{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:47:54Z","timestamp":1789757274162,"version":"4.0.1"},"reference-count":103,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1078694"],"award-info":[{"award-number":["APP1078694"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2015.00465","type":"journal-article","created":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T05:29:36Z","timestamp":1443418176000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":45,"title":["Animal Models to Study Links between Cardiovascular Disease and Renal Failure and Their Relevance to Human Pathology"],"prefix":"10.3389","volume":"6","author":[{"given":"Tim D.","family":"Hewitson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen G.","family":"Holt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2015,9,17]]},"reference":[{"issue":"2","key":"B1","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.atherosclerosis.2011.02.049","article-title":"Is the kidney just a modified blood vessel? Unravelling the direction of causality between cardiovascular and renal disease","volume":"216","author":"Tomlinson","year":"2011","journal-title":"Atherosclerosis"},{"issue":"8","key":"B2","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1111\/j.1440-1681.2011.05632.x","article-title":"Cardiorenal syndrome: pathophysiology, preclinical models, management and potential role of uraemic toxins","volume":"39","author":"Liu","year":"2012","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"3","key":"B3","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1007\/s10741-011-9279-6","article-title":"Animal models of cardiorenal syndrome: a review","volume":"17","author":"Szymanski","year":"2012","journal-title":"Heart Fail Rev"},{"issue":"9","key":"B4","doi-asserted-by":"publisher","first-page":"F1253","DOI":"10.1152\/ajprenal.00392.2012","article-title":"Target organ cross talk in cardiorenal syndrome: animal models","volume":"303","author":"Bongartz","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"B5","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/MNH.0000000000000099","article-title":"Cardiorenal syndrome in chronic kidney disease","volume":"24","author":"Tsuruya","year":"2015","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"11","key":"B6","doi-asserted-by":"publisher","first-page":"2816","DOI":"10.1097\/01.ASN.0000133698.80390.37","article-title":"The relationship between hyperinsulinemia, hypertension and progressive renal disease","volume":"15","author":"El-Atat","year":"2004","journal-title":"J Am Soc Nephrol"},{"issue":"19","key":"B7","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/j.jacc.2008.07.051","article-title":"Cardiorenal syndrome","volume":"52","author":"Ronco","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"B8","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1093\/ndt\/gfq180","article-title":"Prevention of cardio-renal syndromes: workgroup statements from the 7th ADQI consensus conference","volume":"25","author":"McCullough","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"B9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1038\/nrneph.2012.279","article-title":"Cardiorenal syndrome: pathophysiology and potential targets for clinical management","volume":"9","author":"Hatamizadeh","year":"2013","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"B10","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1038\/nrneph.2013.250","article-title":"Cardiorenal syndrome \u2013 current understanding and future perspectives","volume":"10","author":"Braam","year":"2014","journal-title":"Nat Rev Nephrol"},{"issue":"23","key":"B11","doi-asserted-by":"publisher","first-page":"2592","DOI":"10.1161\/CIRCULATIONAHA.109.886473","article-title":"Cardiorenal syndrome: new perspectives","volume":"121","author":"Bock","year":"2010","journal-title":"Circulation"},{"issue":"4","key":"B12","doi-asserted-by":"publisher","first-page":"143","DOI":"10.5527\/wjn.v3.i4.143","article-title":"Why do young people with chronic kidney disease die early?","volume":"3","author":"Kumar","year":"2014","journal-title":"World J Nephrol"},{"issue":"9","key":"B13","doi-asserted-by":"publisher","first-page":"H1884","DOI":"10.1152\/ajpheart.00967.2011","article-title":"Myocardial infarction impairs renal function, induces renal interstitial fibrosis, and increases renal KIM-1 expression: implications for cardiorenal