{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T13:26:11Z","timestamp":1792157171463,"version":"4.4.0"},"reference-count":83,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00475","type":"journal-article","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T08:07:55Z","timestamp":1478246875000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":62,"title":["Environmental Toxicants-Induced Immune Responses in the Olfactory Mucosa"],"prefix":"10.3389","volume":"7","author":[{"given":"Fumiaki","family":"Imamura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanae","family":"Hasegawa-Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,11,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.otc.2007.11.010","article-title":"Allergic rhinitis and rhinosinusitis","volume":"41","author":"Ahmad","year":"2008","journal-title":"Otolaryngol Clin North Am"},{"key":"B2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1097\/00005537-200103000-00008","article-title":"Olfaction and its alteration by nasal obstruction, rhinitis, and rhinosinusitis","volume":"111","author":"Doty","year":"2001","journal-title":"Laryngoscope"},{"key":"B3","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1007\/s11882-004-0031-3","article-title":"Olfaction and anosmia in rhinosinusitis","volume":"4","author":"Dalton","year":"2004","journal-title":"Curr Allergy Asthma Rep"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1097\/00005537-200007000-00001","article-title":"Chronic sinusitis and anosmia: pathologic changes in the olfactory mucosa","volume":"110","author":"Kern","year":"2000","journal-title":"Laryngoscope"},{"key":"B5","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1093\/chemse\/27.7.617","article-title":"Anti-inflammatory and surgical therapy of olfactory disorders related to sino-nasal disease","volume":"27","author":"Wolfensberger","year":"2002","journal-title":"Chem Senses"},{"key":"B6","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1111\/j.1749-6632.2009.04364.x","article-title":"Analysis of the olfactory mucosa in chronic rhinosinusitis","volume":"1170","author":"Yee","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1289\/ehp.8854","article-title":"Satratoxin G from the black mold Stachybotrys chartarum evokes olfactory sensory neuron loss and inflammation in the murine nose and brain","volume":"114","author":"Islam","year":"2006","journal-title":"Environ Health Perspect"},{"key":"B8","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1093\/toxsci\/kfm102","article-title":"Neurotoxicity and inflammation in the nasal airways of mice exposed to the macrocyclic trichothecene mycotoxin roridin a: kinetics and potentiation by bacterial lipopolysaccharide coexposure","volume":"98","author":"Islam","year":"2007","journal-title":"Toxicol Sci"},{"key":"B9","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1080\/00016480601002062","article-title":"Lipopolysaccharide-induced apoptosis of olfactory receptor neurons in rats","volume":"127","author":"Yagi","year":"2007","journal-title":"Acta Otolaryngol"},{"key":"B10","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.otohns.2007.11.029","article-title":"Intranasal Aspergillus fumigatus exposure induces eosinophilic inflammation and olfactory sensory neuron cell death in mice","volume":"138","author":"Epstein","year":"2008","journal-title":"Otolaryngol Head Neck Surg"},{"key":"B11","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1177\/0192623310364026","article-title":"Neurotoxic, inflammatory, and mucosecretory responses in the nasal airways of mice repeatedly exposed to the macrocyclic trichothecene mycotoxin roridin A: dose-response and persistence of injury","volume":"38","author":"Corps","year":"2010","journal-title":"Toxicol Pathol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1523\/JNEUROSCI.4507-09.2010","article-title":"A genetic model of chronic rhinosinusitis-associated olfactory inflammation reveals reversible functional impairment and dramatic neuroepithelial reorganization","volume":"30","author":"Lane","year":"2010","journal-title":"J Neurosci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1177\/0192623312444028","article-title":"Satratoxin-G from the black mold Stachybotrys chartarum induces rhinitis and apoptosis of olfactory sensory neurons in the nasal airways of rhesus monkeys","volume":"40","author":"Carey","year":"2012","journal-title":"Toxicol Pathol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1007\/s00441-014-1848-2","article-title":"Innate immune responses and neuroepithelial degeneration and regeneration in the mouse olfactory mucosa induced by intranasal administration of Poly(I:C)","volume":"357","author":"Kanaya","year":"2014","journal-title":"Cell Tissue Res"},{"key":"B15","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/S1474-4422(06)70471-9","article-title":"Epidemiology of Parkinson\u2019s