{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:24:48Z","timestamp":1792599888168,"version":"4.5.0"},"reference-count":153,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI093104, R01 AI121401"],"award-info":[{"award-number":["R01 AI093104, R01 AI121401"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00442","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T03:18:09Z","timestamp":1477019889000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":71,"title":["Multifunctional and Redundant Roles of Borrelia burgdorferi Outer Surface Proteins in Tissue Adhesion, Colonization, and Complement Evasion"],"prefix":"10.3389","volume":"7","author":[{"given":"Jennifer A.","family":"Caine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenifer","family":"Coburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"B1","author":"Centers for Disease Control and Prevention","year":"2015","journal-title":"Lyme Disease \u2013 Data and Statistics"},{"issue":"2","key":"B2","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1038\/nrmicro2714","article-title":"Of ticks, mice and men: understanding the dual-host lifestyle of Lyme disease spirochaetes","volume":"10","author":"Radolf","year":"2012","journal-title":"Nat Rev Microbiol"},{"issue":"20","key":"B3","doi-asserted-by":"publisher","first-page":"11642","DOI":"10.1073\/pnas.1434553100","article-title":"An enzootic transmission cycle of Lyme borreliosis spirochetes in the southeastern United States","volume":"100","author":"Oliver","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"B4","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1056\/NEJM198303313081301","article-title":"The spirochetal etiology of Lyme disease","volume":"308","author":"Steere","year":"1983","journal-title":"N Engl J Med"},{"issue":"4A","key":"B5","doi-asserted-by":"publisher","first-page":"44S","DOI":"10.1016\/S0002-9343(99)80043-6","article-title":"Musculoskeletal manifestations of Lyme disease","volume":"98","author":"Steere","year":"1995","journal-title":"Am J Med"},{"issue":"1","key":"B6","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S0025-7125(05)70510-1","article-title":"Diagnosis and treatment of Lyme arthritis","volume":"81","author":"Steere","year":"1997","journal-title":"Med Clin North Am"},{"issue":"2","key":"B7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1056\/NEJM200107123450207","article-title":"Lyme disease","volume":"345","author":"Steere","year":"2001","journal-title":"N Engl J Med"},{"issue":"3","key":"B8","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1099\/00207713-42-3-378","article-title":"Delineation of Borrelia burgdorferi sensu stricto, Borrelia garinii sp. nov., and group VS461 associated with Lyme borreliosis","volume":"42","author":"Baranton","year":"1992","journal-title":"Int J Syst Bacteriol"},{"issue":"4","key":"B9","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1093\/clinids\/17.4.708","article-title":"Different genospecies of Borrelia burgdorferi are associated with distinct clinical manifestations of Lyme borreliosis","volume":"17","author":"van Dam","year":"1993","journal-title":"Clin Infect Dis"},{"issue":"6","key":"B10","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1086\/506936","article-title":"Comparison of findings for patients with Borrelia garinii and Borrelia afzelii isolated from cerebrospinal fluid","volume":"43","author":"Strle","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"7","key":"B11","doi-asserted-by":"publisher","first-page":"2909","DOI":"10.1073\/pnas.92.7.2909","article-title":"Induction of an outer surface protein on Borrelia burgdorferi during tick feeding","volume":"92","author":"Schwan","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"11","key":"B12","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1128\/IAI.63.11.4535-4539.1995","article-title":"Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferi","volume":"63","author":"Stevenson","year":"1995","journal-title":"Infect Immun"},{"issue":"4","key":"B13","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1128\/IAI.65.4.1165-1171.1997","article-title":"Cell-density-dependent expression of Borrelia burgdorferi lipoproteins in vitro","volume":"65","author":"Indest","year":"1997","journal-title":"Infect Immun"},{"issue":"6","key":"B14","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1046\/j.1365-2958.2000.02104.x","article-title":"Interdependence of environmental factors influencing reciprocal patterns of gene expression in virulent Borrelia burgdorferi","volume":"37","author":"Yang","year":"2000","journal-title":"Mol Microbiol"},{"issue":"3","key":"B15","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1111\/mmi.12882","article-title":"Stage-specific global alterations in the transcriptomes of Lyme disease spirochetes during tick feeding and following mammalian host-adaptation","volume":"95","author":"Iyer","year":"2015","journal-title":"Mol Microbiol"},{"issue":"2","key":"B16","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1128\/JB.01109-06","article-title":"Borrelia burgdorferi alters its gene expression and antigenic profile in response to CO2 levels","volume":"189","author":"Hyde","year":"2007","journal-title":"J Bacteriol"},{"issue":"5","key":"B17","doi-asserted-by":"publisher","first-page":"2139","DOI":"10.1128\/JB.01653-06","article-title":"Evidence that RpoS (\u03c3S) in Borrelia burgdorferi is controlled directly by RpoN (\u03c354\/\u03c3N)","volume":"189","author":"Smith","year":"2007","journal-title":"J Bacteriol"},{"issue":"9","key":"B18","doi-asserted-by":"publisher","first-page":"3844","DOI":"10.1128\/IAI.00467-08","article-title":"Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi","volume":"76","author":"Boardman","year":"2008","journal-title":"Infect Immun"},{"issue":"22","key":"B19","doi-asserted-by":"publisher","first-page":"12724","DOI":"10.1073\/pnas.231442498","article-title":"Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN\u2013RpoS regulatory