syndrome","volume":"302","author":"Lekawanvijit","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"B14","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1161\/HYPERTENSIONAHA.114.03594","article-title":"Serelaxin is a more efficacious antifibrotic than enalapril in an experimental model of heart disease","volume":"64","author":"Samuel","year":"2014","journal-title":"Hypertension"},{"issue":"7","key":"B15","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1681\/ASN.2009070759","article-title":"Macula densa sensing and signaling mechanisms of renin release","volume":"21","author":"Peti-Peterdi","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"B16","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1096\/fj.000569fje","article-title":"Possible role of uncoupling protein in regulation of myocardial energy metabolism in aortic regurgitation model rats","volume":"15","author":"Noma","year":"2001","journal-title":"FASEB J"},{"issue":"11","key":"B17","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1161\/CIRCULATIONAHA.111.064097","article-title":"Renal sympathetic denervation suppresses de novo podocyte injury and albuminuria in rats with aortic regurgitation","volume":"125","author":"Rafiq","year":"2012","journal-title":"Circulation"},{"issue":"6","key":"B18","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1097\/00005373-199907000-00076","article-title":"Effect of increased renal venous pressure on renal function","volume":"47","author":"Doty","year":"1999","journal-title":"J Trauma"},{"issue":"Suppl 1","key":"B19","doi-asserted-by":"publisher","first-page":"S14","DOI":"10.1186\/1755-1536-5-S1-S14","article-title":"Fibrosis in the kidney: is a problem shared a problem halved?","volume":"5","author":"Hewitson","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"7","key":"B20","doi-asserted-by":"publisher","first-page":"2850","DOI":"10.1172\/JCI76628","article-title":"Cardiac fibroblasts in pressure overload hypertrophy: the enemy within?","volume":"124","author":"Bursac","year":"2014","journal-title":"J Clin Invest"},{"key":"B21","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-1-59745-352-3_4","article-title":"Small animal models of kidney disease: a review","volume":"466","author":"Hewitson","year":"2009","journal-title":"Methods Mol Biol"},{"issue":"5","key":"B22","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/ki.1985.197","article-title":"Myocardial hypertrophy in rats with renal insufficiency","volume":"28","author":"Rambausek","year":"1985","journal-title":"Kidney Int"},{"issue":"4","key":"B23","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1038\/ki.1996.444","article-title":"Early increase in blood pressure and diastolic left ventricular malfunction in patients with glomerulonephritis","volume":"50","author":"Stefanski","year":"1996","journal-title":"Kidney Int"},{"issue":"7","key":"B24","doi-asserted-by":"publisher","first-page":"e41281","DOI":"10.1371\/journal.pone.0041281","article-title":"Chronic kidney disease-induced cardiac fibrosis is ameliorated by reducing circulating levels of a non-dialysable uremic toxin, indoxyl sulfate","volume":"7","author":"Lekawanvijit","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"B25","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1159\/000168817","article-title":"Prevention of cardiac hypertrophy in experimental chronic renal failure by long-term ACE inhibitor administration: potential role of lysosomal proteinases","volume":"15","author":"Suzuki","year":"1995","journal-title":"Am J Nephrol"},{"issue":"5","key":"B26","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1038\/ki.1992.390","article-title":"Reduced capillary density in the myocardium of uremic rats \u2013 a stereological study","volume":"42","author":"Amann","year":"1992","journal-title":"Kidney Int"},{"key":"B27","doi-asserted-by":"publisher","first-page":"S25","DOI":"10.1111\/j.1523-1755.2005.09906.x","article-title":"Chronic renal failure: a cardiovascular risk factor","volume":"99","author":"Fort","year":"2005","journal-title":"Kidney Int Suppl"},{"issue":"8 Pt 1","key":"B28","first-page":"2705","article-title":"Adriamycin-induced cardiotoxicity (cardiomyopathy and congestive heart failure) in rats","volume":"37","author":"Mettler","year":"1977","journal-title":"Cancer Res"},{"issue":"1","key":"B29","doi-asserted-by":"publisher","first-page":"e6","DOI":"10.1159\/000093258","article-title":"Efficacy