{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:37:54Z","timestamp":1791398274209,"version":"4.3.3"},"reference-count":68,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00188","type":"journal-article","created":{"date-parts":[[2016,5,18]],"date-time":"2016-05-18T03:15:45Z","timestamp":1463541345000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":50,"title":["NK Cells and Other Innate Lymphoid Cells in Hematopoietic Stem Cell Transplantation"],"prefix":"10.3389","volume":"7","author":[{"given":"Paola","family":"Vacca","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Montaldo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Croxatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Moretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Bertaina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Locatelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Mingari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Moretta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,5,18]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1056\/NEJMra052638","article-title":"Hematopoietic stem-cell transplantation","volume":"354","author":"Copelan","year":"2006","journal-title":"N Engl J Med"},{"key":"B2","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3389\/fimmu.2014.00068","article-title":"Improving engraftment and immune reconstitution in umbilical cord blood transplantation","volume":"5","author":"Danby","year":"2014","journal-title":"Front Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3389\/fimmu.2013.00015","article-title":"Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells","volume":"4","author":"Locatelli","year":"2013","journal-title":"Front Immunol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"2097","DOI":"10.1126\/science.1068440","article-title":"Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants","volume":"295","author":"Ruggeri","year":"2002","journal-title":"Science"},{"key":"B5","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1182\/blood-2010-08-264085","article-title":"Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation","volume":"117","author":"Moretta","year":"2011","journal-title":"Blood"},{"key":"B6","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.immuni.2014.09.005","article-title":"Development, differentiation, and diversity of innate lymphoid cells","volume":"41","author":"Diefenbach","year":"2014","journal-title":"Immunity"},{"key":"B7","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/82_2015_474","article-title":"Development, homeostasis, and heterogeneity of NK cells and ILC1","volume":"395","author":"Seillet","year":"2015","journal-title":"Curr Top Microbiol Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/intimm\/dxv050","article-title":"Group 2 innate lymphoid cells in disease","volume":"28","author":"Halim","year":"2016","journal-title":"Int Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1002\/eji.201545598","article-title":"Group 3 innate lymphoid cells (ILC3s): origin, differentiation, and plasticity in humans and mice","volume":"45","author":"Montaldo","year":"2015","journal-title":"Eur J Immunol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2016.01.007","article-title":"Human innate lymphoid cells","author":"Montaldo","year":"2016","journal-title":"Immunol Lett"},{"key":"B11","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.immuni.2015.07.011","article-title":"Identification of a human natural killer cell lineage-restricted progenitor in fetal and adult tissues","volume":"43","author":"Renoux","year":"2015","journal-title":"Immunity"},{"key":"B12","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.immuni.2014.11.010","article-title":"Human RORgammat(+)CD34(+) cells are lineage-specified progenitors of group 3 RORgammat(+) innate lymphoid cells","volume":"41","author":"Montaldo","year":"2014","journal-title":"Immunity"},{"key":"B13","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.immuni.2014.09.006","article-title":"Innate lymphoid cells in inflammation and immunity","volume":"41","author":"McKenzie","year":"2014","journal-title":"Immunity"},{"key":"B14","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1038\/nm.3892","article-title":"Innate lymphoid cells in the initiation, regulation and resolution of inflammation","volume":"21","author":"Sonnenberg","year":"2015","journal-title":"Nat Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/ni.2534","article-title":"Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues","volume":"14","author":"Bernink","year":"2013","journal-title":"Nat Immunol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.immuni.2013.02.010","article-title":"Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-gamma-producing cells","volume":"38","author":"Fuchs","year":"2013","journal-title":"Immunity"},{"key":"B17","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/mi.2014.63","article-title":"Identification of diverse innate lymphoid cells in human decidua","volume":"8","author":"Vacca","year":"2015","journal-title":"Mucosal Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1016\/j.cell.2014.03.030","article-title":"Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages","volume":"157","author":"Klose","year":"2014","journal-title":"Cell"},{"key":"B19","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3389\/fimmu.2011.00088","article-title":"Activation of natural killer cells during microbial infections","volume":"2","author":"Horowitz","year":"2012","journal-title":"Front Immunol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1038\/nri2276","article-title":"Evolutionary struggles between NK cells and viruses","volume":"8","author":"Lanier","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"87","DOI":"10.3389\/fimmu.2014.00087","article-title":"Human NK cells: from surface receptors to the therapy of leukemias and solid tumors","volume":"5","author":"Moretta","year":"2014","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1038\/nature08636","article-title":"Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells","volume":"463","author":"Moro","year":"2010","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nature08900","article-title":"Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity","volume":"464","author":"Neill","year":"2010","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"11489","DOI":"10.1073\/pnas.1003988107","article-title":"Systemically