pathway","volume":"98","author":"H\u00fcbner","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"B20","doi-asserted-by":"publisher","first-page":"e109307","DOI":"10.1371\/journal.pone.0109307","article-title":"BosR functions as a repressor of the ospAB operon in Borrelia burgdorferi","volume":"9","author":"Shi","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"B21","doi-asserted-by":"publisher","first-page":"e96917","DOI":"10.1371\/journal.pone.0096917","article-title":"Synthesis of RpoS is dependent on a putative enhancer binding protein Rrp2 in Borrelia burgdorferi","volume":"9","author":"Ouyang","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"B22","doi-asserted-by":"publisher","first-page":"1344","DOI":"10.1111\/j.1365-2958.2009.06951.x","article-title":"The BosR regulatory protein of Borrelia burgdorferi interfaces with the RpoS regulatory pathway and modulates both the oxidative stress response and pathogenic properties of the Lyme disease spirochete","volume":"74","author":"Hyde","year":"2009","journal-title":"Mol Microbiol"},{"issue":"6","key":"B23","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1111\/j.1365-2958.2009.06945.x","article-title":"BosR (BB0647) governs virulence expression in Borrelia burgdorferi","volume":"74","author":"Ouyang","year":"2009","journal-title":"Mol Microbiol"},{"issue":"5","key":"B24","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1111\/j.1365-2958.2007.05860.x","article-title":"Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycle","volume":"65","author":"Caimano","year":"2007","journal-title":"Mol Microbiol"},{"issue":"10","key":"B25","doi-asserted-by":"publisher","first-page":"3429","DOI":"10.1128\/JB.00085-08","article-title":"Reciprocal expression of ospA and ospC in single cells of Borrelia burgdorferi","volume":"190","author":"Srivastava","year":"2008","journal-title":"J Bacteriol"},{"issue":"6","key":"B26","doi-asserted-by":"publisher","first-page":"3618","DOI":"10.1128\/IAI.69.6.3618-3627.2001","article-title":"Regulation of OspE-related, OspF-related, and Elp lipoproteins of Borrelia burgdorferi strain 297 by mammalian host-specific signals","volume":"69","author":"Hefty","year":"2001","journal-title":"Infect Immun"},{"issue":"1","key":"B27","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/JCM.38.1.382-388.2000","article-title":"Temporal changes in outer surface proteins A and C of the Lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and mice","volume":"38","author":"Schwan","year":"2000","journal-title":"J Clin Microbiol"},{"issue":"9","key":"B28","doi-asserted-by":"publisher","first-page":"5042","DOI":"10.1128\/IAI.71.9.5042-5055.2003","article-title":"Borrelia burgdorferi population dynamics and prototype gene expression during infection of immunocompetent and immunodeficient mice","volume":"71","author":"Hodzic","year":"2003","journal-title":"Infect Immun"},{"issue":"6","key":"B29","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.1128\/IAI.01950-05","article-title":"Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infection","volume":"74","author":"Tilly","year":"2006","journal-title":"Infect Immun"},{"issue":"11","key":"B30","doi-asserted-by":"publisher","first-page":"7083","DOI":"10.1128\/IAI.69.11.7083-7090.2001","article-title":"Analysis of Borrelia burgdorferi vlsE gene expression and recombination in the tick vector","volume":"69","author":"Indest","year":"2001","journal-title":"Infect Immun"},{"issue":"10","key":"B31","doi-asserted-by":"publisher","first-page":"5759","DOI":"10.1128\/IAI.72.10.5759-5767.2004","article-title":"Borrelia burgdorferi changes its surface antigenic expression in response to host immune responses","volume":"72","author":"Liang","year":"2004","journal-title":"Infect Immun"},{"issue":"2","key":"B32","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/S0092-8674(00)80206-8","article-title":"Antigenic variation in Lyme disease Borreliae by promiscuous recombination of VMP-like sequence cassettes","volume":"89","author":"Zhang","year":"1997","journal-title":"Cell"},{"issue":"0","key":"B33","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.meegid.2014.04.020","article-title":"Potentially conflicting selective forces that shape the vls antigenic variation system in Borrelia burgdorferi","volume":"27","author":"Zhou","year":"2014","journal-title":"Infect Genet Evol"},{"issue":"12","key":"B34","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1128\/JCM.37.12.3997-4004.1999","article-title":"Human antibody responses to vlse antigenic variation protein of Borrelia burgdorferi","volume":"37","author":"Lawrenz","year":"1999","journal-title":"J Clin Microbiol"},{"issue":"10","key":"B35","doi-asserted-by":"publisher","first-page":"e1000169","DOI":"10.1371\/journal.ppat.1000169","article-title":"Molecular mechanisms involved in vascular interactions of the Lyme disease pathogen in a living host","volume":"4","author":"Norman","year":"2008","journal-title":"PLoS Pathog"},{"issue":"1","key":"B36","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/1471-2180-8-82","article-title":"Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection","volume":"8","author":"Blevins","year":"2008","journal-title":"BMC Microbiol"},{"issue":"12","key":"B37","doi-asserted-by":"publisher","first-page":"6677","DOI":"10.1128\/IAI.68.12.6677-6684.2000","article-title":"Identification of 11 pH-regulated genes in Borrelia burgdorferi localizing to linear plasmids","volume":"68","author":"Carroll","year":"2000","journal-title":"Infect Immun"},{"issue":"9","key":"B38","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1073\/pnas.0306845101","article-title":"Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammals","volume":"101","author":"Grimm","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"B39","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1111\/j.1365-2958.2011.07801.x","article-title":"Bioluminescent imaging of Borrelia burgdorferi in vivo demonstrates that the