of darbepoetin in doxorubicin-induced cardiorenal injury in rats","volume":"104","author":"Noiri","year":"2006","journal-title":"Nephron Exp Nephrol"},{"issue":"1","key":"B30","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.jacc.2005.03.044","article-title":"Erythropoietin induces neovascularization and improves cardiac function in rats with heart failure after myocardial infarction","volume":"46","author":"van der Meer","year":"2005","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"B31","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0735-1097(03)00564-3","article-title":"Do associations with C-reactive protein and extent of coronary artery disease account for the increased cardiovascular risk of renal insufficiency?","volume":"42","author":"Zebrack","year":"2003","journal-title":"J Am Coll Cardiol"},{"issue":"4","key":"B32","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1056\/NEJM199007263230405","article-title":"Elevated circulating levels of tumor necrosis factor in severe chronic heart failure","volume":"323","author":"Levine","year":"1990","journal-title":"N Engl J Med"},{"issue":"6","key":"B33","doi-asserted-by":"publisher","first-page":"1549","DOI":"10.1097\/01.ASN.0000064946.94590.46","article-title":"Distant effects of experimental renal ischemia\/reperfusion injury","volume":"14","author":"Kelly","year":"2003","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"B34","doi-asserted-by":"publisher","first-page":"F1418","DOI":"10.1152\/ajprenal.00633.2013","article-title":"Phosphate overload directly induces systemic inflammation and malnutrition as well as vascular calcification in uremia","volume":"306","author":"Yamada","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"issue":"11","key":"B35","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.1093\/ndt\/gft376","article-title":"Role of inflammation in the pathogenesis of cardiorenal syndrome in a rat myocardial infarction model","volume":"28","author":"Cho","year":"2013","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"B36","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1097\/01.mnh.0000444814.49755.90","article-title":"The emerging role of the inflammasome in kidney diseases","volume":"23","author":"Chang","year":"2014","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"2","key":"B37","doi-asserted-by":"publisher","first-page":"F263","DOI":"10.1152\/ajprenal.00109.2010","article-title":"Statins reverse renal inflammation and endothelial dysfunction induced by chronic high salt intake","volume":"301","author":"Fiore","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"issue":"12","key":"B38","doi-asserted-by":"publisher","first-page":"2449","DOI":"10.1093\/oxfordjournals.ndt.a027213","article-title":"Concentration of dimethyl-L-arginine in the plasma of patients with end-stage renal failure","volume":"11","author":"MacAllister","year":"1996","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"B39","doi-asserted-by":"publisher","first-page":"R815","DOI":"10.1152\/ajpregu.00727.2009","article-title":"Transient nitric oxide reduction induces permanent cardiac systolic dysfunction and worsens kidney damage in rats with chronic kidney disease","volume":"298","author":"Bongartz","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"B40","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/ki.2014.220","article-title":"Renal denervation has blood pressure-independent protective effects on kidney and heart in a rat model of chronic kidney disease","volume":"87","author":"Eriguchi","year":"2015","journal-title":"Kidney Int"},{"issue":"12","key":"B41","doi-asserted-by":"publisher","first-page":"2164","DOI":"10.1016\/S0735-1097(03)00471-6","article-title":"Increased myocardial NADPH oxidase activity in human heart failure","volume":"41","author":"Heymes","year":"2003","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"B42","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1046\/j.1523-1755.2003.00702.x","article-title":"Oxidative stress and dysregulation of superoxide dismutase and NADPH oxidase in renal insufficiency","volume":"63","author":"Vaziri","year":"2003","journal-title":"Kidney Int"},{"issue":"5","key":"B43","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1046\/j.1365-2362.2003.01149.x","article-title":"Endogenous nitric oxide synthase inhibitors and renal perfusion in patients with heart