{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:25:35Z","timestamp":1791343535987,"version":"4.3.1"},"reference-count":45,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-INSB-005"],"award-info":[{"award-number":["ANR-11-INSB-005"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005304","name":"Agence Nationale pour le D\u00e9veloppement de la Recherche en Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005304","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007693","name":"National Infrastructure for Microbiological Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00392","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T23:11:46Z","timestamp":1474931506000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Utility of a Mouse Model of Osteoarthritis to Demonstrate Cartilage Protection by IFN\u03b3-Primed Equine Mesenchymal Stem Cells"],"prefix":"10.3389","volume":"7","author":[{"given":"Marie","family":"Maumus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautier","family":"Roussignol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Toupet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geraldine","family":"Penarier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Bentz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Oustric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Lepage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regis","family":"Steinberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Jorgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00e8le","family":"Noel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,9,27]]},"reference":[{"issue":"1","key":"B1","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.tvjl.2004.07.008","article-title":"Medical treatment of osteoarthritis in the horse \u2013 a review","volume":"171","author":"Goodrich","year":"2006","journal-title":"Vet J"},{"issue":"2","key":"B2","doi-asserted-by":"publisher","first-page":"e0115089","DOI":"10.1371\/journal.pone.0115089","article-title":"Development of an equine groove model to induce metacarpophalangeal osteoarthritis: a pilot study on 6 horses","volume":"10","author":"Maninchedda","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"B3","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1016\/j.tvjl.2014.09.024","article-title":"Stem cell therapies for treating osteoarthritis: prescient or premature?","volume":"202","author":"Whitworth","year":"2014","journal-title":"Vet J"},{"issue":"3","key":"B4","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.tvjl.2013.04.018","article-title":"Therapeutic use of stem cells in horses: which type, how, and when?","volume":"197","author":"Schnabel","year":"2013","journal-title":"Vet J"},{"issue":"7","key":"B5","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1111\/j.1532-950X.2007.00313.x","article-title":"Characterization of equine adipose tissue-derived stromal cells: adipogenic and osteogenic capacity and comparison with bone marrow-derived mesenchymal stromal cells","volume":"36","author":"Vidal","year":"2007","journal-title":"Vet Surg"},{"issue":"1","key":"B6","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1111\/j.2042-3306.2010.00353.x","article-title":"Comparative study of equine bone marrow and adipose tissue-derived mesenchymal stromal cells","volume":"44","author":"Ranera","year":"2011","journal-title":"Equine Vet J"},{"issue":"1","key":"B7","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1186\/scrt414","article-title":"Equine mesenchymal stem cells from bone marrow, adipose tissue and umbilical cord: immunophenotypic characterization and differentiation potential","volume":"5","author":"Barberini","year":"2014","journal-title":"Stem Cell Res Ther"},{"issue":"3\u20134","key":"B8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.vetimm.2015.04.004","article-title":"Expression of genes involved in immune response and in vitro immunosuppressive effect of equine MSCs","volume":"165","author":"Remacha","year":"2015","journal-title":"Vet Immunol Immunopathol"},{"issue":"10","key":"B9","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.2106\/JBJS.I.01284","article-title":"Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model","volume":"92","author":"Fortier","year":"2010","journal-title":"J Bone Joint Surg Am"},{"issue":"4","key":"B10","doi-asserted-by":"publisher","first-page":"419","DOI":"10.3109\/14653249.2010.536213","article-title":"Clinicopathologic findings following intra-articular injection of autologous and allogeneic placentally derived equine mesenchymal stem cells in horses","volume":"13","author":"Carrade","year":"2011","journal-title":"Cytotherapy"},{"issue":"6","key":"B11","doi-asserted-by":"publisher","first-page":"497","DOI":"10.2174\/1574888X09666140826110601","article-title":"Allogenic mesenchymal stem cells as a treatment for equine degenerative joint disease: a pilot study","volume":"9","author":"Broeckx","year":"2014","journal-title":"Curr Stem Cell Res Ther"},{"issue":"1","key":"B12","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.joca.2014.09.007","article-title":"Intra-articular