{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:30:26Z","timestamp":1792301426901,"version":"4.4.0"},"reference-count":468,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2015.00272","type":"journal-article","created":{"date-parts":[[2015,6,8]],"date-time":"2015-06-08T09:29:18Z","timestamp":1433755758000},"source":"Crossref","is-referenced-by-count":311,"title":["Pathogenesis of Systemic Sclerosis"],"prefix":"10.3389","volume":"6","author":[{"given":"Debendra","family":"Pattanaik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley C.","family":"Postlethwaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnold E.","family":"Postlethwaite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,6,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"835948","DOI":"10.1155\/2013\/835948","article-title":"Role of endothelial to mesenchymal transition in the pathogenesis of the vascular alterations in systemic sclerosis","volume":"2013","author":"Jimenez","year":"2013","journal-title":"ISRN Rheumatol"},{"issue":"10","key":"B2","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1093\/rheumatology\/keh671","article-title":"Classification of systemic sclerosis. Visions and reality","volume":"44","author":"Wollheim","year":"2005","journal-title":"Rheumatology"},{"key":"B3","first-page":"2228","volume-title":"Rheumatology","author":"Hochberg","year":"2010","edition":"5th ed"},{"issue":"12","key":"B4","doi-asserted-by":"publisher","first-page":"3902","DOI":"10.1002\/art.24038","article-title":"Autoantibodies and microvascular damage are independent predictive factors for the progression of Raynaud\u00e2\u20ac\u2122s phenomenon to systemic sclerosis: a twenty-year prospective study of 586 patients, with validation of proposed criteria for early systemic sclerosis","volume":"58","author":"Koenig","year":"2008","journal-title":"Arthritis Rheum"},{"key":"B5","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2147\/JIR.S18145","article-title":"Vascular involvement in systemic sclerosis (scleroderma)","volume":"4","author":"Pattanaik","year":"2011","journal-title":"J Inflamm Res"},{"issue":"11","key":"B6","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European league against rheumatism collaborative initiative","volume":"65","author":"van den Hoogen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B7","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1111\/j.1749-6632.2009.04808.x","article-title":"The role of infections in the immunopathogenesis of systemic sclerosis \u00e2\u20ac\u201c evidence from serological studies","volume":"1173","author":"Arnson","year":"2009","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"B8","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1111\/imm.12200","article-title":"Epstein-Barr virus antibodies mark systemic lupus erythematosus and scleroderma patients negative for anti-DNA","volume":"141","author":"Fattal","year":"2014","journal-title":"Immunology"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu469","article-title":"Gene, environment, microbiome and mucosal immune tolerance in rheumatoid arthritis","author":"Catrina","year":"2014","journal-title":"Rheumatology"},{"issue":"8","key":"B10","doi-asserted-by":"publisher","first-page":"2138","DOI":"10.1038\/jid.2014.127","article-title":"High Rhodotorula sequences in skin transcriptome of patients with diffuse systemic sclerosis","volume":"134","author":"Arron","year":"2014","journal-title":"J Invest Dermatol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jaut.2013.01.012","article-title":"Systemic sclerosis: genetics and epigenetics","volume":"41","author":"Luo","year":"2013","journal-title":"J Autoimmun"},{"issue":"6","key":"B12","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1002\/1529-0131(200106)44:61359::AID-ART2283.0.CO;2-S","article-title":"Familial occurrence frequencies and relative risks for systemic sclerosis (scleroderma) in three United States cohorts","volume":"44","author":"Arnett","year":"2001","journal-title":"Arthritis Rheum"},{"issue":"1","key":"B13","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11926-011-0221-7","article-title":"Genetics of systemic sclerosis: an update","volume":"14","author":"Broen","year":"2012","journal-title":"Curr Rheumatol Rep"},{"issue":"1","key":"B14","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ajhg.2013.12.002","article-title":"Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis","volume":"94","author":"Mayes","year":"2014","journal-title":"Am J Hum Genet"},{"issue":"12","key":"B15","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/ng.1015","article-title":"Fine points in mapping autoimmunity","volume":"43","author":"Polychronakos","year":"2011","journal-title":"Nat Genet"},{"issue":"2","key":"B16","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1155\/2013\/301415","article-title":"HLA markers for poor prognosis in systemic sclerosis Brazilian patients","volume":"35","author":"Del Rio","year":"2013","journal-title":"Dis Markers"},{"issue":"8","key":"B17","first-page":"1481","article-title":"HLA markers for susceptibility and expression in scleroderma","volume":"32","author":"Gladman","year":"2005","journal-title":"J Rheumatol"},{"issue":"8","key":"B18","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1002\/art.1780390814","article-title":"Increased prevalence of systemic sclerosis in a native American tribe in Oklahoma. Association with an Amerindian HLA haplotype","volume":"39","author":"Arnett","year":"1996","journal-title":"Arthritis Rheum"},{"issue":"9","key":"B19","doi-asserted-by":"publisher","first-page":"2585","DOI":"10.1002\/art.11220","article-title":"Genome-wide association study for regions of systemic sclerosis susceptibility in a Choctaw Indian population with high disease prevalence","volume":"48","author":"Zhou","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"3","key":"B20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1111\/j.1399-0039.2006.00657.x","article-title":"HLA-B35 upregulates the production of endothelin-1 in HLA-transfected cells: a possible pathogenetic role in pulmonary hypertension","volume":"68","author":"Santaniello","year":"2006","journal-title":"Tissue Antigens"},{"issue":"3","key":"B21","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1046\/j.1365-2249.2000.01320.x","article-title":"Anti-topoisomerase II alpha autoantibodies in systemic sclerosis-association with pulmonary hypertension and HLA-B35","volume":"121","author":"Grigolo","year":"2000","journal-title":"Clin Exp Immunol"},{"issue":"9","key":"B22","doi-asserted-by":"publisher","first-page":"4654","DOI":"10.4049\/jimmunol.0903188","article-title":"HLA-B35 upregulates endothelin-1 and downregulates endothelial nitric oxide synthase via endoplasmic reticulum stress response in endothelial cells","volume":"184","author":"Lenna","year":"2010","journal-title":"J Immunol"},{"issue":"6","key":"B23","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.3899\/jrheum.080552","article-title":"HLA-G expression in the skin of patients with systemic sclerosis","volume":"36","author":"Wastowski","year":"2009","journal-title":"J Rheumatol"},{"issue":"7","key":"B24","doi-asserted-by":"publisher","first-page":"e1002178","DOI":"10.1371\/journal.pgen.1002178","article-title":"Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy","volume":"7","author":"Gorlova","year":"2011","journal-title":"PLoS Genet"},{"issue":"12","key":"B25","doi-asserted-by":"publisher","first-page":"3807","DOI":"10.1002\/art.24982","article-title":"HLA-DPB1 and DPB2 are genetic loci for systemic sclerosis: a genome-wide association study in Koreans with replication in North Americans","volume":"60","author":"Zhou","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"1","key":"B26","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bbrc.2006.09.161","article-title":"A novel human gene ZNF415 with five isoforms inhibits AP-1- and p53-mediated transcriptional activity","volume":"351","author":"Cheng","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"B27","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1136\/ard.2009.111906","article-title":"Major histocompatibility complex (MHC) class II alleles, haplotypes and epitopes which confer susceptibility or protection in systemic sclerosis: analyses in 1300 Caucasian, African-American and Hispanic cases and 1000 controls","volume":"69","author":"Arnett","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"B28","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.3899\/jrheum.090421","article-title":"Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis","volume":"36","author":"Agarwal","year":"2009","journal-title":"J Rheumatol"},{"issue":"5","key":"B29","doi-asserted-by":"publisher","first-page":"e36870","DOI":"10.1371\/journal.pone.0036870","article-title":"Comparing HLA shared epitopes in French Caucasian patients with scleroderma","volume":"7","author":"Azzouz","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"B30","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1093\/rheumatology\/ker335","article-title":"Analysis of Class II human leucocyte antigens in Italian and Spanish systemic sclerosis","volume":"51","author":"Beretta","year":"2012","journal-title":"Rheumatology"},{"issue":"5","key":"B31","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1053\/sarh.2001.20268","article-title":"Systemic sclerosis in 3 US ethnic groups: a comparison of clinical, sociodemographic, serologic, and immunogenetic determinants","volume":"30","author":"Reveille","year":"2001","journal-title":"Semin Arthritis Rheum"},{"issue":"12","key":"B32","doi-asserted-by":"publisher","first-page":"2733","DOI":"10.3899\/jrheum.090377","article-title":"Association of HLA class II genes with systemic sclerosis in Spanish patients","volume":"36","author":"Simeon","year":"2009","journal-title":"J Rheumatol"},{"issue":"8","key":"B33","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.1007\/s00296-013-2686-3","article-title":"Association of HLA-DRB1*15:02 and DRB5*01:02 allele with the susceptibility to systemic sclerosis in Thai patients","volume":"33","author":"Louthrenoo","year":"2013","journal-title":"Rheumatol Int"},{"issue":"2","key":"B34","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1002\/art.30111","article-title":"HLA-DRB1*0407 and *1304 are risk factors for scleroderma renal crisis","volume":"63","author":"Nguyen","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"11","key":"B35","doi-asserted-by":"publisher","first-page":"3447","DOI":"10.1002\/art.24885","article-title":"BANK1 is a genetic risk factor for diffuse cutaneous systemic sclerosis and has additive effects with IRF5 and STAT4","volume":"60","author":"Dieude","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"4","key":"B36","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1136\/ard.2009.118174","article-title":"BANK1 functional variants are associated with susceptibility to diffuse systemic sclerosis in Caucasians","volume":"69","author":"Rueda","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"B37","first-page":"839","article-title":"Association study of B-cell marker gene polymorphisms in European Caucasian patients with systemic sclerosis","volume":"29","author":"Dawidowicz","year":"2011","journal-title":"Clin Exp Rheumatol"},{"issue":"1","key":"B38","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1002\/art.24183","article-title":"Association between the IRF5 rs2004640 functional polymorphism and systemic sclerosis: a new perspective for pulmonary fibrosis","volume":"60","author":"Dieude","year":"2009","journal-title":"Arthritis Rheum"},{"key":"B39","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1741-7015-11-9","article-title":"Genetics of scleroderma: implications for personalized medicine?","volume":"11","author":"Assassi","year":"2013","journal-title":"BMC Med"},{"issue":"4","key":"B40","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1177\/039463201402700420","article-title":"Association of the IRF5 SNP rs2004640 with systemic sclerosis in Han Chinese","volume":"27","author":"Wang","year":"2014","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"7","key":"B41","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1136\/annrheumdis-2011-200901","article-title":"IRF5 polymorphism predicts prognosis in patients with systemic sclerosis","volume":"71","author":"Sharif","year":"2012","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"B42","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1136\/annrheumdis-2012-202742","article-title":"New insight on the Xq28 association with systemic sclerosis","volume":"72","author":"Carmona","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"B43","doi-asserted-by":"publisher","first-page":"987","DOI":"10.3899\/jrheum.091163","article-title":"Phenotype-haplotype correlation of IRF5 in systemic sclerosis: role of 2 haplotypes in disease severity","volume":"37","author":"Dieude","year":"2010","journal-title":"J Rheumatol"},{"issue":"2","key":"B44","doi-asserted-by":"publisher","first-page":"4473","DOI":"10.4238\/2014.June.16.6","article-title":"Association between IRF5 polymorphisms and autoimmune diseases: a meta-analysis","volume":"13","author":"Tang","year":"2014","journal-title":"Genet Mol Res"},{"issue":"6","key":"B45","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1002\/art.24600","article-title":"Association of a functional polymorphism in the IRF5 region with systemic sclerosis in a Japanese population","volume":"60","author":"Ito","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"5","key":"B46","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1186\/s13075-014-0438-8","article-title":"An Immunochip-based interrogation of scleroderma susceptibility variants identifies a novel association at DNASE1L3","volume":"16","author":"Zochling","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"19","key":"B47","doi-asserted-by":"publisher","first-page":"4021","DOI":"10.1093\/hmg\/ddt248","article-title":"A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci","volume":"22","author":"Martin","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"6","key":"B48","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1097\/BOR.0b013e328358575b","article-title":"The genetics of scleroderma: looking into the postgenomic era","volume":"24","author":"Mayes","year":"2012","journal-title":"Curr Opin Rheumatol"},{"issue":"5","key":"B49","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1038\/ng.565","article-title":"Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus","volume":"42","author":"Radstake","year":"2010","journal-title":"Nat Genet"},{"issue":"11","key":"B50","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1093\/hmg\/ddp119","article-title":"The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype","volume":"18","author":"Rueda","year":"2009","journal-title":"Hum Mol Genet"},{"issue":"8","key":"B51","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1136\/ard.2009.111310","article-title":"Association of STAT4 polymorphism with systemic sclerosis in a Japanese population","volume":"68","author":"Tsuchiya","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"B52","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/039463201302600220","article-title":"STAT4 is a genetic risk factor for systemic sclerosis in a Chinese population","volume":"26","author":"Yi","year":"2013","journal-title":"Int J Immunopathol Pharmacol"},{"issue":"12","key":"B53","doi-asserted-by":"publisher","first-page":"3794","DOI":"10.1002\/art.24958","article-title":"Polymorphisms in TBX21 and STAT4 increase the risk of systemic sclerosis: evidence of possible gene-gene interaction and alterations in Th1\/Th2 cytokines","volume":"60","author":"Gourh","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"9","key":"B54","doi-asserted-by":"publisher","first-page":"8873","DOI":"10.1007\/s11033-012-1754-1","article-title":"Association of STAT4 rs7574865 polymorphism with autoimmune diseases: a meta-analysis","volume":"39","author":"Liang","year":"2012","journal-title":"Mol Biol Rep"},{"issue":"12","key":"B55","doi-asserted-by":"publisher","first-page":"3945","DOI":"10.1002\/art.22196","article-title":"Association of the PTPN22 R620W polymorphism with anti-topoisomerase I- and anticentromere antibody-positive systemic sclerosis","volume":"54","author":"Gourh","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"3","key":"B56","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1007\/s11033-011-1074-x","article-title":"The association between the PTPN22 C1858T polymorphism and systemic sclerosis: a meta-analysis","volume":"39","author":"Lee","year":"2012","journal-title":"Mol Biol Rep"},{"issue":"3","key":"B57","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1136\/ard.2010.130138","article-title":"Analysis of the influence of PTPN22 gene polymorphisms in systemic sclerosis","volume":"70","author":"Diaz-Gallo","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"B58","doi-asserted-by":"publisher","first-page":"2183","DOI":"10.1002\/art.23601","article-title":"The PTPN22 620W allele confers susceptibility to systemic sclerosis: findings of a large case-control study of European Caucasians