{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:10:31Z","timestamp":1790424631179,"version":"4.1.0"},"reference-count":193,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00433","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T03:07:46Z","timestamp":1477278466000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["Antibody Subclass Repertoire and Graft Outcome Following Solid Organ Transplantation"],"prefix":"10.3389","volume":"7","author":[{"given":"Nicole M.","family":"Valenzuela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle J.","family":"Hickey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine F.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,10,24]]},"reference":[{"issue":"2","key":"B1","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1111\/j.1600-6143.2011.03840.x","article-title":"Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and nonadherence","volume":"12","author":"Sellares","year":"2012","journal-title":"Am J Transplant"},{"issue":"11","key":"B2","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1111\/ajt.13347","article-title":"Rates and determinants of progression to graft failure in kidney allograft recipients with de novo donor-specific antibody","volume":"15","author":"Wiebe","year":"2015","journal-title":"Am J Transplant"},{"issue":"3","key":"B3","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1097\/TP.0b013e31827d62e3","article-title":"Incidence and impact of de novo donor-specific alloantibody in primary renal allografts","volume":"95","author":"Everly","year":"2013","journal-title":"Transplantation"},{"issue":"2","key":"B4","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1111\/j.1600-6143.2010.03383.x","article-title":"De novo donor HLA-specific antibodies after heart transplantation are an independent predictor of poor patient survival","volume":"11","author":"Smith","year":"2011","journal-title":"Am J Transplant"},{"issue":"10","key":"B5","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1016\/j.healun.2015.05.001","article-title":"Effect of persistent versus transient donor-specific HLA antibodies on graft outcomes in pediatric cardiac transplantation","volume":"34","author":"Irving","year":"2015","journal-title":"J Heart Lung Transplant"},{"issue":"1","key":"B6","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.healun.2015.08.008","article-title":"Donor-specific HLA alloantibodies: impact on cardiac allograft vasculopathy, rejection, and survival after pediatric heart transplantation","volume":"35","author":"Tran","year":"2016","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"B7","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1002\/lt.23788","article-title":"Antibody-mediated rejection as a contributor to previously unexplained early liver allograft loss","volume":"20","author":"O\u2019Leary","year":"2014","journal-title":"Liver Transpl"},{"issue":"39","key":"B8","doi-asserted-by":"publisher","first-page":"11016","DOI":"10.3748\/wjg.v21.i39.11016","article-title":"Clinical significance of donor-specific human leukocyte antigen antibodies in liver transplantation","volume":"21","author":"Cuadrado","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"12","key":"B9","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1111\/tri.12654","article-title":"De novo donor-specific anti-HLA antibodies mediated rejection in liver-transplant patients","volume":"28","author":"Del Bello","year":"2015","journal-title":"Transpl Int"},{"issue":"3","key":"B10","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1111\/tan.12626","article-title":"Bronchiolitis obliterans syndrome due to donor-specific HLA-antibodies","volume":"86","author":"Kauke","year":"2015","journal-title":"Tissue Antigens"},{"issue":"4","key":"B11","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1111\/ajt.13589","article-title":"Antibody-mediated rejection in lung transplantation: clinical outcomes and donor-specific antibody characteristics","volume":"16","author":"Roux","year":"2016","journal-title":"Am J Transplant"},{"issue":"11","key":"B12","doi-asserted-by":"publisher","first-page":"2945","DOI":"10.1111\/ajt.12443","article-title":"Acute cellular and antibody-mediated rejection of the pancreas allograft: incidence, risk factors and outcomes","volume":"13","author":"Niederhaus","year":"2013","journal-title":"Am J Transplant"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13848","article-title":"Clinical significance of pre-transplant donor specific antibodies in the setting of negative cell-based flow cytometry crossmatching in kidney transplant recipients","author":"Adebiyi","year":"2016","journal-title":"Am J Transplant"},{"issue":"11","key":"B14","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.1111\/j.1600-6143.2012.04237.x","article-title":"Preformed and de novo donor specific antibodies in visceral transplantation: long-term outcome with special reference to the liver","volume":"12","author":"Abu-Elmagd","year":"2012","journal-title":"Am J Transplant"},{"key":"B15","first-page":"153","article-title":"The role of donor-specific antibodies in intestinal transplantation: experience at the University of California Los Angeles and Literature Review","author":"Cheng","year":"2014","journal-title":"Clin Transpl"},{"issue":"3","key":"B16","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1097\/MOT.0000000000000072","article-title":"An updated Banff schema for diagnosis of antibody-mediated rejection in renal allografts","volume":"19","author":"Haas","year":"2014","journal-title":"Curr Opin Organ Transplant"},{"issue":"2","key":"B17","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1111\/ajt.12590","article-title":"Banff 2013 meeting report: inclusion of c4d-negative antibody-mediated rejection and antibody-associated arterial lesions","volume":"14","author":"Haas","year":"2014","journal-title":"Am J Transplant"},{"issue":"6","key":"B18","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1016\/j.healun.2011.02.015","article-title":"The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: evolution and current status (2005-2011)","volume":"30","author":"Berry","year":"2011","journal-title":"J Heart Lung Transplant"},{"issue":"3","key":"B19","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.healun.2010.11.003","article-title":"Report from a consensus conference on antibody-mediated rejection in heart transplantation","volume":"30","author":"Kobashigawa","year":"2011","journal-title":"J Heart Lung Transplant"},{"issue":"4","key":"B20","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.healun.2016.01.1223","article-title":"Antibody-mediated rejection of the lung: a consensus report of the International Society for Heart and Lung Transplantation","volume":"35","author":"Levine","year":"2016","journal-title":"J Heart Lung Transplant"},{"issue":"9","key":"B21","doi-asserted-by":"publisher","first-page":"1792","DOI":"10.1111\/j.1600-6143.2011.03670.x","article-title":"Guidelines for the diagnosis of antibody-mediated rejection in pancreas allografts-updated Banff grading schema","volume":"11","author":"Drachenberg","year":"2011","journal-title":"Am J Transplant"},{"issue":"2","key":"B22","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/ajt.13476","article-title":"Proposed diagnostic criteria for chronic antibody-mediated rejection in liver allografts","volume":"16","author":"O\u2019Leary","year":"2016","journal-title":"Am J Transplant"},{"issue":"8","key":"B23","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1111\/ajt.13341","article-title":"The