disease","volume":"5","author":"de Lau","year":"2006","journal-title":"Lancet Neurol"},{"key":"B16","doi-asserted-by":"publisher","first-page":"116","DOI":"10.2174\/1567205012666150204121719","article-title":"Role of environmental contaminants in the etiology of Alzheimer\u2019s disease: a review","volume":"12","author":"Yegambaram","year":"2015","journal-title":"Curr Alzheimer Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/ana.21327","article-title":"The olfactory vector hypothesis of neurodegenerative disease: is it viable?","volume":"63","author":"Doty","year":"2008","journal-title":"Ann Neurol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1586\/ern.10.33","article-title":"Should olfactory dysfunction be used as a biomarker of Alzheimer\u2019s disease?","volume":"10","author":"Wesson","year":"2010","journal-title":"Expert Rev Neurother"},{"key":"B19","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nrneurol.2012.80","article-title":"Olfactory dysfunction in Parkinson disease","volume":"8","author":"Doty","year":"2012","journal-title":"Nat Rev Neurol"},{"key":"B20","first-page":"3","article-title":"Nasal toxicity, carcinogenicity, and olfactory uptake of metals","volume":"31","author":"Sunderman","year":"2001","journal-title":"Ann Clin Lab Sci"},{"key":"B21","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1007\/s12640-011-9281-8","article-title":"Intranasal administration of neurotoxicants in animals: support for the olfactory vector hypothesis of Parkinson\u2019s disease","volume":"21","author":"Prediger","year":"2012","journal-title":"Neurotox Res"},{"key":"B22","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1002\/path.4461","article-title":"The olfactory nerve: a shortcut for influenza and other viral diseases into the central nervous system","volume":"235","author":"van Riel","year":"2015","journal-title":"J Pathol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/0304-3940(87)90696-3","article-title":"Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR","volume":"79","author":"McGeer","year":"1987","journal-title":"Neurosci Lett"},{"key":"B24","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1007\/BF00689592","article-title":"Expression of the histocompatibility glycoprotein HLA-DR in neurological disease","volume":"76","author":"McGeer","year":"1988","journal-title":"Acta Neuropathol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S1353-8020(99)00022-X","article-title":"Astrocytes and microglia in the substantia nigra and caudate-putamen in Parkinson\u2019s disease","volume":"5","author":"Knott","year":"1999","journal-title":"Parkinsonism Relat Disord"},{"key":"B26","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/bpa.12088","article-title":"Increased amoeboid microglial density in the olfactory bulb of Parkinson\u2019s and Alzheimer\u2019s patients","volume":"24","author":"Doorn","year":"2014","journal-title":"Brain Pathol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"e78418","DOI":"10.1371\/journal.pone.0078418","article-title":"Intranasal LPS-mediated Parkinson\u2019s model challenges the pathogenesis of nasal cavity and environmental toxins","volume":"8","author":"He","year":"2013","journal-title":"PLoS One"},{"key":"B28","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1007\/s12035-012-8267-8","article-title":"Inflammation and alpha-synuclein\u2019s prion-like behavior in Parkinson\u2019s disease \u2013 is there a link?","volume":"47","author":"Lema Tome","year":"2013","journal-title":"Mol Neurobiol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1212\/01.wnl.0000227906.99570.cc","article-title":"Immunologic diseases, anti-inflammatory drugs, and Parkinson disease: a case-control study","volume":"67","author":"Bower","year":"2006","journal-title":"Neurology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/BF01175561","article-title":"Neurogenesis and neuron regeneration in the olfactory system of mammals. II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy","volume":"8","author":"Graziadei","year":"1979","journal-title":"J Neurocytol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"182","DOI":"10.3389\/fnins.2014.00182","article-title":"A lifetime of neurogenesis in the olfactory system","volume":"8","author":"Brann","year":"2014","journal-title":"Front Neurosci"},{"key":"B32","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1007\/s11882-004-0027-z","article-title":"Refractory chronic rhinosinusitis: pathophysiology and management of chronic rhinosinusitis persisting after endoscopic sinus surgery","volume":"4","author":"Desrosiers","year":"2004","journal-title":"Curr Allergy Asthma Rep"},{"key":"B33","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1001\/archotol.127.6.657","article-title":"Chronic bacterial rhinosinusitis: description of a mouse