{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T13:42:40Z","timestamp":1793540560269,"version":"4.5.0"},"reference-count":100,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR059103"],"award-info":[{"award-number":["AR059103"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00604","type":"journal-article","created":{"date-parts":[[2016,12,20]],"date-time":"2016-12-20T07:21:52Z","timestamp":1482218512000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":257,"title":["Hall of Fame among Pro-inflammatory Cytokines: Interleukin-6 Gene and Its Transcriptional Regulation Mechanisms"],"prefix":"10.3389","volume":"7","author":[{"given":"Yang","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song Guo","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,12,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1378\/chest.118.2.503","article-title":"Proinflammatory cytokines","volume":"118","author":"Dinarello","year":"2000","journal-title":"Chest"},{"key":"B2","doi-asserted-by":"publisher","first-page":"E3246","DOI":"10.1073\/pnas.1421463112","article-title":"Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1","volume":"112","author":"Gao","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1016\/j.jaci.2016.09.011","article-title":"Innate lymphoid cells in allergic and nonallergic inflammation","volume":"138","author":"Morita","year":"2016","journal-title":"J Allergy Clin Immunol"},{"key":"B4","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1096\/fasebj.4.11.2199284","article-title":"Biology of multifunctional cytokines: IL 6 and related molecules (IL 1 and TNF)","volume":"4","author":"Akira","year":"1990","journal-title":"FASEB J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-2776(08)60532-5","article-title":"Interleukin-6 in biology and medicine","volume":"54","author":"Akira","year":"1993","journal-title":"Adv Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/0169-328X(95)00242-K","article-title":"Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide","volume":"36","author":"Goujon","year":"1996","journal-title":"Brain Res Mol Brain Res"},{"key":"B7","doi-asserted-by":"crossref","first-page":"412","DOI":"10.4049\/jimmunol.127.2.412","article-title":"T cell-replacing factor- (TRF) induced IgG secretion in a human B blastoid cell line and demonstration of acceptors for TRF","volume":"127","author":"Muraguchi","year":"1981","journal-title":"J Immunol"},{"key":"B8","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.4049\/jimmunol.128.3.1296","article-title":"Induction of proliferation and Ig production in human B leukemic cells by anti-immunoglobulins and T cell factors","volume":"128","author":"Yoshizaki","year":"1982","journal-title":"J Immunol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1158\/2326-6066.CIR-14-0022","article-title":"The biology and medical implications of interleukin-6","volume":"2","author":"Tanaka","year":"2014","journal-title":"Cancer Immunol Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1002\/eji.1830230226","article-title":"The soluble interleukin-6 receptor is generated by shedding","volume":"23","author":"Mullberg","year":"1993","journal-title":"Eur J Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/0092-8674(89)90438-8","article-title":"Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130","volume":"58","author":"Taga","year":"1989","journal-title":"Cell"},{"key":"B12","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1126\/science.3136546","article-title":"Cloning and expression of the human interleukin-6 (BSF-2\/IFN beta 2) receptor","volume":"241","author":"Yamasaki","year":"1988","journal-title":"Science"},{"key":"B13","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cytogfr.2012.04.001","article-title":"Plasticity and cross-talk of interleukin 6-type cytokines","volume":"23","author":"Garbers","year":"2012","journal-title":"Cytokine Growth Factor Rev"},{"key":"B14","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1007\/s00281-015-0501-9","article-title":"Regulating against the dysregulation: new treatment options in autoinflammation","volume":"37","author":"Kallinich","year":"2015","journal-title":"Semin Immunopathol"},{"issue":"Pt 2","key":"B15","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1042\/bj3000281","article-title":"Soluble receptors for cytokines and growth factors: generation and biological function","volume":"300","author":"Rose-John","year":"1994","journal-title":"Biochem J"},{"key":"B16","doi-asserted-by":"publisher","first-page":"7112","DOI":"10.4049\/jimmunol.180.11.7112","article-title":"Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6","volume":"180","author":"Zheng","year":"2008","journal-title":"J