inoculation of schistosomal 22.6\/26GST coupled sepharose 4B beads","volume":"30","author":"Zhou","year":"2012","journal-title":"Vaccine"},{"key":"B31","doi-asserted-by":"crossref","first-page":"529","DOI":"10.4269\/ajtmh.1988.38.529","article-title":"Examination of the mechanisms of pulmonary phase resistance to Schistosoma mansoni in vaccinated mice","volume":"38","author":"Coulson","year":"1988","journal-title":"Am J Trop Med Hyg"},{"key":"B32","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/S0065-308X(08)60048-2","article-title":"The radiation-attenuated vaccine against schistosomes in animal models: paradigm for a human vaccine?","volume":"39","author":"Coulson","year":"1997","journal-title":"Adv Parasitol"},{"key":"B33","article-title":"Study to evaluate the safety of the vaccine prepared sm14 against schistosomiasis","volume-title":"ClinicalTrials.gov [Internet]","author":"Oswaldo Cruz Foundation","year":"2000"},{"key":"B34","doi-asserted-by":"publisher","first-page":"e1704","DOI":"10.1371\/journal.pntd.0001704","article-title":"Safety and immunogenicity of rSh28GST antigen in humans: phase 1 randomized clinical study of a vaccine candidate against urinary schistosomiasis","volume":"6","author":"Riveau","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"B35","doi-asserted-by":"publisher","first-page":"2342","DOI":"10.4161\/hv.25787","article-title":"Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoni TSP-2 recombinant protein: a vaccine candidate for human intestinal schistosomiasis","volume":"9","author":"Curti","year":"2013","journal-title":"Hum Vaccin Immunother"},{"key":"B36","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/j.1460-2075.1988.tb02834.x","article-title":"The glutathione transferase activity and tissue distribution of a cloned Mr28K protective antigen of Schistosoma mansoni","volume":"7","author":"Taylor","year":"1988","journal-title":"EMBO J"},{"key":"B37","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1017\/S003118200006652X","article-title":"Ultrastructural localization of Sm28 GST protective antigen in Schistosoma mansoni adult worms","volume":"113","author":"Liu","year":"1996","journal-title":"Parasitology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/j.1365-3024.1991.tb00545.x","article-title":"Immunization of mice and baboons with the recombinant Sm28GST affects both worm viability and fecundity after experimental infection with Schistosoma mansoni","volume":"13","author":"Boulanger","year":"1991","journal-title":"Parasite Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/eji.1830230223","article-title":"Protective immunity induced in rat schistosomiasis by a single dose of the Sm28GST recombinant antigen: effector mechanisms involving IgE and IgA antibodies","volume":"23","author":"Grezel","year":"1993","journal-title":"Eur J Immunol"},{"key":"B40","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.4049\/jimmunol.156.11.4309","article-title":"Neutralizing antibody responses elicited in mice immunized with recombinant bacillus Calmette-Gu\u00c3\u00a9rin producing the Schistosoma mansoni glutathione S-transferase","volume":"156","author":"Kremer","year":"1996","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1046\/j.1365-3024.1997.d01-163.x","article-title":"Intradermal immunization of rats with plasmid DNA encoding Schistosoma mansoni 28 kDa glutathione S-transferase","volume":"19","author":"Dupr\u00c3\u00a9","year":"1997","journal-title":"Parasite Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1016\/0161-5890(94)90075-2","article-title":"Evaluation of the effect of Sm28GST-derived peptides in murine hepatosplenic schistosomiasis: interest of the lipopeptidic form of the C-terminal peptide","volume":"31","author":"Pancr\u00c3\u00a9","year":"1994","journal-title":"Mol Immunol"},{"key":"B43","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1128\/IAI.62.9.3723-3730.1994","article-title":"Protective effect of rSm28GST-specific T cells in schistosomiasis: role of gamma interferon","volume":"62","author":"Pancre","year":"1994","journal-title":"Infect Immun"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1016\/S0264-410X(00)00363-7","article-title":"Immunostimulatory effect of IL-18-encoding plasmid in DNA vaccination against murine Schistosoma mansoni infection","volume":"19","author":"Dupr\u00c3\u00a9","year":"2001","journal-title":"Vaccine"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1126\/science.3317823","article-title":"Immunity to schistosomes: progress toward vaccine","volume":"238","author":"Capron","year":"1987","journal-title":"Science"},{"key":"B46","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1111\/j.1365-3024.1995.tb00903.x","article-title":"Vaccination of patas monkeys experimentally infected with Schistosoma haematobium using a recombinant glutathione S-transferase cloned from S. mansoni","volume":"17","author":"Boulanger","year":"1995","journal-title":"Parasite Immunol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0264-410X(98)00202-3","article-title":"Vaccine potential of a recombinant glutathione S-transferase cloned from Schistosoma haematobium in primates experimentally infected with an homologous challenge","volume":"17","author":"Boulanger","year":"1999","journal-title":"Vaccine"},{"key":"B48","doi-asserted-by":"crossref","first-page":"8447","DOI":"10.1016\/S0021-9258(18)92995-9","article-title":"A 14-kDa Schistosoma mansoni polypeptide is homologous to a gene family of fatty acid binding