{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:56:34Z","timestamp":1791276994921,"version":"4.1.0"},"reference-count":45,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","award":["TRA\/2007\/04"],"award-info":[{"award-number":["TRA\/2007\/04"]}],"id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00275","type":"journal-article","created":{"date-parts":[[2016,7,19]],"date-time":"2016-07-19T03:12:27Z","timestamp":1468897947000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":129,"title":["M1- and M2-Type Macrophage Responses Are Predictive of Adverse Outcomes in Human Atherosclerosis"],"prefix":"10.3389","volume":"7","author":[{"given":"Monica","family":"de Gaetano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Crean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orina","family":"Belton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,7,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev.pharmtox.37.1.477","article-title":"Estrogens and atherosclerosis","volume":"37","author":"Nathan","year":"1997","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"3\u20134","key":"B2","first-page":"138","article-title":"[Relation between insulin resistance and small, dense lipoproteins with low density and the development of atherosclerosis in type 2 diabetes mellitus]","volume":"99","author":"Fabryova","year":"1998","journal-title":"Bratisl Lek Listy"},{"issue":"6","key":"B3","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/S0735-1097(98)81787-7","article-title":"Interactive role of infection, inflammation and traditional risk factors in atherosclerosis and coronary artery disease","volume":"31","author":"Mehta","year":"1998","journal-title":"J Am Coll Cardiol"},{"issue":"7203","key":"B4","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature07206","article-title":"The role of exercise and PGC1alpha in inflammation and chronic disease","volume":"454","author":"Handschin","year":"2008","journal-title":"Nature"},{"issue":"3","key":"B5","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.cell.2011.04.005","article-title":"Macrophages in the pathogenesis of atherosclerosis","volume":"145","author":"Moore","year":"2011","journal-title":"Cell"},{"key":"B6","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.yjmcc.2012.11.002","article-title":"Smooth muscle cells in human atherosclerosis: proteomic profiling reveals differences in expression of Annexin A1 and mitochondrial proteins in carotid disease","volume":"54","author":"Viiri","year":"2013","journal-title":"J Mol Cell Cardiol"},{"issue":"2","key":"B7","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1161\/01.CIR.90.1.94","article-title":"Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture","volume":"90","author":"Moreno","year":"1994","journal-title":"Circulation"},{"issue":"6","key":"B8","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/ccd.25578","article-title":"Carotid artery stenting and patient outcomes: the CABANA surveillance study","volume":"84","author":"Hopkins","year":"2014","journal-title":"Catheter Cardiovasc Interv"},{"issue":"3","key":"B9","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/1358836X9800300310","article-title":"Atherothrombosis: mechanisms and clinical therapeutic approaches","volume":"3","author":"Fuster","year":"1998","journal-title":"Vasc Med"},{"issue":"9","key":"B10","doi-asserted-by":"publisher","first-page":"1166","DOI":"10.1038\/nm.3161","article-title":"Local proliferation dominates lesional macrophage accumulation in atherosclerosis","volume":"19","author":"Robbins","year":"2013","journal-title":"Nat Med"},{"issue":"6801","key":"B11","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/35025203","article-title":"Atherosclerosis","volume":"407","author":"Lusis","year":"2000","journal-title":"Nature"},{"issue":"1","key":"B12","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S1097-2765(01)00164-2","article-title":"A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis","volume":"7","author":"Chawla","year":"2001","journal-title":"Mol Cell"},{"issue":"7","key":"B13","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1172\/JCI0216391","article-title":"Regulation and mechanisms of macrophage cholesterol efflux","volume":"110","author":"Tall","year":"2002","journal-title":"J Clin Invest"},{"issue":"8","key":"B14","doi-asserted-by":"publisher","first-page":"1314","DOI":"10.1016\/j.biocel.2006.01.013","article-title":"Regulatory effects of synthetic liver X receptor- and peroxisome-proliferator activated receptor agonists on sterol transport pathways in polarized cerebrovascular endothelial cells","volume":"38","author":"Panzenboeck","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"issue":"3","key":"B15","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/00041433-200206000-00005","article-title":"Conjugated