Immunol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.it.2012.07.003","article-title":"Interleukin-6: from an inflammatory marker to a target for inflammatory diseases","volume":"33","author":"Rincon","year":"2012","journal-title":"Trends Immunol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nature15252","article-title":"Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6","volume":"525","author":"Zhang","year":"2015","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/j.1460-2075.1995.tb07128.x","article-title":"A major role for the protein tyrosine kinase JAK1 in the JAK\/STAT signal transduction pathway in response to interleukin-6","volume":"14","author":"Guschin","year":"1995","journal-title":"EMBO J"},{"key":"B20","doi-asserted-by":"publisher","first-page":"6561","DOI":"10.1007\/s13277-015-4529-1","article-title":"Genetic variants in IL-6\/JAK\/STAT3 pathway and the risk of CRC","volume":"37","author":"Wang","year":"2016","journal-title":"Tumour Biol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/bj20030407","article-title":"Principles of interleukin (IL)-6-type cytokine signalling and its regulation","volume":"374","author":"Heinrich","year":"2003","journal-title":"Biochem J"},{"key":"B22","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.coi.2015.02.008","article-title":"The IL-6\/gp130\/STAT3 signaling axis: recent advances towards specific inhibition","volume":"34","author":"Garbers","year":"2015","journal-title":"Curr Opin Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1124\/mi.8.1.6","article-title":"Oncogenic ras-induced expression of cytokines: a new target of anti-cancer therapeutics","volume":"8","author":"Ancrile","year":"2008","journal-title":"Mol Interv"},{"key":"B24","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/j.cytogfr.2012.09.001","article-title":"Inhibition of the IL-6 signaling pathway: a strategy to combat chronic inflammatory diseases and cancer","volume":"24","author":"Ataie-Kachoie","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"key":"B25","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1073\/pnas.90.6.2207","article-title":"Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6","volume":"90","author":"Nakajima","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B26","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1038\/nrd1902","article-title":"Exploiting the PI3K\/AKT pathway for cancer drug discovery","volume":"4","author":"Hennessy","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"B27","doi-asserted-by":"publisher","first-page":"5219","DOI":"10.1073\/pnas.83.14.5219","article-title":"Human chromosome 7 carries the beta 2 interferon gene","volume":"83","author":"Sehgal","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B28","doi-asserted-by":"publisher","first-page":"2757","DOI":"10.1128\/MCB.10.6.2757","article-title":"Constitutive and interleukin-1 (IL-1)-inducible factors interact with the IL-1-responsive element in the IL-6 gene","volume":"10","author":"Isshiki","year":"1990","journal-title":"Mol Cell Biol"},{"key":"B29","doi-asserted-by":"crossref","first-page":"6177","DOI":"10.1016\/S0021-9258(18)68768-X","article-title":"Synthesis of interleukin 6 (interferon-beta 2\/B cell stimulatory factor 2) in human fibroblasts is triggered by an increase in intracellular cyclic AMP","volume":"263","author":"Zhang","year":"1988","journal-title":"J Biol Chem"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1128\/MCB.9.5.1908","article-title":"Identification of cis-acting sequences responsible for phorbol ester induction of human serum amyloid A gene expression via a nuclear factor kappaB-like transcription factor","volume":"9","author":"Edbrooke","year":"1989","journal-title":"Mol Cell Biol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/0092-8674(87)90611-8","article-title":"Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor","volume":"49","author":"Angel","year":"1987","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"crossref","first-page":"974","DOI":"10.4049\/jimmunol.140.3.974","article-title":"Transcriptional regulation of the interferon-beta 2\/B cell differentiation factor BSF-2\/hepatocyte-stimulating factor gene in human fibroblasts by other cytokines","volume":"140","author":"Walther","year":"1988","journal-title":"J Immunol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"6682","DOI":"10.1073\/pnas.83.18.6682","article-title":"Identification of a cyclic-AMP-responsive element within the rat somatostatin