failure","volume":"33","author":"Kielstein","year":"2003","journal-title":"Eur J Clin Invest"},{"issue":"2","key":"B44","doi-asserted-by":"publisher","first-page":"107","DOI":"10.2174\/1573402111666141231144228","article-title":"RAAS inhibition and cardiorenal syndrome","volume":"10","author":"Onuigbo","year":"2014","journal-title":"Curr Hypertens Rev"},{"issue":"6","key":"B45","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1097\/01.hjh.0000226200.73065.5d","article-title":"Contribution of reactive oxygen species to the pathogenesis of left ventricular failure in Dahl salt-sensitive hypertensive rats: effects of angiotensin II blockade","volume":"24","author":"Guo","year":"2006","journal-title":"J Hypertens"},{"issue":"6","key":"B46","doi-asserted-by":"publisher","first-page":"F579","DOI":"10.1152\/ajprenal.00442.2014","article-title":"Mitochondrial dysfunction in uremic cardiomyopathy","volume":"308","author":"Taylor","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"issue":"11","key":"B47","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1161\/CIRCRESAHA.112.278457","article-title":"Cardiorenal syndrome: the emerging role of protein-bound uremic toxins","volume":"111","author":"Lekawanvijit","year":"2012","journal-title":"Circ Res"},{"issue":"2","key":"B48","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.toxlet.2015.01.021","article-title":"Indoxyl sulfate induces oxidative stress and hypertrophy in cardiomyocytes by inhibiting the AMPK\/UCP2 signaling pathway","volume":"234","author":"Yang","year":"2015","journal-title":"Toxicol Lett"},{"issue":"24\u201326","key":"B49","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1016\/j.lfs.2013.05.008","article-title":"Indoxyl sulfate promotes cardiac fibrosis with enhanced oxidative stress in hypertensive rats","volume":"92","author":"Yisireyili","year":"2013","journal-title":"Life Sci"},{"issue":"5","key":"B50","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/0272-6386(95)90456-5","article-title":"Renal afferent denervation prevents the progression of renal disease in the renal ablation model of chronic renal failure in the rat","volume":"26","author":"Campese","year":"1995","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"B51","doi-asserted-by":"publisher","first-page":"H1519","DOI":"10.1152\/ajpheart.00206.2005","article-title":"Role of renal nerves in development of hypertension in DOCA-salt model in rats: a telemetric approach","volume":"289","author":"Jacob","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1038\/ki.2009.188","article-title":"KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD)","volume":"113","author":"KDIGO CKD-MBD workgroup","year":"2009","journal-title":"Kidney Int Suppl"},{"issue":"20","key":"B53","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1056\/NEJM200005183422003","article-title":"Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis","volume":"342","author":"Goodman","year":"2000","journal-title":"N Engl J Med"},{"key":"B54","first-page":"S42","article-title":"Cardiac hypertrophy and arterial alterations in end-stage renal disease: hemodynamic factors","volume":"41","author":"London","year":"1993","journal-title":"Kidney Int Suppl"},{"issue":"4","key":"B55","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/ki.2012.131","article-title":"Arterial stiffness and pulse pressure in CKD and ESRD","volume":"82","author":"Briet","year":"2012","journal-title":"Kidney Int"},{"issue":"5","key":"B56","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1152\/japplphysiol.90549.2008","article-title":"Effects of central arterial aging on the structure and function of the peripheral vasculature: implications for end-organ damage","volume":"105","author":"Mitchell","year":"2008","journal-title":"J Appl Physiol (1985)"},{"issue":"6","key":"B57","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.2215\/CJN.02190507","article-title":"Progressive vascular calcification over 2 years is associated with arterial stiffening and increased mortality in patients with stages 4 and 5 chronic kidney disease","volume":"2","author":"Sigrist","year":"2007","journal-title":"Clin J Am Soc Nephrol"},{"issue":"6","key":"B58","doi-asserted-by":"publisher","first-page":"F1431","DOI":"10.1152\/ajprenal.00079.2011","article-title":"Aortic stiffness is associated with vascular calcification and remodeling in a chronic kidney disease rat