synergistic effect of class II HLA epitope-mismatch and nonadherence on acute rejection and graft survival","volume":"15","author":"Wiebe","year":"2015","journal-title":"Am J Transplant"},{"issue":"5","key":"B24","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.humimm.2007.01.006","article-title":"Post transplant development of MICA and anti-HLA antibodies is associated with acute rejection episodes and renal allograft loss","volume":"68","author":"Panigrahi","year":"2007","journal-title":"Hum Immunol"},{"issue":"13","key":"B25","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1056\/NEJMoa067160","article-title":"Antibodies against MICA antigens and kidney-transplant rejection","volume":"357","author":"Zou","year":"2007","journal-title":"N Engl J Med"},{"issue":"1","key":"B26","doi-asserted-by":"publisher","first-page":"E1","DOI":"10.1111\/j.1399-3046.2010.01407.x","article-title":"Acute rejection associated with donor-specific anti-MICA antibody in a highly sensitized pediatric renal transplant recipient","volume":"15","author":"Narayan","year":"2011","journal-title":"Pediatr Transplant"},{"issue":"10","key":"B27","doi-asserted-by":"publisher","first-page":"1153","DOI":"10.1097\/TP.0b013e3182157d60","article-title":"HLA and MICA: targets of antibody-mediated rejection in heart transplantation","volume":"91","author":"Zhang","year":"2011","journal-title":"Transplantation"},{"issue":"6","key":"B28","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1097\/01.tp.0000281918.51138.3f","article-title":"Antibodies against donor human leukocyte antigens and the outcome of cardiac allografts in adults and children","volume":"84","author":"Stastny","year":"2007","journal-title":"Transplantation"},{"issue":"5","key":"B29","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.1111\/j.1600-6143.2012.04013.x","article-title":"Evolution and clinical pathologic correlations of de novo donor-specific HLA antibody post kidney transplant","volume":"12","author":"Wiebe","year":"2012","journal-title":"Am J Transplant"},{"issue":"13","key":"B30","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1056\/NEJMoa1302506","article-title":"Complement-binding anti-HLA antibodies and kidney-allograft survival","volume":"369","author":"Loupy","year":"2013","journal-title":"N Engl J Med"},{"issue":"4","key":"B31","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1365-2222.2009.03207.x","article-title":"Immunoglobulin G4: an odd antibody","volume":"39","author":"Aalberse","year":"2009","journal-title":"Clin Exp Allergy"},{"issue":"8","key":"B32","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1182\/blood-2011-04-345579","article-title":"Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways","volume":"118","author":"Berkowska","year":"2011","journal-title":"Blood"},{"issue":"2","key":"B33","first-page":"168","article-title":"Antibodies of different human IgG subclasses show distinct patterns of affinity maturation after immunization with keyhole limpet haemocyanin","volume":"70","author":"Devey","year":"1990","journal-title":"Immunology"},{"issue":"10","key":"B34","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1038\/icb.2015.57","article-title":"BCR repertoire sequencing: different patterns of B-cell activation after two meningococcal vaccines","volume":"93","author":"Galson","year":"2015","journal-title":"Immunol Cell Biol"},{"issue":"8","key":"B35","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1016\/0161-5890(94)90165-1","article-title":"Variable domain-identical antibodies exhibit IgG subclass-related differences in affinity and kinetic constants as determined by surface plasmon resonance","volume":"31","author":"Cooper","year":"1994","journal-title":"Mol Immunol"},{"issue":"2","key":"B36","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1365-2567.1996.tb00001.x","article-title":"Human constant regions influence the antibody binding characteristics of mouse-human chimeric IgG subclasses","volume":"88","author":"McCloskey","year":"1996","journal-title":"Immunology"},{"issue":"Pt 1","key":"B37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1107\/S205225251402209X","article-title":"In-depth analysis of subclass-specific conformational preferences of IgG antibodies","volume":"2","author":"Tian","year":"2015","journal-title":"IUCrJ"},{"issue":"5","key":"B38","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.4049\/jimmunol.179.5.2815","article-title":"Regulation of antibody-dependent cellular cytotoxicity by IgG intrinsic and apparent affinity for target antigen","volume":"179","author":"Tang","year":"2007","journal-title":"J Immunol"},{"issue":"6","key":"B39","doi-asserted-by":"publisher","first-page":"e0157788","DOI":"10.1371\/journal.pone.0157788","article-title":"Enhancement of immune effector functions by modulating IgG\u2019s intrinsic affinity for target antigen","volume":"11","author":"Mazor","year":"2016","journal-title":"PLoS One"},{"key":"B40","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1038\/ncomms1608","article-title":"Competition for FcRn-mediated transport gives rise to short half-life of human IgG3 and offers therapeutic potential","volume":"2","author":"Stapleton","year":"2011","journal-title":"Nat Commun"},{"issue":"8\u20139","key":"B41","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.micinf.2011.04.001","article-title":"Combined effects of Gm or Km immunoglobulin allotypes and age on antibody responses to Plasmodium falciparum VarO rosetting variant in Benin","volume":"13","author":"Migot-Nabias","year":"2011","journal-title":"Microbes Infect"},{"issue":"3","key":"B42","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1111\/trf.12334","article-title":"H435-containing immunoglobulin G3 allotypes are transported efficiently across the human placenta: implications for alloantibody-mediated diseases of the newborn","volume":"54","author":"Einarsdottir","year":"2014","journal-title":"Transfusion"},{"issue":"11","key":"B43","doi-asserted-by":"publisher","first-page":"5415","DOI":"10.4049\/jimmunol.168.11.5415","article-title":"Ligation of HLA class I molecules on endothelial cells induces phosphorylation of Src, paxillin, and focal adhesion kinase in an actin-dependent manner","volume":"168","author":"Jin","year":"2002","journal-title":"J Immunol"},{"issue":"1 Suppl","key":"B44","doi-asserted-by":"publisher","first-page":"S33","DOI":"10.1097\/01.tp.0000231447.34240.3c","article-title":"Anti-HLA antibodies can induce endothelial cell survival or proliferation depending on their concentration","volume":"82","author":"Jindra","year":"2006","journal-title":"Transplantation"},{"issue":"4","key":"B45","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1073\/pnas.0602035104","article-title":"Antibody to human leukocyte antigen triggers endothelial exocytosis","volume":"104","author":"Yamakuchi","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"B46","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.4049\/jimmunol.180.4.2214","article-title":"Anti-MHC class I antibody activation of proliferation and survival signaling in murine cardiac allografts","volume":"180","author":"Jindra","year":"2008","journal-title":"J Immunol"},{"issue":"4","key":"B47","doi-asserted-by":"publisher","first-page":"2357","DOI":"10.4049\/jimmunol.180.4.2357","article-title":"HLA class I antibody-mediated endothelial cell proliferation via the mTOR pathway","volume":"180","author":"Jindra","year":"2008","journal-title":"J