gene","volume":"83","author":"Montminy","year":"1986","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B34","doi-asserted-by":"publisher","first-page":"4443","DOI":"10.1128\/MCB.14.7.4443","article-title":"Multiple regulatory elements in the interleukin-6 gene mediate induction by prostaglandins, cyclic AMP, and lipopolysaccharide","volume":"14","author":"Dendorfer","year":"1994","journal-title":"Mol Cell Biol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/0923-2494(92)80011-9","article-title":"Regulation of IL6 gene expression","volume":"143","author":"Sehgal","year":"1992","journal-title":"Res Immunol"},{"key":"B36","first-page":"47","article-title":"Regulation of expression of the interleukin 6 gene: structure and function of the transcription factor NF-IL6","volume":"167","author":"Akira","year":"1992","journal-title":"Ciba Found Symp"},{"key":"B37","doi-asserted-by":"publisher","first-page":"5537","DOI":"10.1128\/MCB.9.12.5537","article-title":"A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation","volume":"9","author":"Ray","year":"1989","journal-title":"Mol Cell Biol"},{"key":"B38","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.4049\/jimmunol.141.11.3875","article-title":"Genomic structure of the murine IL-6 gene. High degree conservation of potential regulatory sequences between mouse and human","volume":"141","author":"Tanabe","year":"1988","journal-title":"J Immunol"},{"key":"B39","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1681\/ASN.V1071466","article-title":"Transcriptional regulation of the interleukin-6 gene in mesangial cells","volume":"10","author":"Grassl","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"6701","DOI":"10.1073\/pnas.85.18.6701","article-title":"Activation of the human \u201cbeta 2-interferon\/hepatocyte-stimulating factor\/interleukin 6\u201d promoter by cytokines, viruses, and second messenger agonists","volume":"85","author":"Ray","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1128\/MCB.17.1.1","article-title":"The mammalian transcriptional repressor RBP (CBF1) regulates interleukin-6 gene expression","volume":"17","author":"Kannabiran","year":"1997","journal-title":"Mol Cell Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1002\/1521-4141(200001)30:1108::AID-IMMU1083.3.CO;2-W","article-title":"Positive and negative regulatory elements contribute to CpG oligonucleotide-mediated regulation of human IL-6 gene expression","volume":"30","author":"Takeshita","year":"2000","journal-title":"Eur J Immunol"},{"key":"B43","doi-asserted-by":"publisher","first-page":"5488","DOI":"10.1128\/MCB.01657-08","article-title":"Hyperactivated NF-{kappa}B and AP-1 transcription factors promote highly accessible chromatin and constitutive transcription across the interleukin-6 gene promoter in metastatic breast cancer cells","volume":"29","author":"Ndlovu","year":"2009","journal-title":"Mol Cell Biol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1146\/annurev.cb.10.110194.002201","article-title":"Structure, regulation and function of NF-kappa B","volume":"10","author":"Siebenlist","year":"1994","journal-title":"Annu Rev Cell Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2327","DOI":"10.1128\/MCB.10.5.2327","article-title":"Activation of interleukin-6 gene expression through the NF-kappa B transcription factor","volume":"10","author":"Libermann","year":"1990","journal-title":"Mol Cell Biol"},{"key":"B46","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1016\/S1357-2725(96)00159-8","article-title":"Nuclear factor-kappa B","volume":"29","author":"Barnes","year":"1997","journal-title":"Int J Biochem Cell Biol"},{"key":"B47","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1111\/j.1600-065X.2012.01099.x","article-title":"NF-kappaB and the link between inflammation and cancer","volume":"246","author":"DiDonato","year":"2012","journal-title":"Immunol Rev"},{"key":"B48","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/cmi.2013.22","article-title":"Notch signaling regulates expression of Mcl-1 and apoptosis in PPD-treated macrophages","volume":"10","author":"Palaga","year":"2013","journal-title":"Cell Mol Immunol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1016\/0092-8674(86)90807-X","article-title":"Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism","volume":"47","author":"Sen","year":"1986","journal-title":"Cell"},{"key":"B50","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.tibs.2004.11.009","article-title":"Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation","volume":"30","author":"Viatour","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"B51","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.4161\/cc.6.18.4721","article-title":"Inhibition