model","volume":"127","author":"Jacob","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"B34","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.otohns.2005.11.048","article-title":"Development of a murine model of chronic rhinosinusitis","volume":"134","author":"Lindsay","year":"2006","journal-title":"Otolaryngol Head Neck Surg"},{"key":"B35","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.addr.2007.11.005","article-title":"TLR3: interferon induction by double-stranded RNA including poly(I:C)","volume":"60","author":"Matsumoto","year":"2008","journal-title":"Adv Drug Deliv Rev"},{"key":"B36","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/nrmicro1068","article-title":"LPS, TLR4 and infectious disease diversity","volume":"3","author":"Miller","year":"2005","journal-title":"Nat Rev Microbiol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.tins.2009.05.009","article-title":"Air pollution: mechanisms of neuroinflammation and CNS disease","volume":"32","author":"Block","year":"2009","journal-title":"Trends Neurosci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"25457","DOI":"10.1038\/srep25457","article-title":"Endotoxemia-induced cytokine-mediated responses of hippocampal astrocytes transmitted by cells of the brain-immune interface","volume":"6","author":"Hasegawa-Ishii","year":"2016","journal-title":"Sci Rep"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1080\/15287390903129234","article-title":"Purification and comparative neurotoxicity of the trichothecenes satratoxin G and roridin L2 from Stachybotrys chartarum","volume":"72","author":"Islam","year":"2009","journal-title":"J Toxicol Environ Health A"},{"key":"B40","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/glia.20512","article-title":"Bacteria and PAMPs activate nuclear factor kappaB and Gro production in a subset of olfactory ensheathing cells and astrocytes but not in Schwann cells","volume":"55","author":"Vincent","year":"2007","journal-title":"Glia"},{"key":"B41","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1038\/nri1841","article-title":"Neutrophil serine proteases: specific regulators of inflammation","volume":"6","author":"Pham","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"2481","DOI":"10.1002\/lary.22190","article-title":"The role of TNF-alpha in inflammatory olfactory loss","volume":"121","author":"Sultan","year":"2011","journal-title":"Laryngoscope"},{"key":"B43","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1186\/1742-2094-9-109","article-title":"Cytokines and olfactory bulb microglia in response to bacterial challenge in the compromised primary olfactory pathway","volume":"9","author":"Herbert","year":"2012","journal-title":"J Neuroinflammation"},{"key":"B44","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1002\/ar.10047","article-title":"Neural regeneration and the peripheral olfactory system","volume":"269","author":"Schwob","year":"2002","journal-title":"Anat Rec"},{"key":"B45","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1038\/nn0607-673","article-title":"Scent of a stem cell","volume":"10","author":"Duggan","year":"2007","journal-title":"Nat Neurosci"},{"key":"B46","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1002\/cne.10642","article-title":"Globose basal cells are required for reconstitution of olfactory epithelium after methyl bromide lesion","volume":"460","author":"Jang","year":"2003","journal-title":"J Comp Neurol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.jneuroim.2008.09.010","article-title":"CX3CL1\/fractalkine regulates branching and migration of monocyte-derived cells in the mouse olfactory epithelium","volume":"205","author":"Ruitenberg","year":"2008","journal-title":"J Neuroimmunol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1002\/glia.22450","article-title":"Olfactory ensheathing cells: the primary innate immunocytes in the olfactory pathway to engulf apoptotic olfactory nerve debris","volume":"61","author":"Su","year":"2013","journal-title":"Glia"},{"key":"B49","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1002\/cne.23694","article-title":"Olfactory ensheathing cells are the main phagocytic cells that remove axon debris during early development of the olfactory system","volume":"523","author":"Nazareth","year":"2015","journal-title":"J Comp Neurol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1002\/cne.902150403","article-title":"A quantitative analysis of changes in the olfactory epithelium following bulbectomy in hamster","volume":"215","author":"Costanzo","year":"1983","journal-title":"J Comp Neurol"},{"key":"B51","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1523\/JNEUROSCI.11-11-03556.1991","article-title":"Characterization of potential precursor populations in the mouse olfactory epithelium using immunocytochemistry and autoradiography","volume":"11","author":"Schwartz Levey","year":"1991","journal-title":"J Neurosci"},{"key":"B52","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1002\/cne.1193","article-title":"Leukemia