administration of xenogeneic neonatal mesenchymal stromal cells early after meniscal injury down-regulates metalloproteinase gene expression in synovium and prevents cartilage degradation in a rabbit model of osteoarthritis","volume":"23","author":"Saulnier","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"B13","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1111\/j.1532-950X.2014.12100.x","article-title":"Clinical outcome after intra-articular administration of bone marrow derived mesenchymal stem cells in 33 horses with stifle injury","volume":"43","author":"Ferris","year":"2014","journal-title":"Vet Surg"},{"issue":"7","key":"B14","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/jor.20382","article-title":"Enhanced early chondrogenesis in articular defects following arthroscopic mesenchymal stem cell implantation in an equine model","volume":"25","author":"Wilke","year":"2007","journal-title":"J Orthop Res"},{"issue":"12","key":"B15","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1002\/jor.20933","article-title":"Evaluation of adipose-derived stromal vascular fraction or bone marrow-derived mesenchymal stem cells for treatment of osteoarthritis","volume":"27","author":"Frisbie","year":"2009","journal-title":"J Orthop Res"},{"issue":"11","key":"B16","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.1016\/j.arthro.2011.06.002","article-title":"Evaluation of intra-articular mesenchymal stem cells to augment healing of microfractured chondral defects","volume":"27","author":"McIlwraith","year":"2011","journal-title":"Arthroscopy"},{"issue":"1","key":"B17","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1517\/14712598.2016.1093108","article-title":"Therapeutic application of mesenchymal stem cells in osteoarthritis","volume":"16","author":"Ruiz","year":"2015","journal-title":"Expert Opin Biol Ther"},{"issue":"1","key":"B18","doi-asserted-by":"publisher","first-page":"e0114962","DOI":"10.1371\/journal.pone.0114962","article-title":"Survival and biodistribution of xenogenic adipose mesenchymal stem cells is not affected by the degree of inflammation in arthritis","volume":"10","author":"Toupet","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"B19","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1111\/xen.12000","article-title":"Do mesenchymal stem cells function across species barriers? Relevance for xenotransplantation","volume":"19","author":"Li","year":"2012","journal-title":"Xenotransplantation"},{"issue":"4","key":"B20","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1002\/art.22511","article-title":"Cell therapy using allogeneic bone marrow mesenchymal stem cells prevents tissue damage in collagen-induced arthritis","volume":"56","author":"Augello","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"12","key":"B21","doi-asserted-by":"publisher","first-page":"e14247","DOI":"10.1371\/journal.pone.0014247","article-title":"IL-6-dependent PGE2 secretion by mesenchymal stem cells inhibits local inflammation in experimental arthritis","volume":"5","author":"Bouffi","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"B22","doi-asserted-by":"publisher","first-page":"R22","DOI":"10.1186\/ar4156","article-title":"Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model","volume":"15","author":"Desando","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"11","key":"B23","doi-asserted-by":"publisher","first-page":"3604","DOI":"10.1002\/art.34626","article-title":"Antiinflammatory and chondroprotective effects of intraarticular injection of adipose-derived stem cells in experimental osteoarthritis","volume":"64","author":"Ter Huurne","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"8","key":"B24","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1016\/j.joca.2014.05.022","article-title":"Treatment efficacy of adipose-derived stem cells in experimental osteoarthritis is driven by high synovial activation and reflected by S100A8\/A9 serum levels","volume":"22","author":"Schelbergen","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"B25","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1002\/art.37908","article-title":"Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin e2","volume":"65","author":"Manferdini","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"2","key":"B26","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1016\/j.scr.2013.05.008","article-title":"Adipose mesenchymal stem cells protect chondrocytes from degeneration associated with osteoarthritis","volume":"11","author":"Maumus","year":"2013","journal-title":"Stem Cell Res"},{"issue":"11","key":"B27","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1016\/j.joca.2015.03.025","article-title":"Lack of anti-inflammatory and anti-catabolic effects on basal inflamed osteoarthritic chondrocytes or synoviocytes by adipose stem cell-conditioned