{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:53:15Z","timestamp":1790632395493,"version":"4.1.0"},"reference-count":40,"publisher":"Frontiers Media SA","funder":[{"name":"Biovaxim Ltd."},{"DOI":"10.13039\/501100005413","name":"Universit\u00e9 Paris Descartes","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006137","name":"D\u00e9partement Soutien et Formation, Institut de Recherche pour le D\u00e9veloppement","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006137","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00134","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T03:05:57Z","timestamp":1460948757000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":21,"title":["Suppression of HIV Replication by CD8+ Regulatory T-Cells in Elite Controllers"],"prefix":"10.3389","volume":"7","author":[{"given":"Wei","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Dao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weizhong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linchun","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Andrieu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,4,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1097\/QAD.0b013e32832b44c8","article-title":"Prevalence and comparative characteristics of long-term nonprogressors and HIV controller patients in the French Hospital Database on HIV","volume":"23","author":"Grabar","year":"2009","journal-title":"AIDS"},{"key":"B2","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/ng2035","article-title":"Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1","volume":"39","author":"Martin","year":"2007","journal-title":"Nat Genet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/ng934","article-title":"Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS","volume":"31","author":"Martin","year":"2002","journal-title":"Nat Genet"},{"key":"B4","doi-asserted-by":"publisher","first-page":"5140","DOI":"10.1073\/pnas.071548198","article-title":"Control of HIV-1 viremia and protection from AIDS are associated with HLA-Bw4 homozygosity","volume":"98","author":"Flores-Villanueva","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B5","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nri1570","article-title":"MHC class I molecules and KIRs in human history, health and survival","volume":"5","author":"Parham","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1126\/science.1097670","article-title":"HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection","volume":"305","author":"Khakoo","year":"2004","journal-title":"Science"},{"key":"B7","doi-asserted-by":"publisher","first-page":"e1002270","DOI":"10.1371\/journal.ppat.1002270","article-title":"KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection","volume":"7","author":"Seich Al Basatena","year":"2011","journal-title":"PLoS Pathog"},{"key":"B8","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1007\/BF02421207","article-title":"Genetic and serological heterogeneity of the supertypic HLA-B locus specificities Bw4 and Bw6","volume":"30","author":"Muller","year":"1989","journal-title":"Immunogenetics"},{"key":"B9","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1038\/nature10517","article-title":"Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B","volume":"479","author":"Vivian","year":"2013","journal-title":"Nature"},{"key":"B10","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1146\/annurev.immunol.20.092501.134942","article-title":"KIR: diverse, rapidly evolving receptors of innate and adaptive immunity","volume":"20","author":"Vilches","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"6010","DOI":"10.4049\/jimmunol.181.9.6010","article-title":"Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype","volume":"181","author":"Fauriat","year":"2008","journal-title":"J Immunol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3455","DOI":"10.1182\/blood-2012-03-416867","article-title":"CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells","volume":"120","author":"Bjorkstrom","year":"2012","journal-title":"Blood"},{"key":"B13","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.4049\/jimmunol.159.8.3723","article-title":"Phenotypic and cytokine analysis of human peripheral blood gamma delta T cells expressing NK cell receptors","volume":"159","author":"Battistini","year":"1997","journal-title":"J Immunol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"4175","DOI":"10.4049\/jimmunol.0800455","article-title":"Functional killer Ig-like receptors on human memory CD4+ T cells specific for cytomegalovirus","volume":"182","author":"van Bergen","year":"2009","journal-title":"J Immunol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"7223","DOI":"10.4049\/jimmunol.173.12.7223","article-title":"Coordinated expression of Ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells","volume":"173","author":"Anfossi","year":"2004","journal-title":"J Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"3027","DOI":"10.1084\/jem.20070695","article-title":"Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR\/HLA subtypes","volume":"204","author":"Alter","year":"2007","journal-title":"J Exp Med"},{"key":"B17","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.4049\/jimmunol.0902621","article-title":"HIV protective KIR3DL1 and HLA-B genotypes influence NK cell function following stimulation with HLA-devoid cells","volume":"184","author":"Boulet","year":"2010","journal-title":"J Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"5028","DOI":"10.1128\/JVI.02551-08","article-title":"Role of natural killer cells in a cohort of elite suppressors: low frequency of the protective KIR3DS1 allele and limited inhibition of human immunodeficiency virus type 1 replication in vitro","volume":"83","author":"O\u2019Connell","year":"2009","journal-title":"J Virol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"4785","DOI":"10.1128\/JVI.02449-07","article-title":"Conferral