{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:52:53Z","timestamp":1763747573090,"version":"3.37.3"},"reference-count":40,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB643_B15"],"award-info":[{"award-number":["SFB643_B15"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00622","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T03:47:01Z","timestamp":1482292021000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["CD4 T Helper Cells Instruct Lymphopenia-Induced Memory-Like CD8 T Cells for Control of Acute LCMV Infection"],"prefix":"10.3389","volume":"7","author":[{"given":"Michaela E. R.","family":"Schmitt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selina","family":"Sitte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Voehringer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nri853","article-title":"Maintaining the norm: T-cell homeostasis","volume":"2","author":"Jameson","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.immuni.2008.11.002","article-title":"Homeostasis of naive and memory T cells","volume":"29","author":"Surh","year":"2008","journal-title":"Immunity"},{"key":"B3","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.coi.2005.07.020","article-title":"T cell development and receptor diversity during aging","volume":"17","author":"Goronzy","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"B4","doi-asserted-by":"crossref","first-page":"6657","DOI":"10.4049\/jimmunol.151.12.6657","article-title":"Unexpected expansions of CD8-bearing cells in old mice","volume":"151","author":"Callahan","year":"1993","journal-title":"J Immunol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"7446","DOI":"10.4049\/jimmunol.174.11.7446","article-title":"The influence of age on T cell generation and TCR diversity","volume":"174","author":"Naylor","year":"2005","journal-title":"J Immunol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"3364","DOI":"10.4049\/jimmunol.0900641","article-title":"Memory-like CD8+ T cells generated during homeostatic proliferation defer to antigen-experienced memory cells","volume":"183","author":"Cheung","year":"2009","journal-title":"J Immunol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"1700","DOI":"10.4049\/jimmunol.181.3.1700","article-title":"IFN-gamma induces the erosion of preexisting CD8 T cell memory during infection with a heterologous intracellular bacterium","volume":"181","author":"Dudani","year":"2008","journal-title":"J Immunol"},{"key":"B8","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1016\/S1074-7613(00)80147-8","article-title":"Attrition of T cell memory: selective loss of LCMV epitope-specific memory CD8 T cells following infections with heterologous viruses","volume":"11","author":"Selin","year":"1999","journal-title":"Immunity"},{"key":"B9","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S1074-7613(00)80093-X","article-title":"Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts","volume":"11","author":"Goldrath","year":"1999","journal-title":"Immunity"},{"key":"B10","doi-asserted-by":"publisher","first-page":"5664","DOI":"10.4049\/jimmunol.167.10.5664","article-title":"Homeostatic expansion occurs independently of costimulatory signals","volume":"167","author":"Prlic","year":"2001","journal-title":"J Immunol"},{"key":"B11","doi-asserted-by":"publisher","first-page":"20394","DOI":"10.1073\/pnas.0909954106","article-title":"Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo","volume":"106","author":"Do","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B12","doi-asserted-by":"publisher","first-page":"3874","DOI":"10.1073\/pnas.0400606101","article-title":"Spontaneous proliferation, a response of naive CD4 T cells determined by the diversity of the memory cell repertoire","volume":"101","author":"Min","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B13","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0092-8674(04)00335-6","article-title":"Homeostatic expansion of T cells during immune insufficiency generates autoimmunity","volume":"117","author":"King","year":"2004","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1182\/blood-2008-12-192120","article-title":"Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development","volume":"114","author":"Le Campion","year":"2009","journal-title":"Blood"},{"key":"B15","doi-asserted-by":"publisher","first-page":"19414","DOI":"10.1073\/pnas.0807743105","article-title":"Memory-like CD8+ and CD4+ T cells cooperate to break peripheral tolerance under lymphopenic conditions","volume":"105","author":"Le Saout","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B16","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1016\/S1568-9972(02)00086-1","article-title":"HIV and autoimmunity","volume":"1","author":"Zandman-Goddard","year":"2002","journal-title":"Autoimmun Rev"},{"issue":"Suppl 1","key":"B17","doi-asserted-by":"publisher","first-page":"S133","DOI":"10.1016\/j.jcpa.2009.09.009","article-title":"Strategies to improve the effect of vaccination in the elderly: the vaccine producer\u2019s perspective","volume":"142","author":"Guy","year":"2010","journal-title":"J Comp Pathol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1084\/jem.20081829","article-title":"The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion","volume":"206","author":"Haluszczak","year":"2009","journal-title":"J Exp Med"},{"key":"B19","doi-asserted-by":"publisher","first-page":"16885","DOI":"10.1073\/pnas.0407417101","article-title":"The molecular program induced in T cells undergoing homeostatic proliferation","volume":"101","author":"Goldrath","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B20","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1038\/ni1326","article-title":"The generation of protective memory-like CD8+ T cells during homeostatic