Immunol"},{"issue":"7","key":"B48","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1161\/CIRCRESAHA.107.170332","article-title":"In vivo platelet-endothelial cell interactions in response to major histocompatibility complex alloantibody","volume":"102","author":"Morrell","year":"2008","journal-title":"Circ Res"},{"issue":"149","key":"B49","doi-asserted-by":"publisher","first-page":"ra85","DOI":"10.1126\/scisignal.2001158","article-title":"HLA class I molecules partner with integrin \u03b24 to stimulate endothelial cell proliferation and migration","volume":"3","author":"Zhang","year":"2010","journal-title":"Sci Signal"},{"issue":"12","key":"B50","doi-asserted-by":"publisher","first-page":"1150","DOI":"10.1016\/j.humimm.2011.09.004","article-title":"Antibody ligation of human leukocyte antigen class I molecules stimulates migration and proliferation of smooth muscle cells in a focal adhesion kinase-dependent manner","volume":"72","author":"Li","year":"2011","journal-title":"Hum Immunol"},{"issue":"8","key":"B51","doi-asserted-by":"publisher","first-page":"C872","DOI":"10.1152\/ajpcell.00199.2012","article-title":"HLA class I-mediated stress fiber formation requires ERK1\/2 activation in the absence of an increase in intracellular Ca2+ in human aortic endothelial cells","volume":"303","author":"Ziegler","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"B52","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/ajt.12016","article-title":"Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo","volume":"13","author":"Valenzuela","year":"2013","journal-title":"Am J Transplant"},{"issue":"12","key":"B53","doi-asserted-by":"publisher","first-page":"6635","DOI":"10.4049\/jimmunol.1201434","article-title":"HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging FcgammaRs","volume":"190","author":"Valenzuela","year":"2013","journal-title":"J Immunol"},{"issue":"4","key":"B54","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1111\/ajt.12669","article-title":"Everolimus inhibits anti-HLA I antibody-mediated endothelial cell signaling, migration and proliferation more potently than sirolimus","volume":"14","author":"Jin","year":"2014","journal-title":"Am J Transplant"},{"issue":"2","key":"B55","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1006\/cimm.1994.1139","article-title":"In vitro effects of solubilized HLA-DR \u2013 role in immunoregulation?","volume":"155","author":"Claus","year":"1994","journal-title":"Cell Immunol"},{"issue":"9","key":"B56","doi-asserted-by":"crossref","first-page":"3958","DOI":"10.4049\/jimmunol.157.9.3958","article-title":"Cross-linking of MHC class II molecules by staphylococcal enterotoxin A is essential for antigen-presenting cell and T cell activation","volume":"157","author":"Tiedemann","year":"1996","journal-title":"J Immunol"},{"issue":"4","key":"B57","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/S0198-8859(98)00131-1","article-title":"Ligation of MHC class II molecules differentially upregulates TNF beta gene expression in B cell lines of different MHC class II haplotypes","volume":"60","author":"Guo","year":"1999","journal-title":"Hum Immunol"},{"issue":"5","key":"B58","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S1043-4666(03)00123-6","article-title":"Ligation of IFN-gamma-induced HLA-DR molecules on fibroblasts induces RANTES expression via c-Jun N-terminal kinase (JNK) pathway","volume":"22","author":"Meguro","year":"2003","journal-title":"Cytokine"},{"issue":"4","key":"B59","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1093\/intimm\/dxn019","article-title":"Anti-HLA-DR-triggered monocytes mediate in vitro T cell anergy","volume":"20","author":"Kriegel","year":"2008","journal-title":"Int Immunol"},{"key":"B60","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1007\/978-1-62703-218-6_34","article-title":"Study of the allogeneic response induced by endothelial cells expressing HLA class II after lentiviral transduction","volume":"960","author":"Taflin","year":"2013","journal-title":"Methods Mol Biol"},{"issue":"5","key":"B61","doi-asserted-by":"publisher","first-page":"1408","DOI":"10.1111\/ajt.13644","article-title":"HLA class II antibody activation of endothelial cells promotes Th17 and disrupts regulatory T lymphocyte expansion","volume":"16","author":"Lion","year":"2016","journal-title":"Am J Transplant"},{"issue":"10","key":"B62","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1111\/j.1600-6143.2009.02761.x","article-title":"Endothelial gene expression in kidney transplants with alloantibody indicates antibody-mediated damage despite lack of C4d staining","volume":"9","author":"Sis","year":"2009","journal-title":"Am J Transplant"},{"issue":"2","key":"B63","doi-asserted-by":"publisher","first-page":"R65","DOI":"10.1186\/ar4503","article-title":"Angiotensin receptor type 1 and endothelin receptor type A on immune cells mediate migration and the expression of IL-8 and CCL18 when stimulated by autoantibodies from systemic sclerosis patients","volume":"16","author":"Gunther","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"B64","doi-asserted-by":"publisher","first-page":"R29","DOI":"10.1186\/ar4457","article-title":"Autoantibodies to angiotensin and endothelin receptors in systemic sclerosis induce cellular and systemic events associated with disease pathogenesis","volume":"16","author":"Kill","year":"2014","journal-title":"Arthritis Res Ther"},{"issue":"3","key":"B65","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.genm.2012.03.001","article-title":"Agonistic autoantibodies to the angiotensin II type I receptor cause pathophysiologic characteristics of preeclampsia","volume":"9","author":"LaMarca","year":"2012","journal-title":"Gend Med"},{"issue":"1","key":"B66","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jash.2014.10.009","article-title":"Prevalence of angiotensin II type 1 receptor (AT1R)-activating autoantibodies in primary aldosteronism","volume":"9","author":"Li","year":"2015","journal-title":"J Am Soc Hypertens"},{"issue":"6","key":"B67","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1056\/NEJMoa035717","article-title":"Angiotensin II type 1-receptor activating antibodies in renal-allograft rejection","volume":"352","author":"Dragun","year":"2005","journal-title":"N Engl J Med"},{"issue":"3","key":"B68","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1093\/icvts\/ivv344","article-title":"The impact of angiotensin II type 1 receptor antibodies on post-heart transplantation outcome in Heart Mate II bridged recipients","volume":"22","author":"Urban","year":"2016","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"5","key":"B69","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1681\/ASN.2013121277","article-title":"Endothelial cell antibodies associated with novel targets and increased rejection","volume":"26","author":"Jackson","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"B70","doi-asserted-by":"publisher","first-page":"2736","DOI":"10.1182\/blood-2006-04-017921","article-title":"Characterization of a humanized IgG4 anti-HLA-DR monoclonal antibody that lacks effector cell functions but retains direct antilymphoma activity and increases the potency of rituximab","volume":"108","author":"Stein","year":"2006","journal-title":"Blood"},{"issue":"2","key":"B71","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/s00281-003-0133-3","article-title":"Complement in transplant rejection: diagnostic and mechanistic