{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:27:21Z","timestamp":1791217641969,"version":"4.1.0"},"reference-count":74,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2015.00419","type":"journal-article","created":{"date-parts":[[2015,8,19]],"date-time":"2015-08-19T08:48:07Z","timestamp":1439974087000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":30,"title":["Host Immunological Factors Enhancing Mortality of Young Adults during the 1918 Influenza Pandemic"],"prefix":"10.3389","volume":"6","author":[{"given":"Julie L.","family":"McAuley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Kedzierska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena E.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Dennis","family":"Shanks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.1016\/S0140-6736(06)69895-4","article-title":"Estimation of potential global pandemic influenza mortality on the basis of vital registry data from the 1918-20 pandemic: a quantitative analysis","volume":"368","author":"Murray","year":"2006","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3201\/eid1209.05-0979","article-title":"1918 influenza: the mother of all pandemics","volume":"12","author":"Taubenberger","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"B3","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1001\/jama.1919.02610310007003","article-title":"The epidemiology of influenza","volume":"73","author":"Frost","year":"1919","journal-title":"JAMA"},{"key":"B4","doi-asserted-by":"crossref","DOI":"10.1097\/00007611-192109000-00029","volume-title":"Epidemic Respiratory Disease: The Pneumonias and Other Infections of the Respiratory Tract Accompanying Influenza and Measles","author":"Opie","year":"1921"},{"key":"B5","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1001\/jama.1919.02610310015005","article-title":"The symptomatology and complications of influenza","volume":"73","author":"Conner","year":"1919","journal-title":"JAMA"},{"issue":"4975","key":"B6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0140-6736(01)22115-1","article-title":"A further investigation into influenza-pneumococcal and influenza-streptococcal septicaemia","volume":"193","author":"Abrahams","year":"1919","journal-title":"Lancet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1001\/jama.1919.02610090001001","article-title":"Staphylococcus aureus pneumonia","volume":"72","author":"Chickering","year":"1919","journal-title":"JAMA"},{"key":"B8","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1001\/jama.1919.02610310012004","article-title":"Bacteriology of recent pandemics of influenza and complicating infections","volume":"73","author":"Park","year":"1919","journal-title":"JAMA"},{"key":"B9","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3201\/eid1802.102042","article-title":"Pathogenic responses among young adults during the 1918 influenza pandemic","volume":"18","author":"Shanks","year":"2012","journal-title":"Emerg Infect Dis"},{"key":"B10","doi-asserted-by":"publisher","first-page":"e69586","DOI":"10.1371\/journal.pone.0069586","article-title":"Age-specific mortality during the 1918 influenza pandemic: unravelling the mystery of high young adult mortality","volume":"8","author":"Gagnon","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"B11","doi-asserted-by":"publisher","first-page":"993","DOI":"10.1093\/infdis\/jiu191","article-title":"Age-specific mortality during the 1918-19 influenza pandemic and possible relationship to the 1889-92 influenza pandemic","volume":"210","author":"Wilson","year":"2014","journal-title":"J Infect Dis"},{"key":"B12","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1111\/j.1750-2659.2011.00332.x","article-title":"Epidemiological isolation causing variable mortality in Island populations during the 1918-1920 influenza pandemic","volume":"6","author":"Shanks","year":"2012","journal-title":"Influenza Other Respir Viruses"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1872","DOI":"10.1001\/jama.2009.1496","article-title":"Critically ill patients with 2009 influenza A (H1N1) infection in Canada","volume":"302","author":"Kumar","year":"2009","journal-title":"JAMA"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1925","DOI":"10.1056\/NEJMoa0908481","article-title":"Critical care services and 2009 H1N1 influenza in Australia and New Zealand","volume":"361","author":"Investigators","year":"2009","journal-title":"N Engl J Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1056\/NEJMoa0906695","article-title":"Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009","volume":"361","author":"Jain","year":"2009","journal-title":"N Engl J Med"},{"key":"B16","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1093\/cid\/ciu285","article-title":"Complications among adults hospitalized with influenza: a comparison of seasonal influenza and the 2009 H1N1 pandemic","volume":"59","author":"Reed","year":"2014","journal-title":"Clin Infect Dis"},{"key":"B17","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/sj.icb.7100026","article-title":"A question of self-preservation: immunopathology in influenza virus infection","volume":"85","author":"La Gruta","year":"2007","journal-title":"Immunol Cell Biol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1600-065X.1997.tb01010.x","article-title":"Effector CD4+ and CD8+ T-cell mechanisms in the control of respiratory virus infections","volume":"159","author":"Doherty","year":"1997","journal-title":"Immunol Rev"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1056\/NEJMoa1305584","article-title":"Clinical findings in 111 cases of influenza A (H7N9) virus infection","volume":"368","author":"Gao","year":"2013","journal-title":"N Engl J Med"},{"key":"B20","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1073\/pnas.1321748111","article-title":"Early hypercytokinemia is associated with interferon-induced transmembrane protein-3 dysfunction and predictive of fatal H7N9 infection","volume":"111","author":"Wang","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B21","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1126\/science.1119392","article-title":"Characterization of the reconstructed 1918 Spanish influenza pandemic virus","volume":"310","author":"Tumpey","year":"2005","journal-title":"Science"},{"key":"B22","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1002\/(SICI)1099-1654(200003\/04)10:2119::AID-RMV2723.3.CO;2-F","article-title":"Influenza A pandemics of the 20th century with special reference to 1918: virology, pathology and epidemiology","volume":"10","author":"Oxford","year":"2000","journal-title":"Rev Med Virol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1038\/nature05495","article-title":"Aberrant innate immune response in lethal infection of macaques with the 1918 influenza virus","volume":"445","author":"Kobasa","year":"2007","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"12479","DOI":"10.1073\/pnas.0705289104","article-title":"Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection","volume":"104","author":"Salomon","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B25","doi-asserted-by":"publisher","first-page":"e1001014","DOI":"10.1371\/journal.ppat.1001014","article-title":"PB1-F2 proteins from H5N1 and 20 century pandemic influenza viruses cause immunopathology","volume":"6","author":"McAuley","year":"2010","journal-title":"PLoS Pathog"},{"key":"B26","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.chom.2007.09.001","article-title":"Expression of the 1918 Influenza A Virus PB1-F2 enhances the pathogenesis of viral and secondary bacterial pneumonia","volume":"2","author":"McAuley","year":"2007","journal-title":"Cell Host Microbe"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1093\/infdis\/jit062","article-title":"Inducible nitric oxide contributes to viral pathogenesis following highly pathogenic influenza virus infection in mice","volume":"207","author":"Perrone","year":"2013","journal-title":"J Infect Dis"},{"key":"B28","doi-asserted-by":"publisher","first-page":"12576","DOI":"10.1128\/JVI.01310-10","article-title":"Genomic profiling of tumor necrosis factor alpha (TNF-alpha) receptor and interleukin-1 receptor knockout mice reveals a link between TNF-alpha signaling and increased severity of 1918 pandemic influenza virus infection","volume":"84","author":"Belisle","year":"2010","journal-title":"J Virol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2437","DOI":"10.1128\/JVI.06156-11","article-title":"Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival","volume":"86","author":"Cilloniz","year":"2012","journal-title":"J Virol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.antiviral.2013.05.007","article-title":"Type I interferon limits influenza virus-induced acute lung injury by regulation of excessive inflammation in mice","volume":"99","author":"Arimori","year":"2013","journal-title":"Antiviral Res"},{"key":"B31","doi-asserted-by":"publisher","first-page":"e1000745","DOI":"10.1371\/journal.ppat.1000745","article-title":"Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines","volume":"6","author":"Manicassamy","year":"2010","journal-title":"PLoS Pathog"},{"key":"B32","doi-asserted-by":"publisher","first-page":"8107","DOI":"10.1073\/pnas.1324197111","article-title":"Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus","volume":"111","author":"Worobey","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B33","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.4049\/jimmunol.1201574","article-title":"Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity antibodies in the absence of neutralizing antibodies","volume":"190","author":"Jegaskanda","year":"2013","journal-title":"J Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3823","DOI":"10.4049\/jimmunol.1002090","article-title":"Protective B cell responses to flu \u2013 no fluke!","volume":"186","author":"Waffarn","year":"2011","journal-title":"J Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"5598","DOI":"10.4049\/jimmunol.172.9.5598","article-title":"Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity","volume":"172","author":"Jegerlehner","year":"2004","journal-title":"J Immunol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1016\/j.coviro.2013.07.007","article-title":"Influenza virus hemagglutinin stalk-based antibodies and vaccines","volume":"3","author":"Krammer","year":"2013","journal-title":"Curr Opin Virol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/nature11371","article-title":"Structural and genetic basis for development of broadly neutralizing influenza