{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:10:33Z","timestamp":1792296633620,"version":"4.4.0"},"reference-count":76,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["M2015186"],"award-info":[{"award-number":["M2015186"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00542","type":"journal-article","created":{"date-parts":[[2016,11,28]],"date-time":"2016-11-28T09:35:05Z","timestamp":1480325705000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":35,"title":["Complement Regulator FHR-3 Is Elevated either Locally or Systemically in a Selection of Autoimmune Diseases"],"prefix":"10.3389","volume":"7","author":[{"given":"Nicole","family":"Sch\u00e4fer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Grosche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Reinders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie M.","family":"Hauck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard B.","family":"Pouw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taco W.","family":"Kuijpers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Wouters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boris","family":"Ehrenstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Enzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter F.","family":"Zipfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Skerka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Pauly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,11,28]]},"reference":[{"issue":"3","key":"B1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.molimm.2013.06.001","article-title":"Complement factor H related proteins (CFHRs)","volume":"56","author":"Skerka","year":"2013","journal-title":"Mol Immunol"},{"issue":"6","key":"B2","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1007\/s002510050534","article-title":"A radiation hybrid map of complement factor H and factor H-related genes","volume":"49","author":"D\u00edaz-Guill\u00e9n","year":"1999","journal-title":"Immunogenetics"},{"issue":"3","key":"B3","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/S0014-5793(99)01554-9","article-title":"Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and differential regulation by heparin","volume":"462","author":"Hellwage","year":"1999","journal-title":"FEBS Lett"},{"issue":"8","key":"B4","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.it.2008.04.008","article-title":"Factor H family proteins and human diseases","volume":"29","author":"J\u00f3zsi","year":"2008","journal-title":"Trends Immunol"},{"issue":"23","key":"B5","doi-asserted-by":"publisher","first-page":"4694","DOI":"10.1093\/hmg\/ddq399","article-title":"An imbalance of human complement regulatory proteins CFHR1, CFHR3 and factor H influences risk for age-related macular degeneration (AMD)","volume":"19","author":"Fritsche","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"3","key":"B6","doi-asserted-by":"publisher","first-page":"e0152164","DOI":"10.1371\/journal.pone.0152164","article-title":"Complement factor H-related protein 3 serum levels are low compared to factor H and mainly determined by gene copy number variation in CFHR3","volume":"11","author":"Pouw","year":"2016","journal-title":"PLoS One"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201600237","article-title":"A novel, multiplexed targeted mass spectrometry assay for quantification of complement factor H (CFH) variants and CFH-related proteins 1-5 in human plasma","author":"Zhang","year":"2016","journal-title":"Proteomics"},{"key":"B8","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1007\/978-1-62703-724-2_18","article-title":"Factor H-related proteins","volume":"1100","author":"J\u00f3zsi","year":"2014","journal-title":"Methods Mol Biol"},{"issue":"8","key":"B9","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1080\/07853890601097030","article-title":"Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications","volume":"38","author":"Hageman","year":"2006","journal-title":"Ann Med"},{"issue":"10","key":"B10","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1038\/ng1890","article-title":"A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration","volume":"38","author":"Hughes","year":"2006","journal-title":"Nat Genet"},{"issue":"7","key":"B11","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1093\/hmg\/ddm369","article-title":"Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration","volume":"17","author":"Spencer","year":"2008","journal-title":"Hum Mol