considerations","volume":"25","author":"Baldwin","year":"2003","journal-title":"Springer Semin Immunopathol"},{"issue":"3","key":"B72","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.4049\/jimmunol.1400329","article-title":"Epidermal growth factor receptor targeting IgG3 triggers complement-mediated lysis of decay-accelerating factor expressing tumor cells through the alternative pathway amplification loop","volume":"193","author":"Rosner","year":"2014","journal-title":"J Immunol"},{"issue":"3","key":"B73","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1111\/j.1600-6143.2009.02961.x","article-title":"Decay accelerating factor is essential for successful corneal engraftment","volume":"10","author":"Esposito","year":"2010","journal-title":"Am J Transplant"},{"issue":"7","key":"B74","doi-asserted-by":"publisher","first-page":"4580","DOI":"10.4049\/jimmunol.181.7.4580","article-title":"Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection","volume":"181","author":"Pavlov","year":"2008","journal-title":"J Immunol"},{"issue":"8","key":"B75","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1111\/j.1600-6143.2009.02723.x","article-title":"Primed CD8(+) T-cell responses to allogeneic endothelial cells are controlled by local complement activation","volume":"9","author":"Raedler","year":"2009","journal-title":"Am J Transplant"},{"issue":"4","key":"B76","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.healun.2008.01.008","article-title":"Decay-accelerating factor expression may provide immunoprotection against antibody-mediated cardiac allograft rejection","volume":"27","author":"Gonzalez-Stawinski","year":"2008","journal-title":"J Heart Lung Transplant"},{"issue":"10","key":"B77","doi-asserted-by":"publisher","first-page":"6250","DOI":"10.4049\/jimmunol.166.10.6250","article-title":"Activity of human IgG and IgA subclasses in immune defense against Neisseria meningitidis serogroup B","volume":"166","author":"Vidarsson","year":"2001","journal-title":"J Immunol"},{"issue":"3","key":"B78","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1111\/j.1600-6143.2004.00334.x","article-title":"Non-complement- and complement-activating antibodies synergize to cause rejection of cardiac allografts","volume":"4","author":"Rahimi","year":"2004","journal-title":"Am J Transplant"},{"issue":"7","key":"B79","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1002\/j.1460-2075.1988.tb03037.x","article-title":"Segmental flexibility and complement fixation of genetically engineered chimeric human, rabbit and mouse antibodies","volume":"7","author":"Dangl","year":"1988","journal-title":"EMBO J"},{"issue":"14","key":"B80","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1056\/NEJM196904032801401","article-title":"Significance of the positive crossmatch test in kidney transplantation","volume":"280","author":"Patel","year":"1969","journal-title":"N Engl J Med"},{"issue":"8","key":"B81","doi-asserted-by":"publisher","first-page":"4620","DOI":"10.4049\/jimmunol.169.8.4620","article-title":"Membrane attack complex contributes to destruction of vascular integrity in acute lung allograft rejection","volume":"169","author":"Nakashima","year":"2002","journal-title":"J Immunol"},{"issue":"4","key":"B82","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1172\/JCI110509","article-title":"Chemotaxis of monocytes and neutrophils to platelet-derived growth factor","volume":"69","author":"Deuel","year":"1982","journal-title":"J Clin Invest"},{"issue":"5","key":"B83","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/S0006-2952(00)00361-0","article-title":"Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production in vitro by a new C5a receptor antagonist","volume":"60","author":"Haynes","year":"2000","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"B84","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1172\/JCI117430","article-title":"C5a-induced expression of P-selectin in endothelial cells","volume":"94","author":"Foreman","year":"1994","journal-title":"J Clin Invest"},{"issue":"23","key":"B85","doi-asserted-by":"publisher","first-page":"2504","DOI":"10.1161\/CIRCULATIONAHA.113.002972","article-title":"Alloantibody and complement promote T cell-mediated cardiac allograft vasculopathy through noncanonical nuclear factor-kappaB signaling in endothelial cells","volume":"128","author":"Jane-Wit","year":"2013","journal-title":"Circulation"},{"issue":"31","key":"B86","doi-asserted-by":"publisher","first-page":"9686","DOI":"10.1073\/pnas.1503535112","article-title":"Complement membrane attack complexes activate noncanonical NF-kappaB by forming an Akt+ NIK+ signalosome on Rab5+ endosomes","volume":"112","author":"Jane-wit","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"B87","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1111\/j.1600-6143.2009.02958.x","article-title":"Complement independent antibody-mediated endarteritis and transplant arteriopathy in mice","volume":"10","author":"Hirohashi","year":"2010","journal-title":"Am J Transplant"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.13834","article-title":"Complement C5 inhibition reduces T cell-mediated allograft vasculopathy caused by both alloantibody and ischemia reperfusion injury in humanized mice","author":"Qin","year":"2016","journal-title":"Am J Transplant"},{"issue":"5","key":"B89","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.4049\/jimmunol.1000522","article-title":"Complement-dependent transport of antigen into B cell follicles","volume":"185","author":"Gonzalez","year":"2010","journal-title":"J Immunol"},{"issue":"1\u20133","key":"B90","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s12026-012-8327-1","article-title":"Complement regulation of T cell immunity","volume":"54","author":"Kwan","year":"2012","journal-title":"Immunol Res"},{"issue":"4","key":"B91","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1097\/MOT.0000000000000216","article-title":"Effects of complement activation on allograft injury","volume":"20","author":"Sheen","year":"2015","journal-title":"Curr Opin Organ Transplant"},{"issue":"10","key":"B92","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.humimm.2011.07.001","article-title":"Novel C1q assay reveals a clinically relevant subset of human leukocyte antigen antibodies independent of immunoglobulin G strength on single antigen beads","volume":"72","author":"Chen","year":"2011","journal-title":"Hum Immunol"},{"issue":"6","key":"B93","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1111\/j.1600-6143.2011.03985.x","article-title":"Pretransplant donor-specific HLA class-I and -II antibodies are associated with an increased risk for kidney graft failure","volume":"12","author":"Otten","year":"2012","journal-title":"Am J Transplant"},{"issue":"1\u20134","key":"B94","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.trim.2013.07.002","article-title":"Clinical relevance of pretransplant anti-HLA donor-specific antibodies: does C1q-fixation matter?","volume":"29","author":"Crespo","year":"2013","journal-title":"Transpl Immunol"},{"issue":"9","key":"B95","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1097\/TP.0b013e3182888db6","article-title":"The role of immunoglobulin-G subclasses and C1q in de novo HLA-DQ donor-specific antibody kidney transplantation outcomes","volume":"95","author":"Freitas","year":"2013","journal-title":"Transplantation"},{"issue":"1\u20132","key":"B96","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S0022-1759(03)00012-7","article-title":"Flow cytometry based