and a meta-analysis","volume":"58","author":"Dieude","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"3","key":"B59","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1136\/ard.2009.116434","article-title":"Association of TNFSF4 (OX40L) polymorphisms with susceptibility to systemic sclerosis","volume":"69","author":"Gourh","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"B60","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1136\/ard.2010.141838","article-title":"A replication study confirms the association of TNFSF4 (OX40L) polymorphisms with systemic sclerosis in a large European cohort","volume":"70","author":"Bossini-Castillo","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"B61","doi-asserted-by":"publisher","first-page":"997","DOI":"10.3899\/jrheum.111270","article-title":"Independent replication and meta analysis of association studies establish TNFSF4 as a susceptibility gene preferentially associated with the subset of anticentromere-positive patients with systemic sclerosis","volume":"39","author":"Coustet","year":"2012","journal-title":"J Rheumatol"},{"issue":"7","key":"B62","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1002\/art.30379","article-title":"C8orf13-BLK is a genetic risk locus for systemic sclerosis and has additive effects with BANK1: results from a large French cohort and meta-analysis","volume":"63","author":"Coustet","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"2","key":"B63","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/j.jaut.2009.08.014","article-title":"Association of the C8orf13-BLK region with systemic sclerosis in North-American and European populations","volume":"34","author":"Gourh","year":"2010","journal-title":"J Autoimmun"},{"issue":"3","key":"B64","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1002\/art.27303","article-title":"Association of the FAM167A-BLK region with systemic sclerosis","volume":"62","author":"Ito","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"7","key":"B65","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1136\/annrheumdis-2012-202357","article-title":"Implication of IL-2\/IL-21 region in systemic sclerosis genetic susceptibility","volume":"72","author":"Diaz-Gallo","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"B66","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/gene.2011.72","article-title":"The autoimmune disease-associated IL2RA locus is involved in the clinical manifestations of systemic sclerosis","volume":"13","author":"Martin","year":"2012","journal-title":"Genes Immun"},{"issue":"4","key":"B67","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1093\/hmg\/ddr522","article-title":"A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations","volume":"21","author":"Bossini-Castillo","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"2","key":"B68","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/art.37777","article-title":"PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population","volume":"65","author":"Terao","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"9","key":"B69","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1136\/ard.2010.147009","article-title":"Independent replication establishes the CD247 gene as a genetic systemic sclerosis susceptibility factor","volume":"70","author":"Dieude","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"12","key":"B70","doi-asserted-by":"publisher","first-page":"2825","DOI":"10.1093\/hmg\/dds099","article-title":"Identification of CSK as a systemic sclerosis genetic risk factor through genome wide association study follow-up","volume":"21","author":"Martin","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"12","key":"B71","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.1002\/art.38870","article-title":"Identification of IL12RB1 as a novel systemic sclerosis susceptibility locus","volume":"66","author":"Lopez-Isac","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"12","key":"B72","doi-asserted-by":"publisher","first-page":"3979","DOI":"10.1002\/art.30640","article-title":"Evidence of the contribution of the X chromosome to systemic sclerosis susceptibility: association with the functional IRAK1 196Phe\/532Ser haplotype","volume":"63","author":"Dieude","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"7","key":"B73","doi-asserted-by":"publisher","first-page":"e1002091","DOI":"10.1371\/journal.pgen.1002091","article-title":"Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis","volume":"7","author":"Allanore","year":"2011","journal-title":"PLoS Genet"},{"issue":"4","key":"B74","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1136\/annrheumdis-2012-201888","article-title":"Confirmation of TNIP1 but not RHOB and PSORS1C1 as systemic sclerosis risk factors in a large independent replication study","volume":"72","author":"Bossini-Castillo","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"B75","doi-asserted-by":"publisher","first-page":"3661","DOI":"10.1002\/art.22179","article-title":"Macrophage migration inhibitory factor promoter polymorphisms and the clinical expression of scleroderma","volume":"54","author":"Wu","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"2","key":"B76","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/sji.12020","article-title":"Interleukin-10 gene promoter and NFKB1 promoter insertion\/deletion polymorphisms in systemic sclerosis","volume":"77","author":"Salim","year":"2013","journal-title":"Scand J Immunol"},{"issue":"2","key":"B77","doi-asserted-by":"publisher","first-page":"R85","DOI":"10.1186\/ar3809","article-title":"A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis","volume":"14","author":"Bossini-Castillo","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"B78","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1038\/ng2068","article-title":"Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes","volume":"39","author":"Todd","year":"2007","journal-title":"Nat Genet"},{"issue":"1","key":"B79","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/gene.2008.82","article-title":"CD226 Gly307Ser association with multiple autoimmune diseases","volume":"10","author":"Hafler","year":"2009","journal-title":"Genes Immun"},{"issue":"4","key":"B80","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1002\/art.30204","article-title":"Association of the CD226 Ser(307) variant with systemic sclerosis: evidence of a contribution of costimulation pathways in systemic sclerosis pathogenesis","volume":"63","author":"Dieude","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"6","key":"B81","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1097\/BOR.0b013e32833de1a7","article-title":"Peroxisome proliferator-activated receptor gamma: innate protection from excessive fibrogenesis and potential therapeutic target in systemic sclerosis","volume":"22","author":"Wei","year":"2010","journal-title":"Curr Opin Rheumatol"},{"issue":"2","key":"B82","doi-asserted-by":"publisher","first-page":"519","DOI":"10.2353\/ajpath.2009.080574","article-title":"Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma","volume":"174","author":"Wu","year":"2009","journal-title":"Am J Pathol"},{"issue":"1","key":"B83","doi-asserted-by":"publisher","first-page":"R6","DOI":"10.1186\/ar4432","article-title":"A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility","volume":"16","author":"Lopez-Isac","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"B84","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.autrev.2011.07.007","article-title":"Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases","volume":"11","author":"Anaya","year":"2012","journal-title":"Autoimmun Rev"},{"issue":"12","key":"B85","doi-asserted-by":"publisher","first-page":"2598","DOI":"10.3899\/jrheum.110685","article-title":"A nonsynonymous functional variant of the ITGAM gene is not involved in biopsy-proven giant cell arteritis","volume":"38","author":"Carmona","year":"2011","journal-title":"J Rheumatol"},{"issue":"8","key":"B86","doi-asserted-by":"publisher","first-page":"2746","DOI":"10.1002\/art.34490","article-title":"Brief report: candidate gene study in systemic sclerosis identifies a rare and functional variant of the TNFAIP3 locus as a risk factor for polyautoimmunity","volume":"64","author":"Koumakis","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"1","key":"B87","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1136\/annrheumdis-2011-200275","article-title":"Novel identification of the IRF7 region as an anticentromere autoantibody propensity locus in systemic sclerosis","volume":"71","author":"Carmona","year":"2012","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"B88","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1136\/ard.2008.096719","article-title":"The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype","volume":"68","author":"Rueda","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"B89","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1136\/ard.2007.072819","article-title":"Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis","volume":"67","author":"Farago","year":"2008","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"B90","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1002\/art.33325","article-title":"A rare polymorphism in the gene for toll-like receptor 2 is associated with systemic sclerosis phenotype and increases the production of inflammatory mediators","volume":"64","author":"Broen","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"1","key":"B91","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/art.30101","article-title":"A genetic variation located in the promoter region of the UPAR (CD87) gene is associated with the vascular complications of systemic sclerosis","volume":"63","author":"Manetti","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"9","key":"B92","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.3899\/jrheum.100237","article-title":"Association of a functional polymorphism in the matrix metalloproteinase-12 promoter region with systemic sclerosis in an Italian population","volume":"37","author":"Manetti","year":"2010","journal-title":"J Rheumatol"},{"issue":"6","key":"B93","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1007\/s10875-013-9896-z","article-title":"MicroRNA-21 in scleroderma fibrosis and its function in TGF-beta-regulated fibrosis-related genes expression","volume":"33","author":"Zhu","year":"2013","journal-title":"J Clin Immunol"},{"issue":"3","key":"B94","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s10875-011-9647-y","article-title":"MicroRNA expression abnormalities in limited cutaneous scleroderma and diffuse cutaneous scleroderma","volume":"32","author":"Zhu","year":"2012","journal-title":"J Clin Immunol"},{"issue":"11","key":"B95","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1093\/rheumatology\/ket254","article-title":"Alteration of circulating miRNAs in SSc: miR-30b regulates the expression of PDGF receptor beta","volume":"52","author":"Tanaka","year":"2013","journal-title":"Rheumatology"},{"issue":"1","key":"B96","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jdermsci.2010.11.007","article-title":"Circulating miR-29a levels in patients with scleroderma spectrum disorder","volume":"61","author":"Kawashita","year":"2011","journal-title":"J Dermatol Sci"},{"issue":"6","key":"B97","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1002\/art.27443","article-title":"MicroRNA-29, a key regulator of collagen expression in systemic sclerosis","volume":"62","author":"Maurer","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"12","key":"B98","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1111\/exd.12245","article-title":"Hair miR-29a levels are decreased in patients with scleroderma","volume":"22","author":"Takemoto","year":"2013","journal-title":"Exp Dermatol"},{"issue":"7","key":"B99","doi-asserted-by":"publisher","first-page":"3323","DOI":"10.4049\/jimmunol.1100876","article-title":"TGF-beta-mediated downregulation of microRNA-196a contributes to the constitutive upregulated type I collagen expression in scleroderma dermal fibroblasts","volume":"188","author":"Honda","year":"2012","journal-title":"J Immunol"},{"issue":"2","key":"B100","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jdermsci.2013.06.018","article-title":"Detection of hair-microRNAs as the novel potent biomarker: evaluation of the usefulness for the diagnosis of scleroderma","volume":"72","author":"Wang","year":"2013","journal-title":"J Dermatol Sci"},{"issue":"1","key":"B101","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1016\/j.ajpath.2012.09.023","article-title":"miR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin beta3","volume":"182","author":"Honda","year":"2013","journal-title":"Am J Pathol"},{"issue":"1","key":"B102","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1007\/s00403-012-1287-4","article-title":"microRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma","volume":"305","author":"Etoh","year":"2013","journal-title":"Arch Dermatol Res"},{"issue":"2","key":"B103","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.ajpath.2011.10.030","article-title":"Increased accumulation of extracellular thrombospondin-2 due to low degradation activity stimulates type I collagen expression in scleroderma fibroblasts","volume":"180","author":"Kajihara","year":"2012","journal-title":"Am J Pathol"},{"issue":"8","key":"B104","doi-asserted-by":"publisher","first-page":"3905","DOI":"10.4049\/jimmunol.1200822","article-title":"The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma","volume":"190","author":"Makino","year":"2013","journal-title":"J Immunol"},{"issue":"8","key":"B105","doi-asserted-by":"publisher","first-page":"3573","DOI":"10.4049\/jimmunol.1100591","article-title":"Impaired IL-17 signaling pathway contributes to the increased collagen expression in scleroderma fibroblasts","volume":"188","author":"Nakashima","year":"2012","journal-title":"J Immunol"},{"issue":"1","key":"B106","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/j.1365-2230.2011.04158.x","article-title":"Circulating miR-142-3p levels in patients with systemic sclerosis","volume":"37","author":"Makino","year":"2012","journal-title":"Clin Exp Dermatol"},{"issue":"9","key":"B107","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1093\/rheumatology\/kes120","article-title":"microRNA-92a expression in the sera and dermal fibroblasts increases in patients with scleroderma","volume":"51","author":"Sing","year":"2012","journal-title":"Rheumatology"},{"issue":"3","key":"B108","first-page":"210","article-title":"[HLA typing in systemic sclerosis]","volume":"53","author":"Favalli","year":"2001","journal-title":"Reumatismo"},{"issue":"51","key":"B109","first-page":"134","article-title":"The genetics of systemic sclerosis","volume":"10","author":"Agarwal","year":"2010","journal-title":"Discov Med"},{"issue":"10","key":"B110","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1002\/art.24734","article-title":"Clinical and genetic factors predictive of mortality in early systemic sclerosis","volume":"61","author":"Assassi","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"8","key":"B111","doi-asserted-by":"publisher","first-page":"1622","DOI":"10.3899\/jrheum.110071","article-title":"Anti-fibrillarin antibody in African American patients with systemic sclerosis: immunogenetics, clinical features, and survival analysis","volume":"38","author":"Sharif","year":"2011","journal-title":"J Rheumatol"},{"issue":"1","key":"B112","doi-asserted-by":"publisher","first-page":"e87363","DOI":"10.1371\/journal.pone.0087363","article-title":"Association of HLA-DPB1 with scleroderma and its clinical features in Chinese population","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"key":"B113","doi-asserted-by":"publisher","first-page":"43","DOI":"10.2174\/1874312901408010043","article-title":"Lack of association of the CD247 SNP rs2056626 with systemic sclerosis in Han Chinese","volume":"8","author":"Wang","year":"2014","journal-title":"Open Rheumatol J"},{"issue":"2","key":"B114","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/art.27224","article-title":"Systemic sclerosis and lupus: points in an interferon-mediated continuum","volume":"62","author":"Assassi","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"2","key":"B115","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1093\/hmg\/ddu455","article-title":"The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share","volume":"24","author":"Kottyan","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"6","key":"B116","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1183\/09031936.05.00045705","article-title":"Autoimmunity and pulmonary hypertension: a perspective","volume":"26","author":"Nicolls","year":"2005","journal-title":"Eur Respir J"},{"issue":"4","key":"B117","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1161\/CIRCRESAHA.114.302221","article-title":"Evidence for the involvement of type I interferon in pulmonary arterial hypertension","volume":"114","author":"George","year":"2014","journal-title":"Circ Res"},{"issue":"6","key":"B118","doi-asserted-by":"publisher","first-page":"1785","DOI":"10.1007\/s10620-010-1220-7","article-title":"Irreversible