linoleic acid metabolism","volume":"13","author":"Banni","year":"2002","journal-title":"Curr Opin Lipidol"},{"issue":"1","key":"B16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.atherosclerosis.2005.08.024","article-title":"Profound resolution of early atherosclerosis with conjugated linoleic acid","volume":"187","author":"Toomey","year":"2006","journal-title":"Atherosclerosis"},{"issue":"1","key":"B17","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.atherosclerosis.2010.02.003","article-title":"Conjugated linoleic acid suppresses the migratory and inflammatory phenotype of the monocyte\/macrophage cell","volume":"211","author":"McClelland","year":"2010","journal-title":"Atherosclerosis"},{"issue":"8","key":"B18","doi-asserted-by":"publisher","first-page":"4326","DOI":"10.4049\/jimmunol.1300990","article-title":"Conjugated linoleic acid targets beta2 integrin expression to suppress monocyte adhesion","volume":"191","author":"de Gaetano","year":"2013","journal-title":"J Immunol"},{"issue":"2","key":"B19","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1096\/fj.12-215442","article-title":"IL-10 mediates the immunoregulatory response in conjugated linoleic acid-induced regression of atherosclerosis","volume":"27","author":"McCarthy","year":"2013","journal-title":"FASEB J"},{"key":"B20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s12950-015-0060-9","article-title":"Conjugated linoleic acid induces an atheroprotective macrophage MPhi2 phenotype and limits foam cell formation","volume":"12","author":"de Gaetano","year":"2015","journal-title":"J Inflamm (Lond)"},{"issue":"5","key":"B21","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/MOL.0b013e32834a77b4","article-title":"Macrophage polarization in metabolic disorders: functions and regulation","volume":"22","author":"Chinetti-Gbaguidi","year":"2011","journal-title":"Curr Opin Lipidol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1476-9255-8-9","article-title":"Innate immunity and monocyte-macrophage activation in atherosclerosis","volume":"8","author":"Shalhoub","year":"2011","journal-title":"J Inflamm (Lond)"},{"issue":"2","key":"B23","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.cmet.2007.06.010","article-title":"PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties","volume":"6","author":"Bouhlel","year":"2007","journal-title":"Cell Metab"},{"issue":"8","key":"B24","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1161\/CIRCRESAHA.110.233775","article-title":"Human atherosclerotic plaque alternative macrophages display low cholesterol handling but high phagocytosis because of distinct activities of the PPARgamma and LXRalpha pathways","volume":"108","author":"Chinetti-Gbaguidi","year":"2011","journal-title":"Circ Res"},{"issue":"1","key":"B25","first-page":"61","article-title":"Immunohistochemical expression of anti-CD68 antibody in atherosclerotic plaque","volume":"53","author":"Cojocaru","year":"2012","journal-title":"Rom J Morphol Embryol"},{"issue":"4","key":"B26","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.2353\/ajpath.2008.070513","article-title":"Heterogeneity of human macrophages in culture and in atherosclerotic plaques","volume":"172","author":"Waldo","year":"2008","journal-title":"Am J Pathol"},{"issue":"5","key":"B27","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.ejvs.2012.08.005","article-title":"Macrophage subtypes in symptomatic carotid artery and femoral artery plaques","volume":"44","author":"Shaikh","year":"2012","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"7","key":"B28","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.jstrokecerebrovasdis.2012.11.020","article-title":"The phenotype of infiltrating macrophages influences arteriosclerotic plaque vulnerability in the carotid artery","volume":"22","author":"Cho","year":"2013","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"51","key":"B29","doi-asserted-by":"publisher","first-page":"49982","DOI":"10.1074\/jbc.M209649200","article-title":"Scavenger receptors class A-I\/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages","volume":"277","author":"Kunjathoor","year":"2002","journal-title":"J Biol Chem"},{"issue":"2","key":"B30","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1161\/ATVBAHA.112.300663","article-title":"Role of proinflammatory CD68(+) mannose receptor(-) macrophages in peroxiredoxin-1 expression and in abdominal aortic aneurysms in humans","volume":"33","author":"Boytard","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"B31","doi-asserted-by":"publisher","first-page":"e7475","DOI":"10.1371\/journal.pone.0007475","article-title":"Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts","volume":"4","author":"Pilling","year":"2009","journal-title":"PLoS