detection of HLA alloantibody mediated classical complement activation","volume":"275","author":"Wahrmann","year":"2003","journal-title":"J Immunol Methods"},{"issue":"12","key":"B97","doi-asserted-by":"publisher","first-page":"2809","DOI":"10.1111\/j.1600-6143.2007.01991.x","article-title":"C4d fixing, luminex binding antibodies \u2013 a new tool for prediction of graft failure after heart transplantation","volume":"7","author":"Smith","year":"2007","journal-title":"Am J Transplant"},{"issue":"5","key":"B98","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1097\/TP.0b013e31827b3dc3","article-title":"Systematic comparison of four cell- and Luminex-based methods for assessment of complement-activating HLA antibodies","volume":"95","author":"Lachmann","year":"2013","journal-title":"Transplantation"},{"issue":"1","key":"B99","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.humimm.2012.10.012","article-title":"Modified solid-phase alloantibody detection for improved crossmatch prediction","volume":"74","author":"Wahrmann","year":"2013","journal-title":"Hum Immunol"},{"issue":"4\u20135","key":"B100","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.clinbiochem.2015.05.024","article-title":"Detection of alloantibody-mediated complement activation: a diagnostic advance in monitoring kidney transplant rejection?","volume":"49","author":"Bohmig","year":"2016","journal-title":"Clin Biochem"},{"issue":"2","key":"B101","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1681\/ASN.2013101144","article-title":"Detection of C3d-binding donor-specific anti-HLA antibodies at diagnosis of humoral rejection predicts renal graft loss","volume":"26","author":"Sicard","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"B102","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1111\/ajt.13700","article-title":"Acquisition of C3d-binding activity by de novo donor-specific HLA antibodies correlates with graft loss in nonsensitized pediatric kidney recipients","volume":"16","author":"Comoli","year":"2016","journal-title":"Am J Transplant"},{"issue":"10","key":"B103","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1097\/TP.0000000000000190","article-title":"Changes in successive measures of de novo donor-specific anti-human leukocyte antigen antibodies intensity and the development of allograft dysfunction","volume":"98","author":"Dieplinger","year":"2014","journal-title":"Transplantation"},{"issue":"1","key":"B104","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.healun.2012.09.021","article-title":"Persistent strong anti-HLA antibody at high titer is complement binding and associated with increased risk of antibody-mediated rejection in heart transplant recipients","volume":"32","author":"Zeevi","year":"2013","journal-title":"J Heart Lung Transplant"},{"issue":"2","key":"B105","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.healun.2010.08.020","article-title":"Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients","volume":"30","author":"Chin","year":"2011","journal-title":"J Heart Lung Transplant"},{"issue":"3","key":"B106","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1097\/TP.0b013e318203fd26","article-title":"C1q-fixing human leukocyte antigen antibodies are specific for predicting transplant glomerulopathy and late graft failure after kidney transplantation","volume":"91","author":"Yabu","year":"2011","journal-title":"Transplantation"},{"issue":"1","key":"B107","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1399-3046.2011.01599.x","article-title":"Complement-fixing donor-specific antibodies identified by a novel C1q assay are associated with allograft loss","volume":"16","author":"Sutherland","year":"2012","journal-title":"Pediatr Transplant"},{"issue":"5753","key":"B108","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1126\/science.1118948","article-title":"Divergent immunoglobulin g subclass activity through selective Fc receptor binding","volume":"310","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"issue":"1","key":"B109","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.immuni.2005.11.010","article-title":"Fcgamma receptors: old friends and new family members","volume":"24","author":"Nimmerjahn","year":"2006","journal-title":"Immunity"},{"issue":"4","key":"B110","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1093\/infdis\/170.4.854","article-title":"Fc gamma receptor IIa (CD32) heterogeneity in patients with recurrent bacterial respiratory tract infections","volume":"170","author":"Sanders","year":"1994","journal-title":"J Infect Dis"},{"issue":"4","key":"B111","first-page":"24","article-title":"The Fc gamma RIIa polymorphism in patients with acute kidney graft rejection","volume":"8","author":"Pawlik","year":"2003","journal-title":"Ann Transplant"},{"issue":"6","key":"B112","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1093\/ndt\/gfh121","article-title":"Fc gamma RIIa polymorphism: a susceptibility factor for immune complex-mediated lupus nephritis in Brazilian patients","volume":"19","author":"Bazilio","year":"2004","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"B113","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1111\/j.1365-2249.2009.03980.x","article-title":"Functional and clinical consequences of Fc receptor polymorphic and copy number variants","volume":"157","author":"Bournazos","year":"2009","journal-title":"Clin Exp Immunol"},{"key":"B114","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-8722-6-1","article-title":"A critical review of the role of Fc gamma receptor polymorphisms in the response to monoclonal antibodies in cancer","volume":"6","author":"Mellor","year":"2013","journal-title":"J Hematol Oncol"},{"issue":"2","key":"B115","doi-asserted-by":"publisher","first-page":"e89196","DOI":"10.1371\/journal.pone.0089196","article-title":"Functional Fcgamma receptor polymorphisms are associated with human allergy","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS One"},{"issue":"16","key":"B116","doi-asserted-by":"publisher","first-page":"3716","DOI":"10.1182\/blood-2008-09-179754","article-title":"Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses","volume":"113","author":"Bruhns","year":"2009","journal-title":"Blood"},{"issue":"4","key":"B117","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1172\/JCI65579","article-title":"IgG4 subclass antibodies impair antitumor immunity in melanoma","volume":"123","author":"Karagiannis","year":"2013","journal-title":"J Clin Invest"},{"issue":"4","key":"B118","first-page":"681","article-title":"Induction of antibody-dependent cellular cytotoxicity against endothelial cells by renal transplantation","volume":"48","author":"Miltenburg","year":"1989","journal-title":"Transplantation"},{"issue":"6","key":"B119","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1097\/00007890-199306000-00015","article-title":"The clinical significance of allospecific antibodies against endothelial cells detected with an antibody-dependent cellular cytotoxicity assay for vascular rejection and graft loss after renal transplantation","volume":"55","author":"Yard","year":"1993","journal-title":"Transplantation"},{"issue":"12","key":"B120","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1016\/j.humimm.2012.07.330","article-title":"Role of complement and NK cells in antibody mediated rejection","volume":"73","author":"Akiyoshi","year":"2012","journal-title":"Hum Immunol"},{"issue":"6","key":"B121","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1016\/j.kint.2016.02.030","article-title":"Natural