of the canonical IKK\/NF kappa B pathway sensitizes human cancer cells to doxorubicin","volume":"6","author":"Tapia","year":"2007","journal-title":"Cell Cycle"},{"key":"B52","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.cytogfr.2011.02.003","article-title":"IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer","volume":"22","author":"Neurath","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"B53","doi-asserted-by":"publisher","first-page":"266","DOI":"10.2174\/138920010791196283","article-title":"NF-kappa B signature on the aging wall","volume":"11","author":"Zineldeen","year":"2010","journal-title":"Curr Drug Metab"},{"key":"B54","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0092-8674(88)90382-0","article-title":"Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor","volume":"53","author":"Baeuerle","year":"1988","journal-title":"Cell"},{"issue":"Pt 2","key":"B55","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1101\/SQB.1988.053.01.089","article-title":"Phorbol-ester-induced activation of the NF-kappa B transcription factor involves dissociation of an apparently cytoplasmic NF-kappa B\/inhibitor complex","volume":"53","author":"Baeuerle","year":"1988","journal-title":"Cold Spring Harb Symp Quant Biol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1652","DOI":"10.1126\/science.2843985","article-title":"HTLV-I tax induces cellular proteins that activate the kappa B element in the IL-2 receptor alpha gene","volume":"241","author":"Ballard","year":"1988","journal-title":"Science"},{"key":"B57","doi-asserted-by":"publisher","first-page":"2331","DOI":"10.1073\/pnas.86.7.2331","article-title":"Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes","volume":"86","author":"Lowenthal","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B58","doi-asserted-by":"publisher","first-page":"1573","DOI":"10.1126\/science.3109035","article-title":"Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility","volume":"236","author":"Lenardo","year":"1987","journal-title":"Science"},{"key":"B59","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/j.1460-2075.1990.tb08316.x","article-title":"A nuclear factor for IL-6 expression (NF-IL6) is a member of a C\/EBP family","volume":"9","author":"Akira","year":"1990","journal-title":"EMBO J"},{"key":"B60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2015.09.003","article-title":"Inflammatory transcription factors as activation markers and functional readouts in immune-to-brain communication","volume":"54","author":"Rummel","year":"2016","journal-title":"Brain Behav Immun"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1126\/science.3289117","article-title":"The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins","volume":"240","author":"Landschulz","year":"1988","journal-title":"Science"},{"key":"B62","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1101\/gad.5.10.1754","article-title":"cAMP stimulates the C\/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription","volume":"5","author":"Metz","year":"1991","journal-title":"Genes Dev"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11629","article-title":"IkappaB-Kinase-epsilon (IKKepsilon) over-expression promotes the growth of prostate cancer through the C\/EBP-beta dependent activation of IL-6 gene expression","author":"Peant","year":"2016","journal-title":"Oncotarget"},{"key":"B64","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0065-2776(08)60740-3","article-title":"NF-IL6 and NF-kappa B in cytokine gene regulation","volume":"65","author":"Akira","year":"1997","journal-title":"Adv Immunol"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.immunol.23.021704.115806","article-title":"Interleukin-6: from basic science to medicine \u2013 40 years in immunology","volume":"23","author":"Kishimoto","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1002\/jcp.10116","article-title":"Transcription factors C\/EBP-beta and -delta regulate IL-6 production in IL-1beta-stimulated human enterocytes","volume":"192","author":"Hungness","year":"2002","journal-title":"J Cell Physiol"},{"key":"B67","doi-asserted-by":"publisher","first-page":"10193","DOI":"10.1073\/pnas.90.21.10193","article-title":"Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8","volume":"90","author":"Matsusaka","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B68","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1089\/107999001300177510","article-title":"CHOP, a basic leucine zipper transcriptional factor, contributes to the antiproliferative effect of IL-1 on A375 human melanoma cells through augmenting