proliferation requires CD4+ T cells","volume":"7","author":"Hamilton","year":"2006","journal-title":"Nat Immunol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"18484","DOI":"10.1073\/pnas.0806487105","article-title":"The nature of the lymphopenic environment dictates protective function of homeostatic-memory CD8+ T cells","volume":"105","author":"Hamilton","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B22","doi-asserted-by":"publisher","first-page":"4742","DOI":"10.4049\/jimmunol.180.7.4742","article-title":"Homeostasis and effector function of lymphopenia-induced \u201cmemory-like\u201d T cells in constitutively T cell-depleted mice","volume":"180","author":"Voehringer","year":"2008","journal-title":"J Immunol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S1074-7613(01)00227-8","article-title":"A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival","volume":"15","author":"Lee","year":"2001","journal-title":"Immunity"},{"key":"B24","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1002\/eji.200490005","article-title":"Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key","volume":"34","author":"Bachmann","year":"2004","journal-title":"Eur J Immunol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/s002510100314","article-title":"Viral escape from the neutralizing antibody response: the lymphocytic choriomeningitis virus model","volume":"53","author":"Ciurea","year":"2001","journal-title":"Immunogenetics"},{"key":"B26","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1038\/nri1783","article-title":"Antiviral antibody responses: the two extremes of a wide spectrum","volume":"6","author":"Hangartner","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2321","DOI":"10.1084\/jem.20062150","article-title":"Programmed death-1 (PD-1) defines a transient and dysfunctional oligoclonal T cell population in acute homeostatic proliferation","volume":"204","author":"Lin","year":"2007","journal-title":"J Exp Med"},{"key":"B28","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1038\/nature04444","article-title":"Restoring function in exhausted CD8 T cells during chronic viral infection","volume":"439","author":"Barber","year":"2006","journal-title":"Nature"},{"key":"B29","doi-asserted-by":"publisher","first-page":"2124","DOI":"10.4049\/jimmunol.181.3.2124","article-title":"Naive precursor frequencies and MHC binding rather than the degree of epitope diversity shape CD8+ T cell immunodominance","volume":"181","author":"Kotturi","year":"2008","journal-title":"J Immunol"},{"key":"B30","doi-asserted-by":"publisher","first-page":"12907","DOI":"10.1128\/JVI.01722-09","article-title":"High frequencies of virus-specific CD8+ T-cell precursors","volume":"83","author":"Seedhom","year":"2009","journal-title":"J Virol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.4049\/jimmunol.172.5.3151","article-title":"Very diverse CD8 T cell clonotypic responses after virus infections","volume":"172","author":"Pewe","year":"2004","journal-title":"J Immunol"},{"key":"B32","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1111\/j.0105-2896.2006.00395.x","article-title":"Functional signatures of protective antiviral T-cell immunity in human virus infections","volume":"211","author":"Harari","year":"2006","journal-title":"Immunol Rev"},{"key":"B33","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00281-006-0025-4","article-title":"Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection","volume":"28","author":"Makedonas","year":"2006","journal-title":"Springer Semin Immunopathol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1038\/364798a0","article-title":"Mice lacking the tumour necrosis factor receptor 1 are resistant to TNF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes","volume":"364","author":"Rothe","year":"1993","journal-title":"Nature"},{"key":"B35","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1111\/j.1600-065X.1995.tb00090.x","article-title":"Immune defence in mice lacking type I and\/or type II interferon receptors","volume":"148","author":"van den Broek","year":"1995","journal-title":"Immunol Rev"},{"key":"B36","doi-asserted-by":"publisher","first-page":"4838","DOI":"10.4049\/jimmunol.167.9.4838","article-title":"Viral infections induce abundant numbers of senescent CD8 T cells","volume":"167","author":"Voehringer","year":"2001","journal-title":"J Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"3698","DOI":"10.1182\/blood-2002-02-0657","article-title":"Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1)","volume":"100","author":"Voehringer","year":"2002","journal-title":"Blood"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1084\/jem.20142237","article-title":"Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells","volume":"212","author":"Odorizzi","year":"2015","journal-title":"J Exp Med"},{"key":"B39","doi-asserted-by":"publisher","first-page":"14733","DOI":"10.1073\/pnas.1009731107","article-title":"Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection","volume":"107","author":"Jin","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B40","doi-asserted-by":"publisher","first-page":"2604","DOI":"10.1172\/JCI67008","article-title":"PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells","volume":"123","author":"West","year":"2013","journal-title":"J Clin Invest"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00622\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T09:54:38Z","timestamp":1718963678000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00622\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,21]]},"references-count":40,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00622","relation":{},"ISSN":["1664-3224"],"issn-type":[{"type":"electronic","value":"1664-3224"}],"subject":[],"published":{"date-parts":[[2016,12,21]]}}}