killer cells play a critical role in mediating inflammation and graft failure during antibody-mediated rejection of kidney allografts","volume":"89","author":"Kohei","year":"2016","journal-title":"Kidney Int"},{"issue":"8","key":"B122","doi-asserted-by":"publisher","first-page":"1812","DOI":"10.1111\/j.1600-6143.2010.03201.x","article-title":"NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection","volume":"10","author":"Hidalgo","year":"2010","journal-title":"Am J Transplant"},{"issue":"5","key":"B123","doi-asserted-by":"publisher","first-page":"1180","DOI":"10.1111\/j.1600-6143.2011.03970.x","article-title":"Interpreting NK cell transcripts versus T cell transcripts in renal transplant biopsies","volume":"12","author":"Hidalgo","year":"2012","journal-title":"Am J Transplant"},{"issue":"9","key":"B124","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.1182\/blood-2006-08-044669","article-title":"Antiendothelial cell antibodies mediate enhanced leukocyte adhesion to cytokine-activated endothelial cells through a novel mechanism requiring cooperation between Fc{gamma}RIIa and CXCR1\/2","volume":"109","author":"Florey","year":"2007","journal-title":"Blood"},{"issue":"6","key":"B125","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1111\/ajt.13174","article-title":"Monocyte recruitment by HLA IgG-activated endothelium: the relationship between IgG subclass and FcgammaRIIa polymorphisms","volume":"15","author":"Valenzuela","year":"2015","journal-title":"Am J Transplant"},{"issue":"1","key":"B126","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/TP.0b013e31821cdf0d","article-title":"Pretransplant IgG subclasses of donor-specific human leukocyte antigen antibodies and development of antibody-mediated rejection","volume":"92","author":"Honger","year":"2011","journal-title":"Transplantation"},{"issue":"8","key":"B127","doi-asserted-by":"publisher","first-page":"984","DOI":"10.1002\/lt.23451","article-title":"Donor-specific human leukocyte antigen antibodies of the immunoglobulin G3 subclass are associated with chronic rejection and graft loss after liver transplantation","volume":"18","author":"Kaneku","year":"2012","journal-title":"Liver Transpl"},{"issue":"5","key":"B128","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.humimm.2013.01.008","article-title":"Significant IgG subclass heterogeneity in HLA-specific antibodies: implications for pathogenicity, prognosis, and the rejection response","volume":"74","author":"Lowe","year":"2013","journal-title":"Hum Immunol"},{"issue":"12","key":"B129","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1111\/tri.12648","article-title":"Subclass analysis of donor HLA-specific IgG in antibody-incompatible renal transplantation reveals a significant association of IgG4 with rejection and graft failure","volume":"28","author":"Khovanova","year":"2015","journal-title":"Transpl Int"},{"issue":"1","key":"B130","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1681\/ASN.2014111120","article-title":"IgG Donor-specific anti-human HLA antibody subclasses and kidney allograft antibody-mediated injury","volume":"27","author":"Lefaucheur","year":"2016","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"B131","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/TP.0b013e31821b60e9","article-title":"Clinical relevance and IgG subclass determination of non-HLA antibodies identified using endothelial cell precursors isolated from donor blood","volume":"92","author":"Jackson","year":"2011","journal-title":"Transplantation"},{"issue":"11","key":"B132","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1097\/01.TP.0000129408.07168.40","article-title":"Skewing of pretransplant anti-HLA class I antibodies of immunoglobulin G isotype solely toward immunoglobulin G1 subclass is associated with poorer renal allograft survival","volume":"77","author":"Griffiths","year":"2004","journal-title":"Transplantation"},{"issue":"8","key":"B133","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1681\/ASN.2009101065","article-title":"Preexisting donor-specific HLA antibodies predict outcome in kidney transplantation","volume":"21","author":"Lefaucheur","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"B134","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/S0272-6386(96)90136-5","article-title":"Pretransplant rejection risk assessment through enzyme-linked immunosorbent assay analysis of anti-HLA class I antibodies","volume":"28","author":"Regan","year":"1996","journal-title":"Am J Kidney Dis"},{"issue":"1\u20132","key":"B135","doi-asserted-by":"publisher","first-page":"1433","DOI":"10.1016\/S0041-1345(96)00541-6","article-title":"Pretransplant and posttransplant monitoring of anti-HLA class I IgG1 antibodies by ELISA identifies patients at high risk of graft loss","volume":"29","author":"Monteiro","year":"1997","journal-title":"Transplant Proc"},{"issue":"8","key":"B136","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1002\/lt.20154","article-title":"Immunoglobulin-G subclass antidonor reactivity in transplant recipients","volume":"10","author":"Gao","year":"2004","journal-title":"Liver Transpl"},{"issue":"7","key":"B137","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1097\/01.TP.0000136966.63957.E2","article-title":"Human leukocyte antigen antibodies and human complement activation: role of IgG subclass, specificity, and cytotoxic potential","volume":"78","author":"Kushihata","year":"2004","journal-title":"Transplantation"},{"issue":"1\u20132","key":"B138","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.trim.2010.03.003","article-title":"Subtypes of immunoglobulin (Ig)-G antibodies against donor class II HLA and cross-match results in three kidney transplant candidates","volume":"23","author":"Lobashevsky","year":"2010","journal-title":"Transpl Immunol"},{"issue":"5","key":"B139","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1097\/01.TP.0000441362.11232.48","article-title":"Impact of IgM and IgG3 anti-HLA alloantibodies in primary renal allograft recipients","volume":"97","author":"Everly","year":"2014","journal-title":"Transplantation"},{"issue":"2","key":"B140","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4049\/jimmunol.130.2.722","article-title":"Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response","volume":"130","author":"Aalberse","year":"1983","journal-title":"J Immunol"},{"issue":"3","key":"B141","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/tri.12230","article-title":"The complexity of the humoral immune response against HLA antigens","volume":"27","author":"Schaub","year":"2014","journal-title":"Transpl Int"},{"issue":"3","key":"B142","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/tri.12206","article-title":"Donor-specific HLA antibodies: evaluating the risk for graft loss in renal transplant recipients with isotype switch from complement fixing IgG1\/IgG3 to noncomplement fixing IgG2\/IgG4 anti-HLA alloantibodies","volume":"27","author":"Arnold","year":"2014","journal-title":"Transpl Int"},{"issue":"9","key":"B143","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/S0198-8859(00)00162-2","article-title":"Identification of MICA as a new polymorphic alloantigen recognized by antibodies in sera of organ transplant recipients","volume":"61","author":"Zwirner","year":"2000","journal-title":"Hum Immunol"},{"issue":"2","key":"B144","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1097\/00007890-200207270-00019","article-title":"Identification