Genet"},{"issue":"4","key":"B12","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/ng.787","article-title":"Genome-wide association study identifies susceptibility loci for IgA nephropathy","volume":"43","author":"Gharavi","year":"2011","journal-title":"Nat Genet"},{"issue":"19","key":"B13","doi-asserted-by":"publisher","first-page":"4261","DOI":"10.1182\/blood-2009-05-223834","article-title":"Characterization of complement factor H-related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndrome","volume":"114","author":"Abarrategui-Garrido","year":"2009","journal-title":"Blood"},{"issue":"3","key":"B14","doi-asserted-by":"publisher","first-page":"e41","DOI":"10.1371\/journal.pgen.0030041","article-title":"Deletion of complement factor H-related genes CFHR1 and CFHR3 is associated with atypical hemolytic uremic syndrome","volume":"3","author":"Zipfel","year":"2007","journal-title":"PLoS Genet"},{"issue":"5","key":"B15","doi-asserted-by":"publisher","first-page":"e1002079","DOI":"10.1371\/journal.pgen.1002079","article-title":"Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility","volume":"7","author":"Zhao","year":"2011","journal-title":"PLoS Genet"},{"issue":"1","key":"B16","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1006\/clim.2001.5043","article-title":"Complement-regulator factor H and related proteins in otitis media with effusion","volume":"100","author":"N\u00e4rki\u00f6-M\u00e4kel\u00e4","year":"2001","journal-title":"Clin Immunol"},{"issue":"6","key":"B17","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.it.2015.04.008","article-title":"Factor H-related proteins determine complement-activating surfaces","volume":"36","author":"J\u00f3zsi","year":"2015","journal-title":"Trends Immunol"},{"issue":"12","key":"B18","doi-asserted-by":"publisher","first-page":"4685","DOI":"10.1073\/pnas.1219260110","article-title":"Dimerization of complement factor h-related proteins modulates complement activation in vivo","volume":"110","author":"Goicoechea de Jorge","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7554\/eLife.04008","article-title":"Competition between antagonistic complement factors for a single protein on N. meningitidis rules disease susceptibility","volume":"3","author":"Caesar","year":"2014","journal-title":"Elife"},{"key":"B20","volume-title":"The Principles of Humane Experimental Technique","author":"Russell","year":"1959"},{"key":"B21","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.molimm.2016.03.001","article-title":"Rapid isolation of pure complement factor H from serum for functional studies by the use of a monoclonal antibody that discriminates FH from all the other isoforms","volume":"72","author":"Berra","year":"2016","journal-title":"Mol Immunol"},{"issue":"2","key":"B22","doi-asserted-by":"publisher","first-page":"620","DOI":"10.4049\/jimmunol.1600053","article-title":"FHR3 blocks C3d-mediated coactivation of human B cells","volume":"197","author":"Buhlmann","year":"2016","journal-title":"J Immunol"},{"issue":"6","key":"B23","doi-asserted-by":"publisher","first-page":"1528","DOI":"10.1038\/nprot.2007.209","article-title":"The Strep-tag system for one-step purification and high-affinity detection or capturing of proteins","volume":"2","author":"Schmidt","year":"2007","journal-title":"Nat Protoc"},{"issue":"5","key":"B24","doi-asserted-by":"publisher","first-page":"e96371","DOI":"10.1371\/journal.pone.0096371","article-title":"A novel antibody against human properdin inhibits the alternative complement system and specifically detects properdin from blood samples","volume":"9","author":"Pauly","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"B25","doi-asserted-by":"publisher","first-page":"2028","DOI":"10.1039\/b911525k","article-title":"Simultaneous quantification of five bacterial and plant toxins from complex matrices using a multiplexed fluorescent magnetic suspension assay","volume":"134","author":"Pauly","year":"2009","journal-title":"Analyst"},{"issue":"5259","key":"B26","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"key":"B27","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jprot.2012.12.027","article-title":"Changes in the hepatic mitochondrial and membrane proteome in mice fed a non-alcoholic steatohepatitis inducing diet","volume":"80","author":"Thomas","year":"2013","journal-title":"J Proteomics"},{"issue":"5","key":"B28","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparation method for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat Methods"},{"issue":"10","key":"B29","doi-asserted-by":"publisher","first-page":"2292","DOI":"10.1074\/mcp.M110.001073","article-title":"Deciphering membrane-associated molecular processes in target tissue of autoimmune uveitis by label-free quantitative mass spectrometry","volume":"9","author":"Hauck","year":"2010","journal-title":"Mol Cell Proteomics"},{"issue":"8","key":"B30","doi-asserted-by":"publisher","first-page":"2085","DOI":"10.1074\/mcp.M114.045690","article-title":"A combined omics approach to generate the surface atlas of human naive CD4+ T cells during early T-cell receptor activation","volume":"14","author":"Graessel","year":"2015","journal-title":"Mol Cell Proteomics"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.3791\/1431","article-title":"Fast and sensitive colloidal coomassie G-250 staining for proteins in polyacrylamide gels","volume":"30","author":"Dyballa","year":"2009","journal-title":"J Vis Exp"},{"issue":"3","key":"B32","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"issue":"2","key":"B33","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1074\/mcp.M115.052183","article-title":"The proteome of native adult M\u00fcller glial cells from murine retina","volume":"15","author":"Grosche","year":"2016","journal-title":"Mol Cell Proteomics"},{"key":"B34","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-1-62703-125-7_4","article-title":"The culture and maintenance of functional retinal pigment epithelial monolayers from adult human eye","volume":"945","author":"Blenkinsop","year":"2013","journal-title":"Methods Mol Biol"},{"issue":"2","key":"B35","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1006\/exer.1996.0020","article-title":"ARPE-19, a human retinal pigment epithelial cell line with differentiated properties","volume":"62","author":"Dunn","year":"1996","journal-title":"Exp Eye Res"},{"issue":"1","key":"B36","doi-asserted-by":"publisher","first-page":"C154","DOI":"10.1152\/ajpcell.00325.2011","article-title":"NHLBI-AbDesigner: an online tool for design of peptide-directed antibodies","volume":"302","author":"Pisitkun","year":"2012","journal-title":"Am J Physiol Cell Physiol"},{"issue":"Database issue","key":"B37","doi-asserted-by":"publisher","first-page":"D671","DOI":"10.1093\/nar\/gki088","article-title":"VBASE2, an integrative V gene database","volume":"33","author":"Retter","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"B38","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/B978-0-12-381270-4.00019-6","article-title":"ROSETTA3: An object-oriented software suite for the simulation and design of macromolecules","volume":"487","author":"Leaver-Fay","year":"2011","journal-title":"Methods Enzymol"},{"issue":"13","key":"B39","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera \u2013 a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J Comput Chem"},{"issue":"3","key":"B40","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0167-5699(94)90155-4","article-title":"Complement factor H and Related proteins: an expanding family of complement-regulatory proteins?","volume":"15","author":"Zipfel","year":"1994","journal-title":"Immunol Today"},{"issue":"12","key":"B41","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1016\/0161-5890(88)90051-X","article-title":"The Activation of C3 and C4 in human serum by immune complexes containing mouse monoclonal antibodies of different isotype and affinity: effects of solubilisation","volume":"25","author":"Stewart","year":"1988","journal-title":"Mol Immunol"},{"issue":"2","key":"B42","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1111\/j.1365-2249.1993.tb03446.x","article-title":"Activation of human complement by mouse and mouse\/human chimeric monoclonal antibodies","volume":"94","author":"Seino","year":"1993","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"B43","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.4049\/jimmunol.160.7.3342","article-title":"Identification of the second heparin-binding domain in human complement factor H","volume":"160","author":"Blackmore","year":"1998","journal-title":"J Immunol"},{"issue":"Suppl 8","key":"B44","doi-asserted-by":"publisher","first-page":"I9","DOI":"10.1016\/j.molimm.2013.06.001","article-title":"Complement factor H related proteins in immune diseases","volume":"26","author":"Skerka","year":"2008","journal-title":"Vaccine"},{"issue":"12","key":"B45","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1038\/ng.976","article-title":"A Rare penetrant mutation in CFH confers high risk of age-related macular