medium","volume":"23","author":"Manferdini","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"B28","doi-asserted-by":"publisher","first-page":"3837","DOI":"10.1182\/blood-2003-04-1193","article-title":"Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals","volume":"102","author":"Djouad","year":"2003","journal-title":"Blood"},{"issue":"4","key":"B29","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s12015-014-9510-7","article-title":"Mesenchymal stem cell priming: fine-tuning adhesion and function","volume":"10","author":"Kavanagh","year":"2014","journal-title":"Stem Cell Rev"},{"issue":"2","key":"B30","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.stem.2007.11.014","article-title":"Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide","volume":"2","author":"Ren","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"3","key":"B31","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1111\/j.1365-2249.2010.04256.x","article-title":"Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cells","volume":"162","author":"Crop","year":"2010","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"B32","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"B33","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1080\/14653240600855905","article-title":"Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement","volume":"8","author":"Dominici","year":"2006","journal-title":"Cytotherapy"},{"issue":"9","key":"B34","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1016\/j.jcyt.2013.02.010","article-title":"Immunological characterization of multipotent mesenchymal stromal cells \u2013 the International Society for Cellular Therapy (ISCT) working proposal","volume":"15","author":"Krampera","year":"2013","journal-title":"Cytotherapy"},{"issue":"1","key":"B35","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1634\/stemcells.2004-0359","article-title":"Interactions between human mesenchymal stem cells and natural killer cells","volume":"24","author":"Sotiropoulou","year":"2006","journal-title":"Stem Cells"},{"issue":"1","key":"B36","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/scrt2","article-title":"Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications","volume":"1","author":"Ghannam","year":"2010","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"B37","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1002\/term.399","article-title":"Effects of transforming growth factor-beta subtypes on in vitro cartilage production and mineralization of human bone marrow stromal-derived mesenchymal stem cells","volume":"6","author":"Cals","year":"2012","journal-title":"J Tissue Eng Regen Med"},{"issue":"1","key":"B38","doi-asserted-by":"publisher","first-page":"103","DOI":"10.4049\/jimmunol.1302164","article-title":"TGF-beta promotes immune responses in the presence of mesenchymal stem cells","volume":"192","author":"Xu","year":"2014","journal-title":"J Immunol"},{"issue":"6","key":"B39","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.joca.2015.12.021","article-title":"Adipose-derived stem cells induce autophagic activation and inhibit catabolic response to pro-inflammatory cytokines in rat chondrocytes","volume":"24","author":"Jiang","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"B40","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1002\/art.27305","article-title":"Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis","volume":"62","author":"Carames","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"1","key":"B41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2302\/kjm.58.29","article-title":"New perspective in osteoarthritis: the OPG and RANKL system as a potential therapeutic target?","volume":"58","author":"Tat","year":"2009","journal-title":"Keio J Med"},{"key":"B42","doi-asserted-by":"publisher","first-page":"e2062","DOI":"10.1038\/cddis.2015.327","article-title":"Mesenchymal stem cells and immunomodulation: current status and future prospects","volume":"7","author":"Gao","year":"2016","journal-title":"Cell Death Dis"},{"issue":"11","key":"B43","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1038\/ni.3002","article-title":"Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications","volume":"15","author":"Wang","year":"2014","journal-title":"Nat Immunol"},{"issue":"6","key":"B44","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1002\/eji.200738129","article-title":"IFN-gamma activation of mesenchymal stem cells for treatment and prevention of graft versus host disease","volume":"38","author":"Polchert","year":"2008","journal-title":"Eur J Immunol"},{"issue":"11","key":"B45","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1038\/cdd.2014.85","article-title":"Interleukin-17 enhances immunosuppression by mesenchymal stem cells","volume":"21","author":"Han","year":"2014","journal-title":"Cell Death Differ"}],"container-title":["Frontiers in Immunology"],"original-title":[],"deposited":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T13:01:49Z","timestamp":1475586109000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fimmu.2016.00392\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,27]]},"references-count":45,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00392","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,27]]}}}