inhibitory factor, interleukin-6, and their receptors are expressed transiently in the olfactory mucosa after target ablation","volume":"435","author":"Nan","year":"2001","journal-title":"J Comp Neurol"},{"key":"B53","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1756-6606-6-49","article-title":"Molecular events in the cell types of the olfactory epithelium during adult neurogenesis","volume":"6","author":"Heron","year":"2013","journal-title":"Mol Brain"},{"key":"B54","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1002\/glia.22267","article-title":"Two phases of replacement replenish the olfactory ensheathing cell population after injury in postnatal mice","volume":"60","author":"Chehrehasa","year":"2012","journal-title":"Glia"},{"key":"B55","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1006\/exnr.1995.1099","article-title":"Phagocytic cells in the rat olfactory epithelium after bulbectomy","volume":"136","author":"Suzuki","year":"1995","journal-title":"Exp Neurol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1002\/jnr.10090","article-title":"Leukemia inhibitory factor mRNA expression is upregulated in macrophages and olfactory receptor neurons after target ablation","volume":"67","author":"Getchell","year":"2002","journal-title":"J Neurosci Res"},{"key":"B57","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1002\/jnr.10432","article-title":"Chemokine regulation of macrophage recruitment into the olfactory epithelium following target ablation: involvement of macrophage inflammatory protein-1alpha and monocyte chemoattractant protein-1","volume":"70","author":"Getchell","year":"2002","journal-title":"J Neurosci Res"},{"key":"B58","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1523\/JNEUROSCI.23-05-01792.2003","article-title":"Leukemia inhibitory factor is a key signal for injury-induced neurogenesis in the adult mouse olfactory epithelium","volume":"23","author":"Bauer","year":"2003","journal-title":"J Neurosci"},{"key":"B59","doi-asserted-by":"publisher","first-page":"e45018","DOI":"10.1371\/journal.pone.0045018","article-title":"Leukaemia inhibitory factor stimulates proliferation of olfactory neuronal progenitors via inducible nitric oxide synthase","volume":"7","author":"Lopez-Arenas","year":"2012","journal-title":"PLoS One"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1002\/glia.20899","article-title":"Olfactory ensheathing cells: nitric oxide production and innate immunity","volume":"57","author":"Harris","year":"2009","journal-title":"Glia"},{"key":"B61","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1002\/alr.21187","article-title":"Regulation of inflammation-associated olfactory neuronal death and regeneration by the type II tumor necrosis factor receptor","volume":"3","author":"Pozharskaya","year":"2013","journal-title":"Int Forum Allergy Rhinol"},{"key":"B62","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.taap.2013.07.020","article-title":"Mechanisms of permanent loss of olfactory receptor neurons induced by the herbicide 2,6-dichlorobenzonitrile: effects on stem cells and noninvolvement of acute induction of the inflammatory cytokine IL-6","volume":"272","author":"Xie","year":"2013","journal-title":"Toxicol Appl Pharmacol"},{"key":"B63","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.2460\/ajvr.1988.49.07.1107","article-title":"Nasal lesions in rats exposed to hydrogen sulfide for four hours","volume":"49","author":"Lopez","year":"1988","journal-title":"Am J Vet Res"},{"key":"B64","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1177\/019262330002800213","article-title":"Olfactory neuron loss in adult male CD rats following subchronic inhalation exposure to hydrogen sulfide","volume":"28","author":"Brenneman","year":"2000","journal-title":"Toxicol Pathol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1080\/019262302753559533","article-title":"Olfactory mucosal necrosis in male CD rats following acute inhalation exposure to hydrogen sulfide: reversibility and the possible role of regional metabolism","volume":"30","author":"Brenneman","year":"2002","journal-title":"Toxicol Pathol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1093\/toxsci\/65.1.18","article-title":"Cytochrome oxidase inhibition induced by acute hydrogen sulfide inhalation: correlation with tissue sulfide concentrations in the rat brain, liver, lung, and nasal epithelium","volume":"65","author":"Dorman","year":"2002","journal-title":"Toxicol Sci"},{"key":"B67","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1093\/chemse\/bjg053","article-title":"Does intranasal application of zinc sulfate produce anosmia in the mouse? An olfactometric and anatomical study","volume":"28","author":"McBride","year":"2003","journal-title":"Chem Senses"},{"key":"B68","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/S0022-3476(38)80128-1","article-title":"Persistent