degeneration","volume":"43","author":"Raychaudhuri","year":"2011","journal-title":"Nat Genet"},{"issue":"2","key":"B46","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.ajhg.2007.11.007","article-title":"Basal laminar drusen caused by compound heterozygous variants in the CFH gene","volume":"82","author":"Boon","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"2","key":"B47","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1006\/jmbi.2001.5337","article-title":"Molecular modelling of the C-terminal domains of factor H of human complement: a correlation between haemolytic uraemic syndrome and a predicted heparin binding site","volume":"316","author":"Stephen","year":"2002","journal-title":"J Mol Biol"},{"issue":"3","key":"B48","doi-asserted-by":"publisher","first-page":"1512","DOI":"10.1182\/blood-2007-09-109876","article-title":"Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1\/CFHR3 deficiency","volume":"111","author":"J\u00f3zsi","year":"2008","journal-title":"Blood"},{"issue":"23","key":"B49","doi-asserted-by":"publisher","first-page":"3949","DOI":"10.1021\/bi4003452","article-title":"Functional anatomy of complement factor H","volume":"52","author":"Makou","year":"2013","journal-title":"Biochemistry"},{"issue":"6","key":"B50","doi-asserted-by":"publisher","first-page":"314","DOI":"10.5551\/jat.13.314","article-title":"Serum apolipoprotein j in health, coronary heart disease and type 2 diabetes mellitus","volume":"13","author":"Kujiraoka","year":"2006","journal-title":"J Atheroscler Thromb"},{"issue":"2","key":"B51","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1007\/s00251-004-0660-7","article-title":"Genetic and environmental factors influencing the human factor H plasma levels","volume":"56","author":"Esparza-Gordillo","year":"2004","journal-title":"Immunogenetics"},{"key":"B52","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1146\/annurev.immunol.22.012703.104549","article-title":"The Role of Complement in the Development of Systemic Lupus Erythematosus","volume":"22","author":"Manderson","year":"2004","journal-title":"Annu Rev Immunol"},{"issue":"2","key":"B53","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1681\/ASN.2010060647","article-title":"complement factor H deficiency accelerates development of lupus nephritis","volume":"22","author":"Bao","year":"2011","journal-title":"J Am Soc Nephrol"},{"key":"B54","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1186\/s13075-015-0656-8","article-title":"Plasma complement factor H is associated with disease activity of patients with ANCA-associated vasculitis","volume":"17","author":"Chen","year":"2015","journal-title":"Arthritis Res Ther"},{"issue":"6937","key":"B55","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"issue":"7","key":"B56","doi-asserted-by":"publisher","first-page":"3560","DOI":"10.4049\/jimmunol.1203271","article-title":"Essential role of surface-bound complement factor H in controlling immune complex-induced arthritis","volume":"190","author":"Banda","year":"2013","journal-title":"J Immunol"},{"issue":"1","key":"B57","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.molimm.2014.06.028","article-title":"New insights into disease-specific absence of complement factor H related protein C in mouse models of spontaneous autoimmune diseases","volume":"62","author":"Mehta","year":"2014","journal-title":"Mol Immunol"},{"issue":"4","key":"B58","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1056\/NEJMra011913","article-title":"Polymyalgia rheumatica and giant-cell arteritis","volume":"347","author":"Salvarani","year":"2002","journal-title":"N Engl J Med"},{"issue":"3","key":"B59","first-page":"299","article-title":"Antibodies against Chlamydia pneumoniae, cytomegalovirus, enteroviruses and respiratory syncytial virus in patients with polymyalgia rheumatica","volume":"15","author":"Uddhammar","year":"1997","journal-title":"Clin Exp Rheumatol"},{"issue":"3","key":"B60","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/BF00319687","article-title":"Immunohistology of temporal arteritis: phenotyping of infiltrating cells and deposits of complement components","volume":"238","author":"Knecht","year":"1991","journal-title":"J Neurol"},{"issue":"6","key":"B61","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1136\/ard.46.6.468","article-title":"Isolation and analysis of immune complexes from sera of patients with polymyalgia rheumatica and giant cell arteritis","volume":"46","author":"Smith","year":"1987","journal-title":"Ann Rheum