fibronectin-binding protein BBK32 is required for optimal infectivity","volume":"82","author":"Hyde","year":"2011","journal-title":"Mol Microbiol"},{"issue":"6","key":"B40","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1111\/cmi.12407","article-title":"Glycosaminoglycan binding by Borrelia burgdorferi adhesin BBK32 specifically and uniquely promotes joint colonization","volume":"17","author":"Lin","year":"2015","journal-title":"Cell Microbiol"},{"issue":"5","key":"B41","doi-asserted-by":"publisher","first-page":"1116","DOI":"10.1111\/mmi.12045","article-title":"Vascular binding of a pathogen under shear force through mechanistically distinct sequential interactions with host macromolecules","volume":"86","author":"Moriarty","year":"2012","journal-title":"Mol Microbiol"},{"issue":"5","key":"B42","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1111\/j.1365-2958.2005.05042.x","article-title":"Inactivation of the fibronectin-binding adhesin gene bbk32 significantly attenuates the infectivity potential of Borrelia burgdorferi","volume":"59","author":"Seshu","year":"2006","journal-title":"Mol Microbiol"},{"issue":"3","key":"B43","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1128\/IAI.00897-07","article-title":"Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferi","volume":"76","author":"Shi","year":"2008","journal-title":"Infect Immun"},{"issue":"12","key":"B44","doi-asserted-by":"publisher","first-page":"5694","DOI":"10.1128\/IAI.00690-08","article-title":"Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infection","volume":"76","author":"Weening","year":"2008","journal-title":"Infect Immun"},{"issue":"7","key":"B45","doi-asserted-by":"publisher","first-page":"2802","DOI":"10.1128\/IAI.00227-09","article-title":"Borrelia burgdorferi RevA antigen binds host fibronectin","volume":"77","author":"Brissette","year":"2009","journal-title":"Infect Immun"},{"issue":"9","key":"B46","doi-asserted-by":"publisher","first-page":"3675","DOI":"10.1128\/IAI.00530-15","article-title":"Borrelia burgdorferi RevA significantly affects pathogenicity and host response in the mouse model of Lyme disease","volume":"83","author":"Byram","year":"2015","journal-title":"Infect Immun"},{"issue":"3","key":"B47","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1128\/IAI.01725-06","article-title":"Rapid clearance of Lyme disease spirochetes lacking OspC from skin","volume":"75","author":"Tilly","year":"2007","journal-title":"Infect Immun"},{"issue":"12","key":"B48","doi-asserted-by":"publisher","first-page":"4848","DOI":"10.1128\/IAI.01215-15","article-title":"Outer surface protein OspC is an antiphagocytic factor that protects Borrelia burgdorferi from phagocytosis by macrophages","volume":"83","author":"Carrasco","year":"2015","journal-title":"Infect Immun"},{"issue":"10","key":"B49","doi-asserted-by":"publisher","first-page":"e47532","DOI":"10.1371\/journal.pone.0047532","article-title":"Analysis of an ordered, comprehensive STM mutant library in infectious Borrelia burgdorferi: insights into the genes required for mouse infectivity","volume":"7","author":"Lin","year":"2012","journal-title":"PLoS One"},{"issue":"4","key":"B50","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1128\/IAI.01274-10","article-title":"The OspE-related proteins inhibit complement deposition and enhance serum resistance of Borrelia burgdorferi, the Lyme disease spirochete","volume":"79","author":"Kenedy","year":"2011","journal-title":"Infect Immun"},{"issue":"7","key":"B51","doi-asserted-by":"publisher","first-page":"2488","DOI":"10.1128\/IAI.00140-13","article-title":"Borrelia burgdorferi bba66 gene inactivation results in attenuated mouse infection by tick transmission","volume":"81","author":"Patton","year":"2013","journal-title":"Infect Immun"},{"issue":"5\u20136","key":"B52","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.micpath.2008.08.006","article-title":"Borrelia burgdorferi expression of the bba64, bba65, bba66, and bba73 genes in tissues during persistent infection in mice","volume":"45","author":"Gilmore","year":"2008","journal-title":"Microb Pathog"},{"issue":"1","key":"B53","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/cmi.12487","article-title":"Middle region of the Borrelia burgdorferi surface-located protein 1 (Lmp1) interacts with host chondroitin-6-sulfate and independently facilitates infection","volume":"18","author":"Yang","year":"2016","journal-title":"Cell Microbiol"},{"issue":"11","key":"B54","doi-asserted-by":"publisher","first-page":"4477","DOI":"10.1128\/IAI.00501-10","article-title":"Characterization of unique regions of Borrelia burgdorferi surface-located membrane protein 1","volume":"78","author":"Yang","year":"2010","journal-title":"Infect Immun"},{"issue":"3","key":"B55","doi-asserted-by":"publisher","first-page":"e1000326","DOI":"10.1371\/journal.ppat.1000326","article-title":"Chromosomally encoded virulence factor protects the Lyme disease pathogen against host-adaptive immunity","volume":"5","author":"Yang","year":"2009","journal-title":"PLoS Pathog"},{"issue":"11","key":"B56","doi-asserted-by":"publisher","first-page":"4940","DOI":"10.1128\/IAI.01420-08","article-title":"Borrelia burgdorferi BmpA is a laminin-binding protein","volume":"77","author":"Verma","year":"2009","journal-title":"Infect Immun"},{"issue":"1","key":"B57","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1084\/jem.20070962","article-title":"Borrelia burgdorferi basic membrane proteins A and B participate in the genesis of Lyme arthritis","volume":"205","author":"Pal","year":"2008","journal-title":"J Exp Med"},{"issue":"5","key":"B58","doi-asserted-by":"publisher","first-page":"3016","DOI":"10.1128\/IAI.74.5.3016-3020.2006","article-title":"Bgp, a secreted glycosaminoglycan-binding protein of Borrelia burgdorferi strain N40, displays nucleosidase activity and is not essential for infection of immunodeficient mice","volume":"74","author":"Parveen","year":"2006","journal-title":"Infect