pulmonary hypertension associated with the use of interferon alpha for chronic hepatitis C","volume":"55","author":"Dhillon","year":"2010","journal-title":"Dig Dis Sci"},{"issue":"7","key":"B119","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1177\/1352458509104593","article-title":"Pulmonary arterial hypertension associated with interferon beta treatment for multiple sclerosis: a case report","volume":"15","author":"Ledinek","year":"2009","journal-title":"Mult Scler"},{"issue":"5","key":"B120","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1378\/chest.100.5.1268","article-title":"Primary pulmonary hypertension in HIV infection","volume":"100","author":"Speich","year":"1991","journal-title":"Chest"},{"issue":"11","key":"B121","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1136\/ard.62.11.1088","article-title":"Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach","volume":"62","author":"Mukerjee","year":"2003","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"B122","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1136\/ard.2009.121400","article-title":"Type I interferon system activation and association with disease manifestations in systemic sclerosis","volume":"69","author":"Eloranta","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"B123","doi-asserted-by":"publisher","first-page":"1718","DOI":"10.1002\/art.30318","article-title":"Interferon and alternative activation of monocyte\/macrophages in systemic sclerosis-associated pulmonary arterial hypertension","volume":"63","author":"Christmann","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"5","key":"B124","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1007\/s00281-014-0440-x","article-title":"Chance, genetics, and the heterogeneity of disease and pathogenesis in systemic lupus erythematosus","volume":"36","author":"Marion","year":"2014","journal-title":"Semin Immunopathol"},{"issue":"3","key":"B125","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1002\/art.22382","article-title":"A macrophage marker, Siglec-1, is increased on circulating monocytes in patients with systemic sclerosis and induced by type I interferons and toll-like receptor agonists","volume":"56","author":"York","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"8","key":"B126","doi-asserted-by":"publisher","first-page":"e12106","DOI":"10.1371\/journal.pone.0012106","article-title":"Limited systemic sclerosis patients with pulmonary arterial hypertension show biomarkers of inflammation and vascular injury","volume":"5","author":"Pendergrass","year":"2010","journal-title":"PLoS One"},{"issue":"2","key":"B127","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1002\/art.27222","article-title":"Confirmation of an association between rs6822844 at the Il2-Il21 region and multiple autoimmune diseases: evidence of a general susceptibility locus","volume":"62","author":"Maiti","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"11","key":"B128","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1136\/ard.2010.148874","article-title":"Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis","volume":"70","author":"Carmona","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"B129","first-page":"321","article-title":"Lack of association of the PTPN22 gene polymorphism R620W with systemic sclerosis","volume":"24","author":"Balada","year":"2006","journal-title":"Clin Exp Rheumatol"},{"issue":"9","key":"B130","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1136\/ard.2005.048181","article-title":"Lack of association between the protein tyrosine phosphatase non-receptor 22 (PTPN22)*620W allele and systemic sclerosis in the French Caucasian population","volume":"65","author":"Wipff","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"B131","doi-asserted-by":"publisher","first-page":"450","DOI":"10.3389\/fgene.2014.00450","article-title":"Lupus risk variants in the PXK locus alter B-cell receptor internalization","volume":"5","author":"Vaughn","year":"2014","journal-title":"Front Genet"},{"issue":"11","key":"B132","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1039\/b606246f","article-title":"Structure, function, and regulation of STAT proteins","volume":"2","author":"Lim","year":"2006","journal-title":"Mol Biosyst"},{"key":"B133","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1111\/j.0105-2896.2004.00211.x","article-title":"Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4","volume":"202","author":"Watford","year":"2004","journal-title":"Immunol Rev"},{"issue":"6","key":"B134","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1023\/A:1027388508570","article-title":"Advances in the understanding of cytokine signal transduction: the role of Jaks and STATs in immunoregulation and the pathogenesis of immunodeficiency","volume":"17","author":"O\u00e2\u20ac\u2122Shea","year":"1997","journal-title":"J Clin Immunol"},{"issue":"6587","key":"B135","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/382174a0","article-title":"Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice","volume":"382","author":"Kaplan","year":"1996","journal-title":"Nature"},{"issue":"3","key":"B136","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1385\/IR:31:3:231","article-title":"STAT4: a critical regulator of inflammation in vivo","volume":"31","author":"Kaplan","year":"2005","journal-title":"Immunol Res"},{"issue":"3","key":"B137","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1002\/art.30171","article-title":"Inactivation of the transcription factor STAT-4 prevents inflammation-driven fibrosis in animal models of systemic sclerosis","volume":"63","author":"Avouac","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"11","key":"B138","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1093\/rheumatology\/ker259","article-title":"Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population","volume":"50","author":"Bossini-Castillo","year":"2011","journal-title":"Rheumatology"},{"issue":"6 Suppl 86","key":"B139","first-page":"S","article-title":"The expression profile of the toll-like receptor family in scleroderma dermal fibroblasts","volume":"32","author":"Sakoguchi","year":"2014","journal-title":"Clin Exp Rheumatol"},{"issue":"Suppl 2","key":"B140","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1365-2362.2009.02117.x","article-title":"Endothelin receptor selectivity: evidence from in vitro and pre-clinical models of scleroderma","volume":"39","author":"Shiwen","year":"2009","journal-title":"Eur J Clin Invest"},{"issue":"5","key":"B141","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1006\/phrs.1997.0246","article-title":"Highlights on endothelins: a review","volume":"36","author":"Ortega Mateo","year":"1997","journal-title":"Pharmacol Res"},{"issue":"12","key":"B142","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1038\/ncprheum0346","article-title":"Mechanisms of disease: the role of immune cells in the pathogenesis of systemic sclerosis","volume":"2","author":"Sakkas","year":"2006","journal-title":"Nat Clin Pract Rheumatol"},{"issue":"14","key":"B143","doi-asserted-by":"publisher","first-page":"5518","DOI":"10.1128\/MCB.00625-06","article-title":"Constitutive ALK5-independent c-Jun N-terminal kinase activation contributes to endothelin-1 overexpression in pulmonary fibrosis: evidence of an autocrine endothelin loop operating through the endothelin A and B receptors","volume":"26","author":"Shi-Wen","year":"2006","journal-title":"Mol Cell Biol"},{"issue":"4","key":"B144","doi-asserted-by":"publisher","first-page":"R104","DOI":"10.1186\/ar1984","article-title":"NOS2 polymorphisms associated with the susceptibility to pulmonary arterial hypertension with systemic sclerosis: contribution to the transcriptional activity","volume":"8","author":"Kawaguchi","year":"2006","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"B145","doi-asserted-by":"publisher","first-page":"R273","DOI":"10.1186\/ar4124","article-title":"KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor","volume":"14","author":"Bossini-Castillo","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"B146","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/nrm2868","article-title":"MicroRNA control of signal transduction","volume":"11","author":"Inui","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"B147","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s00109-013-1043-z","article-title":"MicroRNA in immunity and autoimmunity","volume":"91","author":"Zhu","year":"2013","journal-title":"J Mol Med"},{"issue":"5","key":"B148","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.gpb.2012.08.005","article-title":"miRT: a database of validated transcription start sites of human microRNAs","volume":"10","author":"Bhattacharyya","year":"2012","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu155","article-title":"Epigenetics, the holy grail in the pathogenesis of systemic sclerosis","author":"Altorok","year":"2014","journal-title":"Rheumatology"},{"issue":"7","key":"B150","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/exd.12173","article-title":"Expression analysis of multiple microRNAs in each patient with scleroderma","volume":"22","author":"Koba","year":"2013","journal-title":"Exp Dermatol"},{"issue":"2","key":"B151","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1165\/rcmb.2010-0323OC","article-title":"miR-29 is a major regulator of genes associated with pulmonary fibrosis","volume":"45","author":"Cushing","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"35","key":"B152","doi-asserted-by":"publisher","first-page":"13027","DOI":"10.1073\/pnas.0805038105","article-title":"Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis","volume":"105","author":"van Rooij","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"B153","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1038\/mt.2012.36","article-title":"miR-29 inhibits bleomycin-induced pulmonary fibrosis in mice","volume":"20","author":"Xiao","year":"2012","journal-title":"Mol Ther"},{"issue":"1","key":"B154","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"issue":"5","key":"B155","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1042\/CS20130367","article-title":"Innate immunity in systemic sclerosis pathogenesis","volume":"126","author":"O\u00e2\u20ac\u2122Reilly","year":"2014","journal-title":"Clin Sci"},{"issue":"5396","key":"B156","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"issue":"13","key":"B157","doi-asserted-by":"publisher","first-page":"10229","DOI":"10.1074\/jbc.M100099200","article-title":"The extra domain A of fibronectin activates toll-like receptor 4","volume":"276","author":"Okamura","year":"2001","journal-title":"J Biol Chem"},{"issue":"9","key":"B158","doi-asserted-by":"publisher","first-page":"7370","DOI":"10.1074\/jbc.M306793200","article-title":"Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein","volume":"279","author":"Park","year":"2004","journal-title":"J Biol Chem"},{"issue":"9","key":"B159","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1038\/nm1638","article-title":"Mrp8 and Mrp14 are endogenous activators of toll-like receptor 4, promoting lethal, endotoxin-induced shock","volume":"13","author":"Vogl","year":"2007","journal-title":"Nat Med"},{"issue":"1","key":"B160","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.ajpath.2012.09.007","article-title":"Toll-like receptor 4 signaling augments transforming growth factor-beta responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma","volume":"182","author":"Bhattacharyya","year":"2013","journal-title":"Am J Pathol"},{"issue":"2","key":"B161","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s10875-008-9252-x","article-title":"Clinical significance of serum HMGB-1 and sRAGE levels in systemic sclerosis: association with disease severity","volume":"29","author":"Yoshizaki","year":"2009","journal-title":"J Clin Immunol"},{"issue":"6","key":"B162","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1136\/annrheumdis-2012-203095","article-title":"Heat shock protein 90 (Hsp90) inhibition targets canonical TGF-beta signalling to prevent fibrosis","volume":"73","author":"Tomcik","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"9","key":"B163","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1136\/ard.44.9.614","article-title":"Raised serum hyaluronate levels in scleroderma: an effect of growth factor induced activation of connective tissue cells?","volume":"44","author":"Engstrom-Laurent","year":"1985","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"B164","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nri1391","article-title":"Toll-like receptor signalling","volume":"4","author":"Akira","year":"2004","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"B165","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"issue":"7","key":"B166","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1002\/art.23486","article-title":"Induction of interferon-alpha by scleroderma sera containing autoantibodies to topoisomerase I: association of higher interferon-alpha activity with lung fibrosis","volume":"58","author":"Kim","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"7","key":"B167","doi-asserted-by":"crossref","first-page":"3130","DOI":"10.4049\/jimmunol.157.7.3130","article-title":"Regulation of sialoadhesin expression on rat macrophages. Induction by glucocorticoids and enhancement by IFN-beta, IFN-gamma, IL-4, and lipopolysaccharide","volume":"157","author":"van den Berg","year":"1996","journal-title":"J Immunol"},{"issue":"3","key":"B168","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/art.38288","article-title":"Association of Interferon- and transforming growth factor beta-regulated genes and macrophage activation with systemic sclerosis-related progressive lung fibrosis","volume":"66","author":"Christmann","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"B169","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1309\/AJCPT94JVWIHBKRD","article-title":"Diagnostic usefulness of p16\/CDKN2A FISH in distinguishing between sarcomatoid mesothelioma and fibrous pleuritis","volume":"139","author":"Wu","year":"2013","journal-title":"Am J Clin Pathol"},{"key":"B170","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1146\/annurev.immunol.26.021607.090400","article-title":"The IRF family transcription factors in immunity and oncogenesis","volume":"26","author":"Tamura","year":"2008","journal-title":"Annu Rev Immunol"},{"issue":"7","key":"B171","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1007\/s00439-011-1137-z","article-title":"Unraveling the genetic component of systemic sclerosis","volume":"131","author":"Martin","year":"2012","journal-title":"Hum Genet"},{"issue":"5","key":"B172","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/ng1782","article-title":"A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus","volume":"38","author":"Graham","year":"2006","journal-title":"Nat Genet"},{"issue":"16","key":"B173","doi-asserted-by":"publisher","first-page":"6758","DOI":"10.1073\/pnas.0701266104","article-title":"Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus","volume":"104","author":"Graham","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"B174","doi-asserted-by":"publisher","first-page":"e54419","DOI":"10.1371\/journal.pone.0054419","article-title":"The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis","volume":"8","author":"Carmona","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"B175","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1093\/rheumatology\/kei244","article-title":"Signatures of differentially regulated interferon gene expression and vasculotrophism in the peripheral blood cells of systemic sclerosis patients","volume":"45","author":"Tan","year":"2006","journal-title":"Rheumatology"},{"issue":"4","key":"B176","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1136\/ard.2010.131243","article-title":"NLRP1 influences the systemic sclerosis phenotype: a new clue for the contribution of innate immunity in systemic sclerosis-related fibrosing alveolitis pathogenesis","volume":"70","author":"Dieude","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"B177","doi-asserted-by":"publisher","first-page":"3563","DOI":"10.1002\/art.30568","article-title":"The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis","volume":"63","author":"Artlett","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"10","key":"B178","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1164\/rccm.200808-1274OC","article-title":"Uric acid is a danger signal activating NALP3 inflammasome in lung injury inflammation and fibrosis","volume":"179","author":"Gasse","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"B179","first-page":"5","article-title":"Expression of NLRP3 inflammasome, cytokines and vascular mediators in the skin of systemic sclerosis patients","volume":"17","author":"Martinez-Godinez","year":"2015","journal-title":"Isr Med Assoc J"},{"issue":"2","key":"B180","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.immuni.2014.07.006","article-title":"MHC-II: a mutual support system for ILCs and T