proteins","volume":"266","author":"Moser","year":"1991","journal-title":"J Biol Chem"},{"key":"B49","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/0169-4758(91)90192-Q","article-title":"Unique roles for lipids in Schistosoma mansoni","volume":"7","author":"Furlong","year":"1991","journal-title":"Parasitol Today"},{"key":"B50","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/0005-2760(70)90170-0","article-title":"Lipid metabolism in the parasitic and free-living flatworms, Schistosoma mansoni and Dugesia dorotocephala","volume":"210","author":"Meyer","year":"1970","journal-title":"Biochim Biophys Acta"},{"key":"B51","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1590\/S0100-879X2002000300014","article-title":"Sm14 gene expression in different stages of the Schistosoma mansoni life cycle and immunolocalization of the Sm14 protein within the adult worm","volume":"35","author":"Brito","year":"2002","journal-title":"Braz J Med Biol Res"},{"key":"B52","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1073\/pnas.93.1.269","article-title":"A Schistosoma mansoni fatty acid-binding protein, Sm14, is the potential basis of a dual-purpose anti-helminth vaccine","volume":"93","author":"Tendler","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B53","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.micinf.2004.10.012","article-title":"Human T cell epitope mapping of the Schistosoma mansoni 14-kDa fatty acid-binding protein using cells from patients living in areas endemic for schistosomiasis","volume":"7","author":"Fonseca","year":"2005","journal-title":"Microbes Infect"},{"key":"B54","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.actatropica.2008.03.003","article-title":"Peptides containing T cell epitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of immune response, reduction in liver pathology and partial protection against Schistosoma mansoni infection in mice","volume":"106","author":"Garcia","year":"2008","journal-title":"Acta Trop"},{"key":"B55","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1016\/j.micinf.2006.06.008","article-title":"Co-administration of plasmid expressing IL-12 with 14-kDa Schistosoma mansoni fatty acid-binding protein cDNA alters immune response profiles and fails to enhance protection induced by Sm14 DNA vaccine alone","volume":"8","author":"Fonseca","year":"2006","journal-title":"Microbes Infect"},{"key":"B56","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1096\/fasebj.11.6.9194523","article-title":"The tetraspanin superfamily: molecular facilitators","volume":"11","author":"Maecker","year":"1997","journal-title":"FASEB J"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1002\/pmic.200500368","article-title":"The tegument surface membranes of the human blood parasite Schistosoma mansoni: a proteomic analysis after differential extraction","volume":"6","author":"Braschi","year":"2006","journal-title":"Proteomics"},{"key":"B58","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1038\/nrm1736","article-title":"Tetraspanin functions and associated microdomains","volume":"6","author":"Hemler","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/nrd2659","article-title":"Targeting of tetraspanin proteins-potential benefits and strategies","volume":"7","author":"Hemler","year":"2008","journal-title":"Nat Rev Drug Discov"},{"key":"B60","doi-asserted-by":"publisher","first-page":"e1000840","DOI":"10.1371\/journal.ppat.1000840","article-title":"Suppression of mRNAs encoding tegument tetraspanins from Schistosoma mansoni results in impaired tegument turnover","volume":"6","author":"Tran","year":"2010","journal-title":"PLoS Pathog"},{"key":"B61","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/nm1430","article-title":"Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis","volume":"12","author":"Tran","year":"2006","journal-title":"Nat Med"},{"key":"B62","doi-asserted-by":"publisher","first-page":"e1564","DOI":"10.1371\/journal.pntd.0001564","article-title":"Enhanced protective efficacy of a chimeric form of the schistosomiasis vaccine antigen Sm-TSP-2","volume":"6","author":"Pearson","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"B63","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.bbrc.2008.05.042","article-title":"Molecular characterization of Schistosoma japonicum tegument protein tetraspanin-2: sequence variation and possible implications for immune evasion","volume":"372","author":"Cai","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"B64","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0925-4439(93)90087-H","article-title":"Characterization of Ca(2+)-dependent neutral protease (calpain) from human blood flukes, Schistosoma mansoni","volume":"1181","author":"Siddiqui","year":"1993","journal-title":"Biochim Biophys Acta"},{"key":"B65","doi-asserted-by":"crossref","first-page":"7057","DOI":"10.4049\/jimmunol.151.12.7057","article-title":"Characterization of a C3 receptor on the envelope of Schistosoma mansoni","volume":"151","author":"Silva","year":"1993","journal-title":"J Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"e781","DOI":"10.1016\/j.ijid.2010.02.2266","article-title":"Protective effects of Sm-p80 in the presence of resiquimod as an adjuvant against challenge infection with Schistosoma mansoni in mice","volume":"14","author":"Ahmad","year":"2010","journal-title":"Int J Infect Dis"},{"key":"B67","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1128\/IAI.69.1.386-391.2001","article-title":"Vaccination with calpain induces a Th1-biased protective