model","volume":"300","author":"Ng","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"issue":"1","key":"B59","doi-asserted-by":"publisher","first-page":"F78","DOI":"10.1152\/ajprenal.00533.2010","article-title":"Effect of medial calcification on vascular function in uremia","volume":"301","author":"Sutliff","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"issue":"2","key":"B60","doi-asserted-by":"publisher","first-page":"161","DOI":"10.3109\/00365597909181172","article-title":"Uraemic arterial disease. An experimental study with special reference to the effect of parathyroidectomy","volume":"13","author":"Ejerblad","year":"1979","journal-title":"Scand J Urol Nephrol"},{"issue":"2","key":"B61","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1046\/j.1523-1755.2003.00126.x","article-title":"Sevelamer hydrochloride prevents ectopic calcification and renal osteodystrophy in chronic renal failure rats","volume":"64","author":"Katsumata","year":"2003","journal-title":"Kidney Int"},{"issue":"1","key":"B62","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/BF00272702","article-title":"A reproducible model for chronic renal failure in the mouse","volume":"11","author":"Gagnon","year":"1983","journal-title":"Urol Res"},{"issue":"6","key":"B63","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1159\/000299794","article-title":"Vascular calcification in animal models of CKD: a review","volume":"31","author":"Shobeiri","year":"2010","journal-title":"Am J Nephrol"},{"issue":"1","key":"B64","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/ki.2013.271","article-title":"Early chronic kidney disease-mineral bone disorder stimulates vascular calcification","volume":"85","author":"Fang","year":"2014","journal-title":"Kidney Int"},{"issue":"3","key":"B65","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1093\/ndt\/gfi273","article-title":"Severe hyperparathyroidism with bone abnormalities and metastatic calcification in rats with adenine-induced uraemia","volume":"21","author":"Tamagaki","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"B66","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/1471-2369-15-69","article-title":"Mineral bone disorder in chronic kidney disease: head-to-head comparison of the 5\/6 nephrectomy and adenine models","volume":"15","author":"Ferrari","year":"2014","journal-title":"BMC Nephrol"},{"issue":"2","key":"B67","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/ki.2008.456","article-title":"A rat model of chronic kidney disease-mineral bone disorder","volume":"75","author":"Moe","year":"2009","journal-title":"Kidney Int"},{"issue":"1","key":"B68","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1002\/jbmr.516","article-title":"Longitudinal evaluation of FGF23 changes and mineral metabolism abnormalities in a mouse model of chronic kidney disease","volume":"27","author":"Stubbs","year":"2012","journal-title":"J Bone Miner Res"},{"issue":"9","key":"B69","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/nrcardio.2010.115","article-title":"Regulatory mechanisms in vascular calcification","volume":"7","author":"Sage","year":"2010","journal-title":"Nat Rev Cardiol"},{"issue":"12","key":"B70","doi-asserted-by":"publisher","first-page":"2589","DOI":"10.1161\/ATVBAHA.107.153668","article-title":"Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-\/- mice","volume":"27","author":"Al-Aly","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"5","key":"B71","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/path.1743","article-title":"Transdifferentiation of smooth muscle cells into chondrocytes in atherosclerotic arteries in situ: implications for diffuse intimal calcification","volume":"205","author":"Bobryshev","year":"2005","journal-title":"J Pathol"},{"issue":"5","key":"B72","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1038\/sj.ki.5002353","article-title":"Endochondral bone formation is involved in media calcification in rats and in men","volume":"72","author":"Neven","year":"2007","journal-title":"Kidney Int"},{"issue":"6","key":"B73","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1097\/01.ASN.0000068404.57780.DD","article-title":"BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure","volume":"14","author":"Davies","year":"2003","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"B74","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1161\/CIRCRESAHA.108.183053","article-title":"Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries","volume":"104","author":"Speer","year":"2009","journal-title":"Circ Res"},{"issue":"12","key":"B75","doi-asserted-by":"publisher","first-page":"1494","DOI":"10.1161\/CIRCRESAHA.110.234260","article-title":"Fetuin-A regulation of calcified matrix metabolism","volume":"108","author":"Jahnen-Dechent","year":"2011","journal-title":"Circ Res"},{"issue":"43","key":"B76","doi-asserted-by":"publisher","first-page":"1676","DOI":"10.1055\/s-0028-1110200","article-title":"[A new autosomal-recessive hereditary syndrome. Multiple peripheral pulmonary stenosis, brachytelephalangia, inner-ear deafness, ossification or calcification of cartilages]","volume":"96","author":"Keutel","year":"1971","journal-title":"Dtsch Med Wochenschr"},{"issue":"4","key":"B77","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/ng1221","article-title":"Mutations in ENPP1 are associated with \u2018idiopathic\u2019 infantile arterial calcification","volume":"34","author":"Rutsch","year":"2003","journal-title":"Nat Genet"},{"issue":"6","key":"B78","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1111\/j.1440-1827.1994.tb01705.x","article-title":"Arthritis and ankylosis in twy mice with hereditary multiple osteochondral lesions: with special reference to calcium deposition","volume":"44","author":"Sakamoto","year":"1994","journal-title":"Pathol Int"},{"issue":"1","key":"B79","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1681\/ASN.2009060640","article-title":"Chronic mineral dysregulation promotes vascular smooth muscle cell adaptation and extracellular matrix calcification","volume":"21","author":"Shroff","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"B80","first-page":"1","article-title":"Difference in coronary artery intima and media calcification in autopsied patients with chronic kidney disease","volume":"75","author":"Yoshida","year":"2011","journal-title":"Clin Nephrol"},{"issue":"3","key":"B81","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/ki.2013.351","article-title":"Breast arterial calcification in chronic kidney disease: absence of smooth muscle apoptosis and osteogenic transdifferentiation","volume":"85","author":"O\u2019Neill","year":"2013","journal-title":"Kidney Int"},{"issue":"1","key":"B82","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0008-6363(98)00077-7","article-title":"Lessons from rat models of hypertension: from Goldblatt to genetic engineering","volume":"39","author":"Pinto","year":"1998","journal-title":"Cardiovasc Res"},{"issue":"8","key":"B83","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1253\/jcj.36.797","article-title":"Cardiovascular lesions in the selectively-bred group of spontaneously hypertensive rats with severe hypertension","volume":"36","author":"Ooshima","year":"1972","journal-title":"Jpn Circ J"},{"issue":"6","key":"B84","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1097\/01.ASN.0000130154.42061.C6","article-title":"Increased infarct size in uremic rats: reduced ischemia tolerance?","volume":"15","author":"Dikow","year":"2004","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"B85","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1046\/j.1523-1755.1998.00019.x","article-title":"A new model of diabetic nephropathy with progressive renal impairment in the transgenic (mRen-2)27 rat (TGR)","volume":"54","author":"Kelly","year":"1998","journal-title":"Kidney Int"},{"issue":"7","key":"B86","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1210\/en.2008-0250","article-title":"Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy","volume":"149","author":"Samuel","year":"2008","journal-title":"Endocrinology"},{"key":"B87","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1093\/ndt\/gfr495","article-title":"Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease","volume":"27","author":"Lian","year":"2012","journal-title":"Nephrol Dial Transplant"},{"issue":"7","key":"B88","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.2337\/diabetes.53.7.1813","article-title":"Advanced glycation end product interventions reduce diabetes-accelerated atherosclerosis","volume":"53","author":"Forbes","year":"2004","journal-title":"Diabetes"},{"issue":"1","key":"B89","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1097\/FJC.0b013e3181ac3a34","article-title":"TRC4186, a novel AGE-breaker, improves diabetic cardiomyopathy