anosmia following zinc sulfate nasal spraying","volume":"13","author":"Tisdall","year":"1938","journal-title":"J Pediatr"},{"key":"B69","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1097\/01.mlg.0000191549.17796.13","article-title":"Intranasal zinc and anosmia: the zinc-induced anosmia syndrome","volume":"116","author":"Alexander","year":"2006","journal-title":"Laryngoscope"},{"key":"B70","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/0092-8674(93)90145-G","article-title":"A zonal organization of odorant receptor gene expression in the olfactory epithelium","volume":"73","author":"Ressler","year":"1993","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1093\/toxsci\/kfl112","article-title":"Use of a pharmacokinetic-driven computational fluid dynamics model to predict nasal extraction of hydrogen sulfide in rats and humans","volume":"94","author":"Schroeter","year":"2006","journal-title":"Toxicol Sci"},{"key":"B72","doi-asserted-by":"crossref","first-page":"5830","DOI":"10.1523\/JNEUROSCI.17-15-05830.1997","article-title":"OCAM: a new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons","volume":"17","author":"Yoshihara","year":"1997","journal-title":"J Neurosci"},{"key":"B73","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1046\/j.1432-1033.2003.03571.x","article-title":"O-MACS, a novel member of the medium-chain acyl-CoA synthetase family, specifically expressed in the olfactory epithelium in a zone-specific manner","volume":"270","author":"Oka","year":"2003","journal-title":"Eur J Biochem"},{"key":"B74","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1111\/j.0953-816X.2004.03331.x","article-title":"NQO1 activity in the main and the accessory olfactory systems correlates with the zonal topography of projection maps","volume":"19","author":"Gussing","year":"2004","journal-title":"Eur J Neurosci"},{"key":"B75","doi-asserted-by":"publisher","first-page":"5229","DOI":"10.1523\/JNEUROSCI.1134-08.2008","article-title":"Foxg1 is required for development of the vertebrate olfactory system","volume":"28","author":"Duggan","year":"2008","journal-title":"J Neurosci"},{"key":"B76","doi-asserted-by":"publisher","first-page":"e56561","DOI":"10.1371\/journal.pone.0056561","article-title":"Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals","volume":"8","author":"Rodriguez-Gil","year":"2013","journal-title":"PLoS One"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1874","DOI":"10.1111\/j.1460-9568.2006.05060.x","article-title":"Persistent penetration of MPTP through the nasal route induces Parkinson\u2019s disease in mice","volume":"24","author":"Rojo","year":"2006","journal-title":"Eur J Neurosci"},{"key":"B78","doi-asserted-by":"publisher","first-page":"14063","DOI":"10.1073\/pnas.0900096106","article-title":"Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration","volume":"106","author":"Jang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B79","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s12640-013-9401-8","article-title":"Evaluation of nigrostriatal neurodegeneration and neuroinflammation following repeated intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in mice, an experimental model of Parkinson\u2019s disease","volume":"25","author":"Tristao","year":"2014","journal-title":"Neurotox Res"},{"key":"B80","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/srep00736","article-title":"Rapid Nipah virus entry into the central nervous system of hamsters via the olfactory route","volume":"2","author":"Munster","year":"2012","journal-title":"Sci Rep"},{"key":"B81","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s11481-012-9392-x","article-title":"Neuroinflammation, neuroautoimmunity, and the co-morbidities of complex regional pain syndrome","volume":"8","author":"Cooper","year":"2013","journal-title":"J Neuroimmune Pharmacol"},{"key":"B82","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.nbd.2015.12.017","article-title":"Ocular inflammation induces trigeminal pain, peripheral and central neuroinflammatory mechanisms","volume":"88","author":"Launay","year":"2016","journal-title":"Neurobiol Dis"},{"key":"B83","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1093\/brain\/awn345","article-title":"Live imaging of Toll-like receptor 2 response in cerebral ischaemia reveals a role of olfactory bulb microglia as modulators of inflammation","volume":"132","author":"Lalancette-Hebert","year":"2009","journal-title":"Brain"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00475\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:06:31Z","timestamp":1749686791000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00475\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,4]]},"references-count":83,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00475","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,4]]}}}