of the nonclassical HLA molecules, mica, as targets for humoral immunity associated with irreversible rejection of kidney allografts","volume":"74","author":"Sumitran-Holgersson","year":"2002","journal-title":"Transplantation"},{"issue":"7","key":"B145","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1097\/00007890-200104150-00011","article-title":"Antivimentin antibodies are an independent predictor of transplant-associated coronary artery disease after cardiac transplantation","volume":"71","author":"Jurcevic","year":"2001","journal-title":"Transplantation"},{"issue":"2","key":"B146","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/j.1600-6143.2005.00690.x","article-title":"Antibody response against the glomerular basement membrane protein agrin in patients with transplant glomerulopathy","volume":"5","author":"Joosten","year":"2005","journal-title":"Am J Transplant"},{"issue":"11","key":"B147","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1097\/01.TP.0000040003.89413.A6","article-title":"Isolation of precursor endothelial cells from peripheral blood for donor-specific crossmatching before organ transplantation","volume":"74","author":"Vermehren","year":"2002","journal-title":"Transplantation"},{"issue":"8","key":"B148","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1111\/j.1600-6143.2009.02722.x","article-title":"Lack of effect of MICA antibodies on graft survival following heart transplantation","volume":"9","author":"Smith","year":"2009","journal-title":"Am J Transplant"},{"issue":"1","key":"B149","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1097\/TP.0b013e31818bd790","article-title":"Donor-specific antibodies against HLA, MICA, and GSTT1 in patients with allograft rejection and C4d deposition in renal biopsies","volume":"87","author":"Alvarez-Marquez","year":"2009","journal-title":"Transplantation"},{"issue":"12","key":"B150","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1097\/TP.0b013e3181fd97f1","article-title":"Anti-angiotensin type 1 receptor antibodies associated with antibody mediated rejection in donor HLA antibody negative patients","volume":"90","author":"Reinsmoen","year":"2010","journal-title":"Transplantation"},{"issue":"7","key":"B151","doi-asserted-by":"publisher","first-page":"1819","DOI":"10.1093\/ndt\/gfm072","article-title":"Agonistic antibody-triggered stimulation of angiotensin II type 1 receptor and renal allograft vascular pathology","volume":"22","author":"Dragun","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1097\/TP.0000000000001231","article-title":"Anti-angiotensin II type 1 receptor and anti-endothelial cell antibodies: a cross-sectional analysis of pathological findings in allograft biopsies","author":"Philogene","year":"2016","journal-title":"Transplantation"},{"issue":"4","key":"B153","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1097\/TP.0b013e3181949d4e","article-title":"Multicenter evaluation of a novel endothelial cell crossmatch test in kidney transplantation","volume":"87","author":"Breimer","year":"2009","journal-title":"Transplantation"},{"issue":"11","key":"B154","doi-asserted-by":"publisher","first-page":"1486","DOI":"10.1016\/j.humimm.2013.07.001","article-title":"Moving beyond HLA: a review of nHLA antibodies in organ transplantation","volume":"74","author":"Sigdel","year":"2013","journal-title":"Hum Immunol"},{"issue":"4","key":"B155","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1111\/ajt.13153","article-title":"Impact of IgG3 subclass and C1q-fixing donor-specific HLA alloantibodies on rejection and survival in liver transplantation","volume":"15","author":"O\u2019Leary","year":"2015","journal-title":"Am J Transplant"},{"issue":"1","key":"B156","first-page":"127","article-title":"IgG2 subclass restriction of antibody to pneumococcal polysaccharides","volume":"63","author":"Barrett","year":"1986","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"B157","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1111\/2049-632X.12034","article-title":"IgG subclass profiles in normal human sera of antibodies specific to five kinds of microbial antigens","volume":"67","author":"Hjelholt","year":"2013","journal-title":"Pathog Dis"},{"issue":"4","key":"B158","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/0091-6749(83)90503-1","article-title":"Antibodies to purified bee venom proteins and peptides. II. A detailed study of changes in IgE and IgG antibodies to individual bee venom antigens","volume":"72","author":"Kemeny","year":"1983","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"B159","doi-asserted-by":"crossref","first-page":"197","DOI":"10.4269\/ajtmh.1996.55.197","article-title":"Neutralization of bee venom lethality by immune serum antibodies","volume":"55","author":"Schumacher","year":"1996","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"B160","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.4049\/jimmunol.134.4.2707","article-title":"Prominence of IgG4 in the IgG antibody response to human filariasis","volume":"134","author":"Ottesen","year":"1985","journal-title":"J Immunol"},{"issue":"9","key":"B161","doi-asserted-by":"crossref","first-page":"3941","DOI":"10.4049\/jimmunol.150.9.3941","article-title":"Differential expression of IgE and IgG4 specific antibody responses in asymptomatic and chronic human filariasis","volume":"150","author":"Kurniawan","year":"1993","journal-title":"J Immunol"},{"issue":"3","key":"B162","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1084\/jem.183.3.937","article-title":"Interleukin-10 induces immunoglobulin G isotype switch recombination in human CD40-activated naive B lymphocytes","volume":"183","author":"Malisan","year":"1996","journal-title":"J Exp Med"},{"issue":"7","key":"B163","doi-asserted-by":"publisher","first-page":"4529","DOI":"10.4049\/jimmunol.173.7.4529","article-title":"Transcription of Ig germline genes in single human B cells and the role of cytokines in isotype determination","volume":"173","author":"Fear","year":"2004","journal-title":"J Immunol"},{"issue":"9","key":"B164","doi-asserted-by":"publisher","first-page":"5154","DOI":"10.4049\/jimmunol.172.9.5154","article-title":"Cutting edge: IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells","volume":"172","author":"Pene","year":"2004","journal-title":"J Immunol"},{"issue":"3","key":"B165","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.4049\/jimmunol.181.3.1767","article-title":"IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4","volume":"181","author":"Avery","year":"2008","journal-title":"J Immunol"},{"issue":"9","key":"B166","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1093\/ndt\/12.9.1806","article-title":"Direct and indirect pathways of alloantigen recognition: relevance to acute and chronic allograft rejection","volume":"12","author":"Hornick","year":"1997","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"B167","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1097\/MOT.0b013e328309ee31","article-title":"Pathways of major histocompatibility complex allorecognition","volume":"13","author":"Afzali","year":"2008","journal-title":"Curr Opin Organ Transplant"},{"issue":"4","key":"B168","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1111\/j.1600-6143.2009.02578.x","article-title":"Preferential priming of alloreactive T cells with indirect reactivity","volume":"9","author":"Brennan","year":"2009","journal-title":"Am J Transplant"},{"issue":"5","key":"B169","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.4049\/jimmunol.0902748","article-title":"NK