dispersed innate IL-13-expressing cells in type 2 immunity","volume":"107","author":"Price","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B25","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.coi.2012.06.003","article-title":"Susceptibility and immunity to helminth parasites","volume":"24","author":"Maizels","year":"2012","journal-title":"Curr Opin Immunol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/nature07537","article-title":"A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity","volume":"457","author":"Cella","year":"2009","journal-title":"Nature"},{"key":"B27","doi-asserted-by":"publisher","first-page":"521","DOI":"10.4049\/jimmunol.1202924","article-title":"Cutting edge: IL-17-secreting innate lymphoid cells are essential for host defense against fungal infection","volume":"190","author":"Gladiator","year":"2013","journal-title":"J Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1016\/j.immuni.2008.11.001","article-title":"Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense","volume":"29","author":"Satoh-Takayama","year":"2008","journal-title":"Immunity"},{"key":"B29","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.immuni.2010.12.009","article-title":"CD4(+) lymphoid tissue-inducer cells promote innate immunity in the gut","volume":"34","author":"Sonnenberg","year":"2011","journal-title":"Immunity"},{"key":"B30","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/nm1720","article-title":"Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens","volume":"14","author":"Zheng","year":"2008","journal-title":"Nat Med"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.10","article-title":"Group 3 innate lymphoid cells regulate neutrophil migration and function in human decidua","author":"Croxatto","year":"2016","journal-title":"Mucosal Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1031\/ni.2131","article-title":"Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus","volume":"12","author":"Monticelli","year":"2011","journal-title":"Nat Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.coi.2005.01.006","article-title":"Fate and function of lymphoid tissue inducer cells","volume":"17","author":"Finke","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/ni.1605","article-title":"Restoration of lymphoid organ integrity through the interaction of lymphoid tissue-inducer cells with stroma of the T cell zone","volume":"9","author":"Scandella","year":"2008","journal-title":"Nat Immunol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.immuni.2012.05.028","article-title":"Interleukin-22 protects intestinal stem cells from immune-mediated tissue damage and regulates sensitivity to graft versus host disease","volume":"37","author":"Hanash","year":"2012","journal-title":"Immunity"},{"key":"B36","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/nature16460","article-title":"Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration","volume":"528","author":"Lindemans","year":"2015","journal-title":"Nature"},{"key":"B37","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1182\/blood-2013-11-536888","article-title":"Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease","volume":"124","author":"Munneke","year":"2014","journal-title":"Blood"},{"key":"B38","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/j.bbmt.2014.09.010","article-title":"High-dose total body irradiation and myeloablative conditioning before allogeneic hematopoietic cell transplantation: time to rethink?","volume":"21","author":"Mohty","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"B39","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/nri2000","article-title":"Graft-versus-host disease","volume":"7","author":"Shlomchik","year":"2007","journal-title":"Nat Rev Immunol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1667\/RR14047.1","article-title":"Long-lasting impact of neonatal exposure to total body gamma radiation on secondary lymphoid organ structure and function","volume":"184","author":"Rangel-Moreno","year":"2015","journal-title":"Radiat Res"},{"key":"B41","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1126\/science.1218004","article-title":"Interleukin-22 drives endogenous thymic regeneration in mice","volume":"336","author":"Dudakov","year":"2012","journal-title":"Science"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2795","DOI":"10.1111\/ajt.13394","article-title":"Innate lymphoid cells in graft-versus-host disease","volume":"15","author":"Konya","year":"2015","journal-title":"Am J Transplant"},{"key":"B43","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1002\/eji.201546079","article-title":"The generation of human innate lymphoid cells is influenced by the source of hematopoietic stem cells and by the use of G-CSF","volume":"46","author":"Moretta","year":"2016","journal-title":"Eur J Immunol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.cytogfr.2014.07.011","article-title":"G-CSF: from granulopoietic stimulant to bone marrow stem cell mobilizing agent","volume":"25","author":"Bendall","year":"2014","journal-title":"Cytokine Growth Factor Rev"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e257","DOI":"10.3324\/haematol.2014.119602","article-title":"CD127+ innate lymphoid cells are dysregulated in treatment naive acute myeloid leukemia patients at diagnosis","volume":"100","author":"Trabanelli","year":"2015","journal-title":"Haematologica"},{"key":"B46","doi-asserted-by":"publisher","first-page":"e42","DOI":"10.3324\/haematol.2014.110494","article-title":"IL-1beta-releasing human acute myeloid leukemia blasts modulate natural killer cell differentiation from CD34+ precursors","volume":"100","author":"Vitale","year":"2015","journal-title":"Haematologica"},{"key":"B47","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1002\/eji.200324668","article-title":"Analysis of the activating receptors and cytolytic function of human natural killer cells undergoing in vivo differentiation after allogeneic bone marrow transplantation","volume":"34","author":"Vitale","year":"2004","journal-title":"Eur J Immunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1530","DOI":"10.1182\/blood-2006-10-048173","article-title":"The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulations","volume":"110","author":"Wang","year":"2007","journal-title":"Blood"},{"key":"B49","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/ni.2545","article-title":"The transcription factor T-bet is essential for the development of NKp46+ innate lymphocytes via the Notch pathway","volume":"14","author":"Rankin","year":"2013","journal-title":"Nat Immunol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.immuni.2014.10.007","article-title":"The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells","volume":"41","author":"Satoh-Takayama","year":"2014","journal-title":"Immunity"},{"key":"B51","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/ni.3332","article-title":"Complementarity and redundancy of IL-22-producing innate lymphoid cells","volume":"17","author":"Rankin","year":"2016","journal-title":"Nat Immunol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.jaci.2013.07.020","article-title":"Natural killer cell deficiency","volume":"132","author":"Orange","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1016\/j.celrep.2013.11.041","article-title":"Human natural killer cells prevent infectious mononucleosis features by targeting lytic Epstein-Barr virus infection","volume":"5","author":"Chijioke","year":"2013","journal-title":"Cell Rep"},{"key":"B54","doi-asserted-by":"publisher","first-page":"573","DOI":"10.3389\/fimmu.2015.00573","article-title":"Activating KIRs and NKG2C in viral infections: toward NK cell memory?","volume":"6","author":"Della Chiesa","year":"2015","journal-title":"Front Immunol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1111\/imr.12157","article-title":"The biology of NK cells and their receptors affects clinical outcomes after hematopoietic cell transplantation (HCT)","volume":"258","author":"Foley","year":"2014","journal-title":"Immunol Rev"},{"key":"B56","doi-asserted-by":"publisher","first-page":"25","DOI":"10.7150\/jca.5049","article-title":"Clinical relevance of natural killer cells following hematopoietic stem cell transplantation","volume":"4","author":"Palmer","year":"2013","journal-title":"J Cancer"},{"key":"B57","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.bbmt.2009.09.019","article-title":"Impact of cytomegalovirus (CMV) reactivation after umbilical cord blood transplantation","volume":"16","author":"Beck","year":"2010","journal-title":"Biol Blood Marrow Transplant"},{"key":"B58","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1002\/eji.201141826","article-title":"CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients","volume":"42","author":"Beziat","year":"2012","journal-title":"Eur J Immunol"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1182\/blood-2012-10-459545","article-title":"NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs","volume":"121","author":"Beziat","year":"2013","journal-title":"Blood"},{"key":"B60","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1084\/jem.20100762","article-title":"Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus","volume":"208","author":"Bjorkstrom","year":"2011","journal-title":"J Exp Med"},{"key":"B61","doi-asserted-by":"publisher","first-page":"e27664","DOI":"10.1371\/journal.pone.0027664","article-title":"Characterization of natural killer cell phenotype and function during recurrent human HSV-2 infection","volume":"6","author":"Bjorkstrom","year":"2011","journal-title":"PLoS One"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.4049\/jimmunol.1302053","article-title":"Human cytomegalovirus infection promotes rapid maturation of NK cells expressing activating killer Ig-like receptor in patients transplanted with NKG2C-\/- umbilical cord blood","volume":"192","author":"Della Chiesa","year":"2014","journal-title":"J Immunol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1182\/blood-2011-08-372003","article-title":"Phenotypic and functional heterogeneity of human NK cells developing after umbilical cord blood transplantation: a role for human cytomegalovirus?","volume":"119","author":"Della Chiesa","year":"2012","journal-title":"Blood"},{"key":"B64","doi-asserted-by":"publisher","first-page":"5082","DOI":"10.4049\/jimmunol.1201964","article-title":"Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen","volume":"189","author":"Foley","year":"2012","journal-title":"J Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1182\/blood-2011-10-386995","article-title":"Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function","volume":"119","author":"Foley","year":"2012","journal-title":"Blood"},{"key":"B66","doi-asserted-by":"publisher","first-page":"3664","DOI":"10.1182\/blood-2004-05-2058","article-title":"Imprint of human cytomegalovirus infection on the NK cell receptor repertoire","volume":"104","author":"Guma","year":"2004","journal-title":"Blood"},{"key":"B67","doi-asserted-by":"publisher","first-page":"371","DOI":"10.3324\/haematol.2015.134155","article-title":"Analysis of memory-like natural killer cells in human cytomegalovirus-infected children undergoing \u03b1\u03b2+T- and B-cell depleted HSCT for hematological malignancies","volume":"101","author":"Muccio","year":"2016","journal-title":"Haematologica"},{"key":"B68","doi-asserted-by":"publisher","first-page":"e1002268","DOI":"10.1371\/journal.ppat.1002268","article-title":"Unconventional repertoire profile is imprinted during acute chikungunya infection for natural killer cells polarization toward cytotoxicity","volume":"7","author":"Petitdemange","year":"2011","journal-title":"PLoS Pathog"}],"container-title":["Frontiers in Immunology"],"original-title":[],"deposited":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T16:56:35Z","timestamp":1466528195000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fimmu.2016.00188\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,18]]},"references-count":68,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00188","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,18]]}}}