Immun"},{"issue":"1","key":"B59","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/1471-2180-9-43","article-title":"Detection and quantification of Lyme spirochetes using sensitive and specific molecular beacon probes","volume":"9","author":"Saidac","year":"2009","journal-title":"BMC Microbiol"},{"issue":"2","key":"B60","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1111\/mmi.12276","article-title":"Lyme disease spirochaetes possess an aggrecan-binding protease with aggrecanase activity","volume":"90","author":"Russell","year":"2013","journal-title":"Mol Microbiol"},{"issue":"5","key":"B61","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1046\/j.1365-2958.1999.01654.x","article-title":"Characterization of a candidate Borrelia burgdorferi \u03b23-chain integrin ligand identified using a phage display library","volume":"34","author":"Coburn","year":"1999","journal-title":"Mol Microbiol"},{"issue":"8","key":"B62","doi-asserted-by":"publisher","first-page":"3184","DOI":"10.1128\/IAI.00349-15","article-title":"Short-term Borrelia burgdorferi infection model identifies tissue tropisms and bloodstream survival conferred by adhesion proteins","volume":"83","author":"Caine","year":"2015","journal-title":"Infect Immun"},{"issue":"6","key":"B63","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1111\/j.1365-2958.2012.08160.x","article-title":"The \u03b23-integrin ligand of Borrelia burgdorferi is critical for infection of mice but not ticks","volume":"85","author":"Ristow","year":"2012","journal-title":"Mol Microbiol"},{"issue":"7","key":"B64","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1111\/cmi.12418","article-title":"Integrin binding by Borrelia burgdorferi P66 facilitates dissemination but is not required for infectivity","volume":"17","author":"Ristow","year":"2015","journal-title":"Cell Microbiol"},{"issue":"12","key":"B65","doi-asserted-by":"publisher","first-page":"7307","DOI":"10.1073\/pnas.1231043100","article-title":"Decorin-binding proteins A and B confer distinct mammalian cell type-specific attachment by Borrelia burgdorferi, the Lyme disease spirochete","volume":"100","author":"Fischer","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"B66","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1046\/j.1365-2958.1998.01103.x","article-title":"Decorin-binding adhesins from Borrelia burgdorferi","volume":"30","author":"Guo","year":"1998","journal-title":"Mol Microbiol"},{"issue":"37","key":"B67","doi-asserted-by":"publisher","first-page":"26272","DOI":"10.1074\/jbc.274.37.26272","article-title":"Adherence of Borrelia burgdorferi: identification of critical lysine residues in DbpA required for decorin binding","volume":"274","author":"Brown","year":"1999","journal-title":"J Biol Chem"},{"issue":"9","key":"B68","doi-asserted-by":"crossref","first-page":"3467","DOI":"10.1128\/IAI.63.9.3467-3472.1995","article-title":"Adherence of Borrelia burgdorferi to the proteoglycan decorin","volume":"63","author":"Guo","year":"1995","journal-title":"Infect Immun"},{"issue":"1","key":"B69","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1111\/mmi.12921","article-title":"The BBA33 lipoprotein binds collagen and impacts Borrelia burgdorferi pathogenesis","volume":"96","author":"Zhi","year":"2015","journal-title":"Mol Microbiol"},{"issue":"2","key":"B70","first-page":"320","article-title":"Borrelia burgdorferi BBB07 interaction with integrin \u03b13\u03b21 stimulates production of pro-inflammatory mediators in primary human chondrocytes","volume":"10","author":"Behera","year":"2008","journal-title":"Cell Microbiol"},{"issue":"20","key":"B71","doi-asserted-by":"publisher","first-page":"16860","DOI":"10.1074\/jbc.M111.290775","article-title":"OspC is potent plasminogen receptor on surface of Borrelia burgdorferi","volume":"287","author":"\u00d6nder","year":"2012","journal-title":"J Biol Chem"},{"issue":"7050","key":"B72","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1038\/nature03812","article-title":"The Lyme disease agent exploits a tick protein to infect the mammalian host","volume":"436","author":"Ramamoorthi","year":"2005","journal-title":"Nature"},{"issue":"12","key":"B73","doi-asserted-by":"publisher","first-page":"e1000680","DOI":"10.1371\/journal.ppat.1000680","article-title":"Investigation of the genes involved in antigenic switching at the vlsE locus in Borrelia burgdorferi: an essential role for the RuvAB branch migrase","volume":"5","author":"Dresser","year":"2009","journal-title":"PLoS Pathog"},{"issue":"6","key":"B74","doi-asserted-by":"publisher","first-page":"1547","DOI":"10.1111\/j.1365-2958.2007.05895.x","article-title":"The role of VlsE antigenic variation in the Lyme disease spirochete: persistence through a mechanism that differs from other pathogens","volume":"65","author":"Bankhead","year":"2007","journal-title":"Mol Microbiol"},{"issue":"12","key":"B75","doi-asserted-by":"publisher","first-page":"e1000679","DOI":"10.1371\/journal.ppat.1000679","article-title":"Central role of the holliday junction helicase RuvAB in vlsE recombination and infectivity of Borrelia burgdorferi","volume":"5","author":"Lin","year":"2009","journal-title":"PLoS Pathog"},{"issue":"6","key":"B76","doi-asserted-by":"publisher","first-page":"3419","DOI":"10.1128\/IAI.71.6.3419-3428.2003","article-title":"Antigenic composition of Borrelia burgdorferi during infection of SCID mice","volume":"71","author":"Crother","year":"2003","journal-title":"Infect Immun"},{"issue":"1","key":"B77","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1128\/IAI.74.1.435-441.2006","article-title":"Fibronectin binding protein BBK32 of the Lyme disease spirochete promotes bacterial attachment to glycosaminoglycans","volume":"74","author":"Fischer","year":"2006","journal-title":"Infect Immun"},{"issue":"5","key":"B78","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1046\/j.1365-2958.1998.01127.x","article-title":"Identification of a 47 kDa fibronectin-binding protein expressed by Borrelia burgdorferi