One"},{"key":"B32","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1016\/j.ijcard.2015.03.055","article-title":"Macrophage phenotypic plasticity in atherosclerosis: the associated features and the peculiarities of the expression of inflammatory genes","volume":"184","author":"Chistiakov","year":"2015","journal-title":"Int J Cardiol"},{"issue":"3","key":"B33","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/S0021-9258(18)46005-X","article-title":"Contribution to ligand binding by multiple carbohydrate-recognition domains in the macrophage mannose receptor","volume":"267","author":"Taylor","year":"1992","journal-title":"J Biol Chem"},{"issue":"28","key":"B34","doi-asserted-by":"publisher","first-page":"21539","DOI":"10.1074\/jbc.M002664200","article-title":"Structure of a C-type carbohydrate recognition domain from the macrophage mannose receptor","volume":"275","author":"Feinberg","year":"2000","journal-title":"J Biol Chem"},{"issue":"17","key":"B35","doi-asserted-by":"publisher","first-page":"2352","DOI":"10.1089\/ars.2012.4834","article-title":"CD163 and inflammation: biological, diagnostic, and therapeutic aspects","volume":"18","author":"Etzerodt","year":"2013","journal-title":"Antioxid Redox Signal"},{"issue":"3","key":"B36","doi-asserted-by":"publisher","first-page":"e60086","DOI":"10.1371\/journal.pone.0060086","article-title":"Dectin-1 regulates IL-10 production via a MSK1\/2 and CREB dependent pathway and promotes the induction of regulatory macrophage markers","volume":"8","author":"Elcombe","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"B37","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.smim.2015.03.013","article-title":"Atherosclerosis \u2013 a matter of unresolved inflammation","volume":"27","author":"Viola","year":"2015","journal-title":"Semin Immunol"},{"issue":"7","key":"B38","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.1002\/jcp.24319","article-title":"Truncated thioredoxin (Trx-80) promotes pro-inflammatory macrophages of the M1 phenotype and enhances atherosclerosis","volume":"228","author":"Mahmood","year":"2013","journal-title":"J Cell Physiol"},{"issue":"3","key":"B39","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1097\/01.mol.0000226116.35555.eb","article-title":"Roles of ATP binding cassette transporters A1 and G1, scavenger receptor BI and membrane lipid domains in cholesterol export from macrophages","volume":"17","author":"Jessup","year":"2006","journal-title":"Curr Opin Lipidol"},{"issue":"5","key":"B40","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1161\/01.ATV.21.5.825","article-title":"Identification of a gamma-interferon-responsive element in the promoter of the human macrophage scavenger receptor A gene","volume":"21","author":"Grewal","year":"2001","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"B41","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1002\/emmm.201302587","article-title":"Macrophage PPAR gamma Co-activator-1 alpha participates in repressing foam cell formation and atherosclerosis in response to conjugated linoleic acid","volume":"5","author":"McCarthy","year":"2013","journal-title":"EMBO Mol Med"},{"issue":"2","key":"B42","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.atherosclerosis.2012.09.013","article-title":"Distribution of macrophage polarization markers in human atherosclerosis","volume":"225","author":"St\u00f6ger","year":"2012","journal-title":"Atherosclerosis"},{"issue":"7540","key":"B43","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nature13989","article-title":"Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors","volume":"518","author":"Gomez Perdiguero","year":"2015","journal-title":"Nature"},{"issue":"6","key":"B44","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1002\/bjs.6157","article-title":"Cost-effectiveness of endarterectomy in patients with asymptomatic carotid artery stenosis","volume":"95","author":"Henriksson","year":"2008","journal-title":"Br J Surg"},{"issue":"6035","key":"B45","doi-asserted-by":"publisher","first-page":"1284","DOI":"10.1126\/science.1204351","article-title":"Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation","volume":"332","author":"Jenkins","year":"2011","journal-title":"Science"}],"container-title":["Frontiers in Immunology"],"original-title":[],"deposited":{"date-parts":[[2022,7,3]],"date-time":"2022-07-03T08:05:47Z","timestamp":1656835547000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fimmu.2016.00275\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,19]]},"references-count":45,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00275","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,19]]}}}