cells?","volume":"41","author":"Maizels","year":"2014","journal-title":"Immunity"},{"issue":"35","key":"B181","doi-asserted-by":"publisher","first-page":"12835","DOI":"10.1073\/pnas.1406908111","article-title":"Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses","volume":"111","author":"von Burg","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"B182","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1038\/nri3365","article-title":"Innate lymphoid cells \u00e2\u20ac\u201c a proposal for uniform nomenclature","volume":"13","author":"Spits","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"B183","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.immuni.2014.06.016","article-title":"MHCII-mediated dialog between group 2 innate lymphoid cells and CD4(+) T cells potentiates type 2 immunity and promotes parasitic helminth expulsion","volume":"41","author":"Oliphant","year":"2014","journal-title":"Immunity"},{"issue":"4","key":"B184","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.immuni.2012.10.003","article-title":"Innate lymphoid cell interactions with microbiota: implications for intestinal health and disease","volume":"37","author":"Sonnenberg","year":"2012","journal-title":"Immunity"},{"key":"B185","doi-asserted-by":"publisher","first-page":"857143","DOI":"10.1155\/2014\/857143","article-title":"The role of dendritic cells in tissue-specific autoimmunity","volume":"2014","author":"Mbongue","year":"2014","journal-title":"J Immunol Res"},{"issue":"1","key":"B186","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/imr.12032","article-title":"Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsets","volume":"252","author":"Yamane","year":"2013","journal-title":"Immunol Rev"},{"issue":"1","key":"B187","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1136\/ard.2007.082495","article-title":"Autologous stem cell transplantation improves microcirculation in systemic sclerosis","volume":"68","author":"Miniati","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"B188","doi-asserted-by":"publisher","first-page":"e1452","DOI":"10.1371\/journal.pone.0001452","article-title":"Capillary regeneration in scleroderma: stem cell therapy reverses phenotype?","volume":"3","author":"Fleming","year":"2008","journal-title":"PLoS One"},{"issue":"2\u00e2\u20ac\u201c4","key":"B189","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3109\/08830189509056716","article-title":"Role of T cells and cytokines in effecting fibrosis","volume":"12","author":"Postlethwaite","year":"1995","journal-title":"Int Rev Immunol"},{"issue":"10","key":"B190","doi-asserted-by":"publisher","first-page":"3459","DOI":"10.1002\/art.22927","article-title":"Presence of CD4+CD8+ double-positive T cells with very high interleukin-4 production potential in lesional skin of patients with systemic sclerosis","volume":"56","author":"Parel","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"6","key":"B191","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/S1074-7613(00)70060-4","article-title":"DNAM-1, a novel adhesion molecule involved in the cytolytic function of T lymphocytes","volume":"4","author":"Shibuya","year":"1996","journal-title":"Immunity"},{"issue":"2","key":"B192","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1002\/1529-0131(199802)41:2327::AID-ART173.3.CO;2-J","article-title":"Circulating Vdelta1+ T cells are activated and accumulate in the skin of systemic sclerosis patients","volume":"41","author":"Giacomelli","year":"1998","journal-title":"Arthritis Rheum"},{"issue":"7","key":"B193","doi-asserted-by":"publisher","first-page":"3649","DOI":"10.4049\/jimmunol.168.7.3649","article-title":"Oligoclonal T cell expansion in the skin of patients with systemic sclerosis","volume":"168","author":"Sakkas","year":"2002","journal-title":"J Immunol"},{"issue":"4","key":"B194","first-page":"601","article-title":"Evidence for cell-mediated immunity to collagen in progressive systemic sclerosis","volume":"88","author":"Stuart","year":"1976","journal-title":"J Lab Clin Med"},{"issue":"4","key":"B195","doi-asserted-by":"publisher","first-page":"R136","DOI":"10.1186\/ar2025","article-title":"Characterisation of the immune response to type I collagen in scleroderma","volume":"8","author":"Warrington","year":"2006","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"B196","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.jaut.2006.03.004","article-title":"T cell lines from systemic sclerosis patients and healthy controls recognize multiple epitopes on DNA topoisomerase I","volume":"26","author":"Hu","year":"2006","journal-title":"J Autoimmun"},{"issue":"4","key":"B197","doi-asserted-by":"publisher","first-page":"233","DOI":"10.3109\/08916939708994732","article-title":"Humoral and cellular immune response to elastin in patients with systemic sclerosis","volume":"25","author":"Daskalova","year":"1997","journal-title":"Autoimmunity"},{"issue":"7","key":"B198","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1002\/art.1780280708","article-title":"Cellular immunity to collagen and laminin in scleroderma","volume":"28","author":"Huffstutter","year":"1985","journal-title":"Arthritis Rheum"},{"issue":"5","key":"B199","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1002\/1529-0131(200005)43:51054::AID-ANR143.0.CO;2-W","article-title":"Induction of immune tolerance to human type I collagen in patients with systemic sclerosis by oral administration of bovine type I collagen","volume":"43","author":"McKown","year":"2000","journal-title":"Arthritis Rheum"},{"issue":"8","key":"B200","doi-asserted-by":"publisher","first-page":"2713","DOI":"10.1002\/art.20361","article-title":"Dosage effects of orally administered bovine type I collagen on immune function in patients with systemic sclerosis","volume":"50","author":"Carbone","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"6","key":"B201","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1002\/art.23501","article-title":"A multicenter, randomized, double-blind, placebo-controlled trial of oral type I collagen treatment in patients with diffuse cutaneous systemic sclerosis: I. oral type I collagen does not improve skin in all patients, but may improve skin in late-phase disease","volume":"58","author":"Postlethwaite","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"1","key":"B202","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s11926-999-0019-z","article-title":"Microchimerism and scleroderma","volume":"1","author":"Nelson","year":"1999","journal-title":"Curr Rheumatol Rep"},{"issue":"3 Suppl 33","key":"B203","first-page":"S28","article-title":"Gamma\/delta T cells in placenta and skin: their different functions may support the paradigm of microchimerism in systemic sclerosis","volume":"22","author":"Giacomelli","year":"2004","journal-title":"Clin Exp Rheumatol"},{"issue":"5","key":"B204","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1080\/08820130802205886","article-title":"Autoimmune disease during pregnancy and the microchimerism legacy of pregnancy","volume":"37","author":"Adams Waldorf","year":"2008","journal-title":"Immunol Invest"},{"issue":"2","key":"B205","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1002\/art.10049","article-title":"Th2-oriented profile of male offspring T cells present in women with systemic sclerosis and reactive with maternal major histocompatibility complex antigens","volume":"46","author":"Scaletti","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"6","key":"B206","doi-asserted-by":"publisher","first-page":"e5903","DOI":"10.1371\/journal.pone.0005903","article-title":"The pronounced Th17 profile in systemic sclerosis (SSc) together with intracellular expression of TGFbeta and IFNgamma distinguishes SSc phenotypes","volume":"4","author":"Radstake","year":"2009","journal-title":"PLoS One"},{"issue":"3","key":"B207","doi-asserted-by":"publisher","first-page":"205","DOI":"10.3109\/03009742.2010.528021","article-title":"Altered T-cell and regulatory cell repertoire in patients with diffuse cutaneous systemic sclerosis","volume":"40","author":"Papp","year":"2011","journal-title":"Scand J Rheumatol"},{"issue":"8","key":"B208","doi-asserted-by":"publisher","first-page":"1475","DOI":"10.1136\/ard.2009.116525","article-title":"Reduction of regulatory T cells in skin lesions but not in peripheral blood of patients with systemic scleroderma","volume":"70","author":"Klein","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"B209","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.cellimm.2009.12.009","article-title":"Regulatory T cells (CD4(+)CD25(bright)FoxP3(+)) expansion in systemic sclerosis correlates with disease activity and severity","volume":"261","author":"Slobodin","year":"2010","journal-title":"Cell Immunol"},{"issue":"3","key":"B210","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.clim.2011.01.013","article-title":"Alteration of Th17 and Treg cell subpopulations co-exist in patients affected with systemic sclerosis","volume":"139","author":"Fenoglio","year":"2011","journal-title":"Clin Immunol"},{"issue":"7","key":"B211","doi-asserted-by":"publisher","first-page":"1227","DOI":"10.1136\/annrheumdis-2011-200709","article-title":"Activated and resting regulatory T cell exhaustion concurs with high levels of interleukin-22 expression in systemic sclerosis lesions","volume":"71","author":"Mathian","year":"2012","journal-title":"Ann Rheum Dis"},{"issue":"7","key":"B212","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/ni.1743","article-title":"The receptor S1P1 overrides regulatory T cell-mediated immune suppression through Akt-mTOR","volume":"10","author":"Liu","year":"2009","journal-title":"Nat Immunol"},{"issue":"13","key":"B213","doi-asserted-by":"publisher","first-page":"2639","DOI":"10.1182\/blood-2009-05-220004","article-title":"Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40\/OX40L axis toward Th17-cell differentiation","volume":"114","author":"Piconese","year":"2009","journal-title":"Blood"},{"issue":"4","key":"B214","doi-asserted-by":"publisher","first-page":"168","DOI":"10.7150\/ijms.6.168","article-title":"Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis","volume":"6","author":"Tokumura","year":"2009","journal-title":"Int J Med Sci"},{"issue":"9","key":"B215","doi-asserted-by":"publisher","first-page":"5425","DOI":"10.4049\/jimmunol.178.9.5425","article-title":"Cutting edge: alternative signaling of Th17 cell development by sphingosine 1-phosphate","volume":"178","author":"Liao","year":"2007","journal-title":"J Immunol"},{"issue":"8","key":"B216","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/j.autrev.2011.02.002","article-title":"Serum 25-OH vitamin D concentrations are linked with various clinical aspects in patients with systemic sclerosis: a retrospective cohort study and review of the literature","volume":"10","author":"Arnson","year":"2011","journal-title":"Autoimmun Rev"},{"issue":"12","key":"B217","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1007\/s10067-010-1478-3","article-title":"Very low levels of vitamin D in systemic sclerosis patients","volume":"29","author":"Caramaschi","year":"2010","journal-title":"Clin Rheumatol"},{"issue":"9","key":"B218","doi-asserted-by":"publisher","first-page":"1924","DOI":"10.3899\/jrheum.081287","article-title":"Vitamin D deficiency and insufficiency in 2 independent cohorts of patients with systemic sclerosis","volume":"36","author":"Vacca","year":"2009","journal-title":"J Rheumatol"},{"issue":"3","key":"B219","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1111\/j.1365-3083.2008.02127.x","article-title":"The complex role of vitamin D in autoimmune diseases","volume":"68","author":"Szodoray","year":"2008","journal-title":"Scand J Immunol"},{"key":"B220","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1111\/nyas.12440","article-title":"Vitamin D effects on B cell function in autoimmunity","volume":"1317","author":"Rolf","year":"2014","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"B221","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/exd.12300","article-title":"Oral vitamin D increases the frequencies of CD38+ human B cells and ameliorates IL-17-producing T cells","volume":"23","author":"Drozdenko","year":"2014","journal-title":"Exp Dermatol"},{"issue":"5","key":"B222","doi-asserted-by":"publisher","first-page":"R221","DOI":"10.1186\/ar4060","article-title":"Restoration of regulatory and effector T cell balance and B cell homeostasis in systemic lupus erythematosus patients through vitamin D supplementation","volume":"14","author":"Terrier","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"51","key":"B223","first-page":"161","article-title":"A role for lysophosphatidic acid and sphingosine 1-phosphate in the pathogenesis of systemic sclerosis","volume":"10","author":"Pattanaik","year":"2010","journal-title":"Discov Med"},{"issue":"2","key":"B224","doi-asserted-by":"crossref","first-page":"227","DOI":"10.18388\/abp.2008_3070","article-title":"Lysophosphatidic acids, cyclic phosphatidic acids and autotaxin as promising targets in therapies of cancer and other diseases","volume":"55","author":"Gendaszewska-Darmach","year":"2008","journal-title":"Acta Biochim Pol"},{"issue":"10","key":"B225","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/nri2400","article-title":"The alliance of sphingosine-1-phosphate and its receptors in immunity","volume":"8","author":"Rivera","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"B226","doi-asserted-by":"publisher","first-page":"4133","DOI":"10.4049\/jimmunol.0903358","article-title":"Redistribution of sphingosine 1-phosphate by sphingosine kinase 2 contributes to lymphopenia","volume":"184","author":"Sensken","year":"2010","journal-title":"J Immunol"},{"issue":"5","key":"B227","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1365-2133.1976.tb00855.x","article-title":"Thymus-dependent (T) lymphocyte deficiency in progressive systemic sclerosis","volume":"95","author":"Hughes","year":"1976","journal-title":"Br J Dermatol"},{"issue":"3","key":"B228","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1365-2567.2008.02842.x","article-title":"Serum lipids regulate dendritic cell CD1 expression and function","volume":"125","author":"Leslie","year":"2008","journal-title":"Immunology"},{"issue":"3","key":"B229","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/0002-9343(69)90044-8","article-title":"Pathologic observations in systemic sclerosis (scleroderma). A study of fifty-eight autopsy cases and fifty-eight matched controls","volume":"46","author":"D\u00e2\u20ac\u2122Angelo","year":"1969","journal-title":"Am J Med"},{"issue":"4","key":"B230","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/S0046-8177(97)90032-0","article-title":"Pathogenesis and evolution of plexiform lesions in pulmonary hypertension associated with scleroderma and human immunodeficiency virus infection","volume":"28","author":"Cool","year":"1997","journal-title":"Hum Pathol"},{"issue":"6","key":"B231","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.humpath.2006.11.022","article-title":"Fibrous remodeling of the pulmonary venous system in pulmonary arterial hypertension associated with connective tissue diseases","volume":"38","author":"Dorfmuller","year":"2007","journal-title":"Hum Pathol"},{"issue":"11","key":"B232","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1111\/j.1346-8138.2007.00381.x","article-title":"Autopsy case of systemic sclerosis with severe pulmonary hypertension","volume":"34","author":"Nagai","year":"2007","journal-title":"J Dermatol"},{"issue":"1","key":"B233","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/00005792-197401000-00001","article-title":"The relationship of hypertension and renal failure in scleroderma (progressive systemic sclerosis) to structural and functional abnormalities of the renal cortical circulation","volume":"53","author":"Cannon","year":"1974","journal-title":"Medicine"},{"issue":"1","key":"B234","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.rdc.2007.12.004","article-title":"Vascular disease in scleroderma: mechanisms of vascular injury","volume":"34","author":"Kahaleh","year":"2008","journal-title":"Rheum Dis Clin North Am"},{"issue":"3","key":"B235","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/path.1711660307","article-title":"Sequential dermal microvascular and perivascular changes in the development of scleroderma","volume":"166","author":"Prescott","year":"1992","journal-title":"J Pathol"},{"issue":"11","key":"B236","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1001\/archderm.112.11.1553","article-title":"Skin capillary changes in early systemic scleroderma. Electron microscopy and \u00e2\u20ac\u0153in vitro\u00e2\u20ac\u009d autoradiography with tritiated thymidine","volume":"112","author":"Fleischmajer","year":"1976","journal-title":"Arch Dermatol"},{"issue":"12","key":"B237","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1002\/art.1780261203","article-title":"Changes in vascular endothelium related to lymphocyte collections in diseased synovia","volume":"26","author":"Freemont","year":"1983","journal-title":"Arthritis Rheum"},{"issue":"6","key":"B238","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1053\/sarh.2001.20269","article-title":"Microvascular