isolate B31","volume":"30","author":"Probert","year":"1998","journal-title":"Mol Microbiol"},{"issue":"32","key":"B79","doi-asserted-by":"publisher","first-page":"22490","DOI":"10.1074\/jbc.M114.578419","article-title":"Borrelia burgdorferi protein BBK32 binds to soluble fibronectin via the N-terminal 70-kDa region, causing fibronectin to undergo conformational extension","volume":"289","author":"Harris","year":"2014","journal-title":"J Biol Chem"},{"issue":"1","key":"B80","doi-asserted-by":"publisher","first-page":"e1005404","DOI":"10.1371\/journal.ppat.1005404","article-title":"Borrelia burgdorferi BBK32 inhibits the classical pathway by blocking activation of the C1 complement complex","volume":"12","author":"Garcia","year":"2016","journal-title":"PLoS Pathog"},{"issue":"7","key":"B81","doi-asserted-by":"publisher","first-page":"3847","DOI":"10.4049\/jimmunol.169.7.3847","article-title":"Complement inhibitor factor H binding to Lyme disease spirochetes is mediated by inducible expression of multiple plasmid-encoded outer surface protein E paralogs","volume":"169","author":"Alitalo","year":"2002","journal-title":"J Immunol"},{"issue":"1","key":"B82","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1086\/518509","article-title":"Binding of human factor H-related protein 1 to serum-resistant Borrelia burgdorferi is mediated by borrelial complement regulator-acquiring surface proteins","volume":"196","author":"Haupt","year":"2007","journal-title":"J Infect Dis"},{"issue":"6","key":"B83","doi-asserted-by":"publisher","first-page":"3587","DOI":"10.1128\/IAI.71.6.3587-3596.2003","article-title":"Analysis of the OspE determinants involved in binding of factor H and OspE-targeting antibodies elicited during Borrelia burgdorferi infection in mice","volume":"71","author":"Metts","year":"2003","journal-title":"Infect Immun"},{"issue":"10","key":"B84","doi-asserted-by":"publisher","first-page":"e13519","DOI":"10.1371\/journal.pone.0013519","article-title":"Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi","volume":"5","author":"Siegel","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"B85","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1128\/IAI.01133-08","article-title":"Borrelia burgdorferi infection-associated surface proteins ErpP, ErpA, and ErpC bind human plasminogen","volume":"77","author":"Brissette","year":"2009","journal-title":"Infect Immun"},{"issue":"21\u201322","key":"B86","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1007\/s00508-006-0691-1","article-title":"Binding of human complement regulators FHL-1 and factor H to CRASP-1 orthologs of Borrelia burgdorferi","volume":"118","author":"Kraiczy","year":"2006","journal-title":"Wien Klin Wochenschr"},{"issue":"6","key":"B87","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1128\/IAI.66.6.2648-2654.1998","article-title":"Borrelia burgdorferi Erp proteins are immunogenic in mammals infected by tick bite, and their synthesis is inducible in cultured bacteria","volume":"66","author":"Stevenson","year":"1998","journal-title":"Infect Immun"},{"issue":"2","key":"B88","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1172\/JCI200419894","article-title":"OspC facilitates Borrelia burgdorferi invasion of Ixodes scapularis salivary glands","volume":"113","author":"Pal","year":"2004","journal-title":"J Clin Invest"},{"issue":"5","key":"B89","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1084\/jem.20031960","article-title":"Essential role for OspA\/B in the life cycle of the Lyme disease spirochete","volume":"199","author":"Yang","year":"2004","journal-title":"J Exp Med"},{"issue":"5","key":"B90","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1111\/j.1365-2958.2006.05318.x","article-title":"Functional characterization of BbCRASP-2, a distinct outer membrane protein of Borrelia burgdorferi that binds host complement regulators factor H and FHL-1","volume":"61","author":"Hartmann","year":"2006","journal-title":"Mol Microbiol"},{"issue":"8","key":"B91","doi-asserted-by":"publisher","first-page":"3010e","DOI":"10.1371\/journal.pone.0003010","article-title":"Borrelia burgdorferi complement regulator-acquiring surface protein 2 does not contribute to complement resistance or host infectivity","volume":"3","author":"Coleman","year":"2008","journal-title":"PLoS One"},{"issue":"4","key":"B92","doi-asserted-by":"publisher","first-page":"e004891","DOI":"10.1128\/mBio.00481-13","article-title":"CspA from Borrelia burgdorferi inhibits the terminal complement pathway","volume":"4","author":"Hallstr\u00f6m","year":"2013","journal-title":"MBio"},{"issue":"1","key":"B93","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1128\/IAI.01094-13","article-title":"Versatile roles of CspA orthologs in complement inactivation of serum-resistant Lyme disease spirochetes","volume":"82","author":"Hammerschmidt","year":"2014","journal-title":"Infect Immun"},{"issue":"4","key":"B94","doi-asserted-by":"publisher","first-page":"2421","DOI":"10.1074\/jbc.M308343200","article-title":"Complement resistance of Borrelia burgdorferi correlates with the expression of BbCRASP-1, a novel linear plasmid-encoded surface protein that interacts with human factor H and FHL-1 and is unrelated to Erp proteins","volume":"279","author":"Kraiczy","year":"2004","journal-title":"J Biol Chem"},{"issue":"7","key":"B95","doi-asserted-by":"publisher","first-page":"2773","DOI":"10.1128\/IAI.00318-09","article-title":"CspA-mediated binding of human factor h inhibits complement deposition and confers serum resistance in Borrelia burgdorferi","volume":"77","author":"Kenedy","year":"2009","journal-title":"Infect Immun"},{"issue":"35","key":"B96","doi-asserted-by":"publisher","first-page":"25229","DOI":"10.1074\/jbc.M112.413872","article-title":"BBA70 of Borrelia burgdorferi is a novel plasminogen-binding protein","volume":"288","author":"Koenigs","year":"2013","journal-title":"J Biol Chem"},{"issue":"10","key":"B97","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1111\/cmi.12448","article-title":"Host