transcription of IL-6","volume":"21","author":"Hattori","year":"2001","journal-title":"J Interferon Cytokine Res"},{"key":"B69","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0014-5793(03)00283-7","article-title":"C\/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform","volume":"541","author":"Hattori","year":"2003","journal-title":"FEBS Lett"},{"key":"B70","doi-asserted-by":"publisher","first-page":"38827","DOI":"10.1074\/jbc.M206224200","article-title":"C\/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters","volume":"277","author":"Gao","year":"2002","journal-title":"J Biol Chem"},{"key":"B71","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.cyto.2010.12.019","article-title":"The CCAAT\/enhancer (C\/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation","volume":"54","author":"Tsukada","year":"2011","journal-title":"Cytokine"},{"key":"B72","first-page":"178","article-title":"Transcription factors as activators of gene transcription: AP-1 and NF-\u03baB","volume":"52","author":"Adcock","year":"1997","journal-title":"Monaldi Arch Chest Dis"},{"key":"B73","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1002\/jcp.24795","article-title":"Sphingosine-1-phosphate mediates COX-2 expression and PGE2\/IL-6 secretion via c-Src-dependent AP-1 activation","volume":"230","author":"Hsu","year":"2015","journal-title":"J Cell Physiol"},{"issue":"Suppl 1","key":"B74","doi-asserted-by":"publisher","first-page":"i86","DOI":"10.1136\/ard.2009.119396","article-title":"Bone development and inflammatory disease is regulated by AP-1 (Fos\/Jun)","volume":"69","author":"Wagner","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"B75","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1006\/excr.1999.4685","article-title":"AP-1: one switch for many signals","volume":"253","author":"Wisdom","year":"1999","journal-title":"Exp Cell Res"},{"key":"B76","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.mce.2007.12.017","article-title":"Activation of the cAMP pathway synergistically increases IL-1-induced IL-6 gene expression in FRTL-5 thyroid cells: involvement of AP-1 transcription factors","volume":"284","author":"Szabo-Fresnais","year":"2008","journal-title":"Mol Cell Endocrinol"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.4161\/cbt.3.10.1141","article-title":"NF-kappaB activates IL-6 expression through cooperation with c-Jun and IL6-AP1 site, but is independent of its IL6-NFkappaB regulatory site in autocrine human multiple myeloma cells","volume":"3","author":"Xiao","year":"2004","journal-title":"Cancer Biol Ther"},{"key":"B78","first-page":"2206","article-title":"Constitutive activation of nuclear factor kappaB p50\/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer","volume":"63","author":"Zerbini","year":"2003","journal-title":"Cancer Res"},{"key":"B79","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/S0303-7207(02)00221-6","article-title":"Regulation of the activity of Sp1-related transcription factors","volume":"195","author":"Bouwman","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"B80","doi-asserted-by":"publisher","first-page":"7330","DOI":"10.1074\/jbc.271.13.7330","article-title":"Binding and functional effects of transcriptional factor Sp1 on the murine interleukin-6 promotor","volume":"271","author":"Kang","year":"1996","journal-title":"J Biol Chem"},{"key":"B81","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1002\/j.1460-2075.1993.tb06029.x","article-title":"A cooperative interaction between NF-kappa B and Sp1 is required for HIV-1 enhancer activation","volume":"12","author":"Perkins","year":"1993","journal-title":"EMBO J"},{"key":"B82","doi-asserted-by":"publisher","first-page":"3162","DOI":"10.1073\/pnas.90.8.3162","article-title":"Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components","volume":"90","author":"Bidwell","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B83","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1016\/j.cellsig.2008.04.004","article-title":"Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells","volume":"20","author":"Gerlo","year":"2008","journal-title":"Cell Signal"},{"key":"B84","doi-asserted-by":"crossref","first-page":"8397","DOI":"10.1021\/bi00084a003","article-title":"Nuclear matrix association of multiple sequence-specific DNA binding activities related to SP-1, ATF, CCAAT, C\/EBP, OCT-1, and AP-1","volume":"32","author":"van Wijnen","year":"1993","journal-title":"Biochemistry"},{"key":"B85","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1002\/eji.1830271140","article-title":"Molecular mechanisms regulating induction of interleukin-6 gene