{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:05:48Z","timestamp":1790201148955,"version":"4.1.0"},"reference-count":41,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81170485, 81170488, 81370657, 81470328"],"award-info":[{"award-number":["81170485, 81170488, 81370657, 81470328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institute","award":["JX10231801"],"award-info":[{"award-number":["JX10231801"]}]},{"name":"Project of National Key Clinical Specialty"},{"name":"National Science & Technology Pillar Program","award":["2014BAI09B12"],"award-info":[{"award-number":["2014BAI09B12"]}]},{"name":"Jiangsu Provincial Special Program of Medical Science","award":["BL2014086"],"award-info":[{"award-number":["BL2014086"]}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Immunol."],"DOI":"10.3389\/fimmu.2016.00654","type":"journal-article","created":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T22:44:12Z","timestamp":1482792252000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":19,"title":["Investigating Factors Associated with Thymic Regeneration after Chemotherapy in Patients with Lymphoma"],"prefix":"10.3389","volume":"7","author":[{"given":"Dao-Ping","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong-Yang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Yuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2016,12,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.smim.2007.10.004","article-title":"T cell immune reconstitution following lymphodepletion","volume":"19","author":"Williams","year":"2007","journal-title":"Semin Immunol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/j.smim.2007.10.001","article-title":"Human thymus regeneration and T cell reconstitution","volume":"19","author":"Legrand","year":"2007","journal-title":"Semin Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1385\/IR:22:2-3:253","article-title":"The human thymus during aging","volume":"22","author":"Haynes","year":"2000","journal-title":"Immunol Res"},{"key":"B4","doi-asserted-by":"publisher","first-page":"269","DOI":"10.2214\/ajr.149.2.269","article-title":"Thymic atrophy and regrowth in response to chemotherapy: CT evaluation","volume":"149","author":"Choyke","year":"1987","journal-title":"AJR Am J Roentgenol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"e1137417","DOI":"10.1080\/2162402X.2015.1137417","article-title":"Thymic hyperplasia after chemotherapy in adults with mature B cell lymphoma and its influence on thymic output and CD4 T cells repopulation","volume":"5","author":"Sun","year":"2016","journal-title":"Oncoimmunology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/j.1365-2362.2005.01499.x","article-title":"Age-related thymic activity in adults following chemotherapy-induced lymphopenia","volume":"35","author":"Sfikakis","year":"2005","journal-title":"Eur J Clin Invest"},{"key":"B7","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1056\/NEJM199501193320303","article-title":"Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy","volume":"332","author":"Mackall","year":"1995","journal-title":"N Engl J Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1093\/jjco\/hyq149","article-title":"Clinical analysis of thymic regrowth following chemotherapy in children and adolescents with malignant lymphoma","volume":"40","author":"Zhen","year":"2010","journal-title":"Jpn J Clin Oncol"},{"key":"B9","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/j.1742-1241.2006.00950.x","article-title":"Rebound thymic enlargement on CT in adults","volume":"61","author":"Yarom","year":"2007","journal-title":"Int J Clin Pract"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.3109\/10428194.2014.986480","article-title":"Thymic hyperplasia following chemotherapy in adults with lymphoma: F-fluorodeoxyglucose positron emission tomography\/computed tomography findings and correlation with T cell repopulation","volume":"56","author":"Sun","year":"2015","journal-title":"Leuk Lymphoma"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.2214\/ajr.173.5.10541115","article-title":"Thymic hyperplasia after high-dose chemotherapy and autologous stem cell transplantation","volume":"173","author":"Hara","year":"1999","journal-title":"AJR Am J Roentgenol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.coph.2010.04.006","article-title":"Getting back at nature: understanding thymic development and overcoming its atrophy","volume":"10","author":"Heng","year":"2010","journal-title":"Curr Opin Pharmacol"},{"key":"B13","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/bjc.1996.474","article-title":"Gonadal atrophy as a cause of thymic hyperplasia after chemotherapy","volume":"74","author":"Sperandio","year":"1996","journal-title":"Br J Cancer"},{"key":"B14","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S1074-7613(00)80517-8","article-title":"The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression","volume":"7","author":"von","year":"1997","journal-title":"Immunity"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1182\/blood.V97.5.1491","article-title":"IL-7 increases both thymic-dependent and thymic-independent T cell regeneration after bone marrow transplantation","volume":"97","author":"Mackall","year":"2001","journal-title":"Blood"},{"key":"B16","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1182\/blood.V98.7.2256","article-title":"Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease","volume":"98","author":"Alpdogan","year":"2001","journal-title":"Blood"},{"key":"B17","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1097\/00002030-200305020-00002","article-title":"Endogenous IL-7 is associated with increased thymic volume in adult HIV-infected patients under highly active antiretroviral therapy","volume":"17","author":"Ruiz-Mateos","year":"2003","journal-title":"AIDS"},{"key":"B18","doi-asserted-by":"publisher","first-page":"R80","DOI":"10.1186\/ar1538","article-title":"Interleukin-7 deficiency in rheumatoid arthritis: consequences for therapy-induced lymphopenia","volume":"7","author":"Ponchel","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"B19","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1089\/rej.2009.0863","article-title":"Elevated proportions of recent thymic emigrants in children and adolescents with type 1 diabetes","volume":"12","author":"Hofer","year":"2009","journal-title":"Rejuvenation