cell heparan sulfate glycosaminoglycans are ligands for OspF-related proteins of the Lyme disease spirochete","volume":"17","author":"Lin","year":"2015","journal-title":"Cell Microbiol"},{"issue":"37","key":"B98","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/S1433-1128(04)80029-9","article-title":"Immunological characterization of the complement regulator factor H-binding CRASP and Erp proteins of Borrelia burgdorferi","volume":"293","author":"Kraiczy","year":"2004","journal-title":"Int J Med Microbiol"},{"issue":"4","key":"B99","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1242\/dev.119.4.1079","article-title":"Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin","volume":"119","author":"George","year":"1993","journal-title":"Development"},{"issue":"7","key":"B100","doi-asserted-by":"publisher","first-page":"e0133195","DOI":"10.1371\/journal.pone.0133195","article-title":"Heterogeneity of Borrelia burgdorferi sensu stricto population and its involvement in Borrelia pathogenicity: study on murine model with specific emphasis on the skin interface","volume":"10","author":"Kern","year":"2015","journal-title":"PLoS One"},{"issue":"22","key":"B101","doi-asserted-by":"publisher","first-page":"8377","DOI":"10.1128\/JB.01199-07","article-title":"Regulation of expression of the fibronectin-binding protein BBK32 in Borrelia burgdorferi","volume":"189","author":"He","year":"2007","journal-title":"J Bacteriol"},{"key":"B102","first-page":"567","article-title":"Role of glycosaminoglycans in infectious disease","volume-title":"Glycosaminoglycans. 1229. Methods in Molecular Biology","author":"Jinno","year":"2015"},{"issue":"4","key":"B103","doi-asserted-by":"publisher","first-page":"e5412","DOI":"10.1371\/journal.pone.0005412","article-title":"A novel fibronectin binding motif in MSCRAMMs targets F3 modules","volume":"4","author":"Prabhakaran","year":"2009","journal-title":"PLoS One"},{"issue":"6","key":"B104","doi-asserted-by":"publisher","first-page":"e1000090","DOI":"10.1371\/journal.ppat.1000090","article-title":"Real-time high resolution 3D imaging of the Lyme disease spirochete adhering to and escaping from the vasculature of a living host","volume":"4","author":"Moriarty","year":"2008","journal-title":"PLoS Pathog"},{"issue":"3","key":"B105","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1099\/mic.0.024604-0","article-title":"The Borrelia burgdorferi outer-surface protein ErpX binds mammalian laminin","volume":"155","author":"Brissette","year":"2009","journal-title":"Microbiology"},{"key":"B106","volume-title":"Integrins. Molecular Biology of the Cell","author":"Alberts","year":"2002","edition":"4th ed"},{"issue":"4","key":"B107","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1128\/JB.01236-13","article-title":"Structural modeling and physicochemical characterization provide evidence that P66 forms a \u03b2-barrel in the Borrelia burgdorferi outer membrane","volume":"196","author":"Kenedy","year":"2014","journal-title":"J Bacteriol"},{"issue":"2","key":"B108","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1128\/IAI.71.2.1001-1007.2003","article-title":"Regulation of expression of the Borrelia burgdorferi \u03b23-chain integrin ligand, P66, in ticks and in culture","volume":"71","author":"Cugini","year":"2003","journal-title":"Infect Immun"},{"issue":"12","key":"B109","doi-asserted-by":"publisher","first-page":"7301","DOI":"10.1073\/pnas.1131117100","article-title":"Targeted mutation of the outer membrane protein P66 disrupts attachment of the Lyme disease agent, Borrelia burgdorferi, to integrin \u03b1(v)\u03b2(3)","volume":"100","author":"Coburn","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"B110","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1086\/653825","article-title":"Complement regulator \u2013 acquiring surface protein 1 of Borrelia burgdorferi binds to human bone morphogenic protein 2, several extracellular matrix proteins, and plasminogen","volume":"202","author":"Hallstr\u00f6m","year":"2010","journal-title":"J Infect Dis"},{"issue":"26","key":"B111","doi-asserted-by":"publisher","first-page":"12594","DOI":"10.1073\/pnas.91.26.12594","article-title":"The outer surface protein A of the spirochete Borrelia burgdorferi is a plasmin(ogen) receptor","volume":"91","author":"Fuchs","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"B112","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.ttbdis.2012.10.039","article-title":"Complement regulator-acquiring surface proteins of Borrelia burgdorferi: structure, function and regulation of gene expression","volume":"4","author":"Kraiczy","year":"2013","journal-title":"Ticks Tick Borne Dis"},{"issue":"9","key":"B113","doi-asserted-by":"publisher","first-page":"3501","DOI":"10.1128\/IAI.00163-11","article-title":"Allelic variation of the lyme disease spirochete adhesin DbpA influences spirochetal binding to decorin, dermatan sulfate, and mammalian cells","volume":"79","author":"Benoit","year":"2011","journal-title":"Infect Immun"},{"issue":"7","key":"B114","doi-asserted-by":"publisher","first-page":"e1004238","DOI":"10.1371\/journal.ppat.1004238","article-title":"Strain-specific variation of the decorin-binding adhesin DbpA influences the tissue tropism of the lyme disease spirochete","volume":"10","author":"Lin","year":"2014","journal-title":"PLoS Pathog"},{"issue":"12","key":"B115","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1016\/j.bbapap.2015.08.003","article-title":"Structure of decorin binding protein B from Borrelia burgdorferi and its interactions with glycosaminoglycans","volume":"1854","author":"Feng","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"B116","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.devcel.2013.06.017","article-title":"Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration","volume":"26","author":"Nolan","year":"2013","journal-title":"Dev