Dis"},{"issue":"6220","key":"B62","doi-asserted-by":"publisher","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"B63","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.preteyeres.2014.11.004","article-title":"Retinal microglia: just bystander or target for therapy?","volume":"45","author":"Karlstetter","year":"2015","journal-title":"Prog Retin Eye Res"},{"issue":"8","key":"B64","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.1167\/iovs.10-7119","article-title":"Analysis of complement expression in light-induced retinal degeneration: synthesis and deposition of C3 by Microglia\/macrophages is associated with focal photoreceptor degeneration","volume":"52","author":"Rutar","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"B65","doi-asserted-by":"publisher","first-page":"e93343","DOI":"10.1371\/journal.pone.0093343","article-title":"Synthesis and propagation of complement C3 by microglia\/monocytes in the aging retina","volume":"9","author":"Rutar","year":"2014","journal-title":"PLoS One"},{"issue":"39","key":"B66","doi-asserted-by":"publisher","first-page":"30192","DOI":"10.1074\/jbc.M110.103986","article-title":"Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch\u2019s membrane in human retina","volume":"285","author":"Clark","year":"2010","journal-title":"J Biol Chem"},{"issue":"14","key":"B67","article-title":"Complement regulatory protein expression by retinal M\u00fcller cells","volume":"53","author":"Sarthy","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"B68","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.exer.2013.04.016","article-title":"Complement expression in retinal pigment epithelial cells is modulated by activated macrophages","volume":"112","author":"Luo","year":"2013","journal-title":"Exp Eye Res"},{"issue":"3","key":"B69","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.exer.2011.01.003","article-title":"Retinal pigment epithelial cells upregulate expression of complement factors after co-culture with activated T cells","volume":"92","author":"Juel","year":"2011","journal-title":"Exp Eye Res"},{"issue":"4","key":"B70","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.molimm.2004.02.005","article-title":"The human complement factor H: functional roles, genetic variations and disease associations","volume":"41","author":"Rodr\u00edguez de C\u00f3rdoba","year":"2004","journal-title":"Mol Immunol"},{"issue":"April","key":"B71","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.redox.2015.11.011","article-title":"Oxidative stress-induced premature senescence dysregulates VEGF and CFH Expression in retinal pigment epithelial cells: implications for age-related macular degeneration","volume":"7","author":"Marazita","year":"2016","journal-title":"Redox Biol"},{"issue":"9","key":"B72","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1136\/bjo.2010.199216","article-title":"C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration","volume":"95","author":"Bhutto","year":"2011","journal-title":"Br J Ophthalmol"},{"issue":"36","key":"B73","doi-asserted-by":"publisher","first-page":"27657","DOI":"10.1074\/jbc.M002903200","article-title":"Each of the three binding sites on complement factor H interacts with a distinct site on C3b","volume":"275","author":"Jokiranta","year":"2000","journal-title":"J Biol Chem"},{"key":"B74","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.ejpb.2015.02.020","article-title":"Antibody therapies in age-related macular degeneration and challenges","volume":"95","author":"Volz","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"issue":"11","key":"B75","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1038\/nrneph.2012.214","article-title":"Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies","volume":"8","author":"Zuber","year":"2012","journal-title":"Nat Rev Nephrol"},{"issue":"5","key":"B76","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1177\/1759720X16665330","article-title":"Combination therapy with biologic agents in rheumatic diseases: current and future prospects","volume":"8","author":"Inui","year":"2016","journal-title":"Ther Adv Musculoskelet Dis"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00542\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T02:37:20Z","timestamp":1692585440000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00542\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,28]]},"references-count":76,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00542","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,28]]}}}