cell patrolling and elimination of donor-derived dendritic cells favor indirect alloreactivity","volume":"184","author":"Garrod","year":"2010","journal-title":"J Immunol"},{"issue":"11","key":"B170","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/0167-5699(92)90069-J","article-title":"Processed MHC class I alloantigen as the stimulus for CD4+ T-cell dependent antibody-mediated graft rejection","volume":"13","author":"Bradley","year":"1992","journal-title":"Immunol Today"},{"issue":"9","key":"B171","doi-asserted-by":"publisher","first-page":"2078","DOI":"10.1002\/eji.1830230906","article-title":"CD4+ T cell-mediated rejection of major histocompatibility complex class I-disparate grafts: a role for alloantibody","volume":"23","author":"Morton","year":"1993","journal-title":"Eur J Immunol"},{"issue":"3","key":"B172","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.4049\/jimmunol.161.3.1292","article-title":"Indirect T cell allorecognition and alloantibody-mediated rejection of MHC class I-disparate heart grafts","volume":"161","author":"Pettigrew","year":"1998","journal-title":"J Immunol"},{"issue":"7","key":"B173","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1097\/01.tp.0000257960.07783.e3","article-title":"Pathways of helper CD4 T cell allorecognition in generating alloantibody and CD8 T cell alloimmunity","volume":"83","author":"Taylor","year":"2007","journal-title":"Transplantation"},{"issue":"12","key":"B174","doi-asserted-by":"publisher","first-page":"5703","DOI":"10.4049\/jimmunol.1202257","article-title":"Unlinked memory helper responses promote long-lasting humoral alloimmunity","volume":"189","author":"Conlon","year":"2012","journal-title":"J Immunol"},{"issue":"3","key":"B175","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1038\/ki.2015.100","article-title":"B-lymphocytes support and regulate indirect T-cell alloreactivity in individual patients with chronic antibody-mediated rejection","volume":"88","author":"Shiu","year":"2015","journal-title":"Kidney Int"},{"issue":"3","key":"B176","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/ki.2015.171","article-title":"B cells regulate antidonor T-cell reactivity in transplantation","volume":"88","author":"Valujskikh","year":"2015","journal-title":"Kidney Int"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-016-3422-5","article-title":"Sirolimus and tacrolimus coefficient of variation is associated with rejection, donor-specific antibodies, and nonadherence","author":"Pizzo","year":"2016","journal-title":"Pediatr Nephrol"},{"issue":"2","key":"B178","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1159\/000020652","article-title":"Treatment with mycophenolate mofetil attenuates the development of Heymann nephritis","volume":"8","author":"Luca","year":"2000","journal-title":"Exp Nephrol"},{"issue":"5","key":"B179","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1093\/ndt\/gfg034","article-title":"Modulation of autoantibody production by mycophenolate mofetil: effects on the development of SLE in (NZB x NZW)F1 mice","volume":"18","author":"Ramos","year":"2003","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"B180","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1365-2249.2009.04051.x","article-title":"Calcineurin inhibitors affect B cell antibody responses indirectly by interfering with T cell help","volume":"159","author":"Heidt","year":"2010","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"B181","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1111\/cei.12604","article-title":"Calcineurin inhibitors dampen humoral immunity by acting directly on naive B cells","volume":"180","author":"De Bruyne","year":"2015","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"B182","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/S1074-7613(00)80333-7","article-title":"B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation","volume":"6","author":"Borriello","year":"1997","journal-title":"Immunity"},{"issue":"1","key":"B183","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/ajt.12526","article-title":"Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection","volume":"14","author":"Kim","year":"2014","journal-title":"Am J Transplant"},{"issue":"12","key":"B184","first-page":"4594","article-title":"CTLA4Ig inhibits alloantibody responses to repeated blood transfusions","volume":"88","author":"Ibrahim","year":"1996","journal-title":"Blood"},{"issue":"2","key":"B185","first-page":"715","article-title":"CTLA4Ig inhibits humoral and cellular immune responses to concordant xenografts","volume":"28","author":"Ibrahim","year":"1996","journal-title":"Transplant Proc"},{"issue":"3","key":"B186","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1111\/j.1600-6143.2011.03914.x","article-title":"Three-year outcomes from BENEFIT-EXT: a phase III study of belatacept versus cyclosporine in recipients of extended criteria donor kidneys","volume":"12","author":"Pestana","year":"2012","journal-title":"Am J Transplant"},{"issue":"4","key":"B187","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1056\/NEJMoa1506027","article-title":"Belatacept and long-term outcomes in kidney transplantation","volume":"374","author":"Vincenti","year":"2016","journal-title":"N Engl J Med"},{"issue":"5","key":"B188","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1111\/ajt.12721","article-title":"Kidney transplant recipients treated with belatacept exhibit increased naive and transitional B cells","volume":"14","author":"Leibler","year":"2014","journal-title":"Am J Transplant"},{"issue":"6","key":"B189","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1038\/nrneph.2016.9","article-title":"Memory T cells in organ transplantation: progress and challenges","volume":"12","author":"Espinosa","year":"2016","journal-title":"Nat Rev Nephrol"},{"issue":"1","key":"B190","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1111\/cei.12390","article-title":"Rituximab impairs immunoglobulin (Ig)M and IgG (subclass) responses after influenza vaccination in rheumatoid arthritis patients","volume":"178","author":"Westra","year":"2014","journal-title":"Clin Exp Immunol"},{"issue":"47","key":"B191","doi-asserted-by":"publisher","first-page":"E5076","DOI":"10.1073\/pnas.1407104111","article-title":"mTOR kinase inhibitors promote antibody class switching via mTORC2 inhibition","volume":"111","author":"Limon","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"B192","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.4049\/jimmunol.160.4.1581","article-title":"Inhibition of JAK3 and STAT6 tyrosine phosphorylation by the immunosuppressive drug leflunomide leads to a block in IgG1 production","volume":"160","author":"Siemasko","year":"1998","journal-title":"J Immunol"},{"issue":"12","key":"B193","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1111\/j.1432-2277.2006.00387.x","article-title":"Janus kinase 3 inhibition with CP-690,550 prevents allograft vasculopathy","volume":"19","author":"Rousvoal","year":"2006","journal-title":"Transpl Int"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00433\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T15:43:39Z","timestamp":1692546219000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00433\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,24]]},"references-count":193,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00433","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,24]]}}}