Cell"},{"issue":"2","key":"B117","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1182\/blood-2006-05-026401","article-title":"Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium","volume":"109","author":"Yano","year":"2007","journal-title":"Blood"},{"key":"B118","article-title":"Proteoglycans and sulfated glycosaminoglycans","volume-title":"Essentials of Glycobiology","author":"Esko","year":"2009","edition":"2nd ed"},{"issue":"10","key":"B119","doi-asserted-by":"publisher","first-page":"5344","DOI":"10.4049\/jimmunol.164.10.5344","article-title":"Arthropod- and host-specific Borrelia burgdorferi BBK32 expression and the inhibition of spirochete transmission","volume":"164","author":"Fikrig","year":"2000","journal-title":"J Immunol"},{"issue":"3","key":"B120","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1128\/IAI.66.3.994-999.1998","article-title":"Different classes of proteoglycans contribute to the attachment of Borrelia burgdorferi to cultured endothelial and brain cells","volume":"66","author":"Leong","year":"1998","journal-title":"Infect Immun"},{"issue":"10","key":"B121","doi-asserted-by":"publisher","first-page":"2593","DOI":"10.1016\/j.celrep.2016.08.013","article-title":"Biomechanics of Borrelia burgdorferi vascular interactions","volume":"16","author":"Ebady","year":"2016","journal-title":"Cell Rep"},{"issue":"1","key":"B122","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/j.1365-2958.2007.05924.x","article-title":"Borrelia burgdorferi adhesins identified using in vivo phage display","volume":"66","author":"Antonara","year":"2007","journal-title":"Mol Microbiol"},{"issue":"2","key":"B123","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1084\/jem.129.2.315","article-title":"The inhibition of plasmin, plasma kallikrein, plasma permeability factor, and the C1r subcomponent of the first componenet of complement by serum C1 esterase inhibitor","volume":"129","author":"Ratnoff","year":"1969","journal-title":"J Exp Med"},{"issue":"18","key":"B124","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/j.molimm.2003.12.002","article-title":"Complement inhibitor C4b-binding protein \u2013 friend or foe in the innate immune system?","volume":"40","author":"Blom","year":"2004","journal-title":"Mol Immunol"},{"issue":"S2","key":"B125","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1423-0410.1998.tb05434.x","article-title":"Complement regulation","volume":"74","author":"Meri","year":"1998","journal-title":"Vox Sang"},{"issue":"1","key":"B126","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1111\/j.1365-2249.1995.tb02289.x","article-title":"Complement inhibition by human vitronectin involves non-heparin binding domains","volume":"101","author":"Sheehan","year":"1995","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"B127","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.bbapap.2014.12.025","article-title":"Crystal structures of the Erp protein family members ErpP and ErpC from Borrelia burgdorferi reveal the reason for different affinities for complement regulator factor H","volume":"1854","author":"Brangulis","year":"2014","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"B128","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1107\/S1744309113013249","article-title":"ErpC, a member of the complement regulator-acquiring family of surface proteins from Borrelia burgdorferi, possesses an architecture previously unseen in this protein family","volume":"69","author":"Caesar","year":"2013","journal-title":"Acta Crystallogr Sect F Struct Biol Cryst Commun"},{"key":"B129","doi-asserted-by":"publisher","first-page":"349657","DOI":"10.1155\/2012\/349657","article-title":"Contribution of the infection-associated complement regulator-acquiring surface protein 4 (ErpC) to complement resistance of Borrelia burgdorferi","volume":"2012","author":"Hammerschmidt","year":"2012","journal-title":"Clin Dev Immunol"},{"issue":"6","key":"B130","doi-asserted-by":"publisher","first-page":"3371","DOI":"10.1128\/IAI.71.6.3371-3383.2003","article-title":"Global analysis of Borrelia burgdorferi genes regulated by mammalian host-specific signals","volume":"71","author":"Brooks","year":"2003","journal-title":"Infect Immun"},{"issue":"9","key":"B131","doi-asserted-by":"publisher","first-page":"4227","DOI":"10.1128\/IAI.00604-07","article-title":"Coordinated expression of Borrelia burgdorferi complement regulator-acquiring surface proteins during the lyme disease spirochete\u2019s mammal-tick infection cycle","volume":"75","author":"Bykowski","year":"2007","journal-title":"Infect Immun"},{"issue":"6","key":"B132","doi-asserted-by":"publisher","first-page":"3214","DOI":"10.4049\/jimmunol.170.6.3214","article-title":"Serum-resistant strains of Borrelia burgdorferi evade complement-mediated killing by expressing a CD59-like complement inhibitory molecule","volume":"170","author":"Pausa","year":"2003","journal-title":"J Immunol"},{"issue":"5","key":"B133","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1128\/IAI.61.5.2104-2107.1993","article-title":"Borrelia burgdorferi infection and immunity in mice deficient in the fifth component of complement","volume":"61","author":"Bockenstedt","year":"1993","journal-title":"Infect Immun"},{"issue":"1","key":"B134","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.ttbdis.2010.10.003","article-title":"Infectivity of Borrelia burgdorferi sensu lato is unaltered in C3-deficient mice","volume":"2","author":"van Burgel","year":"2011","journal-title":"Ticks Tick Borne Dis"},{"issue":"6","key":"B135","doi-asserted-by":"publisher","first-page":"3131","DOI":"10.1128\/IAI.01923-06","article-title":"Borrelia burgdorferi binding of host complement regulator factor H is not required for efficient mammalian infection","volume":"75","author":"Woodman","year":"2007","journal-title":"Infect Immun"},{"issue":"7","key":"B136","doi-asserted-by":"publisher","first-page":"4858","DOI":"10.4049\/jimmunol.180.7.4858","article-title":"Complement factor H-binding protein, a putative virulence determinant of Borrelia