transcription by interferon-gamma","volume":"27","author":"Faggioli","year":"1997","journal-title":"Eur J Immunol"},{"key":"B86","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1016\/j.cellimm.2011.07.014","article-title":"Targeting interferon regulatory factors to inhibit activation of the type I IFN response: implications for treatment of autoimmune disorders","volume":"271","author":"Sweeney","year":"2011","journal-title":"Cell Immunol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.mad.2004.06.010","article-title":"Mechanisms of glucocorticoid receptor signaling during inflammation","volume":"125","author":"Smoak","year":"2004","journal-title":"Mech Ageing Dev"},{"key":"B88","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1189\/jlb.71.1.9","article-title":"Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor","volume":"71","author":"Almawi","year":"2002","journal-title":"J Leukoc Biol"},{"key":"B89","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1002\/jbmr.5650080810","article-title":"Role of the negative glucocorticoid regulatory element in glucocorticoid repression of the human osteocalcin promoter","volume":"8","author":"Morrison","year":"1993","journal-title":"J Bone Miner Res"},{"key":"B90","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1210\/mend.9.4.7659084","article-title":"Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids","volume":"9","author":"Caldenhoven","year":"1995","journal-title":"Mol Endocrinol"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/0092-8674(90)90397-W","article-title":"Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor","volume":"62","author":"Schule","year":"1990","journal-title":"Cell"},{"key":"B92","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.cyto.2004.12.008","article-title":"Estrogen receptor inhibits interleukin-6 gene expression by disruption of nuclear factor kappaB transactivation","volume":"31","author":"Liu","year":"2005","journal-title":"Cytokine"},{"key":"B93","doi-asserted-by":"crossref","first-page":"12940","DOI":"10.1016\/S0021-9258(18)99966-7","article-title":"Down-modulation of interleukin-6 gene expression by 17 beta-estradiol in the absence of high affinity DNA binding by the estrogen receptor","volume":"269","author":"Ray","year":"1994","journal-title":"J Biol Chem"},{"key":"B94","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1146\/annurev.med.51.1.245","article-title":"Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty","volume":"51","author":"Ershler","year":"2000","journal-title":"Annu Rev Med"},{"key":"B95","doi-asserted-by":"publisher","first-page":"18138","DOI":"10.1074\/jbc.M000379200","article-title":"Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation","volume":"275","author":"Terry","year":"2000","journal-title":"J Biol Chem"},{"key":"B96","doi-asserted-by":"publisher","first-page":"479","DOI":"10.4149\/BLL_2014_092","article-title":"IL-6 gene promoter polymorphisms: genetic susceptibility to recurrent pregnancy loss","volume":"115","author":"Demirturk","year":"2014","journal-title":"Bratisl Lek Listy"},{"key":"B97","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1172\/JCI2629","article-title":"The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis","volume":"102","author":"Fishman","year":"1998","journal-title":"J Clin Invest"},{"key":"B98","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/j.1600-0897.2005.00250.x","article-title":"A case-control study in IL6 and TGFB1 gene polymorphisms and recurrent spontaneous abortion in southern Brazilian patients","volume":"53","author":"von Linsingen","year":"2005","journal-title":"Am J Reprod Immunol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/j.jsgi.2005.03.005","article-title":"The interleukin-6 \u2013 174G\/C promoter polymorphism is not associated with endometriosis in South Indian women","volume":"12","author":"Bhanoori","year":"2005","journal-title":"J Soc Gynecol Investig"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1007\/s10815-013-0111-1","article-title":"An interleukin-6 gene promoter polymorphism is associated with polycystic ovary syndrome in South Indian women","volume":"30","author":"Tumu","year":"2013","journal-title":"J Assist Reprod Genet"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00604\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T10:44:43Z","timestamp":1692614683000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00604\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,19]]},"references-count":100,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00604","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,19]]}}}