of enhanced natural killer cell function by KIR3DS1 in early human immunodeficiency virus type 1 infection","volume":"82","author":"Long","year":"2008","journal-title":"J Virol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1089\/aid.2007.0269","article-title":"Molecular tracing of sexual HIV Type 1 transmission in the southwest border of China","volume":"24","author":"Bao","year":"2008","journal-title":"AIDS Res Hum Retroviruses"},{"key":"B21","doi-asserted-by":"publisher","first-page":"e107578","DOI":"10.1371\/journal.pone.0107578","article-title":"Evolving molecular epidemiological profile of human immunodeficiency virus 1 in the southwest border of China","volume":"9","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"B22","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/978-1-60761-362-6_25","article-title":"KIR genotyping by multiplex PCR-SSP","volume":"612","author":"Kulkarni","year":"2010","journal-title":"Methods Mol Biol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/12520","article-title":"Equivalent amplification of intrinsically variable nucleic acid sequences by multiple-primer-induced overlapping amplification assay: applications for universal detection and quantitation","volume":"5","author":"Lu","year":"1999","journal-title":"Nat Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1038\/nm1147","article-title":"Therapeutic dendritic-cell vaccine for chronic HIV-1 infection","volume":"10","author":"Lu","year":"2004","journal-title":"Nat Med"},{"key":"B25","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1084\/jem.184.3.1155","article-title":"Mitochondrial permeability transition is a central coordinating event of apoptosis","volume":"184","author":"Marchetti","year":"1996","journal-title":"J Exp Med"},{"key":"B26","doi-asserted-by":"publisher","first-page":"162","DOI":"10.3389\/fimmu.2013.00162","article-title":"Lessons to be learned from natural control of HIV\u2009\u2013\u2009future directions, therapeutic, and preventive implications","volume":"4","author":"Shasha","year":"2013","journal-title":"Front Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"7888","DOI":"10.1073\/pnas.1509324112","article-title":"Discovery of another anti-HIV protein in the search for the CD8+ cell anti-HIV Factor","volume":"112","author":"Levy","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B28","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/j.coi.2006.05.002","article-title":"Natural killer cells as an initial defense against pathogens","volume":"18","author":"Lodoen","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.1086\/513878","article-title":"Evolution of innate and adaptive effector cell functions during acute HIV-1 infection","volume":"195","author":"Alter","year":"2007","journal-title":"J Infect Dis"},{"key":"B30","doi-asserted-by":"publisher","first-page":"3933","DOI":"10.4049\/jimmunol.166.6.3933","article-title":"Differential expression of leukocyte receptor complex-encoded Ig-like receptors correlates with the transition from effector to memory CTL","volume":"166","author":"Young","year":"2001","journal-title":"J Immunol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/85246","article-title":"Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells","volume":"2","author":"Ugolini","year":"2001","journal-title":"Nat Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"12474","DOI":"10.1073\/pnas.1406240111","article-title":"KLRG+ invariant natural killer T cells are long-lived effectors","volume":"111","author":"Shimizu","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B33","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1146\/annurev.med.54.101601.152346","article-title":"The influence of HLA genotype on AIDS","volume":"54","author":"Carrington","year":"2003","journal-title":"Annu Rev Med"},{"key":"B34","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1038\/nri1417","article-title":"HIV and SIV CTL escape: implications for vaccine design","volume":"4","author":"Goulder","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"6776","DOI":"10.1073\/pnas.0611244104","article-title":"HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype","volume":"104","author":"Saez-Cirion","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1016\/j.immuni.2008.10.010","article-title":"Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control","volume":"29","author":"Migueles","year":"2008","journal-title":"Immunity"},{"key":"B37","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fimmu.2015.00124","article-title":"A new scientific paradigm may be needed to finally develop an HIV vaccine","volume":"6","author":"Esparza","year":"2015","journal-title":"Front Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1126\/science.1250672","article-title":"Immunology. Immune activation with HIV vaccines","volume":"344","author":"Fauci","year":"2014","journal-title":"Science"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1736","DOI":"10.1016\/j.celrep.2012.11.016","article-title":"Induction of CD8+ regulatory T cells protects macaques against SIV challenge","volume":"2","author":"Lu","year":"2012","journal-title":"Cell Rep"},{"key":"B40","doi-asserted-by":"publisher","first-page":"297","DOI":"10.3389\/fimmu.2014.00297","article-title":"Mucosal SIV vaccines comprising inactivated virus particles and bacterial adjuvants induce CD8(+) T-regulatory cells that suppress SIV-positive CD4(+) T-cell activation and prevent SIV infection in the Macaque model","volume":"5","author":"Andrieu","year":"2013","journal-title":"Front Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T17:40:40Z","timestamp":1692294040000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fimmu.2016.00134\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,18]]},"references-count":40,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00134","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,18]]}}}