{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T21:50:00Z","timestamp":1774302600868,"version":"3.50.1"},"reference-count":41,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00227","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T03:28:38Z","timestamp":1465356518000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":99,"title":["Peptidylarginine Deiminase Inhibitor Suppresses Neutrophil Extracellular Trap Formation and MPO-ANCA Production"],"prefix":"10.3389","volume":"7","author":[{"given":"Yoshihiro","family":"Kusunoki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daigo","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruki","family":"Shida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiko","family":"Hattanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arina","family":"Miyoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakiko","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Utano","family":"Tomaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Atsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Ishizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 revised international chapel hill consensus conference nomenclature of vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum"},{"key":"B2","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nrrheum.2014.103","article-title":"Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease","volume":"10","author":"Jennette","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"B3","first-page":"S11","article-title":"Pathogenesis and treatment of ANCA-associated vasculitides","volume":"33","author":"Kallenberg","year":"2015","journal-title":"Clin Exp Rheumatol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/nm.1959","article-title":"Netting neutrophils in autoimmune small-vessel vasculitis","volume":"15","author":"Kessenbrock","year":"2009","journal-title":"Nat Med"},{"key":"B5","doi-asserted-by":"publisher","first-page":"3779","DOI":"10.1002\/art.34619","article-title":"Abnormal conformation and impaired degradation of propylthiouracil-induced neutrophil extracellular traps: implications of disordered neutrophil extracellular traps in a rat model of myeloperoxidase antineutrophil cytoplasmic antibody-associated vasculitis","volume":"64","author":"Nakazawa","year":"2012","journal-title":"Arthritis Rheum"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1182\/blood-2012-03-416156","article-title":"Neutrophil extracellular traps mediate transfer of cytoplasmic neutrophil antigens to myeloid dendritic cells toward ANCA induction and associated autoimmunity","volume":"120","author":"Sangaletti","year":"2012","journal-title":"Blood"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"B8","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"Fuchs","year":"2007","journal-title":"J Cell Biol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1182\/blood-2013-04-457671","article-title":"NETosis: how vital is it?","volume":"122","author":"Yipp","year":"2013","journal-title":"Blood"},{"key":"B10","doi-asserted-by":"publisher","first-page":"7413","DOI":"10.4049\/jimmunol.1000675","article-title":"A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus","volume":"185","author":"Pilsczek","year":"2010","journal-title":"J Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1038\/nm.2847","article-title":"Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo","volume":"18","author":"Yipp","year":"2012","journal-title":"Nat Med"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/nm.2053","article-title":"Extracellular histones are major mediators of death in sepsis","volume":"15","author":"Xu","year":"2009","journal-title":"Nat Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"15880","DOI":"10.1073\/pnas.1005743107","article-title":"Extracellular DNA traps promote thrombosis","volume":"107","author":"Fuchs","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1161\/ATVBAHA.111.242859","article-title":"Neutrophil extracellular trap (NET) impact on deep vein thrombosis","volume":"32","author":"Fuchs","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1038\/nm.3887","article-title":"Diabetes primes neutrophils to undergo NETosis, which impairs wound healing","volume":"21","author":"Wong","year":"2015","journal-title":"Nat Med"},{"issue":"4","key":"B16","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.2337\/db15-0863","article-title":"NETosis delays diabetic wound healing in mice and humans","volume":"65","author":"Fadini","year":"2016","journal-title":"Diabetes"},{"key":"B17","doi-asserted-by":"publisher","first-page":"9813","DOI":"10.1073\/pnas.0909927107","article-title":"Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis","volume":"107","author":"Hakkim","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B18","doi-asserted-by":"publisher","first-page":"2316","DOI":"10.4049\/jimmunol.1102683","article-title":"Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps","volume":"188","author":"Yan","year":"2012","journal-title":"J Immunol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nchembio.496","article-title":"Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation","volume":"7","author":"Hakkim","year":"2011","journal-title":"Nat Chem Biol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/eji.201545605","article-title":"PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling","volume":"46","author":"Desai","year":"2016","journal-title":"Eur J Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"360","DOI":"10.3389\/fimmu.2012.00360","article-title":"Activation of PAD4 in NET formation","volume":"3","author":"Rohrbach","year":"2012","journal-title":"Front Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1016\/j.bbagrm.2013.07.003","article-title":"Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis","volume":"1829","author":"Wang","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1084\/jem.20100239","article-title":"PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps","volume":"207","author":"Li","year":"2010","journal-title":"J Exp Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1083\/jcb.200806072","article-title":"Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation","volume":"184","author":"Wang","year":"2009","journal-title":"J Cell Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"333","DOI":"10.3389\/fimmu.2012.00333","article-title":"Abundant neutrophil extracellular traps in thrombus of patient with microscopic polyangiitis","volume":"3","author":"Nakazawa","year":"2012","journal-title":"Front Immunol"},{"key":"B26","first-page":"149","article-title":"Possible linkage between microscopic polyangiitis and thrombosis via neutrophil extracellular traps","volume":"32","author":"Imamoto","year":"2014","journal-title":"Clin Exp Rheumatol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2981","DOI":"10.1172\/JCI67390","article-title":"Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus","volume":"123","author":"Knight","year":"2013","journal-title":"J Clin Invest"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2619","DOI":"10.1182\/blood-2009-05-221606","article-title":"Restoration of NET formation by gene therapy in CGD controls aspergillosis","volume":"114","author":"Bianchi","year":"2009","journal-title":"Blood"},{"key":"B29","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.it.2009.07.011","article-title":"NETs: a new strategy for using old weapons","volume":"30","author":"Papayannopoulos","year":"2009","journal-title":"Trends Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1126\/stke.3792007pe11","article-title":"Unconventional roles of the NADPH oxidase: signaling, ion homeostasis, and cell death","volume":"2007","author":"Steinberg","year":"2007","journal-title":"Sci STKE"},{"key":"B31","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nm1565","article-title":"Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood","volume":"13","author":"Clark","year":"2007","journal-title":"Nat Med"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1161\/ATVBAHA.113.301889","article-title":"Footprints of neutrophil extracellular traps as predictors of cardiovascular risk","volume":"33","author":"Doring","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1189\/jlb.5BT0615-247R","article-title":"At the bench: neutrophil extracellular traps (NETs) highlight novel aspects of innate immune system involvement in autoimmune diseases","volume":"99","author":"Grayson","year":"2016","journal-title":"J Leukoc Biol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1016\/0006-2952(88)90574-6","article-title":"Inactivation of peroxidases of rat bone marrow by repeated administration of propylthiouracil is accompanied by a change in the heme structure","volume":"37","author":"Lee","year":"1988","journal-title":"Biochem Pharmacol"},{"key":"B35","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1681\/ASN.V871101","article-title":"Th2 responses induce humorally mediated injury in experimental anti-glomerular basement membrane glomerulonephritis","volume":"8","author":"Huang","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"B36","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1046\/j.1365-3083.2002.01086.x","article-title":"A T-cell functional phenotype common among autoimmune-prone rodent strains","volume":"55","author":"Lang","year":"2002","journal-title":"Scand J Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.4049\/jimmunol.180.3.1895","article-title":"Histone deimination as a response to inflammatory stimuli in neutrophils","volume":"180","author":"Neeli","year":"2008","journal-title":"J Immunol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"11727","DOI":"10.1021\/bi061180d","article-title":"Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization","volume":"45","author":"Luo","year":"2006","journal-title":"Biochemistry"},{"key":"B39","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1242\/dmm.010520","article-title":"Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis","volume":"6","author":"Moscarello","year":"2013","journal-title":"Dis Model Mech"},{"key":"B40","doi-asserted-by":"publisher","first-page":"4396","DOI":"10.4049\/jimmunol.1001620","article-title":"N-alpha-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis","volume":"186","author":"Willis","year":"2011","journal-title":"J Immunol"},{"key":"B41","doi-asserted-by":"publisher","first-page":"G929","DOI":"10.1152\/ajpgi.00435.2010","article-title":"Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor","volume":"300","author":"Chumanevich","year":"2011","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"deposited":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T05:37:10Z","timestamp":1656653830000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fimmu.2016.00227\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,8]]},"references-count":41,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00227","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,8]]}}}