and nephropathy in Ob-ZSF1 model of type 2 diabetes","volume":"54","author":"Joshi","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"issue":"2","key":"B90","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1159\/000327022","article-title":"Childhood-adolescent obesity in the cardiorenal syndrome: lessons from animal models","volume":"1","author":"Hayden","year":"2011","journal-title":"Cardiorenal Med"},{"issue":"13\u201314","key":"B91","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1016\/j.lfs.2012.03.032","article-title":"Renal, retinal and cardiac changes in type 2 diabetes are attenuated by macitentan, a dual endothelin receptor antagonist","volume":"91","author":"Sen","year":"2012","journal-title":"Life Sci"},{"issue":"6","key":"B92","first-page":"549","article-title":"Bile acids, oxidative stress, and renal function in biliary obstruction","volume":"17","author":"Bomzon","year":"1997","journal-title":"Semin Nephrol"},{"key":"B93","first-page":"209","article-title":"Biochemical and pathological changes in the heart following bile duct ligation","volume":"2","author":"Tajuddin","year":"1980","journal-title":"Adv Myocardiol"},{"issue":"10","key":"B94","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1080\/09168451.2015.1039481","article-title":"Carbon tetrachloride-induced hepatic and renal damages in rat: inhibitory effects of cacao polyphenol","volume":"79","author":"Suzuki","year":"2015","journal-title":"Biosci Biotechnol Biochem"},{"issue":"5","key":"B95","doi-asserted-by":"publisher","first-page":"G449","DOI":"10.1152\/ajpgi.00199.2012","article-title":"Animal models of chronic liver diseases","volume":"304","author":"Liu","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B96","doi-asserted-by":"publisher","first-page":"271694","DOI":"10.1155\/2011\/271694","article-title":"Murine models of systemic lupus erythematosus","volume":"2011","author":"Perry","year":"2011","journal-title":"J Biomed Biotechnol"},{"issue":"4","key":"B97","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/art.1780170410","article-title":"Spontaneous carditis in the NZB mouse and its hybrids","volume":"17","author":"Pansky","year":"1974","journal-title":"Arthritis Rheum"},{"issue":"3","key":"B98","first-page":"289","article-title":"Animal models of human systemic lupus erythematosus","volume":"52","author":"Huston","year":"1979","journal-title":"Yale J Biol Med"},{"issue":"1","key":"B99","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1007\/s10875-009-9326-4","article-title":"A new model of induced experimental systemic lupus erythematosus (SLE) in pigs and its amelioration by treatment with a tolerogenic peptide","volume":"30","author":"Sharabi","year":"2010","journal-title":"J Clin Immunol"},{"issue":"3","key":"B100","doi-asserted-by":"publisher","first-page":"1866","DOI":"10.1016\/j.ijcard.2012.12.065","article-title":"Subtotal nephrectomy accelerates pathological cardiac remodeling post-myocardial infarction: implications for cardiorenal syndrome","volume":"168","author":"Liu","year":"2013","journal-title":"Int J Cardiol"},{"issue":"10","key":"B101","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1093\/ndt\/gfn233","article-title":"Myocardial infarction does not further impair renal damage in 5\/6 nephrectomized rats","volume":"23","author":"Windt","year":"2008","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"B102","doi-asserted-by":"publisher","first-page":"H845","DOI":"10.1152\/ajpheart.00261.2011","article-title":"Subtotal nephrectomy plus coronary ligation leads to more pronounced damage in both organs than either nephrectomy or coronary ligation","volume":"302","author":"Bongartz","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"12","key":"B103","doi-asserted-by":"publisher","first-page":"3103","DOI":"10.1097\/01.ASN.0000145895.62896.98","article-title":"Myocardial infarction enhances progressive renal damage in an experimental model for cardio-renal interaction","volume":"15","author":"van Dokkum","year":"2004","journal-title":"J Am Soc Nephrol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T21:42:54Z","timestamp":1567201374000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fimmu.2015.00465\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,17]]},"references-count":103,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2015.00465","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,17]]}}}