involvement in systemic sclerosis: capillaroscopic findings","volume":"30","author":"Grassi","year":"2001","journal-title":"Semin Arthritis Rheum"},{"issue":"2","key":"B239","doi-asserted-by":"publisher","first-page":"317","DOI":"10.7326\/0003-4819-73-2-317","article-title":"Vascular disease in progressive systemic sclerosis (scleroderma)","volume":"73","author":"Norton","year":"1970","journal-title":"Ann Intern Med"},{"issue":"2","key":"B240","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0190-9622(80)80396-3","article-title":"Capillary alterations in scleroderma","volume":"2","author":"Fleischmajer","year":"1980","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"B241","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1093\/rheumatology\/keh552","article-title":"Pathogenesis of Raynaud\u00e2\u20ac\u2122s phenomenon","volume":"44","author":"Herrick","year":"2005","journal-title":"Rheumatology"},{"issue":"3 Suppl 29","key":"B242","first-page":"S9","article-title":"Assessment of vascular involvement","volume":"21","author":"Kahaleh","year":"2003","journal-title":"Clin Exp Rheumatol"},{"issue":"Suppl 5","key":"B243","doi-asserted-by":"publisher","first-page":"v14","DOI":"10.1093\/rheumatology\/ken279","article-title":"The microvascular endothelium in scleroderma","volume":"47","author":"Kahaleh","year":"2008","journal-title":"Rheumatology"},{"issue":"10","key":"B244","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1038\/80533","article-title":"Systemic sclerosis immunoglobulin G autoantibodies bind the human cytomegalovirus late protein UL94 and induce apoptosis in human endothelial cells","volume":"6","author":"Lunardi","year":"2000","journal-title":"Nat Med"},{"issue":"7","key":"B245","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1002\/art.21952","article-title":"Induction of apoptosis and fibrillin 1 expression in human dermal endothelial cells by scleroderma sera containing anti-endothelial cell antibodies","volume":"54","author":"Ahmed","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"10","key":"B246","doi-asserted-by":"publisher","first-page":"3086","DOI":"10.1002\/art.30470","article-title":"The specific free radical scavenger edaravone suppresses fibrosis in the bleomycin-induced and tight skin mouse models of systemic sclerosis","volume":"63","author":"Yoshizaki","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"1","key":"B247","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/art.37712","article-title":"Differential expression of junctional adhesion molecules in different stages of systemic sclerosis","volume":"65","author":"Manetti","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"8","key":"B248","first-page":"1325","article-title":"Mechanisms of endothelial cell damage in systemic sclerosis and Raynaud\u00e2\u20ac\u2122s phenomenon","volume":"20","author":"Blann","year":"1993","journal-title":"J Rheumatol"},{"issue":"6","key":"B249","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1097\/00002281-200211000-00010","article-title":"Targeting mediators of vascular injury in scleroderma","volume":"14","author":"Schachna","year":"2002","journal-title":"Curr Opin Rheumatol"},{"issue":"4","key":"B250","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1136\/annrheumdis-2011-200713","article-title":"Quantification of circulating endothelial progenitor cells in systemic sclerosis: a direct comparison of protocols","volume":"71","author":"Kuwana","year":"2012","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"B251","doi-asserted-by":"publisher","first-page":"1296","DOI":"10.1002\/art.20116","article-title":"Circulating endothelial cells as a marker of ongoing vascular disease in systemic sclerosis","volume":"50","author":"Del Papa","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"3","key":"B252","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1172\/JCI118851","article-title":"Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma","volume":"98","author":"Sgonc","year":"1996","journal-title":"J Clin Invest"},{"issue":"11","key":"B253","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1038\/ni722","article-title":"Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells","volume":"2","author":"Albert","year":"2001","journal-title":"Nat Immunol"},{"issue":"2","key":"B254","first-page":"281","article-title":"Apoptosis is associated with increased cell surface tissue factor procoagulant activity","volume":"75","author":"Greeno","year":"1996","journal-title":"Lab Invest"},{"issue":"4","key":"B255","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/oxfordjournals.jbchem.a124598","article-title":"Activation of the alternative pathway of human complement by apoptotic human umbilical vein endothelial cells","volume":"116","author":"Tsuji","year":"1994","journal-title":"J Biochem"},{"issue":"4","key":"B256","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1111\/liv.12099","article-title":"Glutamine synthetase expression in activated hepatocyte progenitor cells and loss of hepatocellular expression in congestion and cirrhosis","volume":"33","author":"Fleming","year":"2013","journal-title":"Liver Int"},{"issue":"5","key":"B257","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1002\/art.37891","article-title":"Increased expression of endoplasmic reticulum stress and unfolded protein response genes in peripheral blood mononuclear cells from patients with limited cutaneous systemic sclerosis and pulmonary arterial hypertension","volume":"65","author":"Lenna","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"11","key":"B258","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1161\/01.ATV.0000242903.41158.a1","article-title":"The unfolded protein response is an important regulator of inflammatory genes in endothelial cells","volume":"26","author":"Gargalovic","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"B259","doi-asserted-by":"publisher","first-page":"R11","DOI":"10.1186\/ar547","article-title":"Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers","volume":"4","author":"Distler","year":"2002","journal-title":"Arthritis Res"},{"issue":"1","key":"B260","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1161\/01.RES.0000134644.89917.96","article-title":"Uncontrolled expression of vascular endothelial growth factor and its receptors leads to insufficient skin angiogenesis in patients with systemic sclerosis","volume":"95","author":"Distler","year":"2004","journal-title":"Circ Res"},{"issue":"2","key":"B261","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11926-006-0053-z","article-title":"Microvascular damage in systemic sclerosis: detection and monitoring with biomarkers","volume":"8","author":"Hummers","year":"2006","journal-title":"Curr Rheumatol Rep"},{"issue":"2","key":"B262","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.humpath.2005.10.007","article-title":"The differential expression of VEGF, VEGFR-2, and GLUT-1 proteins in disease subtypes of systemic sclerosis","volume":"37","author":"Davies","year":"2006","journal-title":"Hum Pathol"},{"issue":"5","key":"B263","first-page":"641","article-title":"Increased but imbalanced expression of VEGF and its receptors has no positive effect on angiogenesis in systemic sclerosis skin","volume":"20","author":"Mackiewicz","year":"2002","journal-title":"Clin Exp Rheumatol"},{"issue":"5\u00e2\u20ac\u201c6","key":"B264","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1159\/000163802","article-title":"In situ expression of cytokines and cellular adhesion molecules in the skin of patients with systemic sclerosis. Their role in early and late disease","volume":"61","author":"Koch","year":"1993","journal-title":"Pathobiology"},{"issue":"10","key":"B265","doi-asserted-by":"publisher","first-page":"3448","DOI":"10.1002\/art.22861","article-title":"Antiangiogenic plasma activity in patients with systemic sclerosis","volume":"56","author":"Mulligan-Kehoe","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"2","key":"B266","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1136\/ard.2008.091918","article-title":"EULAR scleroderma trials and research group statement and recommendations on endothelial precursor cells","volume":"68","author":"Distler","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"B267","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1136\/ard.2007.082131","article-title":"Circulating endothelial progenitor cells in systemic sclerosis: association with disease severity","volume":"67","author":"Avouac","year":"2008","journal-title":"Ann Rheum Dis"},{"issue":"9434","key":"B268","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/S0140-6736(04)16853-0","article-title":"Defective vasculogenesis in systemic sclerosis","volume":"364","author":"Kuwana","year":"2004","journal-title":"Lancet"},{"issue":"6","key":"B269","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1002\/art.21899","article-title":"Increase in circulating endothelial precursors by atorvastatin in patients with systemic sclerosis","volume":"54","author":"Kuwana","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"21","key":"B270","doi-asserted-by":"publisher","first-page":"2156","DOI":"10.1161\/CIRCULATIONAHA.108.787200","article-title":"Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells","volume":"118","author":"Zhu","year":"2008","journal-title":"Circulation"},{"issue":"6","key":"B271","doi-asserted-by":"publisher","first-page":"1994","DOI":"10.1002\/art.22698","article-title":"Impairment of endothelial cell differentiation from bone marrow-derived mesenchymal stem cells: new insight into the pathogenesis of systemic sclerosis","volume":"56","author":"Cipriani","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"8","key":"B272","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1172\/JCI20087","article-title":"What brings pericytes to tumor vessels?","volume":"112","author":"Jain","year":"2003","journal-title":"J Clin Invest"},{"issue":"4","key":"B273","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/S0008-6363(96)00063-6","article-title":"Pericytes in the microvasculature","volume":"32","author":"Hirschi","year":"1996","journal-title":"Cardiovasc Res"},{"issue":"2","key":"B274","first-page":"452","article-title":"Pericytes as collagen-producing cells in excessive dermal scarring","volume":"74","author":"Sundberg","year":"1996","journal-title":"Lab Invest"},{"issue":"5","key":"B275","doi-asserted-by":"publisher","first-page":"R1113","DOI":"10.1186\/ar1790","article-title":"Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis","volume":"7","author":"Rajkumar","year":"2005","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"B276","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1002\/1529-0131(199905)42:5930::AID-ANR113.0.CO;2-1","article-title":"Activation of microvascular pericytes in autoimmune Raynaud\u00e2\u20ac\u2122s phenomenon and systemic sclerosis","volume":"42","author":"Rajkumar","year":"1999","journal-title":"Arthritis Rheum"},{"issue":"1","key":"B277","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.rdc.2008.01.001","article-title":"The pathology of scleroderma vascular disease","volume":"34","author":"Fleming","year":"2008","journal-title":"Rheum Dis Clin North Am"},{"issue":"1","key":"B278","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.tcm.2009.04.002","article-title":"Regulator of G protein signaling 5: a new player in vascular remodeling","volume":"19","author":"Manzur","year":"2009","journal-title":"Trends Cardiovasc Med"},{"issue":"6","key":"B279","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/j.0303-6987.2004.00203.x","article-title":"Hyperplasia of dermal microvascular pericytes in scleroderma","volume":"31","author":"Helmbold","year":"2004","journal-title":"J Cutan Pathol"},{"issue":"Suppl 1","key":"B280","doi-asserted-by":"publisher","first-page":"S7","DOI":"10.1186\/1755-1536-5-S1-S7","article-title":"Molecular mechanisms of endothelial to mesenchymal cell transition (EndoMT) in experimentally induced fibrotic diseases","volume":"5","author":"Piera-Velazquez","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"1","key":"B281","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/cr.2008.326","article-title":"TGF-beta signaling in vascular biology and dysfunction","volume":"19","author":"Goumans","year":"2009","journal-title":"Cell Res"},{"issue":"3","key":"B282","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1042\/BJ20101500","article-title":"Transforming growth factor-beta2 promotes Snail-mediated endothelial-mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling","volume":"437","author":"Medici","year":"2011","journal-title":"Biochem J"},{"issue":"1","key":"B283","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1007\/s00441-011-1222-6","article-title":"Regulation of endothelial cell plasticity by TGF-beta","volume":"347","author":"van Meeteren","year":"2012","journal-title":"Cell Tissue Res"},{"issue":"8","key":"B284","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/nm1613","article-title":"Endothelial-to-mesenchymal transition contributes to cardiac fibrosis","volume":"13","author":"Zeisberg","year":"2007","journal-title":"Nat Med"},{"issue":"8","key":"B285","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1002\/art.30317","article-title":"Protein kinase Cdelta and c-Abl kinase are required for transforming growth factor beta induction of endothelial-mesenchymal transition in vitro","volume":"63","author":"Li","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"Suppl 5","key":"B286","doi-asserted-by":"publisher","first-page":"v2","DOI":"10.1093\/rheumatology\/ken265","article-title":"Role of PDGF in fibrotic diseases and systemic sclerosis","volume":"47","author":"Trojanowska","year":"2008","journal-title":"Rheumatology"},{"issue":"2","key":"B287","doi-asserted-by":"publisher","first-page":"255","DOI":"10.2478\/v10039-011-0025-z","article-title":"Peripheral blood mononuclear cells from patients with systemic sclerosis spontaneously secrete increased amounts of vascular endothelial growth factor (VEGF) already in the early stage of the disease","volume":"56","author":"Bielecki","year":"2011","journal-title":"Adv Med Sci"},{"issue":"6 Suppl","key":"B288","doi-asserted-by":"publisher","first-page":"289S","DOI":"10.1378\/chest.122.6_suppl.289S","article-title":"Roles for insulin-like growth factor I and transforming growth factor-beta in fibrotic lung disease","volume":"122","author":"Krein","year":"2002","journal-title":"Chest"},{"issue":"1","key":"B289","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/art.37705","article-title":"Systemic sclerosis endothelial cells recruit and activate dermal fibroblasts by induction of a connective tissue growth factor (CCN2)\/transforming growth factor beta-dependent mesenchymal-to-mesenchymal transition","volume":"65","author":"Serrati","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"22","key":"B290","doi-asserted-by":"publisher","first-page":"2407","DOI":"10.1161\/CIRCULATIONAHA.110.938217","article-title":"Endothelial cell-derived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition","volume":"121","author":"Widyantoro","year":"2010","journal-title":"Circulation"},{"issue":"5","key":"B291","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.cellsig.2011.12.024","article-title":"Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT","volume":"24","author":"Ghosh","year":"2012","journal-title":"Cell Signal"},{"issue":"2","key":"B292","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1161\/ATVBAHA.111.234286","article-title":"Transforming growth factor-beta-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21","volume":"32","author":"Kumarswamy","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"B293","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/art.1780340220","article-title":"Elevated plasma levels of endothelin-1 in systemic sclerosis","volume":"34","author":"Yamane","year":"1991","journal-title":"Arthritis Rheum"},{"issue":"10","key":"B294","first-page":"1838","article-title":"Circulating endothelin-1 levels in systemic sclerosis subsets \u00e2\u20ac\u201c a marker of fibrosis or vascular dysfunction?","volume":"21","author":"Vancheeswaran","year":"1994","journal-title":"J Rheumatol"},{"issue":"9 Suppl","key":"B295","first-page":"1599","article-title":"Impaired response to mechanical fluid shear-stress (MFSS) by scleroderma (SSC) microvascular endothelial-cells (MVEC) from involved and uninvolved skin","volume":"40","author":"Tomita","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"3","key":"B296","first-page":"403","article-title":"Endothelial-dependent vasodilation is impaired in patients with systemic sclerosis, as assessed by low dose iontophoresis","volume":"21","author":"Anderson","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"B297","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1749-6632.2001.tb03932.x","article-title":"Endothelial atheroprotective and anti-inflammatory mechanisms","volume":"947","author":"Berk","year":"2001","journal-title":"Ann N Y Acad Sci"},{"issue":"5","key":"B298","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1053\/sarh.2002.50011","article-title":"Blood