antibodies","volume":"489","author":"Lingwood","year":"2012","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"5512","DOI":"10.1128\/JVI.03030-12","article-title":"Antibody-dependent cellular cytotoxicity is associated with control of pandemic H1N1 influenza virus infection of macaques","volume":"87","author":"Jegaskanda","year":"2013","journal-title":"J Virol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"13463","DOI":"10.1128\/JVI.05193-11","article-title":"Complement-dependent lysis of influenza A virus-infected cells by broadly cross-reactive human monoclonal antibodies","volume":"85","author":"Terajima","year":"2011","journal-title":"J Virol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.antiviral.2014.08.016","article-title":"Evaluation of a fully human monoclonal antibody against multiple influenza A viral strains in mice and a pandemic H1N1 strain in nonhuman primates","volume":"111","author":"Song","year":"2014","journal-title":"Antiviral Res"},{"key":"B41","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1084\/jem.20101352","article-title":"Broadly cross-reactive antibodies dominate the human B cell response against 2009 pandemic H1N1 influenza virus infection","volume":"208","author":"Wrammert","year":"2011","journal-title":"J Exp Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e1000796","DOI":"10.1371\/journal.ppat.1000796","article-title":"Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins","volume":"6","author":"Wang","year":"2010","journal-title":"PLoS Pathog"},{"key":"B43","doi-asserted-by":"publisher","first-page":"4592","DOI":"10.1073\/pnas.1214913110","article-title":"Structure and accessibility of HA trimers on intact 2009 H1N1 pandemic influenza virus to stem region-specific neutralizing antibodies","volume":"110","author":"Harris","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B44","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1126\/science.1205669","article-title":"A neutralizing antibody selected from plasma cells that binds to group 1 and group 2 influenza A hemagglutinins","volume":"333","author":"Corti","year":"2011","journal-title":"Science"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1172\/JCI74374","article-title":"Preexisting human antibodies neutralize recently emerged H7N9 influenza strains","volume":"125","author":"Henry Dunand","year":"2015","journal-title":"J Clin Invest"},{"key":"B46","doi-asserted-by":"publisher","first-page":"13706","DOI":"10.1128\/JVI.01666-13","article-title":"Standard trivalent influenza virus protein vaccination does not prime antibody-dependent cellular cytotoxicity in macaques","volume":"87","author":"Jegaskanda","year":"2013","journal-title":"J Virol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"13260","DOI":"10.1128\/JVI.02133-14","article-title":"Induction of broadly reactive anti-hemagglutinin stalk antibodies by an H5N1 vaccine in humans","volume":"88","author":"Nachbagauer","year":"2014","journal-title":"J Virol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nature06890","article-title":"Rapid cloning of high-affinity human monoclonal antibodies against influenza virus","volume":"453","author":"Wrammert","year":"2008","journal-title":"Nature"},{"key":"B49","doi-asserted-by":"publisher","first-page":"9047","DOI":"10.1073\/pnas.1118979109","article-title":"Pandemic H1N1 influenza vaccine induces a recall response in humans that favors broadly cross-reactive memory B cells","volume":"109","author":"Li","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B50","doi-asserted-by":"publisher","first-page":"10302","DOI":"10.1128\/JVI.01336-12","article-title":"Hemagglutinin stalk-reactive antibodies are boosted following sequential infection with seasonal and pandemic H1N1 influenza virus in mice","volume":"86","author":"Krammer","year":"2012","journal-title":"J Virol"},{"key":"B51","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1126\/science.1256427","article-title":"Antibody landscapes after influenza virus infection or vaccination","volume":"346","author":"Fonville","year":"2014","journal-title":"Science"},{"key":"B52","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3389\/fmicb.2014.00285","article-title":"Universal immunity to influenza must outwit immune evasion","volume":"5","author":"Quinones-Parra","year":"2014","journal-title":"Front Microbiol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1126\/scitranslmed.3006366","article-title":"Vaccine-induced anti-HA2 antibodies promote virus fusion and enhance influenza virus respiratory disease","volume":"5","author":"Khurana","year":"2013","journal-title":"Sci Transl Med"},{"key":"B54","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1177\/0300985812439724","article-title":"Kinetics of lung lesion development and pro-inflammatory cytokine response in pigs with vaccine-associated enhanced respiratory disease induced by challenge with pandemic (2009) A\/H1N1 influenza virus","volume":"49","author":"Gauger","year":"2012","journal-title":"Vet Pathol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1001\/jama.1967.03130250057008","article-title":"Altered reactivity to measles virus. Atypical measles in children previously immunized with inactivated measles virus vaccines","volume":"202","author":"Fulginiti","year":"1967","journal-title":"JAMA"},{"key":"B56","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1084\/jem.20020781","article-title":"A