hermsii, is an antigenic target for protective B1b lymphocytes","volume":"180","author":"Colombo","year":"2008","journal-title":"J Immunol"},{"issue":"4","key":"B137","doi-asserted-by":"publisher","first-page":"e1003308","DOI":"10.1371\/journal.ppat.1003308","article-title":"Microbes bind complement inhibitor factor H via a common site","volume":"9","author":"Meri","year":"2013","journal-title":"PLoS Pathog"},{"issue":"2","key":"B138","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1111\/mmi.13239","article-title":"BGA66 and BGA71 facilitate complement resistance of Borrelia bavariensis by inhibiting assembly of the membrane attack complex","volume":"99","author":"Hammerschmidt","year":"2016","journal-title":"Mol Microbiol"},{"issue":"7","key":"B139","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1084\/jem.20030543","article-title":"Evasion of phagocytosis through cooperation between two ligand-binding regions in Streptococcus pyogenes M protein","volume":"198","author":"Carlsson","year":"2003","journal-title":"J Exp Med"},{"issue":"9","key":"B140","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1128\/IAI.65.9.3638-3643.1997","article-title":"Bordetella pertussis binds the human complement regulator C4BP: role of filamentous hemagglutinin","volume":"65","author":"Bergg\u00e5rd","year":"1997","journal-title":"Infect Immun"},{"issue":"9","key":"B141","doi-asserted-by":"publisher","first-page":"2771","DOI":"10.1002\/1521-4141(200109)31:92771::AID-IMMU27713.0.CO;2-0","article-title":"Bordetella pertussis binds to human C4b-binding protein (C4BP) at a site similar to that used by the natural ligand C4b","volume":"31","author":"Bergg\u00e5rd","year":"2001","journal-title":"Eur J Immunol"},{"issue":"1","key":"B142","doi-asserted-by":"publisher","first-page":"540","DOI":"10.4049\/jimmunol.179.1.540","article-title":"Molecular characterization of the interaction between porins of Neisseria gonorrhoeae and C4b-binding protein","volume":"179","author":"Jarva","year":"2007","journal-title":"J Immunol"},{"issue":"3","key":"B143","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1084\/jem.193.3.281","article-title":"Binding of C4b-binding protein to porin: a molecular mechanism of serum resistance of Neisseria gonorrhoeae","volume":"193","author":"Ram","year":"2001","journal-title":"J Exp Med"},{"issue":"11","key":"B144","doi-asserted-by":"publisher","first-page":"6764","DOI":"10.4049\/jimmunol.166.11.6764","article-title":"A novel interaction between type IV pili of Neisseria gonorrhoeae and the human complement regulator C4b-binding protein","volume":"166","author":"Blom","year":"2001","journal-title":"J Immunol"},{"issue":"3","key":"B145","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/S1567-5769(00)00037-0","article-title":"C4bp binding to porin mediates stable serum resistance of Neisseria gonorrhoeae","volume":"1","author":"Ram","year":"2001","journal-title":"Int Immunopharmacol"},{"issue":"11","key":"B146","doi-asserted-by":"publisher","first-page":"6352","DOI":"10.4049\/jimmunol.169.11.6352","article-title":"A novel interaction of outer membrane protein A with C4b binding protein mediates serum resistance of Escherichia coli K1","volume":"169","author":"Prasadarao","year":"2002","journal-title":"J Immunol"},{"issue":"10","key":"B147","doi-asserted-by":"publisher","first-page":"3669","DOI":"10.1128\/IAI.00320-12","article-title":"NlpI facilitates deposition of C4bp on Escherichia coli by blocking classical complement-mediated killing, which results in high-level bacteremia","volume":"80","author":"Tseng","year":"2012","journal-title":"Infect Immun"},{"issue":"4","key":"B148","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1111\/j.1365-2567.2006.02323.x","article-title":"Logarithmic phase Escherichia coli K1 efficiently avoids serum killing by promoting C4bp-mediated C3b and C4b degradation","volume":"117","author":"Wooster","year":"2006","journal-title":"Immunology"},{"issue":"3\u20134","key":"B149","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.micpath.2012.06.001","article-title":"Lsa30, a novel adhesin of Leptospira interrogans binds human plasminogen and the complement regulator C4bp","volume":"53","author":"Souza","year":"2012","journal-title":"Microb Pathog"},{"issue":"7","key":"B150","doi-asserted-by":"publisher","first-page":"3593","DOI":"10.4049\/jimmunol.1201145","article-title":"The Yersinia pseudotuberculosis outer membrane protein ail recruits the human complement regulatory protein factor H","volume":"189","author":"Ho","year":"2012","journal-title":"J Immunol"},{"issue":"9","key":"B151","doi-asserted-by":"publisher","first-page":"4450","DOI":"10.4049\/jimmunol.1103149","article-title":"Functional recruitment of the human complement inhibitor C4BP to Yersinia pseudotuberculosis outer membrane protein Ail","volume":"188","author":"Ho","year":"2012","journal-title":"J Immunol"},{"issue":"11","key":"B152","doi-asserted-by":"publisher","first-page":"e27546","DOI":"10.1371\/journal.pone.0027546","article-title":"Functional recruitment of human complement inhibitor C4b-binding protein to outer membrane protein Rck of Salmonella","volume":"6","author":"Ho","year":"2011","journal-title":"PLoS One"},{"issue":"7","key":"B153","doi-asserted-by":"publisher","first-page":"4598","DOI":"10.4049\/jimmunol.173.7.4598","article-title":"The emerging pathogen Moraxella catarrhalis interacts with complement inhibitor C4b binding protein through ubiquitous surface proteins A1 and A2","volume":"173","author":"Nordstr\u00f6m","year":"2004","journal-title":"J Immunol"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00442\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T22:19:09Z","timestamp":1657491549000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00442\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,21]]},"references-count":153,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00442","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,21]]}}}