coagulation, fibrinolysis, and markers of endothelial dysfunction in systemic sclerosis","volume":"32","author":"Cerinic","year":"2003","journal-title":"Semin Arthritis Rheum"},{"issue":"4 Pt 1","key":"B299","doi-asserted-by":"publisher","first-page":"482","DOI":"10.7326\/0003-4819-94-4-482","article-title":"Increased factor VIII\/von Willebrand factor antigen and von Willebrand factor activity in scleroderma and in Raynaud\u00e2\u20ac\u2122s phenomenon","volume":"94","author":"Kahaleh","year":"1981","journal-title":"Ann Intern Med"},{"issue":"4","key":"B300","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1093\/rheumatology\/27.4.281","article-title":"Elevated von Willebrand factor antigen in systemic sclerosis: relationship to visceral disease","volume":"27","author":"Greaves","year":"1988","journal-title":"Br J Rheumatol"},{"issue":"2","key":"B301","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1136\/ard.55.2.122","article-title":"Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud\u00e2\u20ac\u2122s phenomenon and systemic sclerosis","volume":"55","author":"Herrick","year":"1996","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"B302","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1111\/j.1365-2141.1993.tb03145.x","article-title":"Whole blood platelet aggregation and coagulation factors in patients with systemic sclerosis","volume":"84","author":"Goodfield","year":"1993","journal-title":"Br J Haematol"},{"issue":"10","key":"B303","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1093\/rheumatology\/36.10.1045","article-title":"The coagulation\/fibrinolysis balance in systemic sclerosis: evidence for a haematological stress syndrome","volume":"36","author":"Ames","year":"1997","journal-title":"Br J Rheumatol"},{"issue":"3","key":"B304","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1016\/S0002-9440(10)63196-3","article-title":"The plasminogen activation system reduces fibrosis in the lung by a hepatocyte growth factor-dependent mechanism","volume":"164","author":"Hattori","year":"2004","journal-title":"Am J Pathol"},{"key":"B305","first-page":"1","article-title":"Ch. 1: The matrix metalloproteinases family","volume-title":"Matrix Metalloproteinases. Biology of Extracellular Matrix Series","author":"Woessner","year":"1998","edition":"1st ed"},{"issue":"2","key":"B306","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1093\/rheumatology\/keg071","article-title":"Plasma plasmin-alpha2-plasmin inhibitor complex levels are increased in systemic sclerosis patients with pulmonary hypertension","volume":"42","author":"Jinnin","year":"2003","journal-title":"Rheumatology"},{"issue":"2","key":"B307","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/art.37767","article-title":"Alpha2-antiplasmin regulates the development of dermal fibrosis in mice by prostaglandin F(2alpha) synthesis through adipose triglyceride lipase\/calcium-independent phospholipase A(2)","volume":"65","author":"Kanno","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"1","key":"B308","doi-asserted-by":"publisher","first-page":"238","DOI":"10.2353\/ajpath.2010.090150","article-title":"Alpha2-antiplasmin is associated with the progression of fibrosis","volume":"176","author":"Kanno","year":"2010","journal-title":"Am J Pathol"},{"issue":"6","key":"B309","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1097\/BOR.0b013e3282eeb3a4","article-title":"Platelet contributions to the pathogenesis of systemic sclerosis","volume":"19","author":"Postlethwaite","year":"2007","journal-title":"Curr Opin Rheumatol"},{"issue":"3","key":"B310","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/0006-291X(81)91613-2","article-title":"The effect of altered transmembrane ion gradients on membrane potential and aggregation of human platelets in blood plasma","volume":"102","author":"Friedhoff","year":"1981","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"B311","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1172\/JCI108653","article-title":"Binding of collagen alpha1 chains to human platelets","volume":"59","author":"Chiang","year":"1977","journal-title":"J Clin Invest"},{"issue":"2","key":"B312","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1093\/cvr\/cvp064","article-title":"Sphingosine-1-phosphate and modulation of vascular tone","volume":"82","author":"Igarashi","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"1\u00e2\u20ac\u201c3","key":"B313","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ejphar.2012.09.038","article-title":"Contrary effects of sphingosine-1-phosphate on expression of alpha-smooth muscle actin in transforming growth factor beta1-stimulated lung fibroblasts","volume":"696","author":"Kawashima","year":"2012","journal-title":"Eur J Pharmacol"},{"issue":"5","key":"B314","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s00392-011-0408-y","article-title":"Inhibition of neointimal proliferation after bare metal stent implantation with low-pressure drug delivery using a paclitaxel-coated balloon in porcine coronary arteries","volume":"101","author":"Cremers","year":"2012","journal-title":"Clin Res Cardiol"},{"issue":"6","key":"B315","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1084\/jem.20031619","article-title":"Lysophosphatidic acid induces neointima formation through PPARgamma activation","volume":"199","author":"Zhang","year":"2004","journal-title":"J Exp Med"},{"issue":"12","key":"B316","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1016\/j.cellsig.2009.08.003","article-title":"Lysophosphatidic acid-induced arterial wall remodeling: requirement of PPARgamma but not LPA1 or LPA2 GPCR","volume":"21","author":"Cheng","year":"2009","journal-title":"Cell Signal"},{"issue":"2","key":"B317","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1161\/hq0202.104274","article-title":"Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries","volume":"22","author":"Kandabashi","year":"2002","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"B318","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1016\/j.bbagen.2007.04.003","article-title":"A cell model system to study regulation of phosphatidylinositol 3-kinase and protein kinase B activity by cytokines\/growth factors produced by type I collagen stimulated immune cells from patients with systemic sclerosis","volume":"1770","author":"Chiang","year":"2007","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"B319","doi-asserted-by":"publisher","first-page":"1983","DOI":"10.2353\/ajpath.2010.090593","article-title":"Endothelial Fli1 deficiency impairs vascular homeostasis: a role in scleroderma vasculopathy","volume":"176","author":"Asano","year":"2010","journal-title":"Am J Pathol"},{"issue":"6","key":"B320","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1097\/BOR.0b013e3283103d27","article-title":"Caveolin-1, transforming growth factor-beta receptor internalization, and the pathogenesis of systemic sclerosis","volume":"20","author":"Del Galdo","year":"2008","journal-title":"Curr Opin Rheumatol"},{"issue":"1","key":"B321","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/09687860500453673","article-title":"Lipid rafts in T cell receptor signalling","volume":"23","author":"Kabouridis","year":"2006","journal-title":"Mol Membr Biol"},{"issue":"5","key":"B322","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/ncb975","article-title":"Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover","volume":"5","author":"Di Guglielmo","year":"2003","journal-title":"Nat Cell Biol"},{"issue":"9","key":"B323","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.1002\/art.23791","article-title":"Decreased expression of caveolin 1 in patients with systemic sclerosis: crucial role in the pathogenesis of tissue fibrosis","volume":"58","author":"Del Galdo","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"13","key":"B324","doi-asserted-by":"publisher","first-page":"2895","DOI":"10.1084\/jem.20061536","article-title":"Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis","volume":"203","author":"Wang","year":"2006","journal-title":"J Exp Med"},{"issue":"17","key":"B325","doi-asserted-by":"publisher","first-page":"11375","DOI":"10.1073\/pnas.172360799","article-title":"Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice","volume":"99","author":"Zhao","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"B326","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1096\/fj.07-8424com","article-title":"Increased smooth muscle cell expression of caveolin-1 and caveolae contribute to the pathophysiology of idiopathic pulmonary arterial hypertension","volume":"21","author":"Patel","year":"2007","journal-title":"FASEB J"},{"issue":"6","key":"B327","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1136\/annrheumdis-2011-200986","article-title":"Evidence for caveolin-1 as a new susceptibility gene regulating tissue fibrosis in systemic sclerosis","volume":"71","author":"Manetti","year":"2012","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"B328","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1016\/j.vph.2012.12.001","article-title":"The Fra-2 transgenic mouse model of systemic sclerosis","volume":"58","author":"Maurer","year":"2013","journal-title":"Vascul Pharmacol"},{"issue":"1","key":"B329","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1172\/JCI108455","article-title":"Lymphokine stimulation of collagen accumulation","volume":"58","author":"Johnson","year":"1976","journal-title":"J Clin Invest"},{"issue":"6","key":"B330","doi-asserted-by":"publisher","first-page":"1388","DOI":"10.1172\/JCI108594","article-title":"Cutaneous antigen-stimulating lymphokine production by lymphocytes of patients with progressive systemic sclerosis (scleroderma)","volume":"58","author":"Kondo","year":"1976","journal-title":"J Clin Invest"},{"issue":"5","key":"B331","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1084\/jem.144.5.1188","article-title":"The chemotactic attraction of human fibroblasts to a lymphocyte-derived factor","volume":"144","author":"Postlethwaite","year":"1976","journal-title":"J Exp Med"},{"issue":"3","key":"B332","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.4049\/jimmunol.124.3.1462","article-title":"Characterization of guinea pig lymphocyte-derived chemotactic factor for fibroblasts","volume":"124","author":"Postlethwaite","year":"1980","journal-title":"J Immunol"},{"issue":"1","key":"B333","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/0008-8749(82)90445-2","article-title":"Characterization of fibroblast proliferation factors elaborated by antigen- and mitogen-stimulated guinea pig lymph node cells: differentiation from lymphocyte-derived chemotactic factor for fibroblasts, lymphocyte mitogenic factor, and interleukin 1","volume":"73","author":"Postlethwaite","year":"1982","journal-title":"Cell Immunol"},{"issue":"1","key":"B334","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1084\/jem.157.1.47","article-title":"Alterations in collagen production in mixed mononuclear leukocyte-fibroblast cultures","volume":"157","author":"Hibbs","year":"1983","journal-title":"J Exp Med"},{"issue":"1","key":"B335","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/art.1780260104","article-title":"Induction of fibroblast proliferation by human mononuclear leukocyte-derived proteins","volume":"26","author":"Postlethwaite","year":"1983","journal-title":"Arthritis Rheum"},{"issue":"5","key":"B336","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.4049\/jimmunol.132.5.2470","article-title":"Lymphocyte modulation of fibroblast function in vitro: stimulation and inhibition of collagen production by different effector molecules","volume":"132","author":"Postlethwaite","year":"1984","journal-title":"J Immunol"},{"issue":"2","key":"B337","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/0165-2478(85)90145-2","article-title":"Production of collagen synthesis inhibitory lymphokine by human leukemic T-lymphocyte cell lines","volume":"11","author":"Jimenez","year":"1985","journal-title":"Immunol Lett"},{"issue":"6","key":"B338","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1084\/jem.150.6.1421","article-title":"Inhibition of collagen synthesis by mononuclear cell supernates","volume":"150","author":"Jimenez","year":"1979","journal-title":"J Exp Med"},{"issue":"4","key":"B339","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.4049\/jimmunol.125.4.1708","article-title":"Cell-mediated immunity in interstitial nephritis. III. T lymphocyte-mediated fibroblast proliferation and collagen synthesis: an immune mechanism for renal fibrogenesis","volume":"125","author":"Neilson","year":"1980","journal-title":"J Immunol"},{"issue":"3","key":"B340","doi-asserted-by":"crossref","first-page":"942","DOI":"10.4049\/jimmunol.121.3.942","article-title":"Lymphocyte-mediated activation of fibroblast proliferation and collagen production","volume":"121","author":"Wahl","year":"1978","journal-title":"J Immunol"},{"issue":"12","key":"B341","doi-asserted-by":"publisher","first-page":"4167","DOI":"10.1073\/pnas.83.12.4167","article-title":"Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro","volume":"83","author":"Roberts","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"B342","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1016\/S0006-291X(86)80591-5","article-title":"Stimulation of normal human fibroblast collagen production and processing by transforming growth factor-beta","volume":"138","author":"Varga","year":"1986","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"B343","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1016\/S0021-9258(17)35666-1","article-title":"Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix","volume":"261","author":"Ignotz","year":"1986","journal-title":"J Biol Chem"},{"issue":"4","key":"B344","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1172\/JCI112950","article-title":"Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts","volume":"79","author":"Raghow","year":"1987","journal-title":"J Clin Invest"},{"issue":"1","key":"B345","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1084\/jem.165.1.251","article-title":"Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta","volume":"165","author":"Postlethwaite","year":"1987","journal-title":"J Exp Med"},{"issue":"1","key":"B346","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/art.1780290108","article-title":"Persistence of scleroderma-like phenotype in normal fibroblasts after prolonged exposure to soluble mediators from mononuclear cells","volume":"29","author":"Worrall","year":"1986","journal-title":"Arthritis Rheum"},{"issue":"5","key":"B347","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1186\/s13075-014-0411-6","article-title":"Lipoic acid plays a role in scleroderma: insights obtained from scleroderma dermal fibroblasts","volume":"16","author":"Tsou","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"B348","doi-asserted-by":"publisher","first-page":"973","DOI":"10.1007\/s10067-012-1962-z","article-title":"Supernatants from culture of type I collagen-stimulated PBMC from patients with cutaneous systemic sclerosis versus localized scleroderma demonstrate suppression of MMP-1 by fibroblasts","volume":"31","author":"Brown","year":"2012","journal-title":"Clin Rheumatol"},{"issue":"7","key":"B349","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1074\/jbc.270.7.3423","article-title":"Myofibroblasts from scleroderma skin synthesize elevated levels of collagen and tissue inhibitor of metalloproteinase (TIMP-1) with two forms of TIMP-1","volume":"270","author":"Kirk","year":"1995","journal-title":"J Biol Chem"},{"issue":"4","key":"B350","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1172\/JCI107827","article-title":"Increased collagen synthesis by scleroderma skin fibroblasts in vitro: a possible defect in the regulation or activation of the scleroderma fibroblast","volume":"54","author":"LeRoy","year":"1974","journal-title":"J Clin Invest"},{"issue":"3","key":"B351","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1083\/jcb.142.3.873","article-title":"The fibronectin domain ED-A is crucial for myofibroblastic phenotype induction by transforming growth factor-beta1","volume":"142","author":"Serini","year":"1998","journal-title":"J Cell Biol"},{"issue":"6","key":"B352","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1267\/THRO03061002","article-title":"Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling","volume":"90","author":"Hinz","year":"2003","journal-title":"Thromb Haemost"},{"issue":"5","key":"B353","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1517\/14656561003592177","article-title":"Pharmacotherapy of systemic sclerosis","volume":"11","author":"Postlethwaite","year":"2010","journal-title":"Expert Opin Pharmacother"},{"issue":"2","key":"B354","doi-asserted-by":"publisher","first-page":"C535","DOI":"10.1152\/ajpcell.00291.2007","article-title":"ClC-3 is required for LPA-activated Cl-current activity and fibroblast-to-myofibroblast