role for immune complexes in enhanced respiratory syncytial virus disease","volume":"196","author":"Polack","year":"2002","journal-title":"J Exp Med"},{"key":"B57","doi-asserted-by":"publisher","first-page":"658","DOI":"10.3181\/00379727-131-33946","article-title":"Respiratory syncytial virus neutralizing activity in nasal secretions following natural infection","volume":"131","author":"Kim","year":"1969","journal-title":"Proc Soc Exp Biol Med"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1086\/592454","article-title":"Cross-protection between successive waves of the 1918-1919 influenza pandemic: epidemiological evidence from US army camps and from Britain","volume":"198","author":"Barry","year":"2008","journal-title":"J Infect Dis"},{"key":"B59","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.jtbi.2009.08.020","article-title":"Qualitative analysis of the level of cross-protection between epidemic waves of the 1918-1919 influenza pandemic","volume":"261","author":"Rios-Doria","year":"2009","journal-title":"J Theor Biol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1017\/S0950268811000367","article-title":"Host and environmental factors reducing mortality during the 1918-1919 influenza pandemic","volume":"139","author":"Paynter","year":"2011","journal-title":"Epidemiol Infect"},{"key":"B61","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1111\/j.1750-2659.2010.00195.x","article-title":"Low but highly variable mortality among nurses and physicians during the influenza pandemic of 1918-1919","volume":"5","author":"Shanks","year":"2011","journal-title":"Influenza Other Respir Viruses"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1056\/NEJMoa0906453","article-title":"Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus","volume":"361","author":"Hancock","year":"2009","journal-title":"N Engl J Med"},{"key":"B63","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1056\/NEJMc0907256","article-title":"Older age and a reduced likelihood of 2009 H1N1 virus infection","volume":"361","author":"Fisman","year":"2009","journal-title":"N Engl J Med"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1073\/pnas.1322229111","article-title":"Preexisting CD8+ T-cell immunity to the H7N9 Influenza A Virus varies across ethnicities","volume":"111","author":"Quinones-Parra","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1084\/jem.175.4.1143","article-title":"Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge","volume":"175","author":"Bender","year":"1992","journal-title":"J Exp Med"},{"key":"B66","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1086\/498980","article-title":"Prior H1N1 influenza infection and susceptibility of Cleveland family study participants during the H2N2 pandemic of 1957: an experiment of nature","volume":"193","author":"Epstein","year":"2006","journal-title":"J Infect Dis"},{"key":"B67","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJM198307073090103","article-title":"Cytotoxic T-cell immunity to influenza","volume":"309","author":"McMichael","year":"1983","journal-title":"N Engl J Med"},{"key":"B68","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/nm.3350","article-title":"Cellular immune correlates of protection against symptomatic pandemic influenza","volume":"19","author":"Sridhar","year":"2013","journal-title":"Nat Med"},{"key":"B69","doi-asserted-by":"publisher","first-page":"12599","DOI":"10.1073\/pnas.1007270107","article-title":"Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses","volume":"107","author":"Gras","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B70","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.amepre.2006.04.005","article-title":"Cases and deaths during influenza pandemics in the United States","volume":"31","author":"Brundage","year":"2006","journal-title":"Am J Prev Med"},{"key":"B71","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1126\/science.1186430","article-title":"Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus","volume":"328","author":"Xu","year":"2010","journal-title":"Science"},{"key":"B72","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s00018-013-1479-x","article-title":"Switch from protective to adverse inflammation during influenza: viral determinants and hemostasis are caught as culprits","volume":"71","author":"Berri","year":"2014","journal-title":"Cell Mol Life Sci"},{"key":"B73","doi-asserted-by":"publisher","first-page":"16416","DOI":"10.1073\/pnas.1111179108","article-title":"Autopsy series of 68 cases dying before and during the 1918 influenza pandemic peak","volume":"108","author":"Sheng","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B74","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.coi.2010.06.003","article-title":"Host response to influenza virus: protection versus immunopathology","volume":"22","author":"Peiris","year":"2010","journal-title":"Curr Opin Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"deposited":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T15:27:04Z","timestamp":1567092424000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fimmu.2015.00419\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,19]]},"references-count":74,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2015.00419","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,19]]}}}