immune response against Schistosoma japonicum","volume":"69","author":"Zhang","year":"2001","journal-title":"Infect Immun"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.4161\/hv.7.11.17017","article-title":"Schistosomiasis vaccines","volume":"7","author":"Siddiqui","year":"2011","journal-title":"Hum Vaccin"},{"key":"B69","doi-asserted-by":"publisher","first-page":"2882","DOI":"10.1016\/S0264-410X(03)00159-2","article-title":"Enhancement of Sm-p80 (large subunit of calpain) induced protective immunity against Schistosoma mansoni through co-delivery of interleukin-2 and interleukin-12 in a DNA vaccine formulation","volume":"21","author":"Siddiqui","year":"2003","journal-title":"Vaccine"},{"key":"B70","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1051\/parasite\/2005121003","article-title":"Characterization of protective immunity induced against Schistosoma mansoni via DNA priming with the large subunit of calpain (Sm-p80) in the presence of genetic adjuvants","volume":"12","author":"Siddiqui","year":"2005","journal-title":"Parasite"},{"key":"B71","doi-asserted-by":"publisher","first-page":"3844","DOI":"10.1128\/IAI.71.7.3844-3851.2003","article-title":"Induction of protective immunity against Schistosoma mansoni via DNA priming and boosting with the large subunit of calpain (Sm-p80): adjuvant effects of granulocyte-macrophage colony-stimulating factor and interleukin-4","volume":"71","author":"Siddiqui","year":"2003","journal-title":"Infect Immun"},{"key":"B72","doi-asserted-by":"publisher","first-page":"640","DOI":"10.4161\/hv.27576","article-title":"Complement plays a minimal role in Sm-p80-mediated protection against Schistosoma mansoni","volume":"10","author":"Karmakar","year":"2014","journal-title":"Hum Vaccin Immunother"},{"key":"B73","first-page":"609","article-title":"Identification of a new Schistosoma mansoni membrane-bound protein through bioinformatic analysis","volume":"5","author":"Cardoso","year":"2006","journal-title":"Genet Mol Res"},{"key":"B74","doi-asserted-by":"publisher","first-page":"e308","DOI":"10.1371\/journal.pntd.0000308","article-title":"Schistosoma mansoni tegument protein Sm29 is able to induce a Th1-type of immune response and protection against parasite infection","volume":"2","author":"Cardoso","year":"2008","journal-title":"PLoS Negl Trop Dis"},{"key":"B75","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1111\/pim.12118","article-title":"A multivalent chimeric vaccine composed of Schistosoma mansoni SmTSP-2 and Sm29 was able to induce protection against infection in mice","volume":"36","author":"Pinheiro","year":"2014","journal-title":"Parasite Immunol"},{"key":"B76","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.exppara.2014.07.010","article-title":"Combination of the two schistosomal antigens Sm14 and Sm29 elicits significant protection against experimental Schistosoma mansoni infection","volume":"145","author":"Ewaisha","year":"2014","journal-title":"Exp Parasitol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/0035-9203(89)90334-9","article-title":"The human immune response to defined immunogens of Schistosoma mansoni: elevated antibody levels to paramyosin in stool-negative individuals from two endemic areas in Brazil","volume":"83","author":"Correa-Oliveira","year":"1989","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"B78","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1046\/j.1365-3083.2000.00710.x","article-title":"CD4+ T cells of schistosomiasis naturally resistant individuals living in an endemic area produce interferon-gamma and tumour necrosis factor-alpha in response to the recombinant 14KDA Schistosoma mansoni fatty acid-binding protein","volume":"51","author":"Brito","year":"2000","journal-title":"Scand J Immunol"},{"key":"B79","first-page":"41","article-title":"Human IgG1 and IgG3 recognition of Schistosoma mansoni 14kDa fatty acid-binding recombinant protein","volume":"22","author":"Brito","year":"2000","journal-title":"Parasite Immunol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/j.1365-2249.2006.03081.x","article-title":"Human antibody responses of patients living in endemic areas for schistosomiasis to the tegumental protein Sm29 identified through genomic studies","volume":"144","author":"Cardoso","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S1383-5769(99)00024-0","article-title":"Cloning and molecular characterization of calpain, a calcium-activated neutral proteinase, from different strains of Schistosoma japonicum","volume":"48","author":"Zhang","year":"2000","journal-title":"Parasitol Int"},{"key":"B82","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0001-706X(03)00195-5","article-title":"In vitro cellular and humoral responses to Schistosoma mansoni vaccine candidate antigens","volume":"88","author":"Al-Sherbiny","year":"2003","journal-title":"Acta Trop"},{"key":"B83","doi-asserted-by":"crossref","first-page":"527","DOI":"10.4049\/jimmunol.150.2.527","article-title":"IgA antibodies to a protective antigen in human Schistosomiasis mansoni","volume":"150","author":"Grzych","year":"1993","journal-title":"J Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T12:50:58Z","timestamp":1691499058000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.frontiersin.org\/Immunotherapies_and_Vaccines\/10.3389\/fimmu.2015.00095\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,9]]},"references-count":83,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2015.00095","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,9]]}}}