differentiation","volume":"294","author":"Yin","year":"2008","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"B355","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.bbalip.2014.01.008","article-title":"TLR2\/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts","volume":"1841","author":"Hamidi","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"B356","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1111\/1346-8138.12011","article-title":"Serum levels of interleukin-1alpha in patients with systemic sclerosis","volume":"40","author":"Maekawa","year":"2013","journal-title":"J Dermatol"},{"issue":"6","key":"B357","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1002\/art.1780330619","article-title":"Enhanced production of interleukin-1 and tumor necrosis factor alpha by cultured peripheral blood monocytes from patients with scleroderma","volume":"33","author":"Umehara","year":"1990","journal-title":"Arthritis Rheum"},{"issue":"2","key":"B358","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1083\/jcb.106.2.311","article-title":"Modulation of fibroblast functions by interleukin 1: increased steady-state accumulation of type I procollagen messenger RNAs and stimulation of other functions but not chemotaxis by human recombinant interleukin 1 alpha and beta","volume":"106","author":"Postlethwaite","year":"1988","journal-title":"J Cell Biol"},{"issue":"2","key":"B359","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1172\/JCI113927","article-title":"Stimulation of glycosaminoglycan synthesis in cultured human dermal fibroblasts by interleukin 1. Induction of hyaluronic acid synthesis by natural and recombinant interleukin 1s and synthetic interleukin 1 beta peptide 163-171","volume":"83","author":"Postlethwaite","year":"1989","journal-title":"J Clin Invest"},{"issue":"1","key":"B360","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1006\/bbrc.1999.0155","article-title":"IL-1 rescues scleroderma myofibroblasts from serum-starvation-induced cell death","volume":"255","author":"Kirk","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"B361","doi-asserted-by":"crossref","first-page":"3969","DOI":"10.4049\/jimmunol.163.7.3969","article-title":"Intracellular IL-1 receptor antagonist is elevated in human dermal fibroblasts that overexpress intracellular precursor IL-1 alpha","volume":"163","author":"Higgins","year":"1999","journal-title":"J Immunol"},{"issue":"4","key":"B362","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1038\/sj.jid.5700097","article-title":"Novel functions of intracellular IL-1ra in human dermal fibroblasts: implications in the pathogenesis of fibrosis","volume":"126","author":"Kanangat","year":"2006","journal-title":"J Invest Dermatol"},{"issue":"10","key":"B363","first-page":"1946","article-title":"Autocrine activation by interleukin 1alpha induces the fibrogenic phenotype of systemic sclerosis fibroblasts","volume":"31","author":"Kawaguchi","year":"2004","journal-title":"J Rheumatol"},{"issue":"4","key":"B364","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.cytogfr.2013.06.003","article-title":"Unchaining the beast; insights from structural and evolutionary studies on TGFbeta secretion, sequestration, and activation","volume":"24","author":"Robertson","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"issue":"12","key":"B365","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1038\/nrrheum.2014.137","article-title":"Transforming growth factor beta-at the centre of systemic sclerosis","volume":"10","author":"Lafyatis","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"B366","doi-asserted-by":"publisher","first-page":"89","DOI":"10.3389\/fphys.2011.00089","article-title":"Transforming growth factor-beta and endoglin signaling orchestrate wound healing","volume":"2","author":"Valluru","year":"2011","journal-title":"Front Physiol"},{"key":"B367","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/B978-0-12-394308-8.00008-X","article-title":"Role of endoglin in fibrosis and scleroderma","volume":"297","author":"Maring","year":"2012","journal-title":"Int Rev Cell Mol Biol"},{"issue":"24","key":"B368","doi-asserted-by":"publisher","first-page":"2046","DOI":"10.1016\/j.cub.2011.11.037","article-title":"The single-molecule mechanics of the latent TGF-beta1 complex","volume":"21","author":"Buscemi","year":"2011","journal-title":"Curr Biol"},{"issue":"1","key":"B369","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1080\/07853890601098152","article-title":"Update on pathophysiology of scleroderma with special reference to immunoinflammatory events","volume":"39","author":"Chizzolini","year":"2007","journal-title":"Ann Med"},{"issue":"7","key":"B370","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1016\/0092-8674(93)90368-Z","article-title":"Betaglycan presents ligand to the TGF beta signaling receptor","volume":"73","author":"Lopez-Casillas","year":"1993","journal-title":"Cell"},{"key":"B371","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206214","article-title":"Activating transcription factor 3 regulates canonical TGFbeta signalling in systemic sclerosis","author":"Mallano","year":"2015","journal-title":"Ann Rheum Dis"},{"issue":"14","key":"B372","doi-asserted-by":"publisher","first-page":"9952","DOI":"10.1074\/jbc.M113.545822","article-title":"Interleukin-6 (IL-6) trans signaling drives a STAT3-dependent pathway that leads to hyperactive transforming growth factor-beta (TGF-beta) signaling promoting SMAD3 activation and fibrosis via Gremlin protein","volume":"289","author":"O\u00e2\u20ac\u2122Reilly","year":"2014","journal-title":"J Biol Chem"},{"issue":"2","key":"B373","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/path.4131","article-title":"Egr-1: new conductor for the tissue repair orchestra directs harmony (regeneration) or cacophony (fibrosis)","volume":"229","author":"Bhattacharyya","year":"2013","journal-title":"J Pathol"},{"issue":"30","key":"B374","doi-asserted-by":"publisher","first-page":"21183","DOI":"10.1074\/jbc.M603270200","article-title":"The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression","volume":"281","author":"Chen","year":"2006","journal-title":"J Biol Chem"},{"issue":"2","key":"B375","doi-asserted-by":"publisher","first-page":"605","DOI":"10.2353\/ajpath.2009.080991","article-title":"The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms","volume":"175","author":"Yasuoka","year":"2009","journal-title":"Am J Pathol"},{"issue":"4","key":"B376","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1016\/j.ajpath.2013.06.016","article-title":"Early growth response 3 (Egr-3) is induced by transforming growth factor-beta and regulates fibrogenic responses","volume":"183","author":"Fang","year":"2013","journal-title":"Am J Pathol"},{"issue":"3","key":"B377","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1002\/jcp.1041610320","article-title":"Osteogenic protein-1, a bone morphogenic protein member of the TGF-beta superfamily, shares chemotactic but not fibrogenic properties with TGF-beta","volume":"161","author":"Postlethwaite","year":"1994","journal-title":"J Cell Physiol"},{"issue":"3","key":"B378","first-page":"403","article-title":"BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition in human renal proximal tubular epithelial cells","volume":"22","author":"Xu","year":"2009","journal-title":"J Nephrol"},{"issue":"1","key":"B379","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1006\/bbrc.2001.4321","article-title":"Effect of interleukin-10 on the gene expression of type I collagen, fibronectin, and decorin in human skin fibroblasts: differential regulation by transforming growth factor-beta and monocyte chemoattractant protein-1","volume":"281","author":"Yamamoto","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"B380","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1038\/sj.gene.6364180","article-title":"Interleukin-10 genotypes are associated with systemic sclerosis and influence disease-associated autoimmune responses","volume":"6","author":"Hudson","year":"2005","journal-title":"Genes Immun"},{"issue":"6","key":"B381","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1084\/jem.172.6.1749","article-title":"Stimulation of fibroblast chemotaxis by human recombinant tumor necrosis factor alpha (TNF-alpha) and a synthetic TNF-alpha 31-68 peptide","volume":"172","author":"Postlethwaite","year":"1990","journal-title":"J Exp Med"},{"issue":"7","key":"B382","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1002\/art.1780290706","article-title":"Inhibition of excessive scleroderma fibroblast collagen production by recombinant gamma-interferon. Association with a coordinate decrease in types I and III procollagen messenger RNA levels","volume":"29","author":"Rosenbloom","year":"1986","journal-title":"Arthritis Rheum"},{"issue":"2","key":"B383","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1093\/rheumatology\/kem344","article-title":"Effectiveness of etanercept in bleomycin-induced experimental scleroderma","volume":"47","author":"Koca","year":"2008","journal-title":"Rheumatology"},{"issue":"7","key":"B384","first-page":"1636","article-title":"Efficacy and safety of etanercept in the treatment of scleroderma-associated joint disease","volume":"34","author":"Lam","year":"2007","journal-title":"J Rheumatol"},{"issue":"11","key":"B385","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1182\/blood.V95.11.3613","article-title":"Induction of oral tolerance in splenocyte recipients toward pretransplant antigens ameliorates chronic graft versus host disease in a murine model","volume":"95","author":"Ilan","year":"2000","journal-title":"Blood"},{"issue":"5","key":"B386","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1038\/jid.2011.472","article-title":"Intrinsic gene expression subsets of diffuse cutaneous systemic sclerosis are stable in serial skin biopsies","volume":"132","author":"Pendergrass","year":"2012","journal-title":"J Invest Dermatol"},{"issue":"3","key":"B387","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/jid.2009.318","article-title":"A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity","volume":"130","author":"Sargent","year":"2010","journal-title":"J Invest Dermatol"},{"issue":"9","key":"B388","doi-asserted-by":"publisher","first-page":"e23082","DOI":"10.1371\/journal.pone.0023082","article-title":"Egr-1 induces a profibrotic injury\/repair gene program associated with systemic sclerosis","volume":"6","author":"Bhattacharyya","year":"2011","journal-title":"PLoS One"},{"issue":"3","key":"B389","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1016\/j.ajpath.2011.11.024","article-title":"Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets","volume":"180","author":"Greenblatt","year":"2012","journal-title":"Am J Pathol"},{"issue":"1","key":"B390","doi-asserted-by":"publisher","first-page":"e0114017","DOI":"10.1371\/journal.pone.0114017","article-title":"Experimentally-derived fibroblast gene signatures identify molecular pathways associated with distinct subsets of systemic sclerosis patients in three independent cohorts","volume":"10","author":"Johnson","year":"2015","journal-title":"PLoS One"},{"issue":"19","key":"B391","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1056\/NEJMra0806188","article-title":"Scleroderma","volume":"360","author":"Gabrielli","year":"2009","journal-title":"N Engl J Med"},{"issue":"7","key":"B392","doi-asserted-by":"publisher","first-page":"2422","DOI":"10.1002\/art.22721","article-title":"Relationship between change in skin score and disease outcome in diffuse cutaneous systemic sclerosis: application of a latent linear trajectory model","volume":"56","author":"Shand","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"12","key":"B393","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/0309-1651(86)90113-X","article-title":"1 alpha, 25-dihydroxyvitamin D3 modulates the growth of 3T3 cells and human skin fibroblasts stimulated by platelet-derived growth factor","volume":"10","author":"Dosquet-Bernard","year":"1986","journal-title":"Cell Biol Int Rep"},{"issue":"2","key":"B394","first-page":"131","article-title":"1 alpha-hydroxyvitamin D3 in the treatment of primary myelofibrosis: in vitro effect of vitamin D3 metabolites on the bone marrow fibroblasts","volume":"57","author":"Hyodo","year":"1993","journal-title":"Int J Hematol"},{"issue":"2","key":"B395","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0303-7207(95)03681-4","article-title":"1,25-dihydroxyvitamin D3 inhibits proliferation of IMR-90 human fibroblasts and stimulates pyruvate kinase activity in confluent-phase cells","volume":"115","author":"Lunghi","year":"1995","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"B396","first-page":"1143","article-title":"Comparison of the inhibitions of proliferation of normal and psoriatic fibroblasts by 1 alpha,25-dihydroxyvitamin D3 and synthetic analogues of vitamin D3 with an oxygen atom in their side chain","volume":"19","author":"Morimoto","year":"1989","journal-title":"Biochem Int"},{"issue":"1","key":"B397","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1159\/000204591","article-title":"In vitro effect of 1,25-dihydroxyvitamin D3 on proliferation and collagen synthesis by bone marrow fibroblasts","volume":"88","author":"Wang","year":"1992","journal-title":"Acta Haematol"},{"issue":"6","key":"B398","doi-asserted-by":"publisher","first-page":"1236","DOI":"10.1111\/1523-1747.ep12348928","article-title":"1alpha,25-dihydroxyvitamin D3 rapidly inhibits fibroblast-induced collagen gel contraction","volume":"106","author":"Greiling","year":"1996","journal-title":"J Invest Dermatol"},{"issue":"2","key":"B399","first-page":"145","article-title":"Inhibition of IL-6 and IL-8 production in human fibroblast cell lines by 1,25 (OH)2 vitamin D3 and two of its analogs with lower calcemic activity","volume":"83","author":"Srviastava","year":"1994","journal-title":"Res Commun Chem Pathol Pharmacol"},{"issue":"1","key":"B400","doi-asserted-by":"publisher","first-page":"86","DOI":"10.2478\/v10039-010-0012-9","article-title":"Vitamin D derivatives: calcitriol and tacalcitol inhibits interleukin-6 and interleukin-8 expression in human nasal polyp fibroblast cultures","volume":"55","author":"Rostkowska-Nadolska","year":"2010","journal-title":"Adv Med Sci"},{"issue":"1","key":"B401","first-page":"33","article-title":"Vitamin D3 regulation of transforming growth factor-beta system in epithelial and fibroblastic cells \u00e2\u20ac\u201c relationships to plasminogen activation","volume":"1","author":"Koli","year":"1996","journal-title":"J Investig Dermatol Symp Proc"},{"issue":"3","key":"B402","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jsbmb.2009.11.004","article-title":"Vitamin D inhibition of pro-fibrotic effects of transforming growth factor beta1 in lung fibroblasts and epithelial cells","volume":"118","author":"Ramirez","year":"2010","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"5","key":"B403","doi-asserted-by":"crossref","first-page":"364","DOI":"10.2340\/000155557575364366","article-title":"The effect of calcipotriol on lesional fibroblasts from patients with active morphea","volume":"75","author":"Bottomley","year":"1995","journal-title":"Acta Derm Venereol"},{"issue":"3\u00e2\u20ac\u201c5","key":"B404","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.jsbmb.2006.11.011","article-title":"Therapeutic role and potential mechanisms of active Vitamin D in renal interstitial fibrosis","volume":"103","author":"Tan","year":"2007","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"B405","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1006\/taap.2001.9178","article-title":"1,25-dihydroxyvitamin D(3) prevents the conversion of adipose tissue into fibrous tissue in skin exposed to chronic UV irradiation","volume":"173","author":"Koshiishi","year":"2001","journal-title":"Toxicol Appl Pharmacol"},{"issue":"8","key":"B406","first-page":"1196","article-title":"Cutaneous vitamin D3 formation in progressive systemic sclerosis","volume":"18","author":"Matsuoka","year":"1991","journal-title":"J Rheumatol"},{"issue":"4","key":"B407","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2340\/0001555565343345","article-title":"Vitamin D metabolites in generalized scleroderma. Evidence of a normal cutaneous and intestinal supply with vitamin D","volume":"65","author":"Serup","year":"1985","journal-title":"Acta Derm Venereol"},{"issue":"6","key":"B408","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1067\/mjd.2000.108369","article-title":"Double-blind, placebo-controlled study of oral calcitriol for the treatment of localized and systemic scleroderma","volume":"43","author":"Hulshof","year":"2000","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"B409","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1159\/000246550","article-title":"Effects of calcitriol on fibroblasts derived from skin of scleroderma patients","volume":"191","author":"Boelsma","year":"1995","journal-title":"Dermatology"},{"issue":"3","key":"B410","doi-asserted-by":"publisher","first-page":"e20","DOI":"10.1136\/annrheumdis-2013-204378","article-title":"Vitamin D receptor regulates TGF-beta signalling in systemic sclerosis","volume":"74","author":"Zerr","year":"2015","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"B411","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1677\/JOE-08-0241","article-title":"Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells","volume":"200","author":"Artaza","year":"2009","journal-title":"J