Res"},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3109\/15476910903453296","article-title":"An overview of IL-7 biology and its use in immunotherapy","volume":"7","author":"ElKassar","year":"2010","journal-title":"J Immunotoxicol"},{"key":"B21","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.smim.2012.04.010","article-title":"IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis","volume":"24","author":"Carrette","year":"2012","journal-title":"Semin Immunol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/sj.ejhg.5200994","article-title":"Identification of 11 novel and common single nucleotide polymorphisms in the interleukin-7 receptor-alpha gene and their associations with multiple sclerosis","volume":"11","author":"Teutsch","year":"2003","journal-title":"Eur J Hum Genet"},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sj.gene.6364436","article-title":"Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis","volume":"9","author":"McKay","year":"2008","journal-title":"Genes Immun"},{"key":"B24","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1007\/s00109-005-0684-y","article-title":"Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis","volume":"83","author":"Booth","year":"2005","journal-title":"J Mol Med (Berl)"},{"key":"B25","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1038\/gene.2009.106","article-title":"Haplotype 4 of the multiple sclerosis-associated IL-7Ra influences the frequency of RTE","volume":"11","author":"Broux","year":"2010","journal-title":"Genes Immun"},{"key":"B26","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1038\/ng2103","article-title":"Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis","volume":"39","author":"Gregory","year":"2007","journal-title":"Nat Genet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1111\/sji.12077","article-title":"Polymorphism in the interleukin-7 receptor-alpha and outcome after allogeneic hematopoietic cell transplantation with matched unrelated donor","volume":"78","author":"Shamim","year":"2013","journal-title":"Scand J Immunol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1097\/QAD.0000000000000354","article-title":"Polymorphism in interleukin-7 receptor a gene is associated with faster CD4+ T cell recovery after initiation of combination antiretroviral therapy","volume":"28","author":"Hartling","year":"2014","journal-title":"AIDS"},{"key":"B29","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/gene.2011.65","article-title":"The role of SNPs in the alpha-chain of the IL-7R gene in CD4+ T-cell recovery in HIV-infected African patients receiving suppressive cART","volume":"13","author":"Rajasuriar","year":"2012","journal-title":"Genes Immun"},{"key":"B30","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1007\/s10753-013-9777-x","article-title":"Interleukin-7 receptor single nucleotide polymorphism rs6897932 (C\/T) and the susceptibility to systemic lupus erythematosus","volume":"37","author":"Wang","year":"2014","journal-title":"Inflammation"},{"key":"B31","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1097\/TP.0b013e31820f08b2","article-title":"Prognostic significance of interleukin-7 receptor-\u03b1 gene polymorphisms in allogeneic stem-cell transplantation: a confirmatory study","volume":"91","author":"Shamim","year":"2011","journal-title":"Transplantation"},{"key":"B32","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/j.1399-0039.2009.01342.x","article-title":"IL7RA polymorphisms and chronic inflammatory arthropathies","volume":"74","author":"O\u2019Doherty","year":"2009","journal-title":"Tissue Antigens"},{"key":"B33","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1111\/sji.12096","article-title":"Impaired thymic output in patients with chronic hepatitis C virus infection","volume":"78","author":"Hartling","year":"2013","journal-title":"Scand J Immunol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1016\/S1074-7613(00)80056-4","article-title":"Generation of functional thymocytes in the human adult","volume":"10","author":"Jamieson","year":"1999","journal-title":"Immunity"},{"key":"B35","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.blre.2013.07.002","article-title":"Anti-CD20 monoclonal antibodies: beyond B-cells","volume":"27","author":"Avivi","year":"2013","journal-title":"Blood Rev"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.4049\/jimmunol.1600089","article-title":"Features of human CD3+CD20+ T Cells","volume":"197","author":"Schuh","year":"2016","journal-title":"J Immunol"},{"key":"B37","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1097\/MOT.0b013e3283615df9","article-title":"Repairing thymic function","volume":"18","author":"Nunes-Cabaco","year":"2013","journal-title":"Curr Opin Organ Transplant"},{"key":"B38","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1038\/nri3534","article-title":"Thymus involution and regeneration: two sides of the same coin?","volume":"13","author":"Boehm","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1182\/blood.V99.8.2851","article-title":"Effects of exogenous interleukin-7 on human thymus function","volume":"99","author":"Okamoto","year":"2002","journal-title":"Blood"},{"key":"B40","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.jim.2009.11.007","article-title":"A reliable and simplified sj\u03b2-TREC ratio quantification method for human thymic output measurement","volume":"352","author":"Ferrando-Mart\u0131nez","year":"2010","journal-title":"J Immunol Methods"},{"key":"B41","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1182\/blood-2008-07-166223","article-title":"IL-7 sustains CD31 expression in human naive CD4+ T cells and preferentially expands the CD31+ subset in a PI3K-dependent manner","volume":"113","author":"Azevedo","year":"2009","journal-title":"Blood"}],"container-title":["Frontiers in Immunology"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00654\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,12,26]],"date-time":"2016-12-26T22:44:23Z","timestamp":1482792263000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fimmu.2016.00654\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,27]]},"references-count":41,"URL":"https:\/\/doi.org\/10.3389\/fimmu.2016.00654","relation":{},"ISSN":["1664-3224"],"issn-type":[{"value":"1664-3224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,27]]}}}