Endocrinol"},{"issue":"4","key":"B412","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1111\/j.1523-1755.2005.00562.x","article-title":"1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression","volume":"68","author":"Li","year":"2005","journal-title":"Kidney Int"},{"issue":"2","key":"B413","doi-asserted-by":"publisher","first-page":"E298","DOI":"10.1210\/jc.2012-3074","article-title":"20S-hydroxyvitamin D3, noncalcemic product of CYP11A1 action on vitamin D3, exhibits potent antifibrogenic activity in vivo","volume":"98","author":"Slominski","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"B414","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1902\/jop.2004.75.2.297","article-title":"Lysophosphatidic acid modulates the regenerative responses of human gingival fibroblasts and enhances the actions of platelet-derived growth factor","volume":"75","author":"Cerutis","year":"2004","journal-title":"J Periodontol"},{"issue":"4","key":"B415","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.2353\/ajpath.2009.080160","article-title":"Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q)","volume":"174","author":"Xu","year":"2009","journal-title":"Am J Pathol"},{"issue":"Pt 1","key":"B416","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1042\/0264-6021:3520135","article-title":"Lysophosphatidic acid prevents apoptosis in fibroblasts via G(i)-protein-mediated activation of mitogen-activated protein kinase","volume":"352","author":"Fang","year":"2000","journal-title":"Biochem J"},{"issue":"12","key":"B417","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.1093\/rheumatology\/keq260","article-title":"Lysophosphatidic acid-activated Cl-current activity in human systemic sclerosis skin fibroblasts","volume":"49","author":"Yin","year":"2010","journal-title":"Rheumatology"},{"issue":"5","key":"B418","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1002\/art.30262","article-title":"Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma","volume":"63","author":"Castelino","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"6","key":"B419","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1165\/rcmb.2013-0070OC","article-title":"Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice","volume":"49","author":"Huang","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"B420","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1165\/rcmb.2006-0427OC","article-title":"Sphingosine 1-phosphate potentiates human lung fibroblast chemotaxis through the S1P2 receptor","volume":"39","author":"Hashimoto","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"7","key":"B421","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.1002\/art.27463","article-title":"Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels","volume":"62","author":"Bu","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"34","key":"B422","doi-asserted-by":"publisher","first-page":"35255","DOI":"10.1074\/jbc.M312091200","article-title":"Sphingosine 1-phosphate cross-activates the Smad signaling cascade and mimics transforming growth factor-beta-induced cell responses","volume":"279","author":"Xin","year":"2004","journal-title":"J Biol Chem"},{"issue":"52","key":"B423","doi-asserted-by":"publisher","first-page":"53994","DOI":"10.1074\/jbc.M410144200","article-title":"Sphingosine kinase 1 (SPHK1) is induced by transforming growth factor-beta and mediates TIMP-1 up-regulation","volume":"279","author":"Yamanaka","year":"2004","journal-title":"J Biol Chem"},{"issue":"6","key":"B424","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1002\/art.37933","article-title":"FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin","volume":"65","author":"Huu","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"10","key":"B425","doi-asserted-by":"publisher","first-page":"5899","DOI":"10.1021\/cr2002799","article-title":"Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways","volume":"111","author":"Rouzer","year":"2011","journal-title":"Chem Rev"},{"issue":"1","key":"B426","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0014-2999(98)00649-9","article-title":"Endocannabinoids","volume":"359","author":"Mechoulam","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"B427","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.expneurol.2014.06.017","article-title":"CB and GPR55 receptors are co-expressed and form heteromers in rat and monkey striatum","volume":"261C","author":"Martinez-Pinilla","year":"2014","journal-title":"Exp Neurol"},{"issue":"23","key":"B428","doi-asserted-by":"publisher","first-page":"5387","DOI":"10.1111\/bph.12850","article-title":"Heteromerization of GPR55 and cannabinoid CB receptors modulates signalling","volume":"171","author":"Balenga","year":"2014","journal-title":"Br J Pharmacol"},{"issue":"1","key":"B429","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1124\/jpet.113.209213","article-title":"The novel endocannabinoid receptor GPR18 is expressed in the rostral ventrolateral medulla and exerts tonic restraining influence on blood pressure","volume":"349","author":"Penumarti","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"B430","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ejphar.2014.03.055","article-title":"Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature","volume":"735","author":"MacIntyre","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"B431","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1471-2202-11-44","article-title":"N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor","volume":"11","author":"McHugh","year":"2010","journal-title":"BMC Neurosci"},{"issue":"12","key":"B432","doi-asserted-by":"publisher","first-page":"2051","DOI":"10.1136\/annrheumdis-2012-201823","article-title":"Inactivation of fatty acid amide hydrolase exacerbates experimental fibrosis by enhanced endocannabinoid-mediated activation of CB1","volume":"71","author":"Palumbo-Zerr","year":"2012","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"B433","doi-asserted-by":"publisher","first-page":"6155","DOI":"10.1073\/pnas.97.11.6155","article-title":"Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances","volume":"97","author":"Hwang","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"B434","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/art.23168","article-title":"Investigation of sensory neurogenic components in a bleomycin-induced scleroderma model using transient receptor potential vanilloid 1 receptor- and calcitonin gene-related peptide-knockout mice","volume":"58","author":"Szabo","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"5","key":"B435","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1007\/s11481-013-9493-1","article-title":"Cannabinoids decrease the th17 inflammatory autoimmune phenotype","volume":"8","author":"Kozela","year":"2013","journal-title":"J Neuroimmune Pharmacol"},{"issue":"7","key":"B436","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1038\/bjp.2008.371","article-title":"Virodhamine relaxes the human pulmonary artery through the endothelial cannabinoid receptor and indirectly through a COX product","volume":"155","author":"Kozlowska","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"4","key":"B437","doi-asserted-by":"publisher","first-page":"H2210","DOI":"10.1152\/ajpheart.00688.2007","article-title":"CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion","volume":"293","author":"Rajesh","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"B438","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/j.bbrc.2008.10.159","article-title":"Cannabinoid CB1 receptor inhibition decreases vascular smooth muscle migration and proliferation","volume":"377","author":"Rajesh","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"issue":"9","key":"B439","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1093\/rheumatology\/kep189","article-title":"Cannabinoids inhibit fibrogenesis in diffuse systemic sclerosis fibroblasts","volume":"48","author":"Garcia-Gonzalez","year":"2009","journal-title":"Rheumatology"},{"issue":"4","key":"B440","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1136\/ard.2010.137539","article-title":"The cannabinoid WIN55, 212-2 abrogates dermal fibrosis in scleroderma bleomycin model","volume":"70","author":"Balistreri","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"B441","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1111\/j.1432-1033.1993.tb17910.x","article-title":"Cannabinoid-receptor expression in human leukocytes","volume":"214","author":"Bouaboula","year":"1993","journal-title":"Eur J Biochem"},{"issue":"1","key":"B442","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/j.1432-1033.1995.tb20780.x","article-title":"Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations","volume":"232","author":"Galiegue","year":"1995","journal-title":"Eur J Biochem"},{"issue":"3","key":"B443","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.pharmthera.2012.12.004","article-title":"The role of CB1 in immune modulation by cannabinoids","volume":"137","author":"Kaplan","year":"2013","journal-title":"Pharmacol Ther"},{"issue":"1","key":"B444","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1189\/jlb.0306224","article-title":"Transcriptional regulation of the cannabinoid receptor type 1 gene in T cells by cannabinoids","volume":"81","author":"Borner","year":"2007","journal-title":"J Leukoc Biol"},{"issue":"4","key":"B445","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.4049\/jimmunol.173.4.2373","article-title":"Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation","volume":"173","author":"Do","year":"2004","journal-title":"J Immunol"},{"issue":"1\u00e2\u20ac\u201c2","key":"B446","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.ejphar.2005.12.040","article-title":"Role of cannabinoid receptors in delta-9-tetrahydrocannabinol suppression of IL-12p40 in mouse bone marrow-derived dendritic cells infected with Legionella pneumophila","volume":"532","author":"Lu","year":"2006","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"B447","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1189\/jlb.0508282","article-title":"Effects of targeted deletion of cannabinoid receptors CB1 and CB2 on immune competence and sensitivity to immune modulation by delta9-tetrahydrocannabinol","volume":"84","author":"Springs","year":"2008","journal-title":"J Leukoc Biol"},{"issue":"2","key":"B448","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1124\/jpet.102.033506","article-title":"Delta(9)-tetrahydrocannabinol-induced apoptosis in the thymus and spleen as a mechanism of immunosuppression in vitro and in vivo","volume":"302","author":"McKallip","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"issue":"11","key":"B449","doi-asserted-by":"publisher","first-page":"5720","DOI":"10.4049\/jimmunol.1102195","article-title":"Cannabinoid receptor 2 is critical for the homing and retention of marginal zone B lineage cells and for efficient T-independent immune responses","volume":"187","author":"Basu","year":"2011","journal-title":"J Immunol"},{"issue":"1","key":"B450","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s11481-007-9088-9","article-title":"Cannabinoid receptor 2 (CB2) mediates immunoglobulin class switching from IgM to IgE in cultures of murine-purified B lymphocytes","volume":"3","author":"Agudelo","year":"2008","journal-title":"J Neuroimmune Pharmacol"},{"issue":"1","key":"B451","doi-asserted-by":"publisher","first-page":"e8688","DOI":"10.1371\/journal.pone.0008688","article-title":"Anandamide suppresses proliferation and cytokine release from primary human T-lymphocytes mainly via CB2 receptors","volume":"5","author":"Cencioni","year":"2010","journal-title":"PLoS One"},{"issue":"5","key":"B452","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1159\/000339113","article-title":"Anti-inflammatory effect of the endocannabinoid anandamide in experimental periodontitis and stress in the rat","volume":"19","author":"Rettori","year":"2012","journal-title":"Neuroimmunomodulation"},{"key":"B453","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.bbi.2014.01.018","article-title":"Immune system: a possible nexus between cannabinoids and psychosis","volume":"40","author":"Suarez-Pinilla","year":"2014","journal-title":"Brain Behav Immun"},{"issue":"1","key":"B454","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1124\/jpet.104.068635","article-title":"The endocannabinoid 2-arachidonylglycerol decreases the immunological activation of Guinea pig mast cells: involvement of nitric oxide and eicosanoids","volume":"311","author":"Vannacci","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"issue":"1","key":"B455","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cellimm.2013.11.002","article-title":"Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS","volume":"287","author":"Kong","year":"2014","journal-title":"Cell Immunol"},{"issue":"1","key":"B456","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1111\/j.1476-5381.2010.00878.x","article-title":"Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery","volume":"161","author":"Mair","year":"2010","journal-title":"Br J Pharmacol"},{"key":"B457","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.yjmcc.2012.10.016","article-title":"TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals","volume":"54","author":"Adapala","year":"2013","journal-title":"J Mol Cell Cardiol"},{"issue":"30","key":"B458","doi-asserted-by":"publisher","first-page":"9007","DOI":"10.1021\/bi0608008","article-title":"A FAAH-regulated class of N-acyl taurines that activates TRP ion channels","volume":"45","author":"Saghatelian","year":"2006","journal-title":"Biochemistry"},{"issue":"9","key":"B459","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1111\/j.1440-1746.2007.05220.x","article-title":"Effect of a thrombin receptor (protease-activated receptor 1, PAR-1) gene polymorphism in chronic hepatitis C liver fibrosis","volume":"23","author":"Martinelli","year":"2008","journal-title":"J Gastroenterol Hepatol"},{"issue":"4","key":"B460","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1002\/path.2197","article-title":"Analysis of protease-activated receptor-1 and -2 in human scar formation","volume":"212","author":"Materazzi","year":"2007","journal-title":"J Pathol"},{"issue":"4","key":"B461","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1160\/TH08-12-0779","article-title":"Serine proteases, inhibitors and receptors in renal fibrosis","volume":"101","author":"Eddy","year":"2009","journal-title":"Thromb Haemost"},{"issue":"1","key":"B462","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1111\/j.1600-0625.2010.01184.x","article-title":"Role of protease-activated receptors in human skin fibrosis and scleroderma","volume":"20","author":"Cevikbas","year":"2011","journal-title":"Exp Dermatol"},{"issue":"11","key":"B463","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1002\/art.24935","article-title":"Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts","volume":"60","author":"Bogatkevich","year":"2009","journal-title":"Arthritis Rheum"},{"issue":"1","key":"B464","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1124\/mol.110.070441","article-title":"15-Deoxy-delta12,14-prostaglandin J2-glycerol ester, a putative metabolite of 2-arachidonyl glycerol, activates peroxisome proliferator activated receptor gamma","volume":"80","author":"Raman","year":"2011","journal-title":"Mol Pharmacol"},{"issue":"2","key":"B465","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1124\/jpet.104.065524","article-title":"A cyclooxygenase metabolite of anandamide causes inhibition of interleukin-2 secretion in murine splenocytes","volume":"311","author":"Rockwell","year":"2004","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"B466","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1136\/thoraxjnl-2011-200717","article-title":"Proteasomal inhibition after injury prevents fibrosis by modulating TGF-beta(1) signalling","volume":"67","author":"Mutlu","year":"2012","journal-title":"Thorax"},{"issue":"1","key":"B467","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2353\/ajpath.2010.090763","article-title":"Targeting the cannabinoid pathway limits the development of fibrosis and autoimmunity in a mouse model of systemic sclerosis","volume":"177","author":"Servettaz","year":"2010","journal-title":"Am J Pathol"},{"issue":"11","key":"B468","doi-asserted-by":"publisher","first-page":"3467","DOI":"10.1002\/art.27642","article-title":"Inactivation of the cannabinoid receptor CB1 prevents leukocyte infiltration and experimental fibrosis","volume":"62","author":"Marquart","year":"2010","journal-title":"Arthritis Rheum"}],"container-title":["Frontiers in Immunology"],"original-title":[],"deposited":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T07:43:49Z","